Pei Lin

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Expression of PAX5 in CD20-positive multiple myeloma assessed by immunohistochemistry and oligonucleotide microarray
    Pei Lin
    Department of Pathology, University of Arkansas for Medical Science, USA
    Mod Pathol 17:1217-22. 2004
  2. ncbi request reprint Chronic lymphocytic leukemia/small lymphocytic lymphoma associated with IgM paraprotein
    C Cameron Yin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 123:594-602. 2005
  3. doi request reprint Plasma cell myeloma
    Pei Lin
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77070, USA
    Hematol Oncol Clin North Am 23:709-27. 2009
  4. doi request reprint Plasmablastic lymphoma involving the penis: a previously unreported location of a case with aberrant CD3 expression
    Jianlan Sun
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Pathology 43:54-7. 2011
  5. doi request reprint The impact of MYC rearrangements and "double hit" abnormalities in diffuse large B-cell lymphoma
    Pei Lin
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Curr Hematol Malig Rep 8:243-52. 2013
  6. doi request reprint Prognostic value of MYC rearrangement in cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
    Pei Lin
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer 118:1566-73. 2012
  7. doi request reprint JAK2 V617F mutation is uncommon in patients with the 3q21q26 syndrome
    Pei Lin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 41:758-62. 2010
  8. ncbi request reprint Translocation (3;8)(q26;q24): a recurrent chromosomal abnormality in myelodysplastic syndrome and acute myeloid leukemia
    Pei Lin
    Department of Hematopathology, M D Anderson Cancer Center, Box 72, The University of Texas, Houston, TX 77030, USA
    Cancer Genet Cytogenet 166:82-5. 2006
  9. doi request reprint Translocation (18;22)(q21;q11) in B-cell lymphomas: a report of 4 cases and review of the literature
    Pei Lin
    Department of Hematopathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 39:1664-72. 2008
  10. doi request reprint Chronic myeloid leukemia in blast phase associated with t(3;8)(q26;q24)
    Pei Lin
    Department of Hematopathology, Box 72, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Genet Cytogenet 193:119-22. 2009

Detail Information

Publications87

  1. ncbi request reprint Expression of PAX5 in CD20-positive multiple myeloma assessed by immunohistochemistry and oligonucleotide microarray
    Pei Lin
    Department of Pathology, University of Arkansas for Medical Science, USA
    Mod Pathol 17:1217-22. 2004
    ..We conclude that CD20-positive myelomas expressing PAX5/BSAP can present as a diagnostic pitfall mimicking B-cell neoplasms with plasmacytoid differentiation...
  2. ncbi request reprint Chronic lymphocytic leukemia/small lymphocytic lymphoma associated with IgM paraprotein
    C Cameron Yin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 123:594-602. 2005
    ..60). We conclude that CLL/SLL cases with serum IgM paraprotein are similar to other CLL/SLL cases in their clinicopathologic and immunophenotypic features...
  3. doi request reprint Plasma cell myeloma
    Pei Lin
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77070, USA
    Hematol Oncol Clin North Am 23:709-27. 2009
    ..Plasma cell myeloma is a heterogenous disease with variable clinical presentation and outcome. The prognosis is largely determined by tumor biology. Newer therapeutic agents are rapidly changing the survival outlook of myeloma patients...
  4. doi request reprint Plasmablastic lymphoma involving the penis: a previously unreported location of a case with aberrant CD3 expression
    Jianlan Sun
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Pathology 43:54-7. 2011
    ..Lineage ambiguity in terminally differentiated B-cell lymphomas has been reported to be closely related with immune compromise and is associated with Epstein-Barr virus infection. The literature on penile lymphomas is also reviewed...
  5. doi request reprint The impact of MYC rearrangements and "double hit" abnormalities in diffuse large B-cell lymphoma
    Pei Lin
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Curr Hematol Malig Rep 8:243-52. 2013
    ..We also emphasize the evolving nature of these concepts, and outline suggestions for future studies...
