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Genomes and GenesSpecies | Patrick M LynchSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Global quantitative assessment of the colorectal polyp burden in familial adenomatous polyposis by using a web-based toolPatrick M Lynch
Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Gastrointest Endosc 77:455-63. 2013..Accurate measures of the total polyp burden in familial adenomatous polyposis (FAP) are lacking. Current assessment tools include polyp quantitation in limited-field photographs and qualitative total colorectal polyp burden by video...
Current approaches in hereditary nonpolyposis colorectal cancerPatrick M Lynch
Department of Gastroenterology, Hepatology and Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Natl Compr Canc Netw 10:961-7. 2012..For various reasons, however, no agent or combination of agents has yet come into routine use in either condition, with further trials underway or being designed for both conditions...- Small bowel tumorsEmad M Abu-Hamda
Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 436, Houston, TX 77030, USA
Curr Gastroenterol Rep 5:386-93. 2003..The management of primary malignant small bowel tumors is invariably surgical. However, adjuvant chemotherapy and radiotherapy may be warranted, depending on the type of tumor... - New issues in genetic counseling of hereditary colon cancerPatrick M Lynch
Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
Clin Cancer Res 13:6857s-61s. 2007..Finally, as investigators make progress with the genetics of these rare diseases, one can anticipate a "cooperative group" approach to clinical trials... 
Pharmacotherapy for inherited colorectal cancerPatrick M Lynch
The University of Texas MD Anderson Cancer Center, Department of Gastroenterology, Hepatology and Nutrition, 1515 Holcombe Blvd, Unit 1466, Houston, Texas, USA
Expert Opin Pharmacother 11:1101-8. 2010..This review is written in the interest of capturing the current state of chemoprevention in familial adenomatous polyposis (FAP). This will take a decidedly clinical perspective...- Does regular use of aspirin reduce the risk of colorectal cancer?Patrick M Lynch
Department of Gastrointestinal Medicine and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Nat Clin Pract Oncol 3:186-7. 2006 - The safety and efficacy of celecoxib in children with familial adenomatous polyposisPatrick M Lynch
Department of Gastroenterology, Hepatology and Nutrition, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
Am J Gastroenterol 105:1437-43. 2010..Its safety and efficacy for colorectal polyps in children is unknown. We evaluated the short-term (3 months) safety and preliminary efficacy of celecoxib in children with FAP... - Current approaches in familial colorectal cancer: a clinical perspectivePatrick M Lynch
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
J Natl Compr Canc Netw 4:421-30. 2006..The NCCN guidelines are used as a frame of reference for this discussion of selected recent advances in human cancer genetics as they apply to clinical practice... - Standards of care in diagnosis and testing for hereditary colon cancerPatrick M Lynch
Department of Gastrointestinal Medicine and Nutrition 436, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
Fam Cancer 7:65-72. 2008..This paper undertakes to provide practitioners and academics some perspective on clinical practice guidelines and their potential for medical-legal application... - The hMSH2 and hMLH1 genes in hereditary nonpolyposis colorectal cancerPatrick M Lynch
Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Surg Oncol Clin N Am 18:611-24. 2009..It is not always possible to discuss these specific genes without commenting on the broader problem of HNPCC diagnosis and management... - Prevention of colorectal cancer in high-risk populations: the increasing role for endoscopy and chemoprevention in FAP and HNPCCPatrick M Lynch
Department of GI Medicine, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Digestion 76:68-76. 2007..Surveillance, chemoprevention, and imaginative hybrid surveillance/endoscopic therapy/chemoprevention trials may gradually decrease the present dependence on prophylactic colectomy/proctocolectomy... - COX-2 inhibition in clinical cancer preventionP M Lynch
Department of Gastrointestinal Medicine and Nutrition, University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
Oncology (Williston Park) 15:21-6. 2001.... - Chemoprevention with special reference to inherited colorectal cancerPatrick M Lynch
Department of Gastrointestinal Medicine and Nutrition 436, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1402, USA
Fam Cancer 7:59-64. 2008..The historical development of chemoprevention in FAP will be presented, with an emphasis on issues of trial design... - p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian populationJ Shawn Jones
Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 10:5845-9. 2004..We studied the influence of this p53 polymorphism on HNPCC age of onset... - DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onsetJ Shawn Jones
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 15:886-91. 2006.... - ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States)J Shawn Jones
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Causes Control 16:749-53. 2005..ATM germline mutations have been associated with breast and digestive cancers. In a smaller European study, the G-to-A polymorphism was associated with an increased risk of developing an HNPCC-related cancer within HNPCC families... - Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndromeMala Pande
