Richard T Libby

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. ncbi request reprint Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration
    Richard T Libby
    MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
    Exp Eye Res 77:731-9. 2003
  2. ncbi request reprint Complex genetics of glaucoma susceptibility
    Richard T Libby
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Annu Rev Genomics Hum Genet 6:15-44. 2005
  3. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
  4. pmc Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine, USA
    BMC Genet 8:45. 2007
  5. pmc Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Neurosci 8:108. 2007
  6. pmc Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma
    Gareth R Howell
    Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Clin Invest 122:1246-61. 2012
  7. pmc Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME, USA
    BMC Biol 4:20. 2006
  8. ncbi request reprint Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Vis Neurosci 22:637-48. 2005
  9. doi request reprint Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection
    Gareth R Howell
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Prog Brain Res 173:303-21. 2008
  10. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005

Detail Information

Publications19

  1. ncbi request reprint Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration
    Richard T Libby
    MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
    Exp Eye Res 77:731-9. 2003
    ..No functional interaction between cadherin 23 and myosin VIIa was detected by either microscopy or ERG...
  2. ncbi request reprint Complex genetics of glaucoma susceptibility
    Richard T Libby
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Annu Rev Genomics Hum Genet 6:15-44. 2005
    ..In this review, we focus on endogenous genetic susceptibility factors and on how experimental studies will be valuable for dissecting the multifactorial complexity of their interactions...
  3. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
    ..These experiments provide strong evidence for a local insult to axons in the optic nerve...
  4. pmc Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, Maine, USA
    BMC Genet 8:45. 2007
    ..We have shown previously that mutations in two genes, Gpnmb and Tyrp1, initiate the iris disease. However, mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear...
  5. pmc Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Neurosci 8:108. 2007
    ..To test the importance of NOS2 for an inherited glaucoma, in this study we both genetically and pharmacologically decreased NOS2 activity in the DBA/2J mouse glaucoma model...
  6. pmc Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma
    Gareth R Howell
    Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Clin Invest 122:1246-61. 2012
    ..Together, these data support a model of glaucomatous damage involving monocyte entry into the optic nerve...
  7. pmc Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME, USA
    BMC Biol 4:20. 2006
    ..We initiated a study of congenic strains to further define the genetic requirements and disease mechanisms of the D2 glaucoma...
  8. ncbi request reprint Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Vis Neurosci 22:637-48. 2005
    ..This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy...
  9. doi request reprint Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection
    Gareth R Howell
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Prog Brain Res 173:303-21. 2008
    ..We describe how mouse models are adding to both the understanding of glaucomatous neurodegeneration and the development of neuroprotective strategies...
  10. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005
    ..Because of the robust protective effect, this treatment offers another tool for studying mechanisms of neuroprotection...
  11. ncbi request reprint Myosin Va is required for normal photoreceptor synaptic activity
    Richard T Libby
    MRC Institute of Hearing Research, University Park, Nottingham, NG7 2RD, UK
    J Cell Sci 117:4509-15. 2004
    ....
  12. pmc Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
    Gareth R Howell
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    J Clin Invest 121:1429-44. 2011
    ..Targeting early molecular events, such as complement and endothelin induction, may provide effective new treatments for human glaucoma...
  13. pmc Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data
    Gareth R Howell
    The Howard Hughes Medical Institute, Bar Harbor, Maine, USA
    BMC Genomics 12:429. 2011
    ..This reusable software system complements existing repositories such as NCBI GEO or EBI ArrayExpress as it allows the construction of searchable databases to maximize understanding of user-selected transcription profiling datasets...
  14. ncbi request reprint Modification of ocular defects in mouse developmental glaucoma models by tyrosinase
    Richard T Libby
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Science 299:1578-81. 2003
    ..These experiments raise the possibility that a tyrosinase/l-dopa pathway modifies human PCG, which could open new therapeutic avenues...
  15. doi request reprint Intrinsic axonal degeneration pathways are critical for glaucomatous damage
    Gareth R Howell
    The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Exp Neurol 246:54-61. 2013
    ..For developing new therapies, it will be necessary to clearly define and order the molecular events that lead from glaucomatous insults to axon degeneration. ..
  16. pmc Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes
    Daniel Gibbs
    Department of Pharmacology, UCSD School of Medicine, La Jolla, CA 92093 0912, USA
    J Cell Sci 117:6473-83. 2004
    ..The presence of two distinct melanosome velocities in both control and Myo7a-null RPE cells suggests the involvement of at least two motors other than myosin VIIa in melanosome motility, most probably, a microtubule motor and myosin Va...
  17. ncbi request reprint Myosin VI is required for normal retinal function
    Junko Kitamoto
    Department of Pharmacology, UCSD School of Medicine, La Jolla, CA 92093 0912, USA
    Exp Eye Res 81:116-20. 2005
    ..Our results indicate that myosin VI is required in photoreceptor cells for normal retinal electrophysiology...
  18. pmc Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
    Tatjana C Jakobs
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114
    J Cell Biol 171:313-25. 2005
    ..However, the architecture of the mouse eye seems to preclude a commonly postulated source of mechanical damage within the nerve head...
  19. ncbi request reprint Glaucoma: thinking in new ways-a rĂ´le for autonomous axonal self-destruction and other compartmentalised processes?
    Alan V Whitmore
    Divisions of Pathology and Cell Biology, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Prog Retin Eye Res 24:639-62. 2005
    ....