D Li

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer
    Hideo Suzuki
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1184-91. 2008
  2. pmc Insights into pancreatic cancer etiology from pathway analysis of genome-wide association study data
    Peng Wei
    Division of Biostatistics and Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas, United States of America
    PLoS ONE 7:e46887. 2012
  3. pmc Association of diabetes and perineural invasion in pancreatic cancer
    Ibrahim Halil Sahin
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Med 1:357-62. 2012
  4. ncbi request reprint In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck
    D Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 93:436-40. 2001
  5. ncbi request reprint DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, M D Anderson Cancer Center, The University of Texas, 1400 Holcombe Blvd, Box 426, Houston, TX 77030, USA
    Mutat Res 513:37-48. 2002
  6. ncbi request reprint Molecular epidemiology of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 426, Houston, TX 77030, USA
    Int J Gastrointest Cancer 33:3-14. 2003
  7. pmc Body mass index and risk, age of onset, and survival in patients with pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, Unit 426, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:2553-62. 2009
  8. ncbi request reprint Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 9:991-7. 2003
  9. ncbi request reprint Characterization of a major aromatic DNA adduct detected in human breast tissues
    Donghui Li
    Department of Gastrointestinal Medical Oncology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Environ Mol Mutagen 39:193-200. 2002
  10. ncbi request reprint Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4566-70. 2002

Research Grants

  1. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2004
  2. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2005
  3. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2006
  4. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2007

