Craig Logsdon

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment
    Vijaya Ramachandran
    Department of Cancer Biology, University of Texas MD Anderson Cancer Centre, Houston, Texas, United States of America
    PLoS ONE 4:e7502. 2009
  2. pmc Targeting pancreatic ductal adenocarcinoma acidic microenvironment
    Zobeida Cruz-Monserrate
    Department of Cancer Biology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Sci Rep 4:4410. 2014
  3. pmc The role of protein synthesis and digestive enzymes in acinar cell injury
    Craig D Logsdon
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 953, Houston, TX 77030, USA
    Nat Rev Gastroenterol Hepatol 10:362-70. 2013
  4. pmc Designing and developing S100P inhibitor 5-methyl cromolyn for pancreatic cancer therapy
    Thiruvengadam Arumugam
    Department of Cancer Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 12:654-62. 2013
  5. pmc Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models
    Zobeida Cruz-Monserrate
    Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Gut 61:1315-22. 2012
  6. ncbi request reprint RAGE and RAGE ligands in cancer
    Craig D Logsdon
    Department of Cancer Biology, The University of Texas Anderson Cancer Center, Unit 953, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Curr Mol Med 7:777-89. 2007
  7. pmc Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer
    Craig D Logsdon
    Department of Cancer Biology and GI Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 7:S40-3. 2009
  8. doi request reprint Synthesis and ex vivo autoradiographic evaluation of ethyl-β-D-galactopyranosyl-(1,4')-2'-deoxy-2'-[18F]fluoro-β-D-glucopyranoside--a novel radioligand for lactose-binding protein: implications for early detection of pancreatic carcinomas with PET
    Yunming Ying
    Department of Experimental Diagnostic Imaging, Center for Advanced Biomedical Imaging Research CABIR, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Imaging Biol 13:536-46. 2011
  9. pmc Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling
    Shumei Song
    Department of Gastroenterology, Hepatology, and Nutrition, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e42699. 2012
  10. pmc Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression
    David Z Chang
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Hematol Oncol 5:15. 2012

Research Grants

  1. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2002
  2. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2001
  3. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2003
  4. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2003
  5. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2004
  6. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2004
  7. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2007
  8. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2009
  9. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2002
  10. MOLECULAR MECHANISMS OF PANCREATITIS
    Craig Logsdon; Fiscal Year: 1999

