Hui Kuan Lin

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
    Hui Kuan Lin
    Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Cell Biol 11:420-32. 2009
  2. pmc K63-linked ubiquitination in kinase activation and cancer
    Guocan Wang
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center Houston, TX, USA
    Front Oncol 2:5. 2012
  3. pmc Emerging Cellular Functions of Cytoplasmic PML
    Guoxiang Jin
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Front Oncol 3:147. 2013
  4. pmc Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis
    Guocan Wang
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Chin J Cancer 31:169-77. 2012
  5. pmc Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
    Hui Kuan Lin
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nature 464:374-9. 2010
  6. ncbi request reprint Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells
    Lin Yang
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 305:462-9. 2003
  7. ncbi request reprint Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:50902-7. 2003
  8. pmc Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
    Chia Hsin Chan
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Cell Biol 12:457-67. 2010
  9. pmc Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling
    Wei Lei Yang
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Sci Signal 6:ra3. 2013
  10. ncbi request reprint Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 277:36570-6. 2002

Collaborators

Detail Information

Publications39

  1. pmc Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
    Hui Kuan Lin
    Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Cell Biol 11:420-32. 2009
    ..Finally, we demonstrate that high levels of activation of Akt correlate with the cytosolic accumulation of Skp2 in human cancer specimens. Our results therefore define a novel proto-oncogenic Akt/PKB-dependent signalling pathway...
  2. pmc K63-linked ubiquitination in kinase activation and cancer
    Guocan Wang
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center Houston, TX, USA
    Front Oncol 2:5. 2012
    ..The advancement in the understanding of the novel functions of ubiquitination in signal transduction pathways downstream of growth factor receptors may provide novel paradigms for the treatment of human cancers...
  3. pmc Emerging Cellular Functions of Cytoplasmic PML
    Guoxiang Jin
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Front Oncol 3:147. 2013
    ..In this review, we will summarize the emerging roles of cPML in cellular functions...
  4. pmc Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis
    Guocan Wang
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Chin J Cancer 31:169-77. 2012
    ..This review discusses the recent discoveries on the novel roles of Skp2 in regulating cellular senescence, cancer progression, and metastasis, as well as the therapeutic potential of targeting Skp2 for human cancer treatment...
  5. pmc Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
    Hui Kuan Lin
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nature 464:374-9. 2010
    ..Our findings therefore provide proof-of-principle evidence that pharmacological inhibition of Skp2 may represent a general approach for cancer prevention and therapy...
  6. ncbi request reprint Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells
    Lin Yang
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 305:462-9. 2003
    ..Together, our results indicate that the balance of these various pathways may then determine the overall effect of IL-6 on AR transactivation...
  7. ncbi request reprint Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:50902-7. 2003
    ....
  8. pmc Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
    Chia Hsin Chan
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Cell Biol 12:457-67. 2010
    ..Our study provides insight into how oncogenic Skp2 and Myc coordinate to induce RhoA transcription and establishes a novel SCF-Skp2 E3-ligase-independent function for oncogenic Skp2 in transcription and cancer metastasis...
  9. pmc Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling
    Wei Lei Yang
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Sci Signal 6:ra3. 2013
    ..Our findings reveal the crucial role of cycles of ubiquitination and deubiquitination of Akt in determining its plasma membrane localization and activation--and further identify CYLD as a molecular switch for these processes...
  10. ncbi request reprint Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 277:36570-6. 2002
    ....
  11. pmc Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression
    Chia Hsin Chan
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell 154:556-68. 2013
    ..Our study thus provides pharmacological evidence that Skp2 is a promising target for restricting cancer stem cell and cancer progression. ..
  12. pmc The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal
    Jing Wang
    Department of Molecular and Cellular Oncology, M D Anderson Cancer Center, The University of Texas, Houston, TX, USA
