Yong Jun Liu

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 197:1059-63. 2003
  2. pmc TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    Tomoki Ito
    Center for Cancer Immunology Research, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    J Exp Med 202:1213-23. 2005
  3. pmc IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1837-47. 2007
  4. pmc Thymic stromal lymphopoietin: master switch for allergic inflammation
    Yong Jun Liu
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 203:269-73. 2006
  5. ncbi request reprint IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    Yong Jun Liu
    Department of Immunology and Center for Cancer Immunology Research, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Immunol 23:275-306. 2005
  6. ncbi request reprint Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation
    Yong Jun Liu
    Department of Immunology and Center for Cancer Immunology Research, M D Anderson Cancer Center, University of Texas, Houston, TX 77030 1903, USA
    J Allergy Clin Immunol 120:238-44; quiz 245-6. 2007
  7. ncbi request reprint TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
    Yong Jun Liu
    Department of Immunology, Center of Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Immunol 25:193-219. 2007
  8. ncbi request reprint Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    Norihiko Watanabe
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas, M D Anderson Cancer Center, 7455 Fannin Street, Houston, Texas 77054, USA
    Nature 436:1181-5. 2005
  9. ncbi request reprint Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential
    Norihiko Watanabe
    DNAX Research Institute, Palo Alto, CA, USA
    Blood 105:4749-51. 2005
  10. ncbi request reprint Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 910, Houston, 77030 1903, USA
    Blood 107:3617-23. 2006

Research Grants

  1. TSLP and Allergic Inflammation
    Yong Jun Liu; Fiscal Year: 2007
  2. Asthma and Allergic Diseases Cooperative Research Center
    Yong Jun Liu; Fiscal Year: 2007
  3. DC-mediated Homeostatic Prolif. of CD4 T Cells by TSLP
    Yong Jun Liu; Fiscal Year: 2009
  4. IPC Developmental Pathways and Regulation
    Yong Jun Liu; Fiscal Year: 2009
  5. TSLP and Allergic Inflammation
    Yong Jun Liu; Fiscal Year: 2004
  6. DC-mediated Homeostatic Prolif. of CD4 T Cells by TSLP
    Yong Jun Liu; Fiscal Year: 2006
  7. IPC Developmental Pathways and Regulation
    Yong Jun Liu; Fiscal Year: 2007
  8. DC-mediated Homeostatic Prolif. of CD4 T Cells by TSLP
    Yong Jun Liu; Fiscal Year: 2007
  9. Asthma and Allergic Diseases Cooperative Research Center
    Yong Jun Liu; Fiscal Year: 2006
  10. TSLP and Allergic Inflammation
    Yong Jun Liu; Fiscal Year: 2006

Collaborators

Detail Information

Publications100

  1. pmc Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 197:1059-63. 2003
    ....
  2. pmc TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    Tomoki Ito
    Center for Cancer Immunology Research, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    J Exp Med 202:1213-23. 2005
    ..We conclude that OX40L on TSLP-activated DCs triggers Th2 cell polarization in the absence of IL-12, and propose that OX40L can switch IL-10-producing regulatory Th cell responses into TNF-alpha-producing inflammatory Th cell responses...
  3. pmc IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1837-47. 2007
    ..Our results provide a plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells...
  4. pmc Thymic stromal lymphopoietin: master switch for allergic inflammation
    Yong Jun Liu
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 203:269-73. 2006
    ..New reports now establish a direct link between TSLP expression and the pathogenesis of atopic dermatitis and asthma in vivo, and begin to reveal the molecular mechanisms underlying TSLP-induced allergic inflammation...
  5. ncbi request reprint IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    Yong Jun Liu
    Department of Immunology and Center for Cancer Immunology Research, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Immunol 23:275-306. 2005
    ..Understanding IPC biology holds future promise for developing cures for infectious diseases, cancer, and autoimmune diseases...
  6. ncbi request reprint Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation
    Yong Jun Liu
    Department of Immunology and Center for Cancer Immunology Research, M D Anderson Cancer Center, University of Texas, Houston, TX 77030 1903, USA
    J Allergy Clin Immunol 120:238-44; quiz 245-6. 2007
    ..Therefore, TSLP and OX40 ligand may represent important targets for intervention of the initiation of allergic inflammatory responses...
