Wenjie Luo

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
    Wenjie Luo
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University and Fisher Foundation for Alzheimer s Disease, New York, NY 10021, USA
    BMC Neurosci 9:S7. 2008
  2. pmc Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action
    Karima Bettayeb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    FASEB J 26:5115-23. 2012
  3. ncbi request reprint Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention
    Aaron Carman
    Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Associate Attending, Breast Cancer Service, Department of Medicine, Memorial Hospital, Memorial Sloan Kettering Cancer Center, ZRB2103, Associate Professor, Weill Graduate School of Medical Sciences, New York, USA
    Curr Alzheimer Res 11:59-68. 2014
  4. pmc Heat shock protein 90 in neurodegenerative diseases
    Wenjie Luo
    Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Neurodegener 5:24. 2010
  5. pmc Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
    Gen He
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 467:95-8. 2010

Collaborators

  • William J Netzer
  • Karima Bettayeb
  • Aaron Carman
  • Marc Flajolet
  • Paul Greengard
  • Gen He
  • Gabriela Chiosis
  • John Iii Koren
  • Sarah Kishinevsky
  • Victor Bustos
  • Hervé Galons
  • Yuanyuan Zhang
  • Laurent Meijer
  • Nassima Oumata
  • Fred Gorelick
  • Peng Li
  • Joseph Hendrick
  • Lawrence P Wennogle
  • Christine Remmers

Detail Information

Publications5

  1. pmc Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
    Wenjie Luo
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University and Fisher Foundation for Alzheimer s Disease, New York, NY 10021, USA
    BMC Neurosci 9:S7. 2008
    ..It will present experimentally demonstrated, but also hypothetical, roles that suggest Hsp90 can act as a regulator of pathogenic changes that lead to the neurodegenerative phenotype in Alzheimer's disease...
  2. pmc Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action
    Karima Bettayeb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    FASEB J 26:5115-23. 2012
    ..In summary, treatment with three Aβ42 raising agents induced similar biochemical alterations that lead to comparable cellular phenotypes in vitro, suggesting a common mechanism of action involving three structural cellular targets...
  3. ncbi request reprint Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention
    Aaron Carman
    Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Associate Attending, Breast Cancer Service, Department of Medicine, Memorial Hospital, Memorial Sloan Kettering Cancer Center, ZRB2103, Associate Professor, Weill Graduate School of Medical Sciences, New York, USA
    Curr Alzheimer Res 11:59-68. 2014
    ..Here we discuss how chaperone interactions and small molecule inhibitors can regulate the burden of aberrant client signaling in these neurological disorders. ..
  4. pmc Heat shock protein 90 in neurodegenerative diseases
    Wenjie Luo
    Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Neurodegener 5:24. 2010
    ..This mini-review will summarize our current knowledge on Hsp90 in neurodegeneration and will focus on the potential beneficial application of Hsp90 inhibitors in neurodegenerative diseases...
  5. pmc Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
    Gen He
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 467:95-8. 2010
    ..Thus, GSAP can serve as an amyloid-beta-lowering therapeutic target without affecting other key functions of gamma-secretase...