  6. doi request reprint Prognostic value of MYC rearrangement in cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
    Pei Lin
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer 118:1566-73. 2012
    ..Currently, there is no established standard therapy for these neoplasms...
  7. doi request reprint JAK2 V617F mutation is uncommon in patients with the 3q21q26 syndrome
    Pei Lin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 41:758-62. 2010
    ..We conclude that JAK2 V617F mutation is uncommon in the 3q21q26 syndrome and that its presence may indicate an unusual coexistence of a myeloproliferative neoplasm...
  8. ncbi request reprint Translocation (3;8)(q26;q24): a recurrent chromosomal abnormality in myelodysplastic syndrome and acute myeloid leukemia
    Pei Lin
    Department of Hematopathology, M D Anderson Cancer Center, Box 72, The University of Texas, Houston, TX 77030, USA
    Cancer Genet Cytogenet 166:82-5. 2006
    ..We conclude that the t(3;8)(q26;q24) is a recurrent translocation associated with therapy-related MDS/AML or de novo AML, and is frequently associated with monosomy 7...
  9. doi request reprint Translocation (18;22)(q21;q11) in B-cell lymphomas: a report of 4 cases and review of the literature
    Pei Lin
    Department of Hematopathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 39:1664-72. 2008
    ..These cases illustrate that t(18;22)(q21;q11) is more commonly observed in chronic lymphocytic leukemia and may represent either an initial or secondary genetic event...
  10. doi request reprint Chronic myeloid leukemia in blast phase associated with t(3;8)(q26;q24)
    Pei Lin
    Department of Hematopathology, Box 72, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Genet Cytogenet 193:119-22. 2009
    ..These findings extend the known disease spectrum associated with this cytogenetic aberration...
  11. doi request reprint Acute myeloid leukemia harboring t(8;21)(q22;q22): a heterogeneous disease with poor outcome in a subset of patients unrelated to secondary cytogenetic aberrations
    Pei Lin
    Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77003, USA
    Mod Pathol 21:1029-36. 2008
    ..We conclude that acute myeloid leukemia associated with t(8;21) is a heterogeneous disease with poor survival in a subset of patients unrelated to common secondary cytogenetic aberrations...
  12. ncbi request reprint Waldenstrom macroglobulinemia involving extramedullary sites: morphologic and immunophenotypic findings in 44 patients
    Pei Lin
    Department of Hematopathology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Surg Pathol 27:1104-13. 2003
    ..CD5+ B-cell lymphomas with features otherwise typical of LPL are rare, and we think these tumors are part of the spectrum of LPL...
  13. doi request reprint Immunophenotypic heterogeneity of normal plasma cells: comparison with minimal residual plasma cell myeloma
    Dingsheng Liu
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Pathol 65:823-9. 2012
    ..With advances in multicolour flow cytometry and application of recently validated markers, PCM MRD may still be reliably distinguished from non-neoplastic plasma cells...
  14. ncbi request reprint Morphologic, cytogenetic, and molecular abnormalities in therapy-related acute promyelocytic leukemia
    C Cameron Yin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Am J Clin Pathol 123:840-8. 2005
    ..Mutations of the flt3 gene were detected by PCR in 5 (42%) of 12 cases. We conclude that dysplastic features, secondary cytogenetic abnormalities, and flt3 mutations are common in tAPL...
  15. doi request reprint MYC/BCL2 double-hit high-grade B-cell lymphoma
    Shaoying Li
    Department of Pathology, Microbiology, and Immunology, Division of Hematopathology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Adv Anat Pathol 20:315-26. 2013
    ..These tumors show overlap with MYC/BCL2 DHL, but are not equivalent. In this review, we discuss the clinicopathologic, immunophenotypic, cytogenetic, and prognostic features of MYC/BCL2 DHL. ..
  16. ncbi request reprint Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis
    Anuradha Kanungo
    Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 19:25-33. 2006
    ..However, this combination of molecular abnormalities can also rarely occur in other neoplasms, such as the cases of low-grade B-cell lymphoma and plasmablastic myeloma in this study...
