Genomes and Genes
Affiliation: The Rockefeller University
- Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?Wenjie Luo
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University and Fisher Foundation for Alzheimer s Disease, New York, NY 10021, USA
BMC Neurosci 9:S7. 2008..It will present experimentally demonstrated, but also hypothetical, roles that suggest Hsp90 can act as a regulator of pathogenic changes that lead to the neurodegenerative phenotype in Alzheimer's disease...
- Small-molecule inducers of Aβ-42 peptide production share a common mechanism of actionKarima Bettayeb
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
FASEB J 26:5115-23. 2012..In summary, treatment with three Aβ42 raising agents induced similar biochemical alterations that lead to comparable cellular phenotypes in vitro, suggesting a common mechanism of action involving three structural cellular targets...
- Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic interventionAaron Carman
Molecular Pharmacology and Chemistry, Sloan Kettering Institute, Associate Attending, Breast Cancer Service, Department of Medicine, Memorial Hospital, Memorial Sloan Kettering Cancer Center, ZRB2103, Associate Professor, Weill Graduate School of Medical Sciences, New York, USA
Curr Alzheimer Res 11:59-68. 2014..Here we discuss how chaperone interactions and small molecule inhibitors can regulate the burden of aberrant client signaling in these neurological disorders. ..
- Heat shock protein 90 in neurodegenerative diseasesWenjie Luo
Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Neurodegener 5:24. 2010..This mini-review will summarize our current knowledge on Hsp90 in neurodegeneration and will focus on the potential beneficial application of Hsp90 inhibitors in neurodegenerative diseases...
- Gamma-secretase activating protein is a therapeutic target for Alzheimer's diseaseGen He
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Nature 467:95-8. 2010..Thus, GSAP can serve as an amyloid-beta-lowering therapeutic target without affecting other key functions of gamma-secretase...