  7. ncbi request reprint TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
    Yong Jun Liu
    Department of Immunology, Center of Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Immunol 25:193-219. 2007
    ..We review recent progress on how TSLP expressed within thymus and peripheral lymphoid and nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses...
  8. ncbi request reprint Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    Norihiko Watanabe
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas, M D Anderson Cancer Center, 7455 Fannin Street, Houston, Texas 77054, USA
    Nature 436:1181-5. 2005
    ....
  9. ncbi request reprint Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential
    Norihiko Watanabe
    DNAX Research Institute, Palo Alto, CA, USA
    Blood 105:4749-51. 2005
    ..Thus, TSLP is a major regulatory cytokine for IL-12 production by DCs, and TSLP-activated DCs could promote the persistence of Th2 inflammation even in the presence of IL-12-inducing signals...
  10. ncbi request reprint Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 910, Houston, 77030 1903, USA
    Blood 107:3617-23. 2006
    ..This study reveals a novel function of GITR/GITRL in pDC-mediated coactivation of NK cells...
  11. pmc Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030 1903, USA
    J Immunol 184:2999-3007. 2010
    ..The inability of TSLP to induce DC maturation without producing Th1- or Th2-polarizing cytokines may provide a thymic niche for T(R) development...
  12. pmc OX40 ligand shuts down IL-10-producing regulatory T cells
    Tomoki Ito
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, 77030 1903, USA
    Proc Natl Acad Sci U S A 103:13138-43. 2006
    ..These two novel functions of OX40L shed light on the mechanism by which OX40/OX40L regulates immunity and tolerance...
  13. ncbi request reprint Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    Vassili Soumelis
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Immunol 3:673-80. 2002
    ..TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation...
  14. ncbi request reprint Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells
    Yui Hsi Wang
    Department of Immunology, Center of Cancer Immunology Research, Graduate School of Biomedical Science, Houston, Texas 77030, USA
    Immunity 24:827-38. 2006
    ....
  15. pmc TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasis
    Ning Lu
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 206:2111-9. 2009
    ..5%. TSLP could only induce naive CD4(+) T cells to differentiate into Th2 cells in the presence of allogeneic mDCs. These results demonstrate that IL-7 and TSLP use different mechanisms to regulate human CD4(+) T cell homeostasis...
  16. ncbi request reprint Vaccine site inflammation potentiates idiotype DNA vaccine-induced therapeutic T cell-, and not B cell-, dependent antilymphoma immunity
    Hong Qin
    Department of Lymphoma and Myeloma, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 114:4142-9. 2009
    ..These studies also challenge the paradigm that antibody responses are the primary of idiotype-specific antitumor effects and support the optimization of idiotype vaccines designed to induce primarily T-cell immunity...
  17. pmc Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production
    Wei Cao
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 203:1399-405. 2006
    ..Therefore, the ILT7-Fc epsilonRI gamma receptor complex negatively regulates the innate immune functions of human pDCs...
  18. ncbi request reprint Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells
    Tomoki Ito
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1903, USA
    Blood 107:2423-31. 2006
    ..This study provides formal proof that the plasticity of DC subsets is limited and that different DC subsets evolve to perform distinct functions in linking innate and adaptive immunity...
  19. ncbi request reprint Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion
    Norihiko Watanabe
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304 1104, USA
    Nat Immunol 5:426-34. 2004
    ..These results, together with findings of TSLP expression in epithelial cells of mucosal lymphoid tissues and thymus, indicate that TSLP is involved in DC-mediated CD4(+) T cell homeostasis...
  20. pmc Interleukin 25 promotes the initiation of proallergic type 2 responses
    Pornpimon Angkasekwinai
    University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1509-17. 2007
    ..Thus, IL-25 is a critical factor regulating the initiation of innate and adaptive proallergic responses...
  21. pmc Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand
    Tomoki Ito
    Department of Immunology, M D Anderson Cancer Center, Graduate School of Biomedical Sciences at Houston, The University of Texas, Houston, TX 77030, USA
    J Exp Med 204:105-15. 2007
    ..Our findings demonstrate that mDC and pDCs are intrinsically different in the expression of costimulatory molecules that drive distinct types of T cell responses...
