Jeanne F Loring

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Transcriptome coexpression map of human embryonic stem cells
    Huai Li
    Bioinformatics Unit, Branch of Research Resources, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    BMC Genomics 7:103. 2006
  2. pmc Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines
    Ying Liu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    BMC Dev Biol 6:20. 2006
  3. pmc A molecular scheme for improved characterization of human embryonic stem cell lines
    Richard Josephson
    Stem Cell Center, American Type Culture Collection ATCC, Manassas, VA, USA
    BMC Biol 4:28. 2006
  4. ncbi request reprint Evolution of microarray analysis
    Jeanne F Loring
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Neurobiol Aging 27:1084-6. 2006
  5. ncbi request reprint Establishing standards for the characterization of human embryonic stem cell lines
    Jeanne F Loring
    Stem Cell Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Stem Cells 24:145-50. 2006
  6. ncbi request reprint Science and law. Intellectual property and human embryonic stem cell research
    Jeanne F Loring
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Science 311:1716-7. 2006
  7. pmc Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives
    Kristopher L Nazor
    Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 10:620-34. 2012
  8. pmc Regulatory networks define phenotypic classes of human stem cell lines
    Franz Josef Muller
    Center for Regenerative Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 455:401-5. 2008
  9. pmc Conversion of human fibroblasts to angioblast-like progenitor cells
    Leo Kurian
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Methods 10:77-83. 2013
  10. pmc Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis
    Yu Chieh Wang
    The Scripps Research Institute, Department of Chemical Physiology, La Jolla, CA 92037, USA
    Cell Res 21:1551-63. 2011

