Patrick M Lynch

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Small bowel tumors
    Emad M Abu-Hamda
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 436, Houston, TX 77030, USA
    Curr Gastroenterol Rep 5:386-93. 2003
  2. ncbi request reprint Current approaches in hereditary nonpolyposis colorectal cancer
    Patrick M Lynch
    Department of Gastroenterology, Hepatology and Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Natl Compr Canc Netw 10:961-7. 2012
  3. pmc Global quantitative assessment of the colorectal polyp burden in familial adenomatous polyposis by using a web-based tool
    Patrick M Lynch
    Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Gastrointest Endosc 77:455-63. 2013
  4. ncbi request reprint The safety and efficacy of celecoxib in children with familial adenomatous polyposis
    Patrick M Lynch
    Department of Gastroenterology, Hepatology and Nutrition, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Am J Gastroenterol 105:1437-43. 2010
  5. ncbi request reprint Current approaches in familial colorectal cancer: a clinical perspective
    Patrick M Lynch
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Natl Compr Canc Netw 4:421-30. 2006
  6. ncbi request reprint Does regular use of aspirin reduce the risk of colorectal cancer?
    Patrick M Lynch
    Department of Gastrointestinal Medicine and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Nat Clin Pract Oncol 3:186-7. 2006
  7. ncbi request reprint COX-2 inhibition in clinical cancer prevention
    P M Lynch
    Department of Gastrointestinal Medicine and Nutrition, University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Oncology (Williston Park) 15:21-6. 2001
  8. doi request reprint Pharmacotherapy for inherited colorectal cancer
    Patrick M Lynch
    The University of Texas MD Anderson Cancer Center, Department of Gastroenterology, Hepatology and Nutrition, 1515 Holcombe Blvd, Unit 1466, Houston, Texas, USA
    Expert Opin Pharmacother 11:1101-8. 2010
  9. doi request reprint The hMSH2 and hMLH1 genes in hereditary nonpolyposis colorectal cancer
    Patrick M Lynch
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Surg Oncol Clin N Am 18:611-24. 2009
  10. ncbi request reprint New issues in genetic counseling of hereditary colon cancer
    Patrick M Lynch
    Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Cancer Res 13:6857s-61s. 2007

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Small bowel tumors
    Emad M Abu-Hamda
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 436, Houston, TX 77030, USA
    Curr Gastroenterol Rep 5:386-93. 2003
    ..The management of primary malignant small bowel tumors is invariably surgical. However, adjuvant chemotherapy and radiotherapy may be warranted, depending on the type of tumor...
  2. ncbi request reprint Current approaches in hereditary nonpolyposis colorectal cancer
    Patrick M Lynch
    Department of Gastroenterology, Hepatology and Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Natl Compr Canc Netw 10:961-7. 2012
    ..For various reasons, however, no agent or combination of agents has yet come into routine use in either condition, with further trials underway or being designed for both conditions...
  3. pmc Global quantitative assessment of the colorectal polyp burden in familial adenomatous polyposis by using a web-based tool
    Patrick M Lynch
    Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Gastrointest Endosc 77:455-63. 2013
    ..Accurate measures of the total polyp burden in familial adenomatous polyposis (FAP) are lacking. Current assessment tools include polyp quantitation in limited-field photographs and qualitative total colorectal polyp burden by video...
  4. ncbi request reprint The safety and efficacy of celecoxib in children with familial adenomatous polyposis
    Patrick M Lynch
    Department of Gastroenterology, Hepatology and Nutrition, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Am J Gastroenterol 105:1437-43. 2010
    ..Its safety and efficacy for colorectal polyps in children is unknown. We evaluated the short-term (3 months) safety and preliminary efficacy of celecoxib in children with FAP...
  5. ncbi request reprint Current approaches in familial colorectal cancer: a clinical perspective
    Patrick M Lynch
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Natl Compr Canc Netw 4:421-30. 2006
    ..The NCCN guidelines are used as a frame of reference for this discussion of selected recent advances in human cancer genetics as they apply to clinical practice...