  17. doi request reprint Residual monotypic plasma cells in patients with waldenstrom macroglobulinemia after therapy
    Fareed H Barakat
    Dept of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Clin Pathol 135:365-73. 2011
    ..This finding has implications for the immunophenotypic assessment of WM after therapy and may explain persistent IgM paraproteinemia in patients with WM with no evidence of a clonal B-lymphocyte population...
  18. doi request reprint Expression of serine 194-phosphorylated Fas-associated death domain protein correlates with proliferation in B-cell non-Hodgkin lymphomas
    Elias Drakos
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 42:1117-24. 2011
    ..9, P < .0001). These data provide evidence that serine 194 phosphorylated Fas-associated death domain protein is involved in the proliferation of normal and neoplastic B cells and has features of a novel proliferation marker...
  19. ncbi request reprint Aberrant EVI1 expression in acute myeloid leukemias associated with the t(3;8)(q26;q24)
    Patrick A Lennon
    School of Health Sciences, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Cancer Genet Cytogenet 177:37-42. 2007
    ..Western blot analysis detected EVI1 in one case analyzed. We conclude that the t(3;8)(q26;q24) results in deregulated EVI1 expression, similar to other balanced or unbalanced chromosomal translocations involving chromosome 3q26...
  20. ncbi request reprint Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma
    C Cameron Yin
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 20:1-7. 2007
    ..These results support the concept that blastoid MCL arising in patients with typical MCL represents histologic transformation of the original neoplastic clone...
  21. doi request reprint High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis
    Rashmi Kanagal-Shamanna
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Histopathology 61:945-54. 2012
    ..At a haematopathology workshop, experts had suggested the term 'high-grade B cell lymphoma, unclassifiable, with blastoid features', and recommended further studies...
  22. doi request reprint Extranodal NK/T-cell lymphoma, nasal type: a report of 73 cases at MD Anderson Cancer Center
    Shaoying Li
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 37:14-23. 2013
    ..The International Prognostic Index score, anatomic site of disease, and proliferation rate had prognostic value in this patient cohort...
  23. ncbi request reprint The role of Janus Kinase 2 V617F mutation in extramedullary hematopoiesis of the spleen in neoplastic myeloid disorders
    Pin Pen Hsieh
    Department of Pathology and Laboratory Medicine, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mod Pathol 20:929-35. 2007
    ..Also, dysregulation of downstream pathways such as Bcl-xL may be important to CMPD disease pathogenesis in the spleen...
  24. doi request reprint De novo acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): a clinicopathologic and cytogenetic study of an entity recently added to the WHO classification
    Jianlan Sun
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 24:384-9. 2011
    ..Allogeneic stem cell transplantation seems to improve outcome in patients with this disease...
  25. doi request reprint Therapy-related acute myeloid leukemia with t(8;21) (q22;q22) shares many features with de novo acute myeloid leukemia with t(8;21)(q22;q22) but does not have a favorable outcome
    Steven A Gustafson
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 131:647-55. 2009
    ..002). These findings suggest that t-AML-t(8;21) shares many features with de novo AML-t(8;21)(q22;q22), but affected patients have a worse outcome...
  26. ncbi request reprint Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia and does not correlate with p65 NF-kappaB activation
    Mihai Merzianu
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 19:891-8. 2006
    ..These results indicate that nuclear BCL-10 expression is common in LPL/WM and does not correlate with MALT lymphoma-associated translocations or p65 NF-kappaB nuclear staining...
  27. ncbi request reprint Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis
    Jing Yang
    Department of Lymphoma and Myeloma, Division of Cancer Medicine, and the Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 12:252-65. 2007
    ..CRP also enhanced myeloma cell secretion of IL-6 and synergized with IL-6 to protect myeloma cells from chemotherapy drug-induced apoptosis. Thus, our results implicate CRP as a potential target for cancer treatment...
