Research Topics
Genomes and Genes
| Kang LiuSummaryAffiliation: The Rockefeller University Country: USA Publications
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Detail Information
Publications
In vivo analysis of dendritic cell development and homeostasisKang Liu
Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
Science 324:392-7. 2009..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
Origin and development of dendritic cellsKang Liu
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
Immunol Rev 234:45-54. 2010..Within tissues and during development, DC division and homeostasis are regulated by the hormone Flt3L...- The origin and development of nonlymphoid tissue CD103+ DCsFlorent Ginhoux
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Exp Med 206:3115-30. 2009..Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program... - Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineageMatthew M Meredith
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
J Exp Med 209:1153-65. 2012..Our results indicate that CD11c-expressing non-cDCs make significant contributions to initiating immunity to parasites and tumors... 
The innate functions of dendritic cells in peripheral lymphoid tissuesRalph M Steinman
Laboratories of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021-6399, USA
Adv Exp Med Biol 560:83-97. 2005- Origin of the lamina propria dendritic cell networkMilena Bogunovic
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
Immunity 31:513-25. 2009..Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system... - Differential antigen processing by dendritic cell subsets in vivoDiana Dudziak
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
Science 315:107-11. 2007..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing... - The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissuesClaudia Waskow
Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
Nat Immunol 9:676-83. 2008..In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery... - Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady stateMatthew M Meredith
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
J Exp Med 209:1583-93. 2012..Thus, zDC is a TLR-responsive, cDC-specific transcriptional repressor that is in part responsible for preventing cDC maturation in the steady state... - Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brainNiroshana Anandasabapathy
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
J Exp Med 208:1695-705. 2011..Therefore, the meninges and choroid plexus of a steady-state brain contain DCs that derive from local precursors and exhibit a differentiation and antigen-presenting program similar to spleen DCs and distinct from microglia... - Feedback control of regulatory T cell homeostasis by dendritic cells in vivoGuillaume Darrasse-Jèze
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
J Exp Med 206:1853-62. 2009..The increase in T reg cells induced by DC expansion is sufficient to prevent type 1 autoimmune diabetes and IBD, which suggests that interference with this feedback loop will create new opportunities for immune-based therapies... - Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cellsKang Liu
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 202:1507-16. 2005..Therefore, the access of dying tumor cells to DCs that are maturing to activated NKT cells efficiently induces long-lived adaptive resistance... - Origin of dendritic cells in peripheral lymphoid organs of miceKang Liu
Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10021, USA
Nat Immunol 8:578-83. 2007..Daughter DCs presented antigens captured by their progenitors, suggesting that DC division in peripheral lymphoid organs can prolong the duration of antigen presentation in vivo... - Development and homeostasis of dendritic cellsKang Liu
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA
Eur J Immunol 40:2099-102. 2010..DC's functional versatility is enabled in part by the various DC subsets with heterogeneous cell surface markers and anatomic locations. Here, we review the development and homeostasis of DC found in lymphoid and nonlymphoid tissues... - Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestineKanako L Lewis
Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
Immunity 35:780-91. 2011..Thus, Notch2 is a common differentiation signal for T cell-priming CD11b(+) DC subsets in the spleen and intestine... - The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulationShin ichiro Fujii
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 199:1607-18. 2004.... - Dendritic cell function in vivo during the steady state: a role in peripheral toleranceRalph M Steinman
The Rockefeller University, Laboratories of Cellular Physiology and Immunology, Molecular Immunology, Molecular Genetics and Immunology, and Human Immunology and Immune Therapy, New York, New York 10021 6399, USA
Ann N Y Acad Sci 987:15-25. 2003..It is proposed that dendritic cells play a major role in defining immunologic self, not only centrally in the thymus but also in the periphery... - CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brainKaren Bulloch
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10065, USA
J Comp Neurol 508:687-710. 2008..Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population... - Immune tolerance after delivery of dying cells to dendritic cells in situKang Liu
Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
J Exp Med 196:1091-7. 2002..The specific tolerance that develops when dendritic cells process self tissues in the steady state should prevent or reduce the development of autoimmunity when dying cells are subsequently processed during infection...