Research Topics
| Brendan LoftusSummaryAffiliation: The Institute for Genomic Research Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformansBrendan J Loftus
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 307:1321-4. 2005..neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes...
The genome of the protist parasite Entamoeba histolyticaBrendan Loftus
TIGR, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 433:865-8. 2005..Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen...- Genome sequence of Aedes aegypti, a major arbovirus vectorVishvanath Nene
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 316:1718-23. 2007..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species... - Entamoeba histolytica: observations on metabolism based on the genome sequenceIain J Anderson
Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
Exp Parasitol 110:173-7. 2005..histolytica. The usual eukaryotic glucose transporters are not present, but members of a prokaryotic monosaccharide transporter family are present... - The genome sequence of the malaria mosquito Anopheles gambiaeRobert A Holt
Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
Science 298:129-49. 2002..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect... - Gene discovery in the Acanthamoeba castellanii genomeIain J Anderson
Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
Protist 156:203-14. 2005..histolytica. Serine, cysteine and metalloproteases were identified, some of which are likely involved in pathogenicity... - Unique organisation of tRNA genes in Entamoeba histolyticaC Graham Clark
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Mol Biochem Parasitol 146:24-9. 2006..The number and organisation of tRNA genes in E. histolytica is unprecedented. In addition to encoding the tRNAs of the organism we propose that the arrays may fulfil a structural role in the genome... - A spliceosomal intron in Giardia lambliaJulie E J Nixon
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115-6018, USA
Proc Natl Acad Sci U S A 99:3701-5. 2002..If introns were added during eukaryotic evolution (the introns-late hypothesis), then these results push back the date of this event before the branching of G. lamblia... - Iron-dependent hydrogenases of Entamoeba histolytica and Giardia lamblia: activity of the recombinant entamoebic enzyme and evidence for lateral gene transferJulie E J Nixon
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Ave, Boston, Massachusetts, USA
Biol Bull 204:1-9. 2003..These results are discussed in the context of competing ideas for the origins of genes encoding fermentation enzymes of these protists... - Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolyticaJulie E J Nixon
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Eukaryot Cell 1:181-90. 2002..In further support of lateral transfer, the G. lamblia NADH oxidase and adh3 genes appeared to have an evolutionary history distinct from those of E. histolytica... - The diversity of Rab GTPases in Entamoeba histolyticaYumiko Saito-Nakano
Department of Parasitology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan
Exp Parasitol 110:244-52. 2005..We propose annotation of amebic Rab genes and discuss biological significance of this extraordinary diversity of EhRab proteins in this organism... - Entamoeba: still more to be learned from the genomeBrendan J Loftus
Trends Parasitol 21:453. 2005 - The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivationIris Bruchhaus
Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Eukaryot Cell 2:501-9. 2003..histolytica or E. dispar trophozoites during in vitro cultivation. Therefore, it is likely that at least some of these enzymes are required for infection of the human host and/or for completion of the parasite life cycle... 
Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assemblyNeil F Lobo
Center for Global Health and Infectious Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 0369, USA
Genome Biol 8:R88. 2007..PCR and sequencing were used to experimentally confirm expression and sequence of a subset of these transcripts...- The Aedes aegypti glutathione transferase familyNongkran Lumjuan
Vector Group, Liverpool School of Tropical Medicine, Pembroke Palace, Liverpool L3 5QA, UK
Insect Biochem Mol Biol 37:1026-35. 2007....
Research Grants
- ENTAMOEBA HISTOLYTICA GENOME PROJECTBrendan Loftus; Fiscal Year: 2002..The vast majority of the research needs and applications will be met by obtaining 99 percent of the genomic sequence. ..