Collaborators

Detail Information

Publications45

  1. pmc The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment
    Vijaya Ramachandran
    Department of Cancer Biology, University of Texas MD Anderson Cancer Centre, Houston, Texas, United States of America
    PLoS ONE 4:e7502. 2009
    ..The current study examines the role of specific AM receptors on tumor and cells resembling the tumor microenvironment (human pancreatic stellate--HPSC, human umbilical vein-- HUVEC and mouse lung endothelial cells--MLEC)...
  2. pmc Targeting pancreatic ductal adenocarcinoma acidic microenvironment
    Zobeida Cruz-Monserrate
    Department of Cancer Biology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Sci Rep 4:4410. 2014
    ..This novel approach may improve detection, differential diagnosis and staging of PDAC. ..
  3. pmc The role of protein synthesis and digestive enzymes in acinar cell injury
    Craig D Logsdon
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 953, Houston, TX 77030, USA
    Nat Rev Gastroenterol Hepatol 10:362-70. 2013
    ..This Review focuses on protein synthesis and active digestive enzymes--two key stressors faced by the acinar cell that are likely to be the major drivers of pathology encountered in the pancreas...
  4. pmc Designing and developing S100P inhibitor 5-methyl cromolyn for pancreatic cancer therapy
    Thiruvengadam Arumugam
    Department of Cancer Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 12:654-62. 2013
    ..Therefore, the cromolyn analog, C5OH, was found to be more efficient and potent than cromolyn as a therapeutic for PDAC...
  5. pmc Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models
    Zobeida Cruz-Monserrate
    Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Gut 61:1315-22. 2012
    ....
  6. ncbi request reprint RAGE and RAGE ligands in cancer
    Craig D Logsdon
    Department of Cancer Biology, The University of Texas Anderson Cancer Center, Unit 953, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Curr Mol Med 7:777-89. 2007
    ..Despite these complications, the bulk of the evidence supports the premise that the ligand-RAGE axis is an important target for therapeutic intervention in cancer...
  7. pmc Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer
    Craig D Logsdon
    Department of Cancer Biology and GI Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 7:S40-3. 2009
    ..We proposed a new model in which Ras activity is the direct link between these 2 diseases. Here we will briefly review the shared properties between CP and PDAC and describe the new model...
  8. doi request reprint Synthesis and ex vivo autoradiographic evaluation of ethyl-β-D-galactopyranosyl-(1,4')-2'-deoxy-2'-[18F]fluoro-β-D-glucopyranoside--a novel radioligand for lactose-binding protein: implications for early detection of pancreatic carcinomas with PET
    Yunming Ying
    Department of Experimental Diagnostic Imaging, Center for Advanced Biomedical Imaging Research CABIR, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Imaging Biol 13:536-46. 2011
    ....
  9. pmc Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling
    Shumei Song
    Department of Gastroenterology, Hepatology, and Nutrition, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e42699. 2012
    ..These results suggest that Gal-3 contributes to pancreatic cancer progression, in part, by binding Ras and activating Ras signaling. Gal-3 may therefore be a potential novel target for this deadly disease...
  10. pmc Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression
    David Z Chang
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Hematol Oncol 5:15. 2012
    ..In this retrospective study, we determined whether aberrant CDC20 expression can be used as a biomarker in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and whether its expression reflects clinical progression...
  11. ncbi request reprint Molecular profiling of direct xenograft tumors established from human pancreatic adenocarcinoma after neoadjuvant therapy
    Michael P Kim
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 19:S395-403. 2012
    ..We sought to identify consistent, differentially expressed genes between treatment of naive pancreatic tumors and those exposed to neoadjuvant therapy using a strict, in vivo direct xenograft model system...
  12. pmc Cancer-associated stromal fibroblasts promote pancreatic tumor progression
    Rosa F Hwang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer Res 68:918-26. 2008
    ..These data indicate that stellate cells have an important role in supporting and promoting pancreatic cancer. Identification of HPSC-derived factors may lead to novel stroma-targeted therapies for pancreatic cancer...
  13. ncbi request reprint S100P promotes pancreatic cancer growth, survival, and invasion
    Thiruvengadam Arumugam
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:5356-64. 2005
    ..In the current study, we examined the functional significance and mechanism of action of S100P in pancreatic cancer cells...
  14. pmc Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer
    Zhimin Tong
    Department of Gastroenterology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:6100-8. 2008
    ..Thus, NGAL is a potential suppressor of invasion and angiogenesis in advanced PaCa...
  15. ncbi request reprint Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models
    Thiruvengadam Arumugam
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 98:1806-18. 2006
    ..In the current study, we investigated the ability of the antiallergy drug, cromolyn, to block S100P function...
  16. doi request reprint Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival
    Vijaya Ramachandran
    Departments of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:7811-8. 2008
    ..In summary, AGR2 is expressed and secreted during pancreatic cancer development and plays an important role in cancer cell growth and survival. These observations suggest that AGR2 may be a useful molecular target in pancreatic cancer...
  17. pmc Ras activity levels control the development of pancreatic diseases
    Baoan Ji
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 137:1072-82, 1082.e1-6. 2009
    ..However, we hypothesized that acinar cells would develop PDAC in the presence of Ras activity levels mimicking those of human tumor cells...
  18. doi request reprint Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer
    Hua Wang
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 69:1063-70. 2009
    ..Thus, HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer...
  19. ncbi request reprint Dual targeting of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma
    Chunhua Lu
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:4209-17. 2007
    ..Pericytes are known to provide a survival advantage for endothelial cells. We hypothesize that strategies aimed at dual targeting of tumor-associated endothelial cells and pericytes will be highly efficacious...
  20. doi request reprint Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
    Thiruvengadam Arumugam
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 69:5820-8. 2009
    ..012). Therefore, our results suggest that Zeb-1 and other regulators of EMT may maintain drug resistance in human pancreatic cancer cells, and therapeutic strategies to inhibit Zeb-1 and reverse EMT should be evaluated...
  21. pmc Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:18636-41. 2007
    ..These data reveal an important outcome of aberrant ZIP4 expression in contributing to pancreatic cancer pathogenesis and progression. It may suggest a therapeutic strategy whereby ZIP4 is targeted to control pancreatic cancer growth...
  22. ncbi request reprint Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR
    Vijaya Ramachandran
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:2666-75. 2007
    ..These data indicate that adrenomedullin acting via ADMR increases the aggressiveness of pancreatic cancer cells and suggests that these molecules may be useful therapeutic targets...
  23. pmc Detection of pancreatic carcinomas by imaging lactose-binding protein expression in peritumoral pancreas using [18F]fluoroethyl-deoxylactose PET/CT
    Leo Garcia Flores
    Department of Experimental Diagnostic Imaging, Center for Advanced Biomedical Imaging Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 4:e7977. 2009
