Research Topics
| Xiaoying LuSummaryAffiliation: The Scripps Research Institute Country: USA Publications
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Detail Information
Publications
The brain galanin receptors: targets for novel antidepressant drugsXiaoying Lu
Molecular and Integrative Neuroscience Department MIND and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Rd SR 307, La Jolla, CA 92037, USA
CNS Neurol Disord Drug Targets 6:183-92. 2007..Since both GalR2 and GalR3 are G-protein coupled receptors (GPCRs), a favorite target class for drug development, we believe that the pace of developing galaninergic antidepressants will increase significantly from now on...
Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral testsXiaoying Lu
The Harold L Dorris Neurological Institute, Department of Molecular and Integrative Neurosciences, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuropeptides 42:387-97. 2008..The present findings are consistent with a predicted antidepressant-like effect of GalR2 signaling, suggesting that GalR2 might be a valid drug target for depressive disorders...- Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim testsTamas Bartfai
Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:10470-5. 2004..These data further implicate brain and spinal cord galanin receptors as drug targets and provide an example of a systemically active compound based on a scaffold that mimics protein surfaces... - A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleusXiaoying Lu
Department of Neuropharmacology and The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 102:874-9. 2005.... - Galanin receptor ligandsXiaoying Lu
Department of Neuropharmacology, The Harold L. Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuropeptides 39:143-6. 2005..The present paper summarizes the properties of the galanin ligands used at the end of 2004 in the ca. 2000 publications and complements their pharmacological characterization with new data... - GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal modelsXiaoying Lu
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 107:15229-34. 2010..CYM2503 also attenuated electroshock-induced seizures in mice. Thus, CYM2503 provides a starting point for the development of anticonvulsant therapy using the galanin R2 receptor as target... - Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypesXiaoying Lu
Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuropeptides 39:165-7. 2005..For now one needs to interpret the data obtained at lower galanin (2-11) concentrations as effects mediated by non-GalR1 type galanin receptors, i.e., GalR2 and/or GalR3... - Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activityXiaoying Lu
Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuropeptides 39:147-52. 2005.... - A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical testsAlasdair M Barr
Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA, United States
Neurosci Lett 405:111-5. 2006..These combined data from two species indicate that GalR3 receptor antagonists may exhibit antidepressant-like effects... - Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2Vasudeva Naidu Sagi
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, United States
Bioorg Med Chem Lett 21:7210-5. 2011..Optimization of a series of 2,4,6-triaminopyrimidines led to the discovery of several analogs with IC50 values ranging from 0.3 to 1 μM... - Synthesis of galmic: a nonpeptide galanin receptor agonistSusana Conde Ceide
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:16727-32. 2004..The present work describes the total synthesis of galmic, the synthesis of its oxazole precursors, the coupling of the building blocks into a linear trimer, and the macrolactamization reaction... - Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdalaMichal Bajo
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Addict Biol 17:694-705. 2012..These findings may increase understanding of the complex cellular mechanisms that underlie the anxiety-related behavioral effects of galanin and ethanol in CeA... - Analyzing the validity of GalR1 and GalR2 antibodies using knockout miceXiaoying Lu
The Harold L Dorris Neurological Research Institute, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, SR 307, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Naunyn Schmiedebergs Arch Pharmacol 379:417-20. 2009..These findings argue for taking precaution when using antibodies to galanin receptors... - Homodimerization and internalization of galanin type 1 receptor in living CHO cellsSebastian A Wirz
Department of Neuropharmacology, Harold L. Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropeptides 39:535-46. 2005..Internalization and dimerization of GalR1 is shown, contributing to the regulation of galanergic signaling... - Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviourTie Jun Sten Shi
Department of Neuroscience, Karolinska Institutet, S171 77 Stockholm, Sweden
Eur J Neurosci 23:627-36. 2006..These data are in line with earlier observations from the peripheral and central nervous system, suggesting that galanin actions mediated by GalR2 subtype are of importance in neurodevelopment and neuroprotection... - Important pharmacophores for binding to galanin receptor 2Linda Lundström
Department of Neurochemistry and Neurotoxicology, Stockholm University, Svante Arrheniusv 21A, 106 91 Stockholm, Sweden
Neuropeptides 39:169-71. 2005..This information is useful in the rational design of non-peptide type GalR2 receptor ligands... - Carbamoylcholine chloride induces a rapid increase in IL6 in the nasal cavity of C57BL/6 miceXiaoying Lu
Department of Periodontics, College of Public Health, The University of Iowa, Iowa City, IA, USA
Comp Med 57:349-54. 2007..In summary, carbamoylcholine chloride induces a rapid, elevated IL6 response in the nasal cavity and respiratory tract of mice but does not alter the levels of other Th1, Th2, or proinflammatory cytokines... - Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrusAndrey Mazarati
West Los Angeles VA Medical Center, and Department of Neurology, D Geffen Medical School, UCLA, Los Angeles, CA, USA
Eur J Neurosci 19:3235-44. 2004..These results are important for understanding the role of galanin and galanin receptor subtypes in the hippocampus both under normal conditions and in excitotoxic injury...