    Blood 118:5429-38. 2011
    ..Our findings show that Skp2 is a novel regulator for HSC quiescence and self-renewal and that targeting Skp2 may have therapeutic implications for BM transplantation and leukemia stem cell treatment...
  13. ncbi request reprint Cytoplasmic PML function in TGF-beta signalling
    Hui Kuan Lin
    Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York, 10021, USA
    Nature 431:205-11. 2004
    ..Our findings identify cytoplasmic PML as a critical TGF-beta regulator, and further implicate deregulated TGF-beta signalling in cancer pathogenesis...
  14. pmc Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response
    Ching Yuan Wu
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 286:30806-15. 2011
    ..Our study therefore suggests that monoubiquitination of H2AX is an important step for DNA damage response and may have important clinical implications for the treatment of cancers...
  15. ncbi request reprint Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells
    Saleh Altuwaijri
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Cancer Res 63:7106-12. 2003
    ..These data describe a signaling pathway that could potentially be useful in proposed therapeutic treatment strategies exploiting combinations of different agents that control apoptosis in prostate tumors...
  16. ncbi request reprint Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells
    Shaozhen Xie
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    Prostate 60:61-7. 2004
    ..In this study, we investigate how androgen plays a role in IL-6-mediated NE differentiation in LNCaP cell line...
  17. ncbi request reprint Deregulated TGF-beta signaling in leukemogenesis
    Hui Kuan Lin
    Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Oncogene 24:5693-700. 2005
    ..In this review, we summarize the current progress towards the understanding of the molecular mechanisms by which aberrant TGF-beta signaling may participate in leukemogenesis...
  18. pmc LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker
    Dahu Chen
    Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 18:1511-7. 2012
    ..These findings identify LIFR as a metastasis suppressor that functions through the Hippo-YAP pathway and has significant prognostic power...
  19. doi request reprint ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor
    Chien Hung Chen
    Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Sci Signal 4:ra10. 2011
    ..Thus, in response to cellular stress, GSK-3β restrains mTORC2-Akt signaling by specifically phosphorylating rictor, thereby balancing the activities of GSK-3β and Akt, two opposing players in glucose metabolism...
  20. pmc Loss of TGF-β adaptor β2SP activates notch signaling and SOX9 expression in esophageal adenocarcinoma
    Shumei Song
    Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 73:2159-69. 2013
    ..Taken together, our findings suggest that loss of β2SP switches TGF-β signaling from tumor suppression to tumor promotion by engaging Notch signaling and activating SOX9...
  21. ncbi request reprint E3-ligase Skp2 regulates β-catenin expression and maintains hematopoietic stem cell homing
    Jing Wang
    State Key Laboratory of Oncology in South China and Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, China Department of Molecular and Cellular Oncology, M D Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Biochem Biophys Res Commun 445:566-71. 2014
    ..Our study not only identified Skp2 as a new regulator for maintaining β-catenin expression and HSC homing, but also suggested that Skp2 may serve as a predictive marker for monitoring the transplantation efficiency. ..
  22. pmc Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    Zhenbang Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 436:725-30. 2005
    ..Our results demonstrate the relevance of cellular senescence in restricting tumorigenesis in vivo and support a model for cooperative tumour suppression in which p53 is an essential failsafe protein of Pten-deficient tumours...
  23. ncbi request reprint APPL suppresses androgen receptor transactivation via potentiating Akt activity
    Lin Yang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:16820-7. 2003
    ..Together, our data indicate that APPL may suppress AR transactivation via potentiating Akt activity...
  24. pmc The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
    Chia Hsin Chan
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell 149:1098-111. 2012
    ..Our study suggests that distinct E3 ligases are utilized by diverse growth factors for Akt activation and that targeting glycolysis sensitizes Her2-positive tumors to Herceptin treatment...
  25. ncbi request reprint Regulation of Skp2 expression and activity and its role in cancer progression
    Chia Hsin Chan
    1Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    ScientificWorldJournal 10:1001-15. 2010
    ..The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers...
  26. pmc Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus
    Yan Liu
    Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Sci Signal 5:ra77. 2012
    ....
  27. pmc Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis
    Quan Qiu
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    EMBO J 32:2477-90. 2013
    ....
  28. ncbi request reprint Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells
    Liang Wang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, New York 14642, USA
    J Biol Chem 279:32444-52. 2004
    ..Together, our data demonstrated that GSK3 beta may function as a repressor to suppress AR-mediated transactivation and cell growth, which may provide a new strategy to modulate the AR-mediated prostate cancer growth...
  29. pmc Regulation of Akt signaling activation by ubiquitination
    Wei Lei Yang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cell Cycle 9:487-97. 2010
    ..Thus, this novel posttranslational modification on Akt reveals an exciting avenue that has advanced our current understandings of how Akt signaling activation is regulated...
  30. pmc Novel ARF/p53-independent senescence pathways in cancer repression
    Chia Hsin Chan
    Department of Molecular and Cellular Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Mol Med (Berl) 89:857-67. 2011
    ..Recent discoveries of novel regulators involved in ARF/p53-independent cellular senescence not only reveal novel paradigms for cellular senescence but also provide alternative approaches for cancer therapy...
  31. ncbi request reprint Cloning, expression, and functional analysis of genomic miRNA using retroviral system in cancer cells
    Abdol Hossein Rezaeian
    Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Methods Mol Biol 936:157-72. 2013
    ..Furthermore, the procedure eliminates miRNA extraction and cDNA synthesis before cloning and sequential cloning of more than one miRNA makes this protocol cost- and time-effective to eliminate many frequent cell culturing...
  32. pmc The E3 ligase TRAF6 regulates Akt ubiquitination and activation
    Wei Lei Yang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1134-8. 2009
    ..Thus, Akt ubiquitination is an important step for oncogenic Akt activation...
  33. pmc PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
    Rong Hua Tao
    Departments of Lymphoma and Myeloma, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 118:3107-18. 2011
    ..The presence of PML-Fas complexes across different tissues implicates that PML functions in apoptosis regulation and tumor suppression are mediated by direct interaction with Fas...
  34. pmc Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice
    Betty Lamothe
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 7:e51228. 2012
    ..Consequently, we found TAK1 deletion in 13 of 30 AML patients (43%), thus providing direct genetic evidence of TAK1's role in leukemogenesis...
  35. pmc The mechanisms of PML-nuclear body formation
    Tian Huai Shen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell 24:331-9. 2006
    ....
  36. doi request reprint Cytoplasmic PML: from molecular regulation to biological functions
    Guoxiang Jin
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030
    J Cell Biochem 115:812-8. 2014
    ..In this prospective, we will summarize the current viewpoints on the regulation and biological significance of cPML and discuss the important questions that still need to be further answered...
  37. pmc Akt: a new activation mechanism
    Yuan Gao
    1 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 2 The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA
    Cell Res 24:785-6. 2014
    ..Akt phosphorylation at S473 and T308 has been believed to be the prerequisites for its activation for years. Now, new phosphorylation event on Akt is identified and can trigger Akt activation and lead to its downstream oncogenic events. ..
  38. pmc Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells
    Wen Bin Tsai
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77053, USA
    Cancer Res 72:2622-33. 2012
    ....
  39. pmc Differential p53-independent outcomes of p19(Arf) loss in oncogenesis
    Zhenbang Chen
    Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 2:ra44. 2009
    ..Collectively, these data reveal differential consequences of p19(Arf) inactivation in prostate cancer and MEFs upon Pten loss that are independent of the p53 pathway...

Research Grants2

  1. The crosstalk between the PI3K/Akt signal and Skp2 in prostate cancer progression
    Hui Kuan Lin; Fiscal Year: 2010
    ..Understanding the important role of Skp2 and Skp2 S72 phopshorylation in prostate cancer progression and metastasis may provide an important therapeutic implication for human prostate cancers. ..
  2. Regulation of Akt signaling activation by polyubiquitination
    Hui Kuan Lin; Fiscal Year: 2010
    ..Understanding the mechanism by which Akt activation is regulated may not only provide a great insight into how the oncogenic Akt signaling is regulated, but also offer the important therapeutic implications for human cancers. ..