Junan Li

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer
    Junan Li
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 31:2683-92. 2011
  2. pmc Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer
    Junan Li
    Division of Environmental Health Sciences, College of Public Health, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 50:5566-82. 2011
  3. ncbi request reprint Ankyrin repeat: a unique motif mediating protein-protein interactions
    Junan Li
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:15168-78. 2006
  4. ncbi request reprint Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)
    Junan Li
    Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 44:13246-56. 2005
  5. ncbi request reprint The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner
    Junan Li
    Surgery Department, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 43:4394-9. 2004
  6. doi request reprint Comparisons of the conformational stability of cyclin-dependent kinase (CDK) 4-interacting ankyrin repeat (AR) proteins
    Yi Guo
    Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 48:4050-62. 2009
  7. pmc Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16
    Anjali Mahajan
    Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
    J Mol Biol 373:990-1005. 2007
  8. pmc Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis
    Ming J Poi
    Department of Pharmacy, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, OH 43210, United States
    Biochem Biophys Res Commun 436:217-22. 2013
  9. ncbi request reprint Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship
    Chunhua Yuan
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 43:12152-61. 2004
  10. ncbi request reprint An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4
    Junan Li
    Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 42:13476-83. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer
    Junan Li
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 31:2683-92. 2011
    ..In this study, the levels of gankyrin mRNA and protein expression were assessed in human oral epithelial cell lines, at-risk normal oral tissues, premalignant oral lesions, and primary oral squamous cell carcinomas (OSCCs)...
  2. pmc Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer
    Junan Li
    Division of Environmental Health Sciences, College of Public Health, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 50:5566-82. 2011
    ..Here, we discuss the regulatory mechanisms of P16 function at the DNA level, the transcription level, and the posttranscriptional level, as well as their implications for the structure-function relationship of P16 and for human cancers...
  3. ncbi request reprint Ankyrin repeat: a unique motif mediating protein-protein interactions
    Junan Li
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:15168-78. 2006
    ....
  4. ncbi request reprint Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)
    Junan Li
    Department of Surgery, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 44:13246-56. 2005
    ..These results provide important information on the molecular mechanism of the functions of SEI-1 and on the comparison between SEI-1 and p16 at both molecular and cellular levels...
  5. ncbi request reprint The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner
    Junan Li
    Surgery Department, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 43:4394-9. 2004
    ....
  6. doi request reprint Comparisons of the conformational stability of cyclin-dependent kinase (CDK) 4-interacting ankyrin repeat (AR) proteins
    Yi Guo
    Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 48:4050-62. 2009
    ..Overall, our results provide important insights into understanding the biophysical properties of AR proteins...
  7. pmc Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16
    Anjali Mahajan
    Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
    J Mol Biol 373:990-1005. 2007
    ....
  8. pmc Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis
    Ming J Poi
    Department of Pharmacy, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, OH 43210, United States
    Biochem Biophys Res Commun 436:217-22. 2013
    ..These results support that P12 is a tumor suppressive protein distinct from P16, and its genetic inactivation is associated with pancreatic carcinogenesis. ..
  9. ncbi request reprint Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship
    Chunhua Yuan
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 43:12152-61. 2004
    ..These results and analyses will shed light on the structural basis of the function of human gankyrin...
  10. ncbi request reprint An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4
    Junan Li
    Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 42:13476-83. 2003
    ....
  11. ncbi request reprint Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A
    Junan Li
    Department of Surgery, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 304:241-7. 2003
    ..From a biochemical perspective, these data strongly support the study of p16-related pancreatic oncogenesis and cancer therapies in the hamster model...
  12. ncbi request reprint Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens
    Peter Muscarella
    Department of Surgery, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Gene Expr 14:207-16. 2008
    ..7%. Taken together, our results demonstrate that reduced expression of pl6 is a common event in human pheochromocytomas, and the primary cause for such downregulation is inactivating genetic abnormalities in the p16 gene...
  13. doi request reprint Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors
    Junan Li
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Carcinog 47:733-8. 2008
    ....
  14. pmc Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins
    Yi Guo
    Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    J Mol Biol 399:168-81. 2010
    ....
  15. ncbi request reprint Direct binding of the N-terminus of HTLV-1 tax oncoprotein to cyclin-dependent kinase 4 is a dominant path to stimulate the kinase activity
    Junan Li
    Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 42:6921-8. 2003
    ..We also report that Tax40N retains the transactivation ability. These results of in vitro studies demonstrate a potentially novel, p16-independent route to regulate CDK4 activity by the Tax oncoprotein in HTLV-1 infected cells...
  16. ncbi request reprint A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth
    Junan Li
    Departments of Surgery and Internal Medicine, College of Medicine, The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA
    J Gastrointest Surg 10:207-14. 2006
    ..Further analyses indicate that OSU-03012 induces both proapoptotic and antiproliferative effects in these cells. Taken together, these data suggest that OSU-03012 has potential value as a novel therapy for pancreatic cancer...
  17. ncbi request reprint Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors
    Junan Li
    Department of Surgery, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 25:263-8. 2004
    ..These findings indicate that p16 inactivation is a common event in chemically induced hamster tumors, and that this animal model is appropriate for comparative studies evaluating pancreatic cancer therapeutic strategies targeting p16...
  18. pmc IKKbeta specifically binds to P16 and phosphorylates Ser8 of P16
    Yi Guo
    Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 393:504-8. 2010
    ..Our results reveal the novel role of IKKbeta in P16 phosphorylation and broaden our understanding of the regulation of P16...
  19. pmc The Study of pH-Dependent Stability Shows that the TPLH-Mediated Hydrogen-Bonding Network Is Important for the Conformation and Stability of Human Gankyrin
    Chunhua Yuan
    Campus Chemical Instrument Center, Ohio State Biochemistry Program, Division of Environmental Health Sciences, College of Public Health, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, United States
    Biochemistry 52:4848-57. 2013
    ....
  20. ncbi request reprint Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb
    Junan Li
    Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 41:3977-83. 2002
    ..These results demonstrate the potential importance of gankyrin in cell cycle control and tumorigenesis and suggest an expanded INK4-CDK4/6-Rb pathway...
  21. pmc Localization of a region in the fusion protein of avian metapneumovirus that modulates cell-cell fusion
    Yongwei Wei
    Department of Food Science and Technology, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Columbus, Ohio, USA
    J Virol 86:11800-14. 2012
    ..Taken together, we have identified a region in the aMPV F protein that modulates the extent of membrane fusion. A model for fusion consistent with these data is presented...
  22. pmc Development and optimization of a direct plaque assay for human and avian metapneumoviruses
    Yu Zhang
    Department of Food Science and Technology, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Columbus, OH 43210, USA
    J Virol Methods 185:61-8. 2012
    ..The direct plaque assay will be a valuable method for the quantitation and evaluation of the biological properties of some metapneumoviruses...
  23. pmc Lack of correlation between virus barosensitivity and the presence of a viral envelope during inactivation of human rotavirus, vesicular stomatitis virus, and avian metapneumovirus by high-pressure processing
    Fangfei Lou
    Department of Food Science and Technology, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Columbus, OH 43210, USA
    Appl Environ Microbiol 77:8538-47. 2011
    ..Taken together, our findings suggest that HPP is a promising technology to eliminate viral contaminants in high-risk foods, water, and other fomites...