Affiliation: The Rockefeller University
- Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?Wenjie Luo
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University and Fisher Foundation for Alzheimer s Disease, New York, NY 10021, USA
BMC Neurosci 9:S7. 2008..It will present experimentally demonstrated, but also hypothetical, roles that suggest Hsp90 can act as a regulator of pathogenic changes that lead to the neurodegenerative phenotype in Alzheimer's disease...
- Small-molecule inducers of Aβ-42 peptide production share a common mechanism of actionKarima Bettayeb
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
FASEB J 26:5115-23. 2012..In summary, treatment with three Aβ42 raising agents induced similar biochemical alterations that lead to comparable cellular phenotypes in vitro, suggesting a common mechanism of action involving three structural cellular targets...
- Heat shock protein 90 in neurodegenerative diseasesWenjie Luo
Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Neurodegener 5:24. 2010..This mini-review will summarize our current knowledge on Hsp90 in neurodegeneration and will focus on the potential beneficial application of Hsp90 inhibitors in neurodegenerative diseases...
- Gamma-secretase activating protein is a therapeutic target for Alzheimer's diseaseGen He
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Nature 467:95-8. 2010..Thus, GSAP can serve as an amyloid-beta-lowering therapeutic target without affecting other key functions of gamma-secretase...