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 17:2393-401. 2008..Our results suggest that the I462V and Msp1 polymorphisms in CYP1A1 may be an additional susceptibility factor for disease expression in Lynch syndrome because they modify the age of colorectal cancer onset by up to 4 years... - Cell proliferation and apoptotic indices predict adenoma regression in a placebo-controlled trial of celecoxib in familial adenomatous polyposis patientsFrank A Sinicrope
Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston, USA
Cancer Epidemiol Biomarkers Prev 13:920-7. 2004.... - Failure patterns correlate with the proportion of residual carcinoma after preoperative chemoradiotherapy for carcinoma of the esophagusPooja R Rohatgi
Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 104:1349-55. 2005..Future investigations should focus on reducing the proportion of residual carcinoma and metastatic disease progression in patients with esophageal carcinoma... - Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndromeJinyun Chen
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1155 Pressler Boulevard, Houston, TX 77030, USA
Cancer Causes Control 20:1769-77. 2009..Our goal was to take a pathway-based approach to investigate the influence of polymorphisms in cell cycle-related genes on age of onset for Lynch syndrome using a tree model... - Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patientsJinyun Chen
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Carcinogenesis 34:299-306. 2013..67, 95% CI = 3.16-6.92). The additional genetic markers identified may help in refining risk groups for more tailored screening and follow-up of non-Hispanic white patients with Lynch syndrome... - Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registryMala Pande
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Unit 1365, PO Box 301439, Houston, TX, 77230 1439, USA
Fam Cancer 11:441-7. 2012..This has clinical relevance both for diagnosis of Lynch syndrome and surveillance for cancers of different sites during follow-up of these patients... - IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancerMaja Zecevic
Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Natl Cancer Inst 98:139-43. 2006..This is the first report, to our knowledge, to show that IGF1 variant genotypes modify risk of a hereditary form of cancer... - Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome populationMala Pande
Department of Epidemiology, Unit 1365, The University of Texas M D Anderson Cancer Center, 1155 Hermann P Pressler Boulevard, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 16:1753-9. 2007..This is the first report to our knowledge to provide evidence that the C677T polymorphism modifies the age at onset of colorectal cancer in Caucasian Lynch syndrome subjects with the 677T allele having a protective effect... - Health and lifestyle behaviors among persons at risk of Lynch syndromeAllison M Burton
Department of Behavioral Science Unit 1330, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
Cancer Causes Control 21:513-21. 2010.... - Clinical stage after preoperative chemoradiation is a better predictor of patient outcome than the baseline stage for localized gastric cancerPooja R Patel
Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer 110:989-95. 2007..The authors hypothesized that presurgical (postCTRT) stage would also correlate better with patient outcome than the baseline stage... - Endoscopic ultrasound after preoperative chemoradiation can help identify patients who benefit maximally after surgical esophageal resectionBanke Agarwal
Department of GI Medicine and Nutrition, Medical Oncology and Thoracic and Cardiovascular Surgery, MD Anderson Cancer Center, Houston, Texas, USA
Am J Gastroenterol 99:1258-66. 2004..EUS and EUS-guided FNA can be helpful in identifying residual tumor in the lymph nodes after preoperative chemoXRT to select patients who benefit maximally from surgery... - Significance of post-chemoradiation biopsy in predicting residual esophageal carcinoma in the surgical specimenQ Yang
Department of Pathology, The University of Texas M.D, Anderson Cancer Center, Houston, Texas, USA
Dis Esophagus 17:38-43. 2004..The utility of PCEB in predicting residual cancer in the lymph nodes needs to be explored further along with molecular predictors of response to preoperative therapy... - Endoscopic management of duodenal adenomas in familial adenomatous polyposis--a single-center experienceSathya Jaganmohan
Department of Gastroenterology, MD Anderson Cancer Center, Houston, TX, USA
Dig Dis Sci 57:732-7. 2012..Duodenal lesions (DLS) are common in patients with familial adenomatosis polyposis (FAP), and screening for duodenal adenocarcinoma (DA) is currently recommended. Endoscopic treatment of DLS is controversial... - Microsatellite instability in the peripheral blood leukocytes of HNPCC patientsMary I Coolbaugh-Murphy
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Hum Mutat 31:317-24. 2010.... - Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer CenterMala Pande
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 16:1331-9. 2010..There is some evidence that smoking is a risk factor for CRCs with high MSI; however, the association of smoking with CRC among those with Lynch syndrome is unknown... - Evolving role of self-expanding metal stents in the treatment of malignant dysphagia and fistulasWilliam A Ross