  28. ncbi request reprint Expression of B cell-specific activator protein/PAX5 in acute myeloid leukemia with t(8;21)(q22;q22)
    Jose R Valbuena
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 126:235-40. 2006
    ..These results indicate that silencing of PAX5 is not required for commitment to myeloid differentiation and that BSAP expression in AML is found mainly in cases with t(8;21)...
  29. ncbi request reprint Therapy may unmask hypoplastic myelodysplastic syndrome that mimics aplastic anemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1520-6. 2007
    ..There has been controversy regarding whether the initial diagnosis of AA is correct or whether these patients have hypocellular MDS at the onset of pancytopenia...
  30. ncbi request reprint Activating FLT3 mutations are detectable in chronic and blast phase of chronic myeloproliferative disorders other than chronic myeloid leukemia
    Pei Lin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 126:530-3. 2006
    ..By contrast, no FLT3 mutations were detected in CML, including 108 chronic and 11 blast phase cases. FLT3 mutations occur in approximately 10% of CMPD and CMPD/MDS but are not observed in JAK2+ CMPD or in CML...
  31. doi request reprint Potential therapeutic biomarkers in plasma cell myeloma: a flow cytometry study
    Wenli Zheng
    Department of Hematopathology, The University of Texas M D, Anderson Cancer Center, Houston, TX, USA
    Cytometry B Clin Cytom 84:222-8. 2013
    ..To investigate the expression profile of potential therapeutic biomarkers in plasma cell myeloma (PCM) by multicolor flow cytometry analysis...
  32. doi request reprint B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome
    Shaoying Li
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 25:145-56. 2012
    ..Tumors with extra MYC signals plus IGH@BCL2 or MYC rearrangement plus extra BCL2 signals, respectively, appear to behave as poorly as MYC/BCL2 lymphomas, possibly expanding the disease spectrum...
  33. doi request reprint Classical Hodgkin lymphoma arising in the setting of iatrogenic immunodeficiency: a clinicopathologic study of 10 cases
    Eric Y Loo
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 37:1290-7. 2013
    ..We conclude that iatrogenic immunodeficiency-associated CHL is highly associated with Epstein-Barr virus infection, and patients usually have a good outcome after discontinuation of immunomodulatory agents and chemotherapy for CHL. ..
  34. doi request reprint Splenic B-cell lymphomas with more than 55% prolymphocytes in blood: evidence for prolymphocytoid transformation
    Daniela Hoehn
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 43:1828-38. 2012
    ..We conclude that splenic B-cell lymphoma of various types can undergo prolymphocytoid transformation with more than 55% prolymphocytes in the blood mimicking B-cell prolymphocytic leukemia...
  35. pmc Precursor B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related?
    Guilin Tang
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Haematologica 97:919-25. 2012
    ..Precursor B-acute lymphoblastic leukemia occurring in patients with a history of malignancies is uncommon, and this condition is not well understood...
  36. doi request reprint CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases
    Jesse Jaso
    Department of Pathology, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Hum Pathol 43:1436-43. 2012
    ..Our results show that CD5 expression is rare in MALT lymphoma, and is often associated with nongastric disease and an increased tendency to present with disseminated disease. Overall survival is excellent with appropriate therapy...
  37. doi request reprint Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue involving different sites
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Clin Pathol 134:112-8. 2010
    ....
  38. doi request reprint Usefulness of flow cytometric immunophenotyping for bone marrow staging in patients with mantle cell lymphoma after therapy
    Wei Liu
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Am J Clin Pathol 137:634-40. 2012
    ..We conclude that FCI is more sensitive than morphologic examination of BM at the time of restaging in patients with MCL and that positivity by only FCI in BM often correlates with concurrent disease or subsequent relapse...
  39. ncbi request reprint Lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia: an evolving concept
    Pei Lin
    From the Department of Hematopathology, UTMD Anderson Cancer Center, Houston, Texas 77030, USA
    Adv Anat Pathol 12:246-55. 2005
    ..In some cases, in our opinion, distinguishing LPL/WM from marginal zone B-cell lymphomas seems arbitrary using currently recommended criteria...
