Affiliation: The University of Texas
- Identifying molecular drivers of gastric cancer through next-generation sequencingHan Liang
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA Electronic address
Cancer Lett 340:241-6. 2013..We also discuss the challenges and future directions of such efforts. ..
- BM-Map: an efficient software package for accurately allocating multireads of RNA-sequencing dataYuan Yuan
Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
BMC Genomics 13:S9. 2012..Allocating these multireads is challenging but critical for interpreting RNA-seq data. We recently developed a Bayesian stochastic model that allocates multireads more accurately than alternative methods (Ji et al. Biometrics 2011)...
- Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancerHan Liang
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Genome Res 22:2120-9. 2012..Our study presents the first unbiased view of somatic coding mutations in endometrial cancer and provides functional evidence for diverse driver genes and mutations in this disease...
- The spatial distribution of cis regulatory elements in yeast promoters and its implications for transcriptional regulationZhenguo Lin
Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
BMC Genomics 11:581. 2010..In this study, we reexamined the spatial distribution of TFBSs, investigated various promoter features that may affect the distribution, and studied the effect of TFBS distribution on transcriptional regulation...
- AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancerYon Hui Kim
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 72:2512-21. 2012....
- LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic markerDahu Chen
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Nat Med 18:1511-7. 2012..These findings identify LIFR as a metastasis suppressor that functions through the Hippo-YAP pathway and has significant prognostic power...