Shaoguang Li

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. pmc A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9
    Ajeeta B Dash
    Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:7622-7. 2002
  2. ncbi Heat shock protein 90: a potential therapeutic target in leukemic progenitor and stem cells harboring mutant BCR-ABL resistant to kinase inhibitors
    Cong Peng
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cell Cycle 6:2227-31. 2007
  3. pmc Src kinase signaling in leukaemia
    Shaoguang Li
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Int J Biochem Cell Biol 39:1483-8. 2007
  4. doi Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors
    Shaoguang Li
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Cell Mol Med 11:1251-62. 2007
  5. pmc Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia
    Shaoguang Li
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Leuk Lymphoma 49:19-26. 2008
  6. pmc Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
    Yiguo Hu
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 103:16870-5. 2006
  7. ncbi Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    Yiguo Hu
    The Jackson Laboratory, 600 Main St, Bar Harbor, Maine 04609, USA
    Nat Genet 36:453-61. 2004
  8. pmc Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells
    Cong Peng
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 110:678-85. 2007
  9. ncbi Curcumin inhibits proliferation and induces apoptosis of leukemic cells expressing wild-type or T315I-BCR-ABL and prolongs survival of mice with acute lymphoblastic leukemia
    Basem M William
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Hematology 13:333-43. 2008
  10. ncbi Src kinases as targets for B cell acute lymphoblastic leukaemia therapy
    Shaoguang Li
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Expert Opin Ther Targets 9:329-41. 2005

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9
    Ajeeta B Dash
    Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:7622-7. 2002
    ..Furthermore, these data indicate that despite acquisition of additional mutations, CML blast crisis cells retain their dependence on BCR/ABL for proliferation and survival...
  2. ncbi Heat shock protein 90: a potential therapeutic target in leukemic progenitor and stem cells harboring mutant BCR-ABL resistant to kinase inhibitors
    Cong Peng
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cell Cycle 6:2227-31. 2007
    ....
  3. pmc Src kinase signaling in leukaemia
    Shaoguang Li
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Int J Biochem Cell Biol 39:1483-8. 2007
    ..Leukaemic stem cells exist in acute lymphoblastic leukaemia, and complete eradication of this group of cells would provide a curative therapy for this disease...
  4. doi Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors
    Shaoguang Li
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Cell Mol Med 11:1251-62. 2007
    ..Apart from BCR-ABL and SRC kinases, stem cell pathways must also be targeted for curative therapy of Ph+ leukaemia...
  5. pmc Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia
    Shaoguang Li
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Leuk Lymphoma 49:19-26. 2008
    ....
  6. pmc Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
    Yiguo Hu
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 103:16870-5. 2006
    ..However, curing B-ALL and CML mice requires killing leukemic stem cells insensitive to both imatinib and dasatinib. Besides BCR-ABL and SRC kinases, stem cell pathways must be targeted for curative therapy of Ph(+) leukemia...
  7. ncbi Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    Yiguo Hu
    The Jackson Laboratory, 600 Main St, Bar Harbor, Maine 04609, USA
    Nat Genet 36:453-61. 2004
    ..These results implicate Src family kinases as therapeutic targets in Ph(+) B-ALL and suggest that simultaneous inhibition of Src and Bcr-Abl kinases may benefit individuals with Ph(+) acute leukemia...
  8. pmc Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells
    Cong Peng
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 110:678-85. 2007
    ..Rather than inhibiting kinase activity, elimination of mutant kinases provides a new therapeutic strategy for treating BCR-ABL-induced leukemia as well as other cancers resistant to treatment with tyrosine kinase inhibitors...
  9. ncbi Curcumin inhibits proliferation and induces apoptosis of leukemic cells expressing wild-type or T315I-BCR-ABL and prolongs survival of mice with acute lymphoblastic leukemia
    Basem M William
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Hematology 13:333-43. 2008
    ..We tested whether curcumin has an inhibitory effect on BCR-ABL B-cell acute lymphoblastic leukemia (B-ALL) in vitro and in vivo...
  10. ncbi Src kinases as targets for B cell acute lymphoblastic leukaemia therapy
    Shaoguang Li
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Expert Opin Ther Targets 9:329-41. 2005
    ..Simultaneous targeting of both BCR-ABL and Src kinases may benefit human B-ALL patients. Leukaemic stem cells may exist in Ph+ B-ALL, and eradication of this group of cells would provide a curative method for this disease...
  11. ncbi Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice
    Shawn D Pelletier
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Blood 104:2163-71. 2004
    ....
  12. ncbi Critical role for Gab2 in transformation by BCR/ABL
    Martin Sattler
    Dana Farber Cancer Institute, Department of Adult Oncology, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cancer Cell 1:479-92. 2002
    ..Our results identify Gab2 and its associated proteins as key determinants of the lineage and severity of BCR/ABL transformation...

Research Grants2

  1. Survival Mechanisms of Cancer-initiating (Stem) Cells in Ph+ Leukemia
    Shaoguang Li; Fiscal Year: 2007
    ..This study will help to understand the biology of leukemia stem cells and develop novel anti-stem cell strategies for Ph+ leukemias. ..