Kang Liu

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
  2. doi request reprint Origin and development of dendritic cells
    Kang Liu
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Immunol Rev 234:45-54. 2010
  3. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
  4. pmc Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage
    Matthew M Meredith
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 209:1153-65. 2012
  5. ncbi request reprint The innate functions of dendritic cells in peripheral lymphoid tissues
    Ralph M Steinman
    Laboratories of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021 6399, USA
    Adv Exp Med Biol 560:83-97. 2005
  6. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
  7. ncbi request reprint Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
  8. pmc The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    Claudia Waskow
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nat Immunol 9:676-83. 2008
  9. pmc Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state
    Matthew M Meredith
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 209:1583-93. 2012
  10. pmc Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
    Niroshana Anandasabapathy
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 208:1695-705. 2011

Collaborators

Detail Information

Publications19

  1. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    ..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
  2. doi request reprint Origin and development of dendritic cells
    Kang Liu
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Immunol Rev 234:45-54. 2010
    ..Within tissues and during development, DC division and homeostasis are regulated by the hormone Flt3L...
  3. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
    ..Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program...
  4. pmc Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage
    Matthew M Meredith
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 209:1153-65. 2012
    ..Our results indicate that CD11c-expressing non-cDCs make significant contributions to initiating immunity to parasites and tumors...
  5. ncbi request reprint The innate functions of dendritic cells in peripheral lymphoid tissues
    Ralph M Steinman
    Laboratories of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021 6399, USA
    Adv Exp Med Biol 560:83-97. 2005
  6. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
    ..Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system...
  7. ncbi request reprint Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  8. pmc The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    Claudia Waskow
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nat Immunol 9:676-83. 2008
    ..In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery...
  9. pmc Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state
    Matthew M Meredith
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 209:1583-93. 2012
    ..Thus, zDC is a TLR-responsive, cDC-specific transcriptional repressor that is in part responsible for preventing cDC maturation in the steady state...
  10. pmc Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
    Niroshana Anandasabapathy
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 208:1695-705. 2011
    ..Therefore, the meninges and choroid plexus of a steady-state brain contain DCs that derive from local precursors and exhibit a differentiation and antigen-presenting program similar to spleen DCs and distinct from microglia...
  11. pmc Feedback control of regulatory T cell homeostasis by dendritic cells in vivo
    Guillaume Darrasse-Jèze
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1853-62. 2009
    ..The increase in T reg cells induced by DC expansion is sufficient to prevent type 1 autoimmune diabetes and IBD, which suggests that interference with this feedback loop will create new opportunities for immune-based therapies...
  12. pmc Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
    Kang Liu
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:1507-16. 2005
    ..Therefore, the access of dying tumor cells to DCs that are maturing to activated NKT cells efficiently induces long-lived adaptive resistance...
  13. ncbi request reprint Origin of dendritic cells in peripheral lymphoid organs of mice
    Kang Liu
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10021, USA
    Nat Immunol 8:578-83. 2007
    ..Daughter DCs presented antigens captured by their progenitors, suggesting that DC division in peripheral lymphoid organs can prolong the duration of antigen presentation in vivo...
  14. doi request reprint Development and homeostasis of dendritic cells
    Kang Liu
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA
    Eur J Immunol 40:2099-102. 2010
    ..DC's functional versatility is enabled in part by the various DC subsets with heterogeneous cell surface markers and anatomic locations. Here, we review the development and homeostasis of DC found in lymphoid and nonlymphoid tissues...
  15. pmc Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
    Kanako L Lewis
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Immunity 35:780-91. 2011
    ..Thus, Notch2 is a common differentiation signal for T cell-priming CD11b(+) DC subsets in the spleen and intestine...
  16. pmc The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:1607-18. 2004
    ....
  17. ncbi request reprint Dendritic cell function in vivo during the steady state: a role in peripheral tolerance
    Ralph M Steinman
    The Rockefeller University, Laboratories of Cellular Physiology and Immunology, Molecular Immunology, Molecular Genetics and Immunology, and Human Immunology and Immune Therapy, New York, New York 10021 6399, USA
    Ann N Y Acad Sci 987:15-25. 2003
    ..It is proposed that dendritic cells play a major role in defining immunologic self, not only centrally in the thymus but also in the periphery...
  18. doi request reprint CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain
    Karen Bulloch
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 508:687-710. 2008
    ..Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population...
  19. pmc Immune tolerance after delivery of dying cells to dendritic cells in situ
    Kang Liu
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1091-7. 2002
    ..The specific tolerance that develops when dendritic cells process self tissues in the steady state should prevent or reduce the development of autoimmunity when dying cells are subsequently processed during infection...