  6. ncbi request reprint Does regular use of aspirin reduce the risk of colorectal cancer?
    Patrick M Lynch
    Department of Gastrointestinal Medicine and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Nat Clin Pract Oncol 3:186-7. 2006
  7. ncbi request reprint COX-2 inhibition in clinical cancer prevention
    P M Lynch
    Department of Gastrointestinal Medicine and Nutrition, University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Oncology (Williston Park) 15:21-6. 2001
    ....
  8. doi request reprint Pharmacotherapy for inherited colorectal cancer
    Patrick M Lynch
    The University of Texas MD Anderson Cancer Center, Department of Gastroenterology, Hepatology and Nutrition, 1515 Holcombe Blvd, Unit 1466, Houston, Texas, USA
    Expert Opin Pharmacother 11:1101-8. 2010
    ..This review is written in the interest of capturing the current state of chemoprevention in familial adenomatous polyposis (FAP). This will take a decidedly clinical perspective...
  9. doi request reprint The hMSH2 and hMLH1 genes in hereditary nonpolyposis colorectal cancer
    Patrick M Lynch
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Surg Oncol Clin N Am 18:611-24. 2009
    ..It is not always possible to discuss these specific genes without commenting on the broader problem of HNPCC diagnosis and management...
  10. ncbi request reprint New issues in genetic counseling of hereditary colon cancer
    Patrick M Lynch
    Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Cancer Res 13:6857s-61s. 2007
    ..Finally, as investigators make progress with the genetics of these rare diseases, one can anticipate a "cooperative group" approach to clinical trials...
  11. ncbi request reprint Chemoprevention with special reference to inherited colorectal cancer
    Patrick M Lynch
    Department of Gastrointestinal Medicine and Nutrition 436, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1402, USA
    Fam Cancer 7:59-64. 2008
    ..The historical development of chemoprevention in FAP will be presented, with an emphasis on issues of trial design...
  12. ncbi request reprint Prevention of colorectal cancer in high-risk populations: the increasing role for endoscopy and chemoprevention in FAP and HNPCC
    Patrick M Lynch
    Department of GI Medicine, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Digestion 76:68-76. 2007
    ..Surveillance, chemoprevention, and imaginative hybrid surveillance/endoscopic therapy/chemoprevention trials may gradually decrease the present dependence on prophylactic colectomy/proctocolectomy...
  13. ncbi request reprint Standards of care in diagnosis and testing for hereditary colon cancer
    Patrick M Lynch
    Department of Gastrointestinal Medicine and Nutrition 436, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Fam Cancer 7:65-72. 2008
    ..This paper undertakes to provide practitioners and academics some perspective on clinical practice guidelines and their potential for medical-legal application...
  14. ncbi request reprint p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population
    J Shawn Jones
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:5845-9. 2004
    ..We studied the influence of this p53 polymorphism on HNPCC age of onset...
  15. ncbi request reprint ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States)
    J Shawn Jones
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Causes Control 16:749-53. 2005
    ..ATM germline mutations have been associated with breast and digestive cancers. In a smaller European study, the G-to-A polymorphism was associated with an increased risk of developing an HNPCC-related cancer within HNPCC families...
  16. ncbi request reprint DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset
    J Shawn Jones
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 15:886-91. 2006
    ....
  17. pmc Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome
    Mala Pande
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:2393-401. 2008
    ..Our results suggest that the I462V and Msp1 polymorphisms in CYP1A1 may be an additional susceptibility factor for disease expression in Lynch syndrome because they modify the age of colorectal cancer onset by up to 4 years...
  18. ncbi request reprint Cell proliferation and apoptotic indices predict adenoma regression in a placebo-controlled trial of celecoxib in familial adenomatous polyposis patients
    Frank A Sinicrope
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston, USA
    Cancer Epidemiol Biomarkers Prev 13:920-7. 2004
    ....