Department of GI Medicine and Nutrition, MD Anderson Cancer Center, Houston, Texas 77030, USA
Gastrointest Endosc 65:70-6. 2007..However, usage at MD Anderson has fallen in recent years, despite a greater volume of patients with esophageal cancer... - Psychological impact of genetic testing for hereditary nonpolyposis colorectal cancerEllen R Gritz
Department of Behavioral Science, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd 243, Houston, TX 77030 4009, USA
J Clin Oncol 23:1902-10. 2005..This study examines the impact of hereditary nonpolyposis colorectal cancer (HNPCC) genetic test results on psychological outcomes among cancer-affected and -unaffected participants up to 1 year after results disclosure... - Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancerMarsha L Frazier
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 63:4805-8. 2003..Patients with methylation at all four loci were 14 times more likely to have a family history of cancer than patients with methylation at none of the four loci. These findings suggest that there may be a genetic component to CIMP in CRC... - Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15Li Kuo Su
Department of Molecular and Cellular Oncology, Box 79, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030, USA
Hum Genet 111:88-95. 2002..A surprising finding was that one proband had the typical FAP phenotype, whereas the other had a phenotype consistent with that of AFAP... - Genotype-phenotype correlations in Peutz-Jeghers syndromeC I Amos
Department of Epidemiology, U T M D Anderson Cancer Center HMB, Houston 77030, USA
J Med Genet 41:327-33. 2004..Time to onset of symptoms was characterised for a large collection of individuals with PJS who had been tested for STK11 mutations and genotype-phenotype correlations were evaluated... - Paclitaxel-based chemoradiotherapy in localized gastric carcinoma: degree of pathologic response and not clinical parameters dictated patient outcomeJ A Ajani
Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
J Clin Oncol 23:1237-44. 2005.... - Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinomaJ A Ajani
Department of Gastrointestinal Medical Oncology, Stop 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 22:2774-80. 2004..A multi-institutional study of preoperative chemoradiotherapy was done to assess the R0 resection rate, pathologic complete response (pathCR) rate, safety, and survival in patients with resectable gastric carcinoma... - Enhanced staging and all chemotherapy preoperatively in patients with potentially resectable gastric carcinomaJ A Ajani
Departments of Gastrointestinal Medical Oncology and Digestive Diseases and Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
J Clin Oncol 17:2403-11. 1999.... - Colitis associated with docetaxel-based chemotherapy in patients with metastatic breast cancerN K Ibrahim
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Lancet 355:281-3. 2000.... - A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junctionJ A Ajani
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 92:279-86. 2001..After chemoradiotherapy, patients underwent surgery. The feasibility of this approach, curative resection rates, patient survival, and patterns of failure were assessed... - Unusual tumors associated with the hereditary nonpolyposis colorectal cancer syndromeRussell R Broaddus
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Mod Pathol 17:981-9. 2004..Therefore, when analyzing unusual tumors in patients with known or suspected HNPCC syndrome, we advocate the performance of immunohistochemistry for mismatch repair gene products in addition to microsatellite instability analysis... - Preoperative induction of CPT-11 and cisplatin chemotherapy followed by chemoradiotherapy in patients with locoregional carcinoma of the esophagus or gastroesophageal junctionJaffer A Ajani
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cancer 100:2347-54. 2004..Patients with localized esophageal carcinoma often develop locoregional and distant disease recurrence. The current study investigated the outcome of a new chemotherapy combination as induction therapy before chemoradiotherapy... - Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosisLing Zhang
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Nature 464:1058-61. 2010.... - The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposisG Steinbach
University of Texas M D Anderson Cancer Center, Houston 77030, USA
N Engl J Med 342:1946-52. 2000..Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2... - Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposisL K Su
Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
Am J Hum Genet 67:582-90. 2000..However, these patients develop colorectal tumors more frequently than does the general population because APC(AS9) is inactivated by mutations that do not inactivate the wild-type APC... - Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancersF A Sinicrope
Department of Gastrointestinal Medical Oncology and Digestive Diseases, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Gastroenterology 117:350-8. 1999..Given that COX-2 is induced by transforming growth factor (TGF)-beta and that TGF-beta type II receptor (RII) mutations are found in HNPCCs, we determined the relationship between RII status and COX-2 expression... - GSTM1 polymorphism does not affect hereditary nonpolyposis colorectal cancer age of onsetJ Shawn Jones