    ..6pl pancreatic carcinomas in mice. [(18)F]FEDL is a novel radioligand of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP), which is overexpressed in peritumoral pancreatic acinar cells...
  24. pmc ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB
    Yuqing Zhang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Molecular Surgeon Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 16:1423-30. 2010
    ..We have recently found that ZIP4 is overexpressed in pancreatic cancer. In this study, we investigated the signaling pathway through which ZIP4 regulates pancreatic cancer growth...
  25. pmc Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation
    Baoan Ji
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Biol Chem 284:17488-98. 2009
    ..This new model will greatly improve our understanding of the role of active trypsin in pancreatitis and its associated inflammatory response...
  26. pmc Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts
    Min Li
    Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 15:5993-6001. 2009
    ..We recently found that a zinc transporter, ZIP4, is overexpressed in pancreatic cancer. In this study, we further deciphered the role that ZIP4 plays in a pancreatic cancer mouse model by silencing ZIP4...
  27. pmc Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer
    Tobias Grote
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Proteomics 8:3051-60. 2008
    ..75%). As RPPA is a high-throughput method that shows results comparable to that of ELISA, we propose that RPPA is a viable technique for rapid experimental screening and validation of candidate biomarkers in blood samples...
  28. doi request reprint Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver
    Michael J Gray
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    J Natl Cancer Inst 100:109-20. 2008
    ..Neuropilin-2 (NRP2) is a high-affinity kinase-deficient receptor for vascular endothelial growth factor (VEGF) and semaphorin 3F. We investigated its function in human colorectal cancers...
  29. ncbi request reprint Progress on molecular markers of pancreatic cancer
    Tobias Grote
    Department of Cancer Biology, University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Curr Opin Gastroenterol 23:508-14. 2007
    ..To describe advances in the development of biomarkers for pancreatic cancer over the past year...
  30. ncbi request reprint Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells
    Constanze H Kubisch
    The Univ of Texas M D Anderson Cancer Center, Dept of Cancer Biology, Unit 0953, SCRB2 2021, 7435 Fannin St, PO Box 301429, Houston, TX 77230 1429, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1804-12. 2007
    ..In conclusion, ER stress response mechanisms appear to be involved in both pancreatic physiology and pathophysiology, and future efforts should be directed at understanding the roles of these mechanisms in the pancreas...
  31. ncbi request reprint Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells
    Sanaz Khanbolooki
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:2251-60. 2006
    ....
  32. ncbi request reprint S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE)
    Thiruvengadam Arumugam
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:5059-65. 2004
    ..These data suggest that S100P can act in an autocrine manner via RAGE to stimulate cell proliferation and survival...
  33. ncbi request reprint The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma
    Charles E Binkley
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Pancreas 29:254-63. 2004
    ....
  34. ncbi request reprint Oligonucleotide-directed microarray gene profiling of pancreatic adenocarcinoma
    David E Misek
    Department of Pediatric Oncology, University of Michigan, Ann Arbor, USA
    Methods Mol Med 103:175-87. 2005
    ..The details of the approach we utilized are reported here, including information on experimental design, sample collection, expression level measurements, and data analysis for gene profiling...
  35. ncbi request reprint RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways
    Maren K Fuentes
    Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Dis Colon Rectum 50:1230-40. 2007
    ..This study was initiated to explore the potential role of the receptor for advanced glycation end-products and S100P in modulation of key properties of human colon cancer cells...
  36. ncbi request reprint Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells
    Bradley J Segura
    Department of Surgery, University of Michigan Medical Center, 2101 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0331, USA
    Brain Res Mol Brain Res 133:325-8. 2005
    ..420+/-44%). RT-PCR analysis and sequencing demonstrated the presence of previously unidentified LPA-responsive Endothelial Differentiation Gene (EDG) receptor mRNAs in C6 cells: EDG-2 and EDG-4...
  37. ncbi request reprint Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
    Craig D Logsdon
    Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:2649-57. 2003
    ..These data provide new insights into the molecular pathology of pancreatic cancer that may be useful for detection, diagnosis, and treatment...
  38. ncbi request reprint CEACAM1, a novel serum biomarker for pancreatic cancer
    Diane M Simeone
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Pancreas 34:436-43. 2007
    ..We recently observed elevated expression of CEACAM1 in pancreatic adenocarcinomas and sought to determine whether serum CEACAM1 levels were elevated in pancreatic cancer patients...
  39. pmc A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A
    Lizhi Zhang
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 24:2169-80. 2004
    ..Taken together, these data indicate an important and previously unrecognized interaction between the TGFbeta and PKA signaling pathways...
  40. ncbi request reprint Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer
    Jiro Okami
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 0622, USA
    Cancer Res 64:5338-46. 2004
    ..In conclusion, down-regulation of BNIP3 by CpG methylation likely contributes to resistance to hypoxia-induced cell death in pancreatic cancer...
  41. ncbi request reprint An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer
    Su Hyung Hong
    Department of Pediatrics, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0656, USA
    Cancer Res 64:5504-10. 2004
    ..The detection of autoantibodies to calreticulin isoforms may have utility for the early diagnosis of pancreatic cancer...
  42. ncbi request reprint Role of small GTP binding proteins in the growth-promoting and antiapoptotic actions of gastrin
    Vinzenz Stepan
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0682, USA
    Am J Physiol Gastrointest Liver Physiol 287:G715-25. 2004
    ..Whereas Ras activates Akt and MAPK, Rho and Cdc42 appear to regulate Akt and possibly other as yet unidentified kinases mediating the growth-stimulatory actions of G17...
  43. ncbi request reprint Raf kinase inhibitory protein inhibits beta-cell proliferation
    Lizhi Zhang
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich, USA
    Surgery 136:708-15. 2004
    ..Raf-1 kinase inhibitory protein (RKIP) was recently identified as a physiologic endogenous inhibitor of the extracellular signal-regulated kinase (ERK) pathway. The expression and role of RKIP within the pancreas are unknown...
  44. ncbi request reprint Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer
    Lizhi Zhang
    Department of Surgery, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Cancer Res 66:898-906. 2006
    ..Furthermore, we showed a high frequency of loss of heterozygosity of rap1GAP in pancreatic cancer. Collectively, our data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer...
  45. ncbi request reprint Human pancreatic acinar cells do not respond to cholecystokinin
    Baoan Ji
    Department of Physiology, University of Michigan, Ann Arbor, MI 48109 0622, USA
    Pharmacol Toxicol 91:327-32. 2002
    ..These results indicate that human pancreatic acinar cells do not respond directly to CCK receptor activation and this is likely due to an insufficient level of receptor expression...

