Stuart Lipton


Affiliation: The Burnham Institute
Country: USA


  1. request reprint
    Lipton S, Choi Y, Takahashi H, Zhang D, Li W, Godzik A, et al. Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation. Trends Neurosci. 2002;25:474-80 pubmed
    ..This article reviews the basis for these molecular cysteine switches, drawing on the NMDA receptor as an exemplary protein, and proposes a molecular model for the action of S-nitrosylation based on recently derived crystal structures. ..
  2. request reprint
    Lipton S, Nakamura T, Yao D, Shi Z, Uehara T, Gu Z. Comment on "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function". Science. 2005;308:1870; author reply 1870 pubmed
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    Lipton S. Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation. Curr Drug Targets. 2007;8:621-32 pubmed
    ..These second-generation drugs take advantage of the fact that the NMDA receptor has other modulatory sites in addition to its ion channel that potentially could also be used for safe but effective clinical intervention. ..