  19. ncbi request reprint Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome
    Jinyun Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Cancer Causes Control 20:1769-77. 2009
    ..Our goal was to take a pathway-based approach to investigate the influence of polymorphisms in cell cycle-related genes on age of onset for Lynch syndrome using a tree model...
  20. pmc Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients
    Jinyun Chen
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 34:299-306. 2013
    ..67, 95% CI = 3.16-6.92). The additional genetic markers identified may help in refining risk groups for more tailored screening and follow-up of non-Hispanic white patients with Lynch syndrome...
  21. ncbi request reprint Failure patterns correlate with the proportion of residual carcinoma after preoperative chemoradiotherapy for carcinoma of the esophagus
    Pooja R Rohatgi
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 104:1349-55. 2005
    ..The current study was conducted to test the hypothesis that patterns of failure are correlated with the degree of residual carcinoma after preoperative chemoradiotherapy (CRT) in patients with esophageal carcinoma...
  22. pmc Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry
    Mala Pande
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Unit 1365, PO Box 301439, Houston, TX, 77230 1439, USA
    Fam Cancer 11:441-7. 2012
    ..This has clinical relevance both for diagnosis of Lynch syndrome and surveillance for cancers of different sites during follow-up of these patients...
  23. ncbi request reprint IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer
    Maja Zecevic
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 98:139-43. 2006
    ..This is the first report, to our knowledge, to show that IGF1 variant genotypes modify risk of a hereditary form of cancer...
  24. ncbi request reprint Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population
    Mala Pande
    Department of Epidemiology, Unit 1365, The University of Texas M D Anderson Cancer Center, 1155 Hermann P Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:1753-9. 2007
    ..This is the first report to our knowledge to provide evidence that the C677T polymorphism modifies the age at onset of colorectal cancer in Caucasian Lynch syndrome subjects with the 677T allele having a protective effect...
  25. doi request reprint Health and lifestyle behaviors among persons at risk of Lynch syndrome
    Allison M Burton
    Department of Behavioral Science Unit 1330, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    Cancer Causes Control 21:513-21. 2010
    ....
  26. ncbi request reprint Endoscopic ultrasound after preoperative chemoradiation can help identify patients who benefit maximally after surgical esophageal resection
    Banke Agarwal
    Department of GI Medicine and Nutrition, Medical Oncology and Thoracic and Cardiovascular Surgery, MD Anderson Cancer Center, Houston, Texas, USA
    Am J Gastroenterol 99:1258-66. 2004
    ..Based on these data, we reevaluated the role of EUS in identifying patients who maximally benefit from surgical esophageal resection after preoperative chemoXRT...
  27. ncbi request reprint Significance of post-chemoradiation biopsy in predicting residual esophageal carcinoma in the surgical specimen
    Q Yang
    Department of Pathology, The University of Texas M D, Anderson Cancer Center, Houston, Texas, USA
    Dis Esophagus 17:38-43. 2004
    ..The utility of PCEB in predicting residual cancer in the lymph nodes needs to be explored further along with molecular predictors of response to preoperative therapy...
  28. ncbi request reprint Clinical stage after preoperative chemoradiation is a better predictor of patient outcome than the baseline stage for localized gastric cancer
    Pooja R Patel
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 110:989-95. 2007
    ..The authors hypothesized that presurgical (postCTRT) stage would also correlate better with patient outcome than the baseline stage...
  29. ncbi request reprint Evolving role of self-expanding metal stents in the treatment of malignant dysphagia and fistulas
    William A Ross
    Department of GI Medicine and Nutrition, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Gastrointest Endosc 65:70-6. 2007
    ..However, usage at MD Anderson has fallen in recent years, despite a greater volume of patients with esophageal cancer...