Research Grants

Collaborators

Detail Information

Publications31

  1. pmc Transcriptome coexpression map of human embryonic stem cells
    Huai Li
    Bioinformatics Unit, Branch of Research Resources, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    BMC Genomics 7:103. 2006
    ..However, no systematic analysis has yet addressed whether gene expression in human ES cells may be regulated in chromosomal domains, and no chromosomal domains of coexpression have been identified...
  2. pmc Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines
    Ying Liu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    BMC Dev Biol 6:20. 2006
    ....
  3. pmc A molecular scheme for improved characterization of human embryonic stem cell lines
    Richard Josephson
    Stem Cell Center, American Type Culture Collection ATCC, Manassas, VA, USA
    BMC Biol 4:28. 2006
    ..However, hESC must be routinely analyzed at the genomic level to guard against deleterious changes during extensive propagation, expansion, and manipulation in vitro...
  4. ncbi request reprint Evolution of microarray analysis
    Jeanne F Loring
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Neurobiol Aging 27:1084-6. 2006
    ....
  5. ncbi request reprint Establishing standards for the characterization of human embryonic stem cell lines
    Jeanne F Loring
    Stem Cell Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Stem Cells 24:145-50. 2006
    ..We expect that as data accumulate and standards evolve, a core set of tests will become the norm for routine assessment of hESC cultures and that these tests will lay the groundwork for clinical applications of these cells...
  6. ncbi request reprint Science and law. Intellectual property and human embryonic stem cell research
    Jeanne F Loring
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Science 311:1716-7. 2006
  7. pmc Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives
    Kristopher L Nazor
    Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 10:620-34. 2012
    ....
  8. pmc Regulatory networks define phenotypic classes of human stem cell lines
    Franz Josef Muller
    Center for Regenerative Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 455:401-5. 2008
    ..Our results offer a new strategy for classifying stem cells and support the idea that pluripotency and self-renewal are under tight control by specific molecular networks...
  9. pmc Conversion of human fibroblasts to angioblast-like progenitor cells
    Leo Kurian
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Methods 10:77-83. 2013
    ..This methodology for indirect lineage conversion to angioblast-like cells adds to the armamentarium of reprogramming approaches aimed at the study and treatment of ischemic pathologies...
  10. pmc Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis
    Yu Chieh Wang
    The Scripps Research Institute, Department of Chemical Physiology, La Jolla, CA 92037, USA
    Cell Res 21:1551-63. 2011
    ....
  11. pmc Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    Louise C Laurent
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Stem Cell 8:106-18. 2011
    ..Our results illustrate the dynamic nature of genomic abnormalities in pluripotent stem cells and the need for frequent genomic monitoring to assure phenotypic stability and clinical safety...
  12. doi request reprint Comprehensive microRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence
    Louise C Laurent
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Stem Cells 26:1506-16. 2008
    ..We propose that miRNAs are coordinately controlled in hESCs, and are key regulators of pluripotence and differentiation. Disclosure of potential conflicts of interest is found at the end of this article...
  13. doi request reprint The functions of microRNAs in pluripotency and reprogramming
    Trevor R Leonardo
    Department of Chemical Physiology, The Scripps Research Institute and the Center for Regenerative Medicine, La Jolla, California 92037, USA
    Nat Cell Biol 14:1114-21. 2012
    ..Detailed studies of miRNAs and their targets in PSCs should help to parse the regulatory networks that underlie developmental processes and cellular reprogramming...
  14. ncbi request reprint Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells
    Igor I Katkov
    UCSD Cancer Center, San Diego, CA 92122, USA Stem Cell Center Core, Burnham Institute for Medical Research BIMR, La Jolla, CA 92037, USA
    Cryobiology 53:194-205. 2006
    ..It is concluded that new protocols and media are required for freezing hESC and safe storage at -80 degrees C as well as studies of the mechanisms of stress-related events associated with cell cryopreservation...
  15. doi request reprint A call to standardize teratoma assays used to define human pluripotent cell lines
    Franz Josef Muller
    Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Stem Cell 6:412-4. 2010
    ..However, reports of new human ESC and iPSC lines vary widely in both methods and analysis of teratoma data. We call for consensus standards to be established to make this assay worthy of its "golden" status...
  16. pmc Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins
    Franz Josef Mueller
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Stem Cells 24:2367-72. 2006
    ....
  17. ncbi request reprint Gene therapy: can neural stem cells deliver?
    Franz Josef Muller
    Burnham Institute for Medical Research, La Jolla, California, USA
    Nat Rev Neurosci 7:75-84. 2006
    ..Here, we speculate on the ways in which neural stem cells might be exploited as delivery vehicles for gene therapy in the CNS...
  18. ncbi request reprint Beyond fraud--stem-cell research continues
    Evan Y Snyder
    Stem Cell Resource in the Program in Stem Cells and Regeneration, Developmental and Regenerative Cell Biology, Burnham Institute for Medical Research, La Jolla, Calif, USA
    N Engl J Med 354:321-4. 2006
  19. doi request reprint Preparation of autogenic human feeder cells for growth of human embryonic stem cells
    Rodolfo Gonzalez
    University of California, San Diego, La Jolla, California, USA
    Curr Protoc Stem Cell Biol . 2008
    ..Curr. Protoc. Stem Cell Biol. 4:1C.5.1-1C.5.15. (c) 2008 by John Wiley & Sons, Inc...
  20. doi request reprint Ethnically diverse pluripotent stem cells for drug development
    Eyitayo S Fakunle
    Department of Chemical Physiology, Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Mol Med 18:709-16. 2012
    ..Here, we discuss the benefits and challenges of using iPSCs to introduce genetic diversity into the drug development process...
  21. ncbi request reprint A role for stem cell biology in the physiological and pathological aspects of aging
    Evan Y Snyder
    Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Geriatr Soc 53:S287-91. 2005
    ..Therefore, stem cells may be used for cell replacement, for therapeutic interventions, and potentially to modify aging...
  22. pmc Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA⋅TTC triplet repeat instability
    Sherman Ku
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 7:631-7. 2010
    ....
  23. doi request reprint The ACTCellerate initiative: large-scale combinatorial cloning of novel human embryonic stem cell derivatives
    Michael D West
    BioTime, Inc, Alameda, CA 94502, USA
    Regen Med 3:287-308. 2008
    ..All hEP lines studied appear to have a finite replicative lifespan but have longer telomeres than most fetal- or adult-derived cells, thereby facilitating their use in the manufacture of purified lineages for research and human therapy...
  24. pmc Human embryonic stem cells have a unique epigenetic signature
    Marina Bibikova
    Illumina, Inc, San Diego, California 92121, USA
    Genome Res 16:1075-83. 2006
    ..Our results indicate that hES cells have a unique epigenetic signature that may contribute to their developmental potential...
  25. ncbi request reprint Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice
    Chad A Dickey
    Alzheimer s Disease Research Laboratory, Department of Pharmacology, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    J Neurosci 23:5219-26. 2003
    ..This suggests that the memory loss in APP+PS1 transgenic mice may model the early memory dysfunction in AD before the degeneration of synapses and neurons...
  26. ncbi request reprint NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells
    Catherine M Schwartz
    Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Stem Cells Dev 14:517-34. 2005
    ..Therefore, NTera2 cell dopaminergic neuronal differentiation and PSA-NCAM enrichment provides a useful system for the future study of hESCs...
  27. pmc Assessing self-renewal and differentiation in human embryonic stem cell lines
    Jingli Cai
    Laboratory of Neurosciences, National Institute on Aging, Department of Health and Human Services, Baltimore, Maryland, USA
    Stem Cells 24:516-30. 2006
    ..We show that qPCR, with as few as 12 selected genes, can reliably distinguish differentiated cells from undifferentiated hESC populations...
  28. doi request reprint Unraveling epigenetic regulation in embryonic stem cells
    Marina Bibikova
    Illumina, Inc, San Diego, CA 92121, USA
    Cell Stem Cell 2:123-34. 2008
    ..Understanding the interactions among these factors will be critical to the development of improved strategies to reprogram differentiated cells or direct differentiation of pluripotent cells...
  29. doi request reprint Isolation of human embryonic stem cell-derived teratomas for the assessment of pluripotency
    Karin Gertow
    Department of Laboratory Medicine, Clinical Research Center, Unit for Molecular Embryology, Karolinska Institute, Sweden
    Curr Protoc Stem Cell Biol . 2007
    ..Teratomas can also be fixed in Bouin's or cryosectioned for analysis, and they can be analyzed by immunohistochemistry for tissue markers. Methods for these procedures are included in this unit...
  30. pmc Differentiation of neural lineage cells from human pluripotent stem cells
    Philip H Schwartz
    Center for Translational Research, Children s Hospital of Orange County Research Institute, 455 South Main Street, Orange, CA 92868 3874, USA
    Methods 45:142-58. 2008
    ..In addition, we evaluate data comparing and contrasting neural stem cells differentiated from human pluripotent stem cells with those derived directly from the human brain...
  31. ncbi request reprint Complexity of inflammatory responses in endothelial cells and vascular smooth muscle cells determined by microarray analysis
    Olga Bandman
    Incyte Genomics, Palo Alto, California 94304, USA
    Ann N Y Acad Sci 975:77-90. 2002
    ....

Research Grants1

  1. Human Embryonic Stem Cells: Comprehensive Training Program
    Jeanne Loring; Fiscal Year: 2007
    ..Aim 4: Feedback and follow-up: obtain information from students that will improve the course. For this training course, we will use NIH Registry lines WA09 and WA01, BG01, BG03, TE06, and possibly others from the Registry list. ..