  40. ncbi request reprint Acute myeloid leukemia with t(6;9)(p23;q34) is associated with dysplasia and a high frequency of flt3 gene mutations
    Mauricio P Oyarzo
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 122:348-58. 2004
    ..We conclude that t(6;9)-positive AML cases have distinctive morphologic features, an immunophenotype suggesting origin from an early hematopoietic progenitor cell, and a high frequency of flt3 gene mutations...
  41. ncbi request reprint t(8;21)(q22;q22) in blast phase of chronic myelogenous leukemia
    C Cameron Yin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 121:836-42. 2004
    ..These findings suggest that the pathologic features of blast phase CML with the t(8;21) resemble those of de novo AML with the t(8;21)...
  42. pmc Bone marrow stromal cells derived MCP-1 reverses the inhibitory effects of multiple myeloma cells on osteoclastogenesis by upregulating the RANK expression
    Zhiqiang Liu
    Department of Lymphoma and Myeloma, Division of Cancer Medicine, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 8:e82453. 2013
    ..Thus, our studies provide evidences that targeting bone marrow microenvironmental cells and/or cytokines may be a new approach to treating MM bone destruction. ..
  43. pmc Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma
    Deborah J Kuhn
    Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
    Blood 120:3260-70. 2012
    ....
  44. doi request reprint Myelodysplastic syndrome/acute myeloid leukemia with t(3;21)(q26.2;q22) is commonly a therapy-related disease associated with poor outcome
    Shaoying Li
    Department of Hematopathology, Unit 72, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 138:146-52. 2012
    ....
  45. doi request reprint A severe combined immunodeficient-hu in vivo mouse model of human primary mantle cell lymphoma
    Michael Wang
    Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:2154-60. 2008
    ..To establish a severe combined immunodeficient (SCID)-hu in vivo mouse model of human primary mantle cell lymphoma (MCL) for the study of the biology and novel therapy of human MCL...
  46. ncbi request reprint Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 38:1760-3. 2007
    ....
  47. doi request reprint Bacterial artificial chromosome array-based comparative genomic hybridization using paired formalin-fixed, paraffin-embedded and fresh frozen tissue specimens in multiple myeloma
    Patrick A Lennon
    School of Health Sciences, Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:345-54. 2009
    ..Compared with conventional cytogenetics, bacterial artificial chromosome (BAC) array-comparative genomic hybridization (CGH) allows more sensitive detection of chromosomal abnormalities...
  48. ncbi request reprint Myeloid sarcoma of the urinary bladder and epididymis as a primary manifestation of acute myeloid leukemia with inv(16)
    Samer Z Al-Quran
    Department of Anatomic Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Arch Pathol Lab Med 130:862-6. 2006
    ..A high index of suspicion is required to establish the diagnosis of MS involving bladder. Cytogenetic analysis is useful for both demonstrating minimal marrow disease and classifying MS in paraffin-embedded tissue sections...
  49. ncbi request reprint Expression of CD2 in acute promyelocytic leukemia correlates with short form of PML-RARalpha transcripts and poorer prognosis
    Pei Lin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 121:402-7. 2004
    ..07) than CD2- APL. Overall survival for M3v vs M3 (P = .68) and short vs long transcripts (P = .21) was not significantly different. Immunophenotyping is useful for predicting the biologic and clinical behavior of APL...
  50. ncbi request reprint Diffuse large B-cell lymphoma occurring in patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Clinicopathologic features of 12 cases
    Pei Lin
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 120:246-53. 2003
    ..DLBCL, most likely as a result of histologic transformation, occurs in a subset of patients with LPL/WM and is associated with aggressive clinical course and poor outcome. EBV is unlikely to be involved in transformation...
  51. ncbi request reprint c-Jun expression and activation are restricted to CD30+ lymphoproliferative disorders
    Elias Drakos
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 31:447-53. 2007
    ..We conclude that CD30 lymphomas are characterized by common patterns of c-Jun expression and activation suggesting a potential role of c-Jun in the pathogenesis of these tumors...