  30. pmc A pilot study comparing protein expression in different segments of the normal colon and rectum and in normal colon versus adenoma in patients with Lynch syndrome
    Chongjuan Wei
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1155 Pressler St, Houston, TX 77030, USA
    J Cancer Res Clin Oncol 139:1241-50. 2013
    ..Here, we compared the protein expression profiles for normal colorectal samples among different locations as well as between adenomas and matched normal tissue in LS...
  31. doi request reprint Endoscopic management of duodenal adenomas in familial adenomatous polyposis--a single-center experience
    Sathya Jaganmohan
    Department of Gastroenterology, MD Anderson Cancer Center, Houston, TX, USA
    Dig Dis Sci 57:732-7. 2012
    ..Duodenal lesions (DLS) are common in patients with familial adenomatosis polyposis (FAP), and screening for duodenal adenocarcinoma (DA) is currently recommended. Endoscopic treatment of DLS is controversial...
  32. pmc Microsatellite instability in the peripheral blood leukocytes of HNPCC patients
    Mary I Coolbaugh-Murphy
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Hum Mutat 31:317-24. 2010
    ....
  33. pmc Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center
    Mala Pande
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:1331-9. 2010
    ..There is some evidence that smoking is a risk factor for CRCs with high MSI; however, the association of smoking with CRC among those with Lynch syndrome is unknown...
  34. pmc Adenoma detection in patients undergoing a comprehensive colonoscopy screening
    Gottumukkala S Raju
    Department of Gastroenterology, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Med 2:391-402. 2013
    ..4, 1.8). Retrospective study and single endoscopist experience. A comprehensive colonoscopy screening program results in high-quality screening with high detection of adenomas, advanced adenomas, serrated adenomas, and multiple adenomas. ..
  35. ncbi request reprint Psychological impact of genetic testing for hereditary nonpolyposis colorectal cancer
    Ellen R Gritz
    Department of Behavioral Science, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd 243, Houston, TX 77030 4009, USA
    J Clin Oncol 23:1902-10. 2005
    ..This study examines the impact of hereditary nonpolyposis colorectal cancer (HNPCC) genetic test results on psychological outcomes among cancer-affected and -unaffected participants up to 1 year after results disclosure...
  36. ncbi request reprint Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer
    Marsha L Frazier
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:4805-8. 2003
    ..Patients with methylation at all four loci were 14 times more likely to have a family history of cancer than patients with methylation at none of the four loci. These findings suggest that there may be a genetic component to CIMP in CRC...
  37. ncbi request reprint Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15
    Li Kuo Su
    Department of Molecular and Cellular Oncology, Box 79, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030, USA
    Hum Genet 111:88-95. 2002
    ..A surprising finding was that one proband had the typical FAP phenotype, whereas the other had a phenotype consistent with that of AFAP...
  38. ncbi request reprint Enhanced staging and all chemotherapy preoperatively in patients with potentially resectable gastric carcinoma
    J A Ajani
    Departments of Gastrointestinal Medical Oncology and Digestive Diseases and Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    J Clin Oncol 17:2403-11. 1999
    ....
  39. ncbi request reprint Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma
    J A Ajani
    Department of Gastrointestinal Medical Oncology, Stop 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 22:2774-80. 2004
    ..A multi-institutional study of preoperative chemoradiotherapy was done to assess the R0 resection rate, pathologic complete response (pathCR) rate, safety, and survival in patients with resectable gastric carcinoma...
  40. ncbi request reprint Colitis associated with docetaxel-based chemotherapy in patients with metastatic breast cancer
    N K Ibrahim
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Lancet 355:281-3. 2000
    ....
  41. pmc Genotype-phenotype correlations in Peutz-Jeghers syndrome
    C I Amos
    Department of Epidemiology, U T M D Anderson Cancer Center HMB, Houston 77030, USA
    J Med Genet 41:327-33. 2004
    ..Time to onset of symptoms was characterised for a large collection of individuals with PJS who had been tested for STK11 mutations and genotype-phenotype correlations were evaluated...
