Hui Kuan Lin

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
    Hui Kuan Lin
    Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Cell Biol 11:420-32. 2009
  2. ncbi Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis
    Guocan Wang
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Chin J Cancer 31:169-77. 2012
  3. ncbi Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 277:36570-6. 2002
  4. ncbi Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
    Hui Kuan Lin
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nature 464:374-9. 2010
  5. ncbi APPL suppresses androgen receptor transactivation via potentiating Akt activity
    Lin Yang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:16820-7. 2003
  6. ncbi Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells
    Shaozhen Xie
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    Prostate 60:61-7. 2004
  7. ncbi Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    Zhenbang Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 436:725-30. 2005
  8. ncbi Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells
    Liang Wang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, New York 14642, USA
    J Biol Chem 279:32444-52. 2004
  9. ncbi Regulation of Skp2 expression and activity and its role in cancer progression
    Chia Hsin Chan
    1Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    ScientificWorldJournal 10:1001-15. 2010
  10. ncbi Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus
    Yan Liu
    Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Sci Signal 5:ra77. 2012

Research Grants

  1. The crosstalk between the PI3K/Akt signal and Skp2 in prostate cancer progression
    Hui Kuan Lin; Fiscal Year: 2010
  2. Regulation of Akt signaling activation by polyubiquitination
    Hui Kuan Lin; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
    Hui Kuan Lin
    Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Cell Biol 11:420-32. 2009
    ..Finally, we demonstrate that high levels of activation of Akt correlate with the cytosolic accumulation of Skp2 in human cancer specimens. Our results therefore define a novel proto-oncogenic Akt/PKB-dependent signalling pathway...
  2. ncbi Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis
    Guocan Wang
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Chin J Cancer 31:169-77. 2012
    ..This review discusses the recent discoveries on the novel roles of Skp2 in regulating cellular senescence, cancer progression, and metastasis, as well as the therapeutic potential of targeting Skp2 for human cancer treatment...
  3. ncbi Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells
    Hui Kuan Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 277:36570-6. 2002
    ....
  4. ncbi Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
    Hui Kuan Lin
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nature 464:374-9. 2010
    ..Our findings therefore provide proof-of-principle evidence that pharmacological inhibition of Skp2 may represent a general approach for cancer prevention and therapy...
  5. ncbi APPL suppresses androgen receptor transactivation via potentiating Akt activity
    Lin Yang
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 278:16820-7. 2003
    ..Together, our data indicate that APPL may suppress AR transactivation via potentiating Akt activity...
  6. ncbi Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells
    Shaozhen Xie
    George H Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, New York 14642, USA
    Prostate 60:61-7. 2004
    ..In this study, we investigate how androgen plays a role in IL-6-mediated NE differentiation in LNCaP cell line...
  7. ncbi Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    Zhenbang Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 436:725-30. 2005
    ..Our results demonstrate the relevance of cellular senescence in restricting tumorigenesis in vivo and support a model for cooperative tumour suppression in which p53 is an essential failsafe protein of Pten-deficient tumours...
  8. ncbi Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells
    Liang Wang
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, New York 14642, USA
    J Biol Chem 279:32444-52. 2004
    ..Together, our data demonstrated that GSK3 beta may function as a repressor to suppress AR-mediated transactivation and cell growth, which may provide a new strategy to modulate the AR-mediated prostate cancer growth...
  9. ncbi Regulation of Skp2 expression and activity and its role in cancer progression
    Chia Hsin Chan
    1Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    ScientificWorldJournal 10:1001-15. 2010
    ..The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers...
  10. ncbi Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus
    Yan Liu
    Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Sci Signal 5:ra77. 2012
    ....
  11. ncbi The mechanisms of PML-nuclear body formation
    Tian Huai Shen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell 24:331-9. 2006
    ....
  12. ncbi Cytoplasmic PML function in TGF-beta signalling
    Hui Kuan Lin
    Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York, 10021, USA
    Nature 431:205-11. 2004
    ..Our findings identify cytoplasmic PML as a critical TGF-beta regulator, and further implicate deregulated TGF-beta signalling in cancer pathogenesis...
  13. ncbi Differential p53-independent outcomes of p19(Arf) loss in oncogenesis
    Zhenbang Chen
    Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 2:ra44. 2009
    ..Collectively, these data reveal differential consequences of p19(Arf) inactivation in prostate cancer and MEFs upon Pten loss that are independent of the p53 pathway...

Research Grants2

  1. The crosstalk between the PI3K/Akt signal and Skp2 in prostate cancer progression
    Hui Kuan Lin; Fiscal Year: 2010
    ..Understanding the important role of Skp2 and Skp2 S72 phopshorylation in prostate cancer progression and metastasis may provide an important therapeutic implication for human prostate cancers. ..
  2. Regulation of Akt signaling activation by polyubiquitination
    Hui Kuan Lin; Fiscal Year: 2010
    ..Understanding the mechanism by which Akt activation is regulated may not only provide a great insight into how the oncogenic Akt signaling is regulated, but also offer the important therapeutic implications for human cancers. ..