  52. ncbi request reprint Expression of heat-shock protein-90 in non-Hodgkin's lymphomas
    Jose R Valbuena
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:1343-9. 2005
    ..These data suggest that many lymphoma types are suitable targets for modulation of HSP90 activity, and that HSP90 inhibitors are a potential investigational therapy for lymphoma patients...
  53. ncbi request reprint Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type
    Weina Chen
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Br J Haematol 130:726-8. 2005
    ..Over the disease course, changes in FLT3 mutation status were seen in 89% of cases, and were associated with cytogenetic changes. We conclude that FLT3 dual mutations occur rarely in AML, and appear to be related to clonal evolution...
  54. doi request reprint Myelodysplastic syndrome with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) has a high risk for progression to acute myeloid leukemia
    Wei Cui
    Dept of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 136:282-8. 2011
    ..Median survival for patients with de novo disease was similar to that for patients with therapy-related MDS (13 vs 17.5 months). MDS or CMML with inv(3)/t(3;3) are aggressive diseases with a high risk of progression to AML...
  55. doi request reprint Refractory anemia with ring sideroblasts associated with marked thrombocytosis: a mixed group exhibiting a spectrum of morphologic findings
    Inga Gurevich
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Clin Pathol 135:398-403. 2011
    ..The remaining cases usually lack the JAK2(V617F)mutation, have a platelet count less than 600 × 10(3)/μL (600 × 10(9)/L), and may represent an MDS or MPN with thrombocytosis of unknown mechanisms...
  56. ncbi request reprint Lymphoid neoplasms associated with IgM paraprotein: a study of 382 patients
    Pei Lin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 123:200-5. 2005
    ..Thus, serum IgM paraprotein level is not a reliable discriminator in differential diagnosis...
  57. ncbi request reprint inv(16)(p13q22) in chronic myelogenous leukemia in blast phase: a clinicopathologic, cytogenetic, and molecular study of five cases
    Mihai Merzianu
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 124:807-14. 2005
    ..In this setting, unlike de novo AML, inv(16)(p13q22) in CML-BP is not associated with a favorable prognosis...
  58. ncbi request reprint Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 124:414-20. 2005
    ..CD23, usually of dim intensity, and CD11c are expressed commonly in LPL/WM. Rare CD5+ and CD10+ cases of LPL/WM also exist...
  59. ncbi request reprint Primary plasma cell leukemia: morphologic, immunophenotypic, and cytogenetic features of 4 cases treated with chemotherapy and stem cell transplantation
    Malisha R Johnson
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Ann Diagn Pathol 10:263-8. 2006
    ..Of 4 cases, 3 had complex karyotypes, including the t(11;14)(q13;q32) or del(11)(q13). Despite chemotherapy and the use of novel therapeutic agents and stem cell transplantation, all 4 patients had short survival...
  60. doi request reprint Flow cytometric immunophenotyping of anaplastic large cell lymphoma
    Tariq Muzzafar
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Arch Pathol Lab Med 133:49-56. 2009
    ..However, fine-needle aspiration is becoming a popular alternative to lymph node biopsy, and flow-cytometric immunophenotyping is often used to analyze fine-needle aspiration specimens...
  61. ncbi request reprint Acute myeloid leukemia associated with variant t(8;21) detected by conventional cytogenetic and molecular studies: a report of four cases and review of the literature
    Li Huang
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
    Am J Clin Pathol 125:267-72. 2006
    ..A combination of conventional cytogenetic, and molecular analyses allows identification of these variants...
  62. ncbi request reprint Follicular lymphoma in staging bone marrow specimens: correlation of histologic findings with the results of flow cytometry immunophenotypic analysis
    Dan Iancu
    Department of Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Arch Pathol Lab Med 131:282-7. 2007
    ..Bone marrow (BM) examination is part of the staging workup of lymphoma patients. Few studies have compared BM histologic findings with results of flow cytometric immunophenotyping analysis in follicular lymphoma (FL) patients...