  42. ncbi request reprint Paclitaxel-based chemoradiotherapy in localized gastric carcinoma: degree of pathologic response and not clinical parameters dictated patient outcome
    J A Ajani
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Clin Oncol 23:1237-44. 2005
    ....
  43. ncbi request reprint A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction
    J A Ajani
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 92:279-86. 2001
    ..After chemoradiotherapy, patients underwent surgery. The feasibility of this approach, curative resection rates, patient survival, and patterns of failure were assessed...
  44. ncbi request reprint Unusual tumors associated with the hereditary nonpolyposis colorectal cancer syndrome
    Russell R Broaddus
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 17:981-9. 2004
    ..Therefore, when analyzing unusual tumors in patients with known or suspected HNPCC syndrome, we advocate the performance of immunohistochemistry for mismatch repair gene products in addition to microsatellite instability analysis...
  45. pmc Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis
    Ling Zhang
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nature 464:1058-61. 2010
    ....
  46. ncbi request reprint Preoperative induction of CPT-11 and cisplatin chemotherapy followed by chemoradiotherapy in patients with locoregional carcinoma of the esophagus or gastroesophageal junction
    Jaffer A Ajani
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 100:2347-54. 2004
    ..Patients with localized esophageal carcinoma often develop locoregional and distant disease recurrence. The current study investigated the outcome of a new chemotherapy combination as induction therapy before chemoradiotherapy...
  47. ncbi request reprint The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    G Steinbach
    University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 342:1946-52. 2000
    ..Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2...
  48. pmc Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis
    L K Su
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Am J Hum Genet 67:582-90. 2000
    ..However, these patients develop colorectal tumors more frequently than does the general population because APC(AS9) is inactivated by mutations that do not inactivate the wild-type APC...
  49. ncbi request reprint Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers
    F A Sinicrope
    Department of Gastrointestinal Medical Oncology and Digestive Diseases, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 117:350-8. 1999
    ..Given that COX-2 is induced by transforming growth factor (TGF)-beta and that TGF-beta type II receptor (RII) mutations are found in HNPCCs, we determined the relationship between RII status and COX-2 expression...
  50. ncbi request reprint GSTM1 polymorphism does not affect hereditary nonpolyposis colorectal cancer age of onset
    J Shawn Jones
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 13:676-8. 2004
  51. ncbi request reprint Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue. An uncontrolled trial
    G Steinbach
    Department of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas, M D Anderson Cancer Center, and Houston Veterans Affairs Medical Center, 77030, USA
    Ann Intern Med 131:88-95. 1999
    ..Gastric lymphoma of mucosa-associated lymphoid tissue (MALT) is related to Helicobacter pylori infection and may depend on this infection for growth...
  52. ncbi request reprint Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes
    M L Frazier
    Departments of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 61:1269-71. 2001
    ..These findings suggest that NAT2 genotype may be an important factor in tumorigenesis of CRC and cancers related to hereditary nonpolyposis CRC among individuals with mismatch repair defects...
  53. ncbi request reprint Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis
    L K Su
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Hum Genet 106:101-7. 2000
    ..The identification of four genomic rearrangements among 30 mutations suggests that genomic rearrangements are frequent germline APC mutations...
  54. pmc Cellular kinetics in rectal cancer
    N H Terry
    Department of Experimental Radiotherapy, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Br J Cancer 72:435-41. 1995
    ..5%, 26.9%) and Tpot (quartiles 2.4, 5.6 days) that were found are necessary baseline information if these parameters are to be useful in individual treatment selection or as predictors of treatment outcome...
  55. ncbi request reprint Molecular screening for the Lynch syndrome--better than family history?