  22. ncbi request reprint Dendritic cell apoptosis in the maintenance of immune tolerance
    Min Chen
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 311:1160-4. 2006
    ..The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central role for these cells in maintaining immune self-tolerance...
  23. pmc CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl
    Musheng Bao
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 189:786-92. 2012
    ..Therefore, CD2AP positively regulates BDCA2/FcεR1γ signaling by forming a complex with SHIP1 to inhibit the E3 ubiquitin ligase Cbl...
  24. pmc Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
    Tomoki Ito
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:870-80. 2008
    ....
  25. pmc DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells
    Zhiqiang Zhang
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 187:4501-8. 2011
    ..Knockdown of DHX9 expression in mDCs blocked the activation of NF-κB and IFN regulatory factor 3 by dsRNA. Collectively, these results suggest that DHX9 is an important RNA sensor that is dependent on IPS-1 to sense pathogenic RNA...
  26. pmc HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma
    Daniela Buglio
    Departments of Lymphoma and Myeloma, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 117:2910-7. 2011
    ..These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L expression. Pharmacologic inhibition of HDAC11 may produce a favorable antitumor immune response in patients with HL...
  27. pmc Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70
    Joanne Shaw
    Department of Immunology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030 1903, USA
    Blood 115:3051-7. 2010
    ..We have therefore identified CD70 as an important factor in the regulation of B-cell growth and differentiation by pDCs...
  28. ncbi request reprint Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9
    Tomoki Ito
    Department of Immunology and CCIR, The University of Texas, M D Anderson Cancer Center, Houston, TX, 77030, USA
    Springer Semin Immunopathol 26:221-9. 2005
    ..Stimulation of TLR7 or TLR9 leads to type I IFN responses through the MyD88 pathway. Thus, pDC/IPCs may play a central role in host defense against viral infection through the TLR7 and TLR9 system...
  29. pmc Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus
    Eulogia Roman
    Department of Immunology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 185:3819-23. 2010
    ..In addition, Treg selection requires the TCR signal and CD28 costimulation presented in cis on the same APC type in vivo. This study demonstrates a new role, to our knowledge, for HCs in the development of Tregs in thymus...
  30. pmc TSLP in epithelial cell and dendritic cell cross talk
    Yong Jun Liu
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Adv Immunol 101:1-25. 2009
    ..We review recent progress on how TSLP expressed within thymus and peripheral lymphoid and nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses...
  31. pmc The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 195:953-8. 2002
    ..Human IPCs and mouse IPCs display different ability to produce IL-12p70. Large numbers of mouse IPCs can now be obtained from total bone marrow culture...
  32. pmc The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
    Zhiqiang Zhang
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 12:959-65. 2011
    ..Our results suggest that DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA...
  33. ncbi request reprint Human thymic stromal lymphopoietin triggers dendritic cell-mediated allergic inflammation and CD4+ T cell homeostatic expansion
    Norihiko Watanabe
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Adv Exp Med Biol 560:69-75. 2005
  34. pmc Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells
    Natalia Martin-Orozco
    Department of Immunology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 70:9581-90. 2010
    ..Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion...
  35. pmc PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells
    Eiji Esashi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 42:573-9. 2012
    ....
  36. pmc Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
    Amjad H Talukder
    Department of Immunology, Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Res 22:1129-39. 2012
    ..Our study demonstrates that PLSCR1 is a TLR9-interacting protein that plays an important role in pDC's type 1 IFN responses by regulating TLR9 trafficking to the endosomal compartment...
  37. pmc TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells
    Danielle Fontenot
    Departments of Immunology and Veterinary Sciences, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 106:16776-81. 2009
    ..The cross talk between mucosal epithelial cells and DC, mediated by HIV-induced TSLP, may be an important mechanism for the high rate of HIV infection in women through the vaginal mucosa...
  38. pmc BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Biol 5:e248. 2007
    ..Therefore, by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of pDCs...