Research Grants21

  1. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2002
    ..Together these studies will provide important insights into the mechanisms regulating pancreatic acinar cell function. ..
  2. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2001
    ..Together these studies will provide important insights into the mechanisms regulating pancreatic acinar cell function. ..
  3. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2003
    ..Together these studies will provide important insights into the mechanisms regulating pancreatic acinar cell function. ..
  4. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2003
    ..abstract_text> ..
  5. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2004
    ..Together these studies will provide important insights into the mechanisms regulating pancreatic acinar cell function. ..
  6. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2004
    ..abstract_text> ..
  7. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2007
    ..Together these studies will provide insights into the mechanisms of acute pancreatitis that have not previously been possible and which may lead to improved therapies. ..
  8. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2009
    ..Together these studies will provide insights into the mechanisms of acute pancreatitis that have not previously been possible and which may lead to improved therapies. ..
  9. Molecular Mechanisms of Acute Pancreatitis
    Craig Logsdon; Fiscal Year: 2002
    ..abstract_text> ..
  10. MOLECULAR MECHANISMS OF PANCREATITIS
    Craig Logsdon; Fiscal Year: 1999
    ..This will attempt to utilize adenoviral vectors to directly express the specific chemokines in the pancreas in vivo and explore effects on the characteristics of pancreatitis. ..
  11. MOLECULAR MECHANISMS OF PANCREATITIS
    Craig Logsdon; Fiscal Year: 2000
    ..This will attempt to utilize adenoviral vectors to directly express the specific chemokines in the pancreas in vivo and explore effects on the characteristics of pancreatitis. ..
  12. RECEPTORS FOR CCK AND OTHER GI HORMONES
    Craig Logsdon; Fiscal Year: 2000
    ..Together these studies will provide important insights into the mechanisms regulating pancreatic acinar cell function. ..
  13. MOLECULAR MECHANISMS OF PANCREATITIS
    Craig Logsdon; Fiscal Year: 2001
    ..This will attempt to utilize adenoviral vectors to directly express the specific chemokines in the pancreas in vivo and explore effects on the characteristics of pancreatitis. ..
  14. Molecular Mechanisms of Acute Pancreatitis
    Craig D Logsdon; Fiscal Year: 2010
    ..Together these studies will provide insights into the mechanisms of acute pancreatitis that have not previously been possible and which may lead to improved therapies. ..