Zhimin Lu

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Wnt-independent beta-catenin transactivation in tumor development
    Zhimin Lu
    University of Texas M D Anderson Cancer Center, Department of Neuro Oncology, Houston 77030, USA
    Cell Cycle 3:571-3. 2004
  2. ncbi request reprint Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
    Minghao Zhong
    Department of Biological Sciences, Hunter College of the City University of New York, NY 10021, USA
    Oncogene 21:1071-8. 2002
  3. pmc Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors
    Zhimin Lu
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cell Cycle 9:2342-52. 2010
  4. pmc Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis
    Zhimin Lu
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Chin J Cancer 31:5-7. 2012
  5. pmc Degradation of activated protein kinases by ubiquitination
    Zhimin Lu
    Department of Neuro Oncology and Molecular and Cellular Oncology, University of Texas M D Anderson Cancer, Houston, TX 77030, USA
    Annu Rev Biochem 78:435-75. 2009
  6. ncbi request reprint ERK1/2 MAP kinases in cell survival and apoptosis
    Zhimin Lu
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030, USA
    IUBMB Life 58:621-31. 2006
  7. ncbi request reprint Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
  8. pmc EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis
    Weiwei Yang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 48:771-84. 2012
  9. pmc ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
    Weiwei Yang
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Cell Biol 14:1295-304. 2012
  10. pmc Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
    Weiwei Yang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 480:118-22. 2011

