Genomes and Genes
Affiliation: The Scripps Research Institute
- Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasisMihaela Lorger
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 150, La Jolla, CA 92037, USA
Am J Pathol 176:2958-71. 2010..Thus, information on the initial interplay between brain homing tumor cells and reactive host cells may help develop strategies for prevention and treatment of symptomatic breast cancer brain metastases...
- Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasisKarin Staflin
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Clin Exp Metastasis 27:217-31. 2010..Inhibition of advanced metastatic disease by treatment with cancer patient derived single chain antibodies against the activated conformer of integrin alphavbeta3 identifies this form of the receptor as a suitable target for therapy...
- An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiationHeiko Wurdak
The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Stem Cell 6:37-47. 2010..TRRAP knockdown also significantly suppressed tumor formation upon intracranial BTIC implantation into mice. Together, these findings support a critical role for TRRAP in maintaining a tumorigenic, stem cell-like state...
- Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brainMihaela Lorger
Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 150, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:10666-71. 2009..Targeting this molecular mechanism could prove valuable for the inhibition of brain metastasis...