Jan D Lunemann

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Epstein-Barr virus and multiple sclerosis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, Box 390, 1230 York Avenue, New York, NY 10021 6399, USA
    Curr Neurol Neurosci Rep 7:253-8. 2007
  2. ncbi request reprint Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis
    Jan D Lunemann
    Neuroimmunology Branch, Cellular Immunology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Brain 129:1493-506. 2006
  3. doi request reprint Do natural killer cells accelerate or prevent autoimmunity in multiple sclerosis?
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021 6399, USA
    Brain 131:1681-3. 2008
  4. pmc Epstein-barr virus: environmental trigger of multiple sclerosis?
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, Box 390, 1230 York Avenue, New York, NY 10021 6399, USA
    J Virol 81:6777-84. 2007
  5. pmc EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 205:1763-73. 2008
  6. pmc Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
    J Immunol 181:991-1000. 2008
  7. pmc Impaired IFN-γ production and proliferation of NK cells in multiple sclerosis
    Anna Lünemann
    Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Int Immunol 23:139-48. 2011
  8. ncbi request reprint Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Ann Neurol 61:476-83. 2007
  9. pmc Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition
    Anna Lünemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Immunol 181:6170-7. 2008
  10. pmc TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells
    Christian W Keller
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:3970-80. 2011

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Epstein-Barr virus and multiple sclerosis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, Box 390, 1230 York Avenue, New York, NY 10021 6399, USA
    Curr Neurol Neurosci Rep 7:253-8. 2007
    ....
  2. ncbi request reprint Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis
    Jan D Lunemann
    Neuroimmunology Branch, Cellular Immunology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Brain 129:1493-506. 2006
    ..We suggest that the accumulation of highly antigen-sensitive EBNA1-specific Th1 cells in multiple sclerosis is capable of sustaining autoimmunity by cross-recognition of autoantigens or by TCR-independent bystander mechanisms...
  3. doi request reprint Do natural killer cells accelerate or prevent autoimmunity in multiple sclerosis?
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021 6399, USA
    Brain 131:1681-3. 2008
  4. pmc Epstein-barr virus: environmental trigger of multiple sclerosis?
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, Box 390, 1230 York Avenue, New York, NY 10021 6399, USA
    J Virol 81:6777-84. 2007
  5. pmc EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 205:1763-73. 2008
    ..Our data support the concept that clonally expanded EBNA1-specific CD4(+) T cells potentially contribute to the development of MS by cross-recognition of myelin antigens...
  6. pmc Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
    J Immunol 181:991-1000. 2008
    ..Our data show that the regulation of EBV infection is perturbed in RA and suggest that increased EBV-specific effector T cell and Ab responses are driven by an elevated EBV load in RA...
  7. pmc Impaired IFN-γ production and proliferation of NK cells in multiple sclerosis
    Anna Lünemann
    Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Int Immunol 23:139-48. 2011
    ..Thus, characteristic functions of CD56(bright)CD16(-) NK cells, namely cytokine-induced NK cell expansion and IFN-γ production, are compromised in the NK cell compartment of MS patients...
  8. ncbi request reprint Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Ann Neurol 61:476-83. 2007
    ..Therefore, we analyzed macroautophagy of APP in human muscle cell lines and sIBM muscle biopsies...
  9. pmc Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition
    Anna Lünemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Immunol 181:6170-7. 2008
    ..These data suggest that brain-infiltrating NK cells might restrict innate and adaptive immune responses within the human CNS via elimination of resting microglia...
  10. pmc TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells
    Christian W Keller
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:3970-80. 2011
    ....
  11. ncbi request reprint Macroautophagy as a pathomechanism in sporadic inclusion body myositis
    Jan D Lunemann
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10021, USA
    Autophagy 3:384-6. 2007
    ..A better understanding of this pathway in skeletal muscle and in the inflammatory environment of sIBM might provide a rationale for novel therapeutic strategies targeting pathogenic protein aggregation...
  12. pmc Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis
    Jan D Lunemann
    Neuroimmunology Branch, Cellular Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 75:243-51. 2007
    ..burgdorferi-specific T cells is not restricted to chronic and treatment-resistant manifestations...
  13. ncbi request reprint Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, USA
    Arch Gen Psychiatry 63:63-72. 2006
    ..This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD...