Brendan Loftus

Summary

Affiliation: The Institute for Genomic Research
Country: USA

Publications

  1. ncbi request reprint Gene discovery in the Acanthamoeba castellanii genome
    Iain J Anderson
    Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    Protist 156:203-14. 2005
  2. pmc The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans
    Brendan J Loftus
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 307:1321-4. 2005
  3. ncbi request reprint The genome of the protist parasite Entamoeba histolytica
    Brendan Loftus
    TIGR, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 433:865-8. 2005
  4. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
  5. ncbi request reprint Entamoeba histolytica: observations on metabolism based on the genome sequence
    Iain J Anderson
    Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    Exp Parasitol 110:173-7. 2005
  6. ncbi request reprint The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
  7. ncbi request reprint Unique organisation of tRNA genes in Entamoeba histolytica
    C Graham Clark
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Biochem Parasitol 146:24-9. 2006
  8. pmc A spliceosomal intron in Giardia lamblia
    Julie E J Nixon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115 6018, USA
    Proc Natl Acad Sci U S A 99:3701-5. 2002
  9. ncbi request reprint Iron-dependent hydrogenases of Entamoeba histolytica and Giardia lamblia: activity of the recombinant entamoebic enzyme and evidence for lateral gene transfer
    Julie E J Nixon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Ave, Boston, Massachusetts, USA
    Biol Bull 204:1-9. 2003
  10. pmc Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica
    Julie E J Nixon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Eukaryot Cell 1:181-90. 2002

Research Grants

  1. ENTAMOEBA HISTOLYTICA GENOME PROJECT
    Brendan Loftus; Fiscal Year: 2002

Detail Information

Publications15

  1. ncbi request reprint Gene discovery in the Acanthamoeba castellanii genome
    Iain J Anderson
    Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    Protist 156:203-14. 2005
    ..histolytica. Serine, cysteine and metalloproteases were identified, some of which are likely involved in pathogenicity...
  2. pmc The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans
    Brendan J Loftus
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 307:1321-4. 2005
    ..neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes...
  3. ncbi request reprint The genome of the protist parasite Entamoeba histolytica
    Brendan Loftus
    TIGR, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 433:865-8. 2005
    ..Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen...
  4. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...
  5. ncbi request reprint Entamoeba histolytica: observations on metabolism based on the genome sequence
    Iain J Anderson
    Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    Exp Parasitol 110:173-7. 2005
    ..histolytica. The usual eukaryotic glucose transporters are not present, but members of a prokaryotic monosaccharide transporter family are present...
  6. ncbi request reprint The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  7. ncbi request reprint Unique organisation of tRNA genes in Entamoeba histolytica
    C Graham Clark
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Biochem Parasitol 146:24-9. 2006
    ..The number and organisation of tRNA genes in E. histolytica is unprecedented. In addition to encoding the tRNAs of the organism we propose that the arrays may fulfil a structural role in the genome...
  8. pmc A spliceosomal intron in Giardia lamblia
    Julie E J Nixon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115 6018, USA
    Proc Natl Acad Sci U S A 99:3701-5. 2002
    ..If introns were added during eukaryotic evolution (the introns-late hypothesis), then these results push back the date of this event before the branching of G. lamblia...
  9. ncbi request reprint Iron-dependent hydrogenases of Entamoeba histolytica and Giardia lamblia: activity of the recombinant entamoebic enzyme and evidence for lateral gene transfer
    Julie E J Nixon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Ave, Boston, Massachusetts, USA
    Biol Bull 204:1-9. 2003
    ..These results are discussed in the context of competing ideas for the origins of genes encoding fermentation enzymes of these protists...
  10. pmc Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica
    Julie E J Nixon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Eukaryot Cell 1:181-90. 2002
    ..In further support of lateral transfer, the G. lamblia NADH oxidase and adh3 genes appeared to have an evolutionary history distinct from those of E. histolytica...
  11. ncbi request reprint The diversity of Rab GTPases in Entamoeba histolytica
    Yumiko Saito-Nakano
    Department of Parasitology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    Exp Parasitol 110:244-52. 2005
    ..We propose annotation of amebic Rab genes and discuss biological significance of this extraordinary diversity of EhRab proteins in this organism...
  12. ncbi request reprint Entamoeba: still more to be learned from the genome
    Brendan J Loftus
    Trends Parasitol 21:453. 2005
  13. pmc The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation
    Iris Bruchhaus
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Eukaryot Cell 2:501-9. 2003
    ..histolytica or E. dispar trophozoites during in vitro cultivation. Therefore, it is likely that at least some of these enzymes are required for infection of the human host and/or for completion of the parasite life cycle...
  14. pmc Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assembly
    Neil F Lobo
    Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 0369, USA
    Genome Biol 8:R88. 2007
    ..PCR and sequencing were used to experimentally confirm expression and sequence of a subset of these transcripts...
  15. ncbi request reprint The Aedes aegypti glutathione transferase family
    Nongkran Lumjuan
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Palace, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 37:1026-35. 2007
    ....

Research Grants3

  1. ENTAMOEBA HISTOLYTICA GENOME PROJECT
    Brendan Loftus; Fiscal Year: 2002
    ..The vast majority of the research needs and applications will be met by obtaining 99 percent of the genomic sequence. ..