Shiaw-Yih Lin

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
    Shiaw Yih Lin
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6484-9. 2004
  2. pmc BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly
    Shiaw Yih Lin
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 102:15105-9. 2005
  3. pmc Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression
    Shiaw Yih Lin
    Department of Systems Biology, MD Anderson Cancer Center, Houston, TX 77054, USA
    Yonsei Med J 51:295-301. 2010
  4. pmc BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
    Rekha Rai
    Department of Molecular Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Cell 10:145-57. 2006
  5. ncbi request reprint BRIT1/MCPH1: a guardian of genome and an enemy of tumors
    Michael Chaplet
    Department of Molecular Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Cell Cycle 5:2579-83. 2006
  6. pmc A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners
    Zhiyong Ding
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 950, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:15014-9. 2006
  7. ncbi request reprint Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma
    Kaiyi Li
    Department of Surgery, Baylor College of Medicine and The Methodist Hospital, Houston, Texas 77030, USA
    Cancer Res 63:3593-7. 2003
  8. pmc Differential regulation of centrosome integrity by DNA damage response proteins
    Rekha Rai
    Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai, Maharashtra, India
    Cell Cycle 7:2225-33. 2008
  9. ncbi request reprint DNA damage response: the players, the network and the role in tumor suppression
    Rekha Rai
    ACTREC CRI, TMC, Mumbai, Maharashtra, India
    Cancer Genomics Proteomics 4:99-106. 2007

Detail Information

Publications9

  1. pmc Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
    Shiaw Yih Lin
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6484-9. 2004
    ..These results suggest that Claspin has properties of both a tumor suppressor and an oncogene...
  2. pmc BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly
    Shiaw Yih Lin
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 102:15105-9. 2005
    ..We propose that the microcephaly observed in patients with MCPH1 deficiencies is due to disruption of the ATR-BRCA1-Chk1 signaling pathway that is also disrupted in Seckel syndrome patients...
  3. pmc Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression
    Shiaw Yih Lin
    Department of Systems Biology, MD Anderson Cancer Center, Houston, TX 77054, USA
    Yonsei Med J 51:295-301. 2010
    ....
  4. pmc BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
    Rekha Rai
    Department of Molecular Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Cell 10:145-57. 2006
    ..These results identify BRIT1 as a crucial DNA damage regulator in the ATM/ATR pathways and suggest that it functions as a tumor suppressor gene...
  5. ncbi request reprint BRIT1/MCPH1: a guardian of genome and an enemy of tumors
    Michael Chaplet
    Department of Molecular Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Cell Cycle 5:2579-83. 2006
    ..Together, the findings identify BRIT1 as a potential tumor suppressor. Fully elucidating the function of this intriguing protein may lead to new therapeutic approaches for the improved cancer treatment...
  6. pmc A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners
    Zhiyong Ding
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 950, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:15014-9. 2006
    ..Thus, ACTN4 is a critical regulator of AKT1 localization and function...
  7. ncbi request reprint Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma
    Kaiyi Li
    Department of Surgery, Baylor College of Medicine and The Methodist Hospital, Houston, Texas 77030, USA
    Cancer Res 63:3593-7. 2003
    ..Our results also indicate that cyclin E, which is overexpressed in 70% of HCCs, may serve as a novel therapeutic target...
  8. pmc Differential regulation of centrosome integrity by DNA damage response proteins
    Rekha Rai
    Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai, Maharashtra, India
    Cell Cycle 7:2225-33. 2008
    ..Together, MDC1 and BRIT1 may function as tumor-suppressor genes, at least in part by orchestrating proper centrosome duplication and mitotic spindle assembly...
  9. ncbi request reprint DNA damage response: the players, the network and the role in tumor suppression
    Rekha Rai
    ACTREC CRI, TMC, Mumbai, Maharashtra, India
    Cancer Genomics Proteomics 4:99-106. 2007
    ..The recent research discoveries on how dysfunction in DNA damage response contributes to genomic instability and cancer development are also discussed...

Research Grants11

  1. Chk2--Roles in Checkpoint and Breast Tumor Suppression
    Shiaw Yih Lin; Fiscal Year: 2003
    ..We believe that the mechanisms and targets discovered in our studies will be critical for developing more effective approaches in breast cancer therapy in the future. ..
  2. BRIT 1: Roles in Immortalization, Checkpoints and Cancer
    Shiaw Yih Lin; Fiscal Year: 2009
    ..abstract_text> ..
  3. Functional and Clinical Analysis of Rak in Breast Cancer Suppression
    Shiaw Yih Lin; Fiscal Year: 2009
    ..abstract_text> ..
  4. BRIT 1: Roles in Immortalization, Checkpoints and Cancer
    Shiaw Yih Lin; Fiscal Year: 2007
    ..abstract_text> ..
  5. Functional and Clinical Analysis of Rak in Breast Cancer Suppression
    Shiaw Yih Lin; Fiscal Year: 2007
    ....
  6. Functional and Clinical Analysis of Rak in Breast Cancer Suppression
    Shiaw Yih Lin; Fiscal Year: 2011
    ..abstract_text> ..