  39. doi request reprint Generation of an immune microenvironment as a novel mechanism for myotoxins to potentiate genetic vaccines
    Hong Qin
    Department of Lymphoma, University of Texas M D Anderson Cancer Center, Houston, TX 77030, United States
    Vaccine 28:7970-8. 2010
    ..This novel mechanism of immune potentiation may be exploited for development of adjuvants for genetic vaccines against infectious pathogens and cancer...
  40. pmc OX40-OX40L interactions: a promising therapeutic target for allergic diseases?
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 117:3655-7. 2007
    ..The results point to potential therapeutic approaches to targeting the cellular and molecular mechanism underlying TSLP-mediated allergic inflammation...
  41. ncbi request reprint Plasmacytoid dendritic cells synergize with myeloid dendritic cells in the induction of antigen-specific antitumor immune responses
    Yanyan Lou
    Department of Melanoma Medical Oncology, Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 178:1534-41. 2007
    ..Our results demonstrate that pDC and mDC can interact synergistically to induce an Ag-specific antitumor immune response in vivo...
  42. pmc Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells
    Curdin Conrad
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer Res 72:5240-9. 2012
    ..These findings suggest an essential role for pDCs and ICOS-L in immunosuppression mediated by ICOS(+) Foxp3(+) Treg cells, leading to tumor progression in ovarian cancer...
  43. pmc The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development
    Haiyan S Li
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 120:4363-73. 2012
    ..Consistently, STAT3 stimulates Flt3L-responsive expression of the pDC regulator Tcf4 (E2-2). These data suggest that STATs contribute to DC development by controlling transcription factors involved in lineage differentiation...
  44. pmc Distinct signal codes generate dendritic cell functional plasticity
    Kazuhiko Arima
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 901, Houston, TX 77030, USA
    Sci Signal 3:ra4. 2010
    ..Therefore, we propose that the functional plasticity of DCs relies on elaborate signal codes that are generated by different stimuli...
  45. pmc Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    Kui Shin Voo
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:4793-8. 2009
    ..IL-17-producing Treg cells may play critical roles in antimicrobial defense, while controlling autoimmunity and inflammation...
  46. pmc Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells
    Michel Gilliet
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Exp Med 195:695-704. 2002
    ....
  47. pmc Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells
    Jun Wei
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:18169-74. 2007
    ..In addition, these findings also provide an attainable explanation for the general paucity of antigen-triggered de novo generation of Foxp3(+) Tregs in the periphery...
  48. ncbi request reprint IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps
    Joanne L Shaw
    Department of Otorhinolaryngology Head and Neck Surgery, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Medical School at Houston, TX 77030, USA
    Am J Respir Crit Care Med 188:432-9. 2013
    ..The importance of innate lymphoid cells in Th2-mediated inflammatory disease has not been clearly defined...
  49. ncbi request reprint Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells
    Michel Gilliet
    DNAX Research Institute, Palo Alto, California, USA
    Hum Immunol 63:1149-55. 2002
    ..DC2 can be used as tool to drive potent antigen specific Tr-cell differentiation and expansion in vitro and in vivo...
  50. pmc Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines
    Daniela Buglio
    Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 112:1424-33. 2008
    ....
  51. ncbi request reprint Mysterious origin of plasmacytoid dendritic cell precursors
    Yui Hsi Wang
    Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston 77030, USA
    Immunity 21:1-2. 2004
    ..pDCs derived from CMP express RAG gene products and show IgHD-J rearrangement, suggesting that pDC represent a unique lineage whose gene expression program shows substantial plasticity...
  52. pmc Mechanisms regulating dendritic cell specification and development
    Stephanie S Watowich
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunol Rev 238:76-92. 2010
    ..A critical question centers on how cytokines and lineage-restricted transcription factors operate molecularly to direct DC diversification. Here, we review recent findings that provide new insight into the DC developmental process...
  53. pmc Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12
    Salah Eddine Lamhamedi-Cherradi
    Tanox, Houston, TX 77025, USA
    J Immunol 180:6000-9. 2008
    ..These findings provide a mechanism for explaining how proteolytically active allergens could preferentially induce Th2 responses through limited maturation of DCs with reduced production of IL-12...