Research Grants

Detail Information

Publications30

  1. ncbi request reprint Wnt-independent beta-catenin transactivation in tumor development
    Zhimin Lu
    University of Texas M D Anderson Cancer Center, Department of Neuro Oncology, Houston 77030, USA
    Cell Cycle 3:571-3. 2004
    ....
  2. ncbi request reprint Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
    Minghao Zhong
    Department of Biological Sciences, Hunter College of the City University of New York, NY 10021, USA
    Oncogene 21:1071-8. 2002
    ....
  3. pmc Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors
    Zhimin Lu
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cell Cycle 9:2342-52. 2010
    ....
  4. pmc Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis
    Zhimin Lu
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Chin J Cancer 31:5-7. 2012
    ..This nonmetabolic function of PKM2 is essential for epidermal growth factor receptor (EGFR) activation-induced tumorigenesis...
  5. pmc Degradation of activated protein kinases by ubiquitination
    Zhimin Lu
    Department of Neuro Oncology and Molecular and Cellular Oncology, University of Texas M D Anderson Cancer, Houston, TX 77030, USA
    Annu Rev Biochem 78:435-75. 2009
    ..Failure to regulate protein kinase activity or expression levels can cause human diseases...
  6. ncbi request reprint ERK1/2 MAP kinases in cell survival and apoptosis
    Zhimin Lu
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030, USA
    IUBMB Life 58:621-31. 2006
    ..Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions...
  7. ncbi request reprint Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
    ..We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis...
  8. pmc EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis
    Weiwei Yang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 48:771-84. 2012
    ..These findings highlight the distinct regulation of NF-κB by EGF, in contrast to TNF-α, and the importance of the metabolic cooperation between the EGFR and NF-κB pathways in PKM2 upregulation and tumorigenesis...
  9. pmc ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
    Weiwei Yang
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Cell Biol 14:1295-304. 2012
    ..In addition, levels of PKM2 Ser 37 phosphorylation correlate with EGFR and ERK1/2 activity in human glioblastoma specimens. Our findings highlight the importance of nuclear functions of PKM2 in the Warburg effect and tumorigenesis...
  10. pmc Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
    Weiwei Yang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 480:118-22. 2011
    ....
  11. pmc EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin
    Haitao Ji
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Cell 36:547-59. 2009
    ..This EGFR-ERK-CK2-mediated phosphorylation of alpha-catenin promotes beta-catenin transactivation and tumor cell invasion. These findings highlight the importance of the crosstalk between EGFR and Wnt pathways in tumor development...
  12. doi request reprint PKM2 regulates chromosome segregation and mitosis progression of tumor cells
    Yuhui Jiang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 53:75-87. 2014
    ..These findings highlight the role of PKM2 as a protein kinase controlling the fidelity of chromosome segregation, cell-cycle progression, and tumorigenesis...
  13. pmc PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis
    Weiwei Yang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell 150:685-96. 2012
    ..These findings highlight the role of PKM2 as a protein kinase in its nonmetabolic functions of histone modification, which is essential for its epigenetic regulation of gene expression and tumorigenesis...
  14. pmc FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST
    Yanhua Zheng
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 35:11-25. 2009
    ..These findings uncover the importance of sequential modification of FAK-by serine phosphorylation, isomerization, and tyrosine dephosphorylation--in the regulation of FAK activity and, thereby, in Ras-related tumor metastasis...
  15. pmc Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST
    Yanhua Zheng
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell Biol 31:4258-69. 2011
    ..These findings uncover an important mechanism for the regulation of PTP-PEST in activated Ras-induced tumor progression...
  16. pmc Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells
    Yan Xia
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 288:19321-9. 2013
    ..These findings highlight the instrumental role of c-Jun in the resistance of tumors to treatment with CDDP and indicate that c-Jun is a molecular target for improving cancer therapy. ..
  17. pmc AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis
    Haitao Ji
    Brain Tumor Center and Department of Neuro Oncology, Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    EMBO Rep 13:554-60. 2012
    ..Our findings illustrate a pivotal role for AKT-mediated phosphorylation of Niban in protecting cells from genotoxic stress-induced cell apoptosis...
  18. pmc c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis
    Yan Xia
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 25:219-32. 2007
    ....
  19. doi request reprint α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation
    Haitao Ji
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Neurooncol 103:445-51. 2011
    ..These findings reveal the importance of β-catenin regulation by α-catenin in cellular activities of glioblastoma cells...
  20. pmc MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress
    Yan Xia
    Department of Neuro Oncology, Unit 1002, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 27:510-7. 2007
    ..Furthermore, apoptosis induced by osmotic stress was suppressed by overexpression of c-Jun, indicating that the downregulation of c-Jun promotes apoptosis...
  21. doi request reprint Regulation and function of pyruvate kinase M2 in cancer
    Weiwei Yang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Electronic address
    Cancer Lett 339:153-8. 2013
    ..This review outlines the current understanding of PKM2 protein kinase activity and regulatory mechanisms underlying PKM2 expression, enzymatic activity, and nuclear localization, thus highlighting PKM2 as a potential therapeutic target. ..
  22. pmc Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
    Dexing Fang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:11221-9. 2007
    ..Phosphorylation of beta-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that AKT-dependent regulation of beta-catenin plays a critical role in tumor invasion and development...
  23. ncbi request reprint Paradoxical roles of FAK in tumor cell migration and metastasis
    Yanhua Zheng
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cell Cycle 8:3474-9. 2009
    ..Activated Ras may promote tumor cell migration by dephosphorylation of FAK at Y397 and facilitation of focal adhesion turnover at the leading edge of cells...
  24. ncbi request reprint The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 9:945-56. 2002
    ..Therefore, MEKK1 functions not only as an upstream activator of the ERK and JNK through its kinase domain, but also as an E3 ligase through its PHD domain, providing a negative regulatory mechanism for decreasing ERK1/2 activity...
  25. pmc Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST)
    Yanhua Zheng
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Chin J Cancer 32:75-83. 2013
    ..Dephosphorylation of PTP-PEST substrates regulates their enzymatic activities and/or their interaction with other proteins and plays an essential role in the tumor cell migration process...
  26. pmc Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase
    Zhiyong Ding
    Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e9910. 2010
    ..The PDK1-IFPC::IFPN-AKT1 complex provides a cell-based platform to examine specificity of drugs targeting PI3K pathway components...
  27. pmc Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis
    Hehua Chen
    Department of Neuro Oncology, Brain Tumor Center, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 29:3657-64. 2009
    ..The downregulation of Hsp90 beta mediated by caspase-8-dependent caspase-10 activation promoted UVB-induced cell apoptosis...
  28. doi request reprint Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition
    Wen Tai Chiu
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 71:4932-43. 2011
    ..Collectively, our findings provide clinical and mechanistic evidence that Cav-1 is a critical target for suppression by Stat3 in driving invasion and metastasis of breast cancer cells...
  29. pmc Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts
    Shuying Liu
    Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:5248-53. 2008
    ..Thus Ras(V12) and the lack of GSK3beta act in concert to activate the beta-catenin pathway, which may underlie the bypass of senescence and tumorigenic transformation by Ras...
  30. pmc Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition
    Wei Guo
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e28487. 2011
    ..Here we investigated in vitro and in vivo antitumor activity of NSC-743380 (1-[(3-chlorophenyl) methyl]-1H-indole-3-methanol, oncrasin-72), one of most potent analogues of oncrasin-1...

Research Grants5