  63. doi request reprint Absence of terminal deoxynucleotidyl transferase expression identifies a subset of high-risk adult T-lymphoblastic leukemia/lymphoma
    Yi Zhou
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 26:1338-45. 2013
    ..Absence of TdT expression identifies a subset of high-risk T-ALL/LBL that overlaps with, but is not identical to, the ETP leukemia, providing additional prognostic value. ..
  64. doi request reprint Advances in the molecular pathobiology of B-lymphoblastic leukemia
    Yi Zhou
    Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 43:1347-62. 2012
    ....
  65. ncbi request reprint Extranodal lymphomas of the head and neck
    Francisco Vega
    Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Diagn Pathol 9:340-50. 2005
    ....
  66. ncbi request reprint Chronic myeloproliferative diseases with the t(5;12)(q33;p13): clonal evolution is associated with blast crisis
    Xin Han
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 125:49-56. 2006
    ..Of 3 patients treated with imatinib, 2 responded, but only 1 had a sustained response. CMPD with t(5;12) commonly transforms to blast phase, and transformation is associated with cytogenetic evidence of clonal evolution...
  67. pmc Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study
    Sylvia Hoeller
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    Hum Pathol 44:110-21. 2013
    ..The lack of a clonal relationship between the MCL and CLL/SLL components suggests that MCL and CLL/SLL components represent distinct disease processes and do not share a common progenitor B-cell...
  68. doi request reprint CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia
    Daniela Hoehn
    Dept of Hematopathology, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 137:213-9. 2012
    ..CD117 expression alone is sensitive but not specific for FLT3 mutation. The immunophenotypic profile of TdT, CD7, CD13, CD34, and CD117 (bright) is helpful for predicting FLT3 mutation, with a sensitivity of 100% and specificity of 94%...
  69. ncbi request reprint The utility of interphase fluorescence in situ hybridization for the detection of the translocation t(11;14)(q13;q32) in the diagnosis of mantle cell lymphoma on fine-needle aspiration specimens
    Nancy P Caraway
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 105:110-8. 2005
    ....
  70. doi request reprint Aberrant myeloid maturation identified by flow cytometry in primary myelofibrosis
    Bo Feng
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 133:314-20. 2010
    ..Our findings indicate that although there is considerable overlap between PMF and MDS-MF, the smaller granulocytes observed in PMF are a useful distinguishing feature...
  71. ncbi request reprint Myeloid sarcoma involving the testis
    Jose R Valbuena
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 124:445-52. 2005
    ..Including the 2 cases we report here, only 7 cases of myeloid sarcoma isolated to the testis have been reported...
  72. ncbi request reprint Postsplenectomy cytomegaloviral mononucleosis: marked lymphocytosis, TCRgamma gene rearrangements, and impaired IgM response
    Xiang Y Han
    Department of Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 123:612-7. 2005
    ..The infections resolved without specific treatment. These cases suggest that the spleen might be a primary site for specific anti-CMV IgM response...
  73. ncbi request reprint A role for PML3 in centrosome duplication and genome stability
    Zhi Xiang Xu
    Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Mol Cell 17:721-32. 2005
    ..The results of this study implicate a direct role for PML3 in the control of centrosome duplication through suppression of Aurora A activation to prevent centrosome reduplication...
  74. doi request reprint The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningioma
    Suyang Hao
    Department of Pathology, University of Massachusetts Medical Center, Worcester, USA
    Arch Pathol Lab Med 135:1032-6. 2011
    ..One of the major clinical challenges is to predict recurrence of meningioma. Recently, we have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors...
  75. doi request reprint Waldenström macroglobulinemia: a review of the entity and its differential diagnosis
    Saad P Shaheen
    Department of Pathology, Veterans Affairs Medical Center, Louisville, Kentucky, USA
    Adv Anat Pathol 19:11-27. 2012
    ....
