Xiaoying Lu

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint The brain galanin receptors: targets for novel antidepressant drugs
    Xiaoying Lu
    Molecular and Integrative Neuroscience Department MIND and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Rd SR 307, La Jolla, CA 92037, USA
    CNS Neurol Disord Drug Targets 6:183-92. 2007
  2. pmc Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests
    Xiaoying Lu
    The Harold L Dorris Neurological Institute, Department of Molecular and Integrative Neurosciences, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 42:387-97. 2008
  3. pmc Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests
    Tamas Bartfai
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:10470-5. 2004
  4. pmc A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
    Xiaoying Lu
    Department of Neuropharmacology and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:874-9. 2005
  5. ncbi request reprint Galanin receptor ligands
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:143-6. 2005
  6. pmc GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models
    Xiaoying Lu
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:15229-34. 2010
  7. ncbi request reprint Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:165-7. 2005
  8. ncbi request reprint Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:147-52. 2005
  9. ncbi request reprint A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests
    Alasdair M Barr
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA, United States
    Neurosci Lett 405:111-5. 2006
  10. pmc Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2
    Vasudeva Naidu Sagi
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, United States
    Bioorg Med Chem Lett 21:7210-5. 2011

Collaborators

Detail Information

Publications18

  1. ncbi request reprint The brain galanin receptors: targets for novel antidepressant drugs
    Xiaoying Lu
    Molecular and Integrative Neuroscience Department MIND and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Rd SR 307, La Jolla, CA 92037, USA
    CNS Neurol Disord Drug Targets 6:183-92. 2007
    ..Since both GalR2 and GalR3 are G-protein coupled receptors (GPCRs), a favorite target class for drug development, we believe that the pace of developing galaninergic antidepressants will increase significantly from now on...
  2. pmc Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests
    Xiaoying Lu
    The Harold L Dorris Neurological Institute, Department of Molecular and Integrative Neurosciences, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 42:387-97. 2008
    ..The present findings are consistent with a predicted antidepressant-like effect of GalR2 signaling, suggesting that GalR2 might be a valid drug target for depressive disorders...
  3. pmc Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests
    Tamas Bartfai
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:10470-5. 2004
    ..These data further implicate brain and spinal cord galanin receptors as drug targets and provide an example of a systemically active compound based on a scaffold that mimics protein surfaces...
  4. pmc A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
    Xiaoying Lu
    Department of Neuropharmacology and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:874-9. 2005
    ....
  5. ncbi request reprint Galanin receptor ligands
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:143-6. 2005
    ..The present paper summarizes the properties of the galanin ligands used at the end of 2004 in the ca. 2000 publications and complements their pharmacological characterization with new data...
  6. pmc GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models
    Xiaoying Lu
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:15229-34. 2010
    ..CYM2503 also attenuated electroshock-induced seizures in mice. Thus, CYM2503 provides a starting point for the development of anticonvulsant therapy using the galanin R2 receptor as target...
  7. ncbi request reprint Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:165-7. 2005
    ..For now one needs to interpret the data obtained at lower galanin (2-11) concentrations as effects mediated by non-GalR1 type galanin receptors, i.e., GalR2 and/or GalR3...
  8. ncbi request reprint Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:147-52. 2005
    ....
  9. ncbi request reprint A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests
    Alasdair M Barr
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA, United States
    Neurosci Lett 405:111-5. 2006
    ..These combined data from two species indicate that GalR3 receptor antagonists may exhibit antidepressant-like effects...
  10. pmc Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2
    Vasudeva Naidu Sagi
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, United States
    Bioorg Med Chem Lett 21:7210-5. 2011
    ..Optimization of a series of 2,4,6-triaminopyrimidines led to the discovery of several analogs with IC50 values ranging from 0.3 to 1 μM...
  11. pmc Synthesis of galmic: a nonpeptide galanin receptor agonist
    Susana Conde Ceide
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:16727-32. 2004
    ..The present work describes the total synthesis of galmic, the synthesis of its oxazole precursors, the coupling of the building blocks into a linear trimer, and the macrolactamization reaction...
  12. pmc Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala
    Michal Bajo
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Addict Biol 17:694-705. 2012
    ..These findings may increase understanding of the complex cellular mechanisms that underlie the anxiety-related behavioral effects of galanin and ethanol in CeA...
  13. pmc Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice
    Xiaoying Lu
    The Harold L Dorris Neurological Research Institute, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, SR 307, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Naunyn Schmiedebergs Arch Pharmacol 379:417-20. 2009
    ..These findings argue for taking precaution when using antibodies to galanin receptors...
  14. ncbi request reprint Homodimerization and internalization of galanin type 1 receptor in living CHO cells
    Sebastian A Wirz
    Department of Neuropharmacology, Harold L Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropeptides 39:535-46. 2005
    ..Internalization and dimerization of GalR1 is shown, contributing to the regulation of galanergic signaling...
  15. ncbi request reprint Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour
    Tie Jun Sten Shi
    Department of Neuroscience, Karolinska Institutet, S171 77 Stockholm, Sweden
    Eur J Neurosci 23:627-36. 2006
    ..These data are in line with earlier observations from the peripheral and central nervous system, suggesting that galanin actions mediated by GalR2 subtype are of importance in neurodevelopment and neuroprotection...
  16. ncbi request reprint Important pharmacophores for binding to galanin receptor 2
    Linda Lundström
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Svante Arrheniusv 21A, 106 91 Stockholm, Sweden
    Neuropeptides 39:169-71. 2005
    ..This information is useful in the rational design of non-peptide type GalR2 receptor ligands...
  17. ncbi request reprint Carbamoylcholine chloride induces a rapid increase in IL6 in the nasal cavity of C57BL/6 mice
    Xiaoying Lu
    Department of Periodontics, College of Public Health, The University of Iowa, Iowa City, IA, USA
    Comp Med 57:349-54. 2007
    ..In summary, carbamoylcholine chloride induces a rapid, elevated IL6 response in the nasal cavity and respiratory tract of mice but does not alter the levels of other Th1, Th2, or proinflammatory cytokines...
  18. ncbi request reprint Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus
    Andrey Mazarati
    West Los Angeles VA Medical Center, and Department of Neurology, D Geffen Medical School, UCLA, Los Angeles, CA, USA
    Eur J Neurosci 19:3235-44. 2004
    ..These results are important for understanding the role of galanin and galanin receptor subtypes in the hippocampus both under normal conditions and in excitotoxic injury...