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 13:676-8. 2004 - Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue. An uncontrolled trialG Steinbach
Department of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas, M D Anderson Cancer Center, and Houston Veterans Affairs Medical Center, 77030, USA
Ann Intern Med 131:88-95. 1999..Gastric lymphoma of mucosa-associated lymphoid tissue (MALT) is related to Helicobacter pylori infection and may depend on this infection for growth... - Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genesM L Frazier
Departments of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Cancer Res 61:1269-71. 2001..These findings suggest that NAT2 genotype may be an important factor in tumorigenesis of CRC and cancers related to hereditary nonpolyposis CRC among individuals with mismatch repair defects... - Cellular kinetics in rectal cancerN H Terry
Department of Experimental Radiotherapy, University of Texas MD Anderson Cancer Center, Houston 77030, USA
Br J Cancer 72:435-41. 1995..5%, 26.9%) and Tpot (quartiles 2.4, 5.6 days) that were found are necessary baseline information if these parameters are to be useful in individual treatment selection or as predictors of treatment outcome... - Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposisL K Su
Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Hum Genet 106:101-7. 2000..The identification of four genomic rearrangements among 30 mutations suggests that genomic rearrangements are frequent germline APC mutations... - Frequent CpG island methylation in sporadic and syndromic gastric fundic gland polypsSusan C Abraham
Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 122:740-6. 2004..87). Epigenetic alterations involving methylation of CpG islands might have a role in the development of some FGPs, particularly those with a PPI effect. They do not account for the presence or absence of a dysplastic phenotype in FGPs... - Serum proteomic profiles suggest celecoxib-modulated targets and response predictorsZhen Xiao
Laboratory of Proteomics and Analytical Technologies and Advanced Biomedical Computing Center, SAIC-Frederick Inc, National Cancer Institute at Frederick, Frederick, Maryland, USA
Cancer Res 64:2904-9. 2004..In particular, a spectral feature at m/z 16,961.4 was identified as a strong discriminator between response and nonresponse to celecoxib at the highest dose... - Who should be sent for genetic testing in hereditary colorectal cancer syndromes?Henry T Lynch
Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA
J Clin Oncol 25:3534-42. 2007..Genetic counselors may be extremely helpful to the practicing gastroenterologist, oncologist, or surgeon; when more specialized knowledge is called for, referral can be made to a medical geneticist and/or a medical genetics clinic... - Screening colonoscopy for family history of colorectal cancer: a growing consensusPatrick M Lynch
Ann Surg Oncol 9:425-7. 2002 - Common deletion of SMAD4 in juvenile polyposis is a mutational hotspotJames R Howe
Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242 1086, USA
Am J Hum Genet 70:1357-62. 2002.... - Genetic/familial high-risk assessment: breast and ovarianMary B Daly
Fox Chase Cancer Center, Philadelphia, PA, USA
J Natl Compr Canc Netw 4:156-76. 2006 - Molecular screening for the Lynch syndrome--better than family history?Henry T Lynch
N Engl J Med 352:1920-2. 2005 - Colorectal Cancer Screening Clinical Practice GuidelinesBernard Levin
J Natl Compr Canc Netw 4:384-420. 2006 - Mutated DNA in the stool--does it have a role in colorectal cancer screening?Elizabeth E Half
Colorectal Cancer Screening and Prevention Service, Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, Israel
Nat Clin Pract Gastroenterol Hepatol 3:594-5. 2006 - Is the demonstration of adenoma reduction with rofecoxib a pyrrhic victory?Patrick M Lynch
Gastroenterology 131:2003-5. 2006 - Toward a consensus in molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)Henry T Lynch
J Natl Cancer Inst 99:261-3. 2007 - Clinical selection of candidates for mutational testing for cancer susceptibilityHenry T Lynch
Department of Preventive Medicine, Creighton University, School of Medicine, Omaha, Nebraska 68178, USA
Oncology (Williston Park) 20:29-34. 2006..This article is an attempt to crystallize all of these issues in a format that will help physicians-particularly those in the oncology community-to meet this challenge effectively... - Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and managementHenry T Lynch
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
Fam Cancer 7:27-39. 2008.... - Hereditary nonpolyposis colorectal cancer family members' perceptions about the duty to inform and health professionals' role in disseminating genetic informationRebecca D Pentz
Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
Genet Test 9:261-8. 2005..These families with a hereditary colon cancer syndrome favor open sharing of genetic information within the family, and desire the supportive involvement of health care professionals in disseminating genetic information... - Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancerHenry T Lynch
Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
J Invest Dermatol 126:2158-9. 2006..Proof of diagnosis is identification of one of the mismatch repair germline mutations... - New approaches to assessing and treating early-stage colon and rectal cancer: summary statement from 2007 Santa Monica ConferenceLee S Rosen
Premiere Oncology, Santa Monica, CA 90404, USA
Clin Cancer Res 13:6853s-6s. 2007....