    Henry T Lynch
    N Engl J Med 352:1920-2. 2005
  56. ncbi request reprint Frequent CpG island methylation in sporadic and syndromic gastric fundic gland polyps
    Susan C Abraham
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Clin Pathol 122:740-6. 2004
    ..87). Epigenetic alterations involving methylation of CpG islands might have a role in the development of some FGPs, particularly those with a PPI effect. They do not account for the presence or absence of a dysplastic phenotype in FGPs...
  57. ncbi request reprint Serum proteomic profiles suggest celecoxib-modulated targets and response predictors
    Zhen Xiao
    Laboratory of Proteomics and Analytical Technologies and Advanced Biomedical Computing Center, SAIC Frederick Inc, National Cancer Institute at Frederick, Frederick, Maryland, USA
    Cancer Res 64:2904-9. 2004
    ..In particular, a spectral feature at m/z 16,961.4 was identified as a strong discriminator between response and nonresponse to celecoxib at the highest dose...
  58. ncbi request reprint Screening colonoscopy for family history of colorectal cancer: a growing consensus
    Patrick M Lynch
    Ann Surg Oncol 9:425-7. 2002
  59. pmc Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot
    James R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242 1086, USA
    Am J Hum Genet 70:1357-62. 2002
    ....
  60. ncbi request reprint Colorectal Cancer Screening Clinical Practice Guidelines
    Bernard Levin
    J Natl Compr Canc Netw 4:384-420. 2006
  61. ncbi request reprint Who should be sent for genetic testing in hereditary colorectal cancer syndromes?
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Clin Oncol 25:3534-42. 2007
    ..Genetic counselors may be extremely helpful to the practicing gastroenterologist, oncologist, or surgeon; when more specialized knowledge is called for, referral can be made to a medical geneticist and/or a medical genetics clinic...
  62. ncbi request reprint Genetic/familial high-risk assessment: breast and ovarian
    Mary B Daly
    Fox Chase Cancer Center, Philadelphia, PA, USA
    J Natl Compr Canc Netw 4:156-76. 2006
  63. ncbi request reprint Mutated DNA in the stool--does it have a role in colorectal cancer screening?
    Elizabeth E Half
    Colorectal Cancer Screening and Prevention Service, Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Nat Clin Pract Gastroenterol Hepatol 3:594-5. 2006
  64. ncbi request reprint Is the demonstration of adenoma reduction with rofecoxib a pyrrhic victory?
    Patrick M Lynch
    Gastroenterology 131:2003-5. 2006
  65. ncbi request reprint Toward a consensus in molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)
    Henry T Lynch
    J Natl Cancer Inst 99:261-3. 2007
  66. ncbi request reprint Clinical selection of candidates for mutational testing for cancer susceptibility
    Henry T Lynch
    Department of Preventive Medicine, Creighton University, School of Medicine, Omaha, Nebraska 68178, USA
    Oncology (Williston Park) 20:29-34. 2006
    ..This article is an attempt to crystallize all of these issues in a format that will help physicians-particularly those in the oncology community-to meet this challenge effectively...
  67. ncbi request reprint Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Fam Cancer 7:27-39. 2008
    ....
  68. ncbi request reprint Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Invest Dermatol 126:2158-9. 2006
    ..Proof of diagnosis is identification of one of the mismatch repair germline mutations...
  69. ncbi request reprint New approaches to assessing and treating early-stage colon and rectal cancer: summary statement from 2007 Santa Monica Conference
    Lee S Rosen
    Premiere Oncology, Santa Monica, CA 90404, USA
    Clin Cancer Res 13:6853s-6s. 2007
    ....
  70. ncbi request reprint Hereditary nonpolyposis colorectal cancer family members' perceptions about the duty to inform and health professionals' role in disseminating genetic information
    Rebecca D Pentz
    Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Genet Test 9:261-8. 2005
    ..These families with a hereditary colon cancer syndrome favor open sharing of genetic information within the family, and desire the supportive involvement of health care professionals in disseminating genetic information...