  76. ncbi request reprint Targeting beta2-microglobulin for induction of tumor apoptosis in human hematological malignancies
    Jing Yang
    Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Cell 10:295-307. 2006
    ..Therefore, such mAbs offer the potential for a therapeutic approach to hematological malignancies...
  77. ncbi request reprint CD117, but not lysozyme, is positive in cutaneous plasmacytoma
    Ilene B Bayer-Garner
    Department of Pathology, Marshfield Clinic, Marshfield, Wis, USA
    Arch Pathol Lab Med 127:1596-8. 2003
    ..Lysozyme immunoreactivity has been previously shown in 30% of poorly differentiated myelomas, while it is nonreactive in nonmalignant plasma cells...
  78. doi request reprint Lymphoplasmacytic lymphoma and other non-marginal zone lymphomas with plasmacytic differentiation
    Pei Lin
    Department of Hematopathology, The Universityof Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Clin Pathol 136:195-210. 2011
    ....
  79. doi request reprint Rosai-Dorfman disease confined to the breast
    Jerzy J Morkowski
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Diagn Pathol 14:81-7. 2010
    ....
  80. ncbi request reprint High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis
    Pei Lin
    Haematologica 92:1297-301. 2007
  81. pmc Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 104:10494-9. 2007
    ..An increase in histone H3-K4 and H3-K79 methylation within the Bmi-1 promoter provides an epigenetic mechanism for histone modifications in SALL4-mediated Bmi-1 gene deregulation...
  82. ncbi request reprint Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma
    Pei Lin
    Department of Pathology and Laboratory Medicine, University of Arkansas for Medical Sciences, Little Rock, USA
    Am J Clin Pathol 121:482-8. 2004
    ..PC immunophenotyping might be useful for detecting minimal residual disease in cases with aberrant antigen expression and for selection of therapeutic agents that have specific membrane targets...
  83. ncbi request reprint The distinct gene expression profiles of chronic lymphocytic leukemia and multiple myeloma suggest different anti-apoptotic mechanisms but predict only some differences in phenotype
    Clive S Zent
    Division of Hematology Oncology, Central Arkansas Healthcare System and University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    Leuk Res 27:765-74. 2003
    ..CLL and MM differentially expressed 18% of 130 apoptosis related genes, suggesting differences in mechanisms of cell survival...
  84. pmc Bone marrow transplant engraftment analysis with loss of an informative allele
    Steven A Schichman
    Pathology and Laboratory Medicine Service, Central Arkansas Veterans Healthcare System, Little Rock 72205, USA
    J Mol Diagn 4:230-2. 2002
    ..This circumstance is a potential source of error in the interpretation of engraftment analysis, especially if only one informative allele is used to monitor engraftment...
  85. ncbi request reprint Targeting heat shock proteins for immunotherapy in multiple myeloma: generation of myeloma-specific CTLs using dendritic cells pulsed with tumor-derived gp96
    Jianfei Qian
    Myeloma Institute for Research and Therapy, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Clin Cancer Res 11:8808-15. 2005
    ..Recent studies in solid tumors show that tumor-derived heat shock proteins (Hsp) can be used as immunogen; however, no such study has yet been reported in multiple myeloma...
  86. ncbi request reprint Mobilization of CD34+ cells in elderly patients (>/= 70 years) with multiple myeloma: influence of age, prior therapy, platelet count and mobilization regimen
    Christopher L Morris
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Br J Haematol 120:413-23. 2003
    ..Increasing age adversely affected CD34+ yield even with limited premobilization therapy, indicating that early collection is important in elderly patients...
  87. pmc NY-ESO-1 is highly expressed in poor-prognosis multiple myeloma and induces spontaneous humoral and cellular immune responses
    Frits van Rhee
    University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, 4301 West Markham, no 776, Little Rock, AR 72205, USA
    Blood 105:3939-44. 2005
    ..The pool of NY-ESO-1-specific cytotoxic T cells expands easily on NY-ESO-1 peptide stimulation and is functionally active. NY-ESO-1 should therefore be an ideal tumor target antigen for immunotherapy of patients with poor-prognosis MM...