  54. pmc A novel strategy for rapid and efficient isolation of human tumor-specific CD4(+) and CD8(+) T-cell clones
    Seung Tae Lee
    Department of Lymphoma and Myeloma, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol Methods 331:13-26. 2008
    ..The method was simple, efficient, and reproducible, and may have potential application for the development of adoptive immunotherapeutic strategies...
  55. pmc Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response
    Haiyan S Li
    Department of Immunology and Center for Inflammation and Cancer, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 118:3879-89. 2011
    ....
  56. pmc From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, CA 94304, USA
    Immunol Rev 226:132-46. 2008
    ..This review aims to describe the characterization of IL-23 and its receptor, its biological activities, as well as its involvement in the development of human Th17 cells and autoimmunity...
  57. pmc DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells
    Zhiqiang Zhang
    Department of Immunology, Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 34:866-78. 2011
    ..This sensor was localized within the cytosol, independent of the endosomes. Thus, the DDX1-DDX21-DHX36 complex represents a dsRNA sensor that uses the TRIF pathway to activate type I IFN responses in the cytosol of mDCs...
  58. pmc Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
    Taeil Kim
    Department of Immunology, Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:15181-6. 2010
    ..This study demonstrates that DHX9/DHX36 represent the MyD88-dependent DNA sensors in the cytosol of pDCs and suggests a much broader role for DHX helicases in viral sensing...
  59. pmc Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus
    Roberto Lande
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Sci Transl Med 3:73ra19. 2011
    ..Our data establish a link between neutrophils, pDC activation, and autoimmunity in SLE, providing new potential targets for the treatment of this devastating disease...
  60. pmc Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
    Wei Cao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    J Exp Med 206:1603-14. 2009
    ..Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion...
  61. pmc Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice
    Chengwen Liu
    Department of Melanoma Medical Oncology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:1165-75. 2008
    ..Our data thus demonstrated that activated pDCs are capable of initiating effective and systemic antitumor immunity through the orchestration of an immune cascade involving the sequential activation of NK cells, cDCs, and CD8(+) T cells...
  62. ncbi request reprint A unified theory of central tolerance in the thymus
    Yong Jun Liu
    Department of Immunology, and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Trends Immunol 27:215-21. 2006
    ....
  63. ncbi request reprint Metastasis-associated protein 1 transgenic mice: a new model of spontaneous B-cell lymphomas
    Rozita Bagheri-Yarmand
    Department of Molecular and Cellular Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:7062-7. 2007
    ..These observations suggest that MTA1-TG mice represent a new model of spontaneous DLBCL associated with high tumor incidence and could be used for therapeutic intervention studies...
  64. pmc The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome
    Hiroki Mitoma
    Baylor Institute for Immunology Research, Baylor Research Institute, Baylor Health Care System, Dallas, TX 75204, USA
    Immunity 39:123-35. 2013
    ..DHX33 interacted with NLRP3 and formed the inflammasome complex following stimulation with RNA. We therefore identified DHX33 as a cytosolic RNA sensor that activates the NLRP3 inflammasome. ..
  65. pmc TSLP and immune homeostasis
    Shino Hanabuchi
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, TX 77004, USA
    Allergol Int 61:19-25. 2012
    ..Here, we review recent progress made on how TSLP expressed within the thymus and peripheral lymphoid and non-lymphoid tissues regulates DC-mediated T-cell development in the thymus and T-cell homeostasis in the periphery...
  66. doi request reprint Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
    ..Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis...
  67. ncbi request reprint Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    Roberto Lande
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Nature 449:564-9. 2007
    ..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis...
  68. pmc miR-22 controls Irf8 mRNA abundance and murine dendritic cell development
    Haiyan S Li
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e52341. 2012
    ..Collectively, these results suggest that miR-22 targets Irf8 mRNA for posttranscriptional repression and controls DC subset differentiation...
  69. pmc The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8
    Eiji Esashi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:509-20. 2008
    ..Our results therefore show that GM-CSF controls the production of pDCs by employing STAT5 to suppress IRF8 and the pDC transcriptional network in lin- Flt3+ progenitors...
  70. pmc E-box protein E2-2 is a crucial regulator of plasmacytoid DC development
    Eiji Esashi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 38:2386-8. 2008
    ..In this issue of the European Journal of Immunology, new insight is provided into how human pDC development is regulated by various transcription factors, in particular by the Ets family protein Spi-B and E-box protein E2-2...
  71. ncbi request reprint Innate immune functions of plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Opin Immunol 19:24-30. 2007
    ..The recent research progress provides an in-depth understanding of the biology of pDCs and a sensible basis for future therapeutic interventions...
  72. pmc Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma
    David Z Chang
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 17:7015-23. 2011
    ..Inflammatory cells, particularly mast cells, have been shown to play key roles in some cancers. We carried out this study to test the hypothesis that mast cells in the tumor microenvironment are essential for PDAC tumorigenesis...
  73. ncbi request reprint In vivo role of pDCs in regulating adaptive immunity
    Shino Hanabuchi
    Department of Immunology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Immunity 35:851-3. 2011
    ..Plasmacytoid dendritic cells (pDCs) have potential influence on innate and adaptive immune responses. In this issue of Immunity, Takagi et al. (2011) established mice lacking pDCs and explored the impact of pDC ablation in vivo...
  74. pmc Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation
    Andre Boonstra
    Division of Immunoregulation, The National Institute for Medical Research NIMR, NW7 1AA London, United Kingdom
    J Exp Med 197:101-9. 2003
    ..Thus, the net effect of antigen dose, the state of maturation of the DCs together with the stimulation of DCs by pathogen-derived products, will determine whether a Th1 or Th2 response develops...
  75. ncbi request reprint Thymic stromal lymphopoietin in normal and pathogenic T cell development and function
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA
    Nat Immunol 7:709-14. 2006
    ....
  76. ncbi request reprint Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations
    Zhe Xiong Lian
    Division of Rheumatology Allergy Clinical Immunology, University of California, Davis, CA 95616, USA
    J Immunol 170:2323-30. 2003
    ..Our results demonstrate the highly heterogeneous nature of hepatic DC, which is in agreement with the unique requirements for APC in the complex liver environment...
  77. pmc Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors
    Wei Chen
    Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, niversity of Minnesota, Minneapolis, MN 55455, USA
    Blood 103:2547-53. 2004
    ..This culture system, combined with the use of adult peripheral blood CD34+ HPCs purified from G-CSF-mobilized donors, permits the generation of more than 10(9) IPCs from a single blood donor...
  78. ncbi request reprint Mouse and human dendritic cell subtypes
    Ken Shortman
    Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    Nat Rev Immunol 2:151-61. 2002
    ..Therefore, we must study the dynamics of the DC network in response to microbial invasion. Despite the difficulty of comparing the DC systems of humans and mice, recent work has revealed much common ground...
  79. ncbi request reprint Natural type I interferon-producing cells as a link between innate and adaptive immunity
    Norimitsu Kadowaki
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Hum Immunol 63:1126-32. 2002
    ....
  80. ncbi request reprint Modulation of dendritic cell differentiation and maturation by decoy receptor 3
    Tsui Ling Hsu
    Department of Microbiology and Immunology, Immunology Research Center, National Yang Ming University, Shih Pai, Taipei 112, Taiwan
    J Immunol 168:4846-53. 2002
    ..This suggests that DcR3.Fc may act not only as a decoy receptor to FasL and LIGHT, but also as an effector molecule to skew T cell response to the Th2 phenotype...
  81. pmc Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, 8091 Zurich, Switzerland
    J Exp Med 202:135-43. 2005
    ..These findings uncover a novel innate immune pathway for triggering a common human autoimmune disease and suggest that PDCs and PDC-derived IFN-alpha represent potential early targets for the treatment of psoriasis...
  82. ncbi request reprint Development of dendritic-cell lineages
    Li Wu
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 26:741-50. 2007
    ..The development of different populations of DCs is differentially regulated by various transcription factors and cytokines. This review summarizes the recent advances made in the field of DC development...
  83. doi request reprint Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells
    Takashi Yokoi
    First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
    Int Immunol 20:1321-9. 2008
    ..These findings suggest that BCG might be a useful adjuvant for the treatment of allergic diseases that are triggered by TSLP...
  84. pmc TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
    Stephan R Krutzik
    Division of Dermatology, University of California at Los Angeles, 611 Charles Young Drive East, 536 Boyer Hall, Los Angeles, CA 90095, USA
    Nat Med 11:653-60. 2005
    ..Thus, TLR-induced differentiation of monocytes into either macrophages or dendritic cells seems to crucially influence effective host defenses in human infectious disease...
  85. ncbi request reprint Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells
    Irina Rochman
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:6720-4. 2007
    ..Moreover, TSLP increases the sensitivity of human CD4(+) T cells to low doses of IL-2, augmenting responsiveness of these cells to TCR engagement. Our results establish that human CD4(+) T cells are direct targets for TSLP...
  86. ncbi request reprint CD4- plasmacytoid dendritic cells (pDCs) migrate in lymph nodes by CpG inoculation and represent a potent functional subset of pDCs
    Guo Xiang Yang
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    J Immunol 174:3197-203. 2005
    ....
  87. ncbi request reprint Human thymic stromal lymphopoietin: a novel epithelial cell-derived cytokine and a potential key player in the induction of allergic inflammation
    Vassili Soumelis
    Department of Hematology, Necker Hospital, Paris, France
    Springer Semin Immunopathol 25:325-33. 2004
    ..Thus, epithelial- and stromal-cell-derived TSLP might represent one of the factors initiating the allergic responses, and could be a target for a curative therapeutic approach to allergy...
  88. ncbi request reprint Plasmacytoid dendritic cells in immunity
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 5:1219-26. 2004
    ..Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases...
  89. ncbi request reprint Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells
    E Ashley Moseman
    University of Minnesota Cancer Center and Department of Pediatrics, and Division of Hematology, Oncology, and Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    J Immunol 173:4433-42. 2004
    ..This study demonstrates that TLR9 stimulation can promote PDC-mediated generation of CD4(+)CD25(+) Treg cells and suggests PDCs may play an important role in the maintenance of immunological tolerance...
  90. ncbi request reprint Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells
    Susanne Ebner
    Department of Dermatology and Venereology, Kompetenzzentrum Medizin Tirol, Innsbruck, Austria
    J Allergy Clin Immunol 119:982-90. 2007
    ..TSLP is present at high levels in the epidermis of atopic dermatitis where it appears to trigger emigration of epidermal Langerhans cells (LCs); however, nothing else is known about the influence of TSLP on LCs...
  91. ncbi request reprint Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    Andre Boonstra
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 177:7551-8. 2006
    ....
  92. ncbi request reprint Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production
    Nathalie Bendriss-Vermare
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Leukoc Biol 78:954-66. 2005
    ....
  93. pmc Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma
    Luis Vence
    Baylor Institute for Immunology Research and Baylor Research Institute, Baylor University, Dallas, TX 75204, USA
    Proc Natl Acad Sci U S A 104:20884-9. 2007
    ..Such tumor antigen-specific T regs were not detected in healthy individuals. These tumor antigen-specific T regs might thus represent another target for immunotherapy of metastatic melanoma...
  94. ncbi request reprint Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials
    Lu Lu Lü
    National Engineering Research Center of Cell Products, AmCellGene Co Ltd
    Haematologica 91:1017-26. 2006
    ..We isolated MSC from human full term umbilical cord tissues (UC). The biological characteristics of MSC derived from UC (UC-MSC) were further determined and compared with normal adult bone marrow-derived MSC (BM-MSC)...
  95. ncbi request reprint Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity
    Jean Francois Fonteneau
    Laboratory of Molecular Neuro Oncology, Rockefeller University, New York, NY, USA
    Blood 101:3520-6. 2003
    ..Our results pinpoint a new role of pDCs in the induction of antiviral T-cell responses and suggest that these DCs play a prominent role in the adaptive immune response against viruses...
  96. ncbi request reprint Bone marrow stromal cells transduced with human hemangiopoietin gene support hematopoiesis in vitro
    Zhen Shu Xu
    TEDA Life and Technology Research Center, State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
    Haematologica 90:157-65. 2005
    ....
  97. ncbi request reprint Functional diversity and plasticity of human dendritic cell subsets
    Tomoki Ito
    First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
    Int J Hematol 81:188-96. 2005
    ..Elucidating the cellular and molecular mechanisms that modulate the functions of the 2 DC subsets will lead to an understanding of the pathogenesis of various immune-related diseases and to the development of novel immunologic therapies...
  98. ncbi request reprint Molecular and genetic mechanisms of obesity: implications for future management
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Curr Mol Med 3:325-40. 2003
    ..Finally, the implications of the recent advances in the understanding of molecular genetic mechanisms of body weight regulation on prevention and therapeutic intervention of obesity will be discussed...
  99. pmc Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells
    Jean Francois Fonteneau
    Institut de Biologie, INSERM U463, Nantes, France
    J Virol 78:5223-32. 2004
    ..This HIV-1-induced maturation of both DC subsets may explain their disappearance from the blood of patients with high viral loads and may have important consequences on HIV-1 cellular transmission and HIV-1-specific T-cell responses...
  100. ncbi request reprint Natural type 1 interferon producing cells in HIV infection
    Vassili Soumelis
    Department of Hematology, Hopital Necker, Paris, France
    Hum Immunol 63:1206-12. 2002
    ..Thus, the balance between IPCs and HIV replication might be critical in determining the control or progression of HIV infection...

Research Grants17

  1. TSLP and Allergic Inflammation
    Yong Jun Liu; Fiscal Year: 2007
    ..To identify the molecular regulation of TSLP receptor (TSLPR) and IL-7Ralpha co-expression; 3. To elicidate the molecular mechanisms by which TSLP-activated DCs induce TH2 differentiation. ..
  2. Asthma and Allergic Diseases Cooperative Research Center
    Yong Jun Liu; Fiscal Year: 2007
    ..The proposed studies will provide insight into the pathogenic mechanisms of allergic inflammation and define novel targets for developing innovative therapies for allergic asthma and atopy. ..
  3. DC-mediated Homeostatic Prolif. of CD4 T Cells by TSLP
    Yong Jun Liu; Fiscal Year: 2009
    ..abstract_text> ..
  4. IPC Developmental Pathways and Regulation
    Yong Jun Liu; Fiscal Year: 2009
    ..abstract_text> ..
  5. TSLP and Allergic Inflammation
    Yong Jun Liu; Fiscal Year: 2004
    ..To identify the molecular regulation of TSLP receptor (TSLPR) and IL-7Ralpha co-expression; 3. To elicidate the molecular mechanisms by which TSLP-activated DCs induce TH2 differentiation. ..
  6. DC-mediated Homeostatic Prolif. of CD4 T Cells by TSLP
    Yong Jun Liu; Fiscal Year: 2006
    ..abstract_text> ..
  7. IPC Developmental Pathways and Regulation
    Yong Jun Liu; Fiscal Year: 2007
    ..abstract_text> ..
  8. DC-mediated Homeostatic Prolif. of CD4 T Cells by TSLP
    Yong Jun Liu; Fiscal Year: 2007
    ..abstract_text> ..
  9. Asthma and Allergic Diseases Cooperative Research Center
    Yong Jun Liu; Fiscal Year: 2006
    ..The proposed studies will provide insight into the pathogenic mechanisms of allergic inflammation and define novel targets for developing innovative therapies for allergic asthma and atopy. ..
  10. TSLP and Allergic Inflammation
    Yong Jun Liu; Fiscal Year: 2006
    ..To identify the molecular regulation of TSLP receptor (TSLPR) and IL-7Ralpha co-expression; 3. To elicidate the molecular mechanisms by which TSLP-activated DCs induce TH2 differentiation. ..
  11. DC-mediated Homeostatic Prolif. of CD4 T Cells by TSLP
    Yong Jun Liu; Fiscal Year: 2006
    ..abstract_text> ..
  12. IPC Developmental Pathways and Regulation
    Yong Jun Liu; Fiscal Year: 2006
    ..abstract_text> ..
  13. TSLP and Allergic Inflammation
    Yong Jun Liu; Fiscal Year: 2005
    ..To identify the molecular regulation of TSLP receptor (TSLPR) and IL-7Ralpha co-expression; 3. To elicidate the molecular mechanisms by which TSLP-activated DCs induce TH2 differentiation. ..