Collaborators

Detail Information

Publications97

  1. pmc Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer
    Hideo Suzuki
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1184-91. 2008
    ..These data suggest the existence of gender-specific susceptibility to tobacco carcinogen and dietary mutagen exposure in PC...
  2. pmc Insights into pancreatic cancer etiology from pathway analysis of genome-wide association study data
    Peng Wei
    Division of Biostatistics and Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas, United States of America
    PLoS ONE 7:e46887. 2012
    ..To identify genetic susceptibility factors for pancreatic cancer, we conducted pathway analysis of genome-wide association study (GWAS) data in 3,141 pancreatic cancer patients and 3,367 controls with European ancestry...
  3. pmc Association of diabetes and perineural invasion in pancreatic cancer
    Ibrahim Halil Sahin
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Med 1:357-62. 2012
    ....
  4. ncbi request reprint In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck
    D Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 93:436-40. 2001
    ....
  5. ncbi request reprint DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, M D Anderson Cancer Center, The University of Texas, 1400 Holcombe Blvd, Box 426, Houston, TX 77030, USA
    Mutat Res 513:37-48. 2002
    ..Given the limitation of sample size, these preliminary data lend further support the hypothesis that carcinogen exposure and oxidative stress are involved in pancreatic carcinogenesis...
  6. ncbi request reprint Molecular epidemiology of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 426, Houston, TX 77030, USA
    Int J Gastrointest Cancer 33:3-14. 2003
    ....
  7. pmc Body mass index and risk, age of onset, and survival in patients with pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, Unit 426, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:2553-62. 2009
    ..Obesity has been implicated as a risk factor for pancreatic cancer...
  8. ncbi request reprint Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 9:991-7. 2003
    ..The purpose of this study was to investigate the expression and copy number alteration of STK15 in pancreatic cancer...
  9. ncbi request reprint Characterization of a major aromatic DNA adduct detected in human breast tissues
    Donghui Li
    Department of Gastrointestinal Medical Oncology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Environ Mol Mutagen 39:193-200. 2002
    ..These results demonstrate that this major bulky DNA adduct detected in human breast tissues is related to PAH exposure...
  10. ncbi request reprint Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4566-70. 2002
    ..These observations suggest that genetic susceptibility to carcinogen exposure may play an important role in breast carcinogenesis...
  11. pmc Dietary mutagen exposure and risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:655-61. 2007
    ..09 and 0.099, respectively. These data support the hypothesis that dietary mutagen exposure alone and in interaction with other factors contribute to the development of pancreatic cancer...
  12. pmc Effects of base excision repair gene polymorphisms on pancreatic cancer survival
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1402, USA
    Int J Cancer 120:1748-54. 2007
    ..These observations need to be confirmed in a larger study of homogenous patient population...
  13. ncbi request reprint 5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1470-6. 2005
    ..23 (0.88-20.3) for heavy drinkers with the TT genotype compared with nondrinkers with the CC/CT genotypes. These observations support a role for folate metabolism in pancreatic cancer, especially among smokers and heavy drinkers...
  14. pmc Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology Unit 426, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    J Clin Oncol 24:1720-8. 2006
    ..Our goal was to determine whether single nucleotide polymorphisms (SNPs) in DNA repair genes influence the clinical outcome of pancreatic cancer...
  15. ncbi request reprint DNA adducts in normal tissue adjacent to breast cancer: a review
    D Li
    Department of Gastrointestinal Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Detect Prev 23:454-62. 1999
    ..The exogenous source may involve the types of carcinogen exposure other than cigarette smoking, and the endogenous source may involve oxidative stress associated with normal metabolic activities...
  16. pmc Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:2863-72. 2011
    ..Genetic variation in SSTR had been associated with risk of human cancers but had never been investigated in pancreatic cancer...
  17. pmc DNA repair gene polymorphisms and risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 426, Houston, TX 77030, USA
    Clin Cancer Res 15:740-6. 2009
    ..The current research was undertaken to examine the association between genetic variations in DNA repair and pancreatic cancer risk...
  18. doi request reprint Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Causes Control 22:189-97. 2011
    ....
  19. pmc Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA
    Carcinogenesis 27:103-11. 2006
    ..9, 95% CI: 1.2-6.9) and among females (AOR: 2.5, 95% CI: 1.1-5.7). These data suggest that polymorphisms of the CYP1A2 and NAT1 genes modify the risk of pancreatic cancer...
  20. pmc Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer
    Motofumi Tanaka
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 116:5325-35. 2010
    ....
  21. pmc Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer Res 66:3323-30. 2006
    ..These observations suggest that polymorphisms of genes involved in the repair of DNA double-strand breaks significantly affect the clinical outcome of patients with pancreatic cancer...
  22. pmc Antidiabetic therapies affect risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 137:482-8. 2009
    ..We investigated the effect of antidiabetic therapies on the risk of pancreatic cancer...
  23. doi request reprint Metformin as an antitumor agent in cancer prevention and treatment
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Diabetes 3:320-7. 2011
    ..As described in this review, the chemopreventive value of metformin is not restricted to diabetic or obese individuals...
  24. ncbi request reprint Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study
    P Xiong
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 61:8465-9. 2001
    ..Larger studies are needed to confirm our findings...
  25. ncbi request reprint Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer
    Pervez F Firozi
    Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 23:301-6. 2002
    ..Further large-scale studies are required to determine the exact role of these polymorphisms and types of DNA damage in breast cancer susceptibility...
  26. ncbi request reprint Effects of cytochrome P450 inducers on I-compounds in rat liver and kidney DNA
    D Li
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030
    Carcinogenesis 13:1191-8. 1992
    ..These results suggest a major role for cytochrome P450 enzymes in the metabolism of I-compounds...
  27. ncbi request reprint Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy
    D Li
    Section of Cardiology, Baylor College of Medicine, M D Anderson Cancer Center, Houston, Texas, USA
    Circulation 104:2188-93. 2001
    ..Studies indicate that mutations in sarcomeric proteins are responsible for FHCM and suggest that mutations in cytoskeletal proteins cause FDCM. Evidence is evolving, however, that such conclusions are premature...
  28. ncbi request reprint Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis
    Donna L White
    The Section of Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Am J Epidemiol 167:377-89. 2008
    ..However, given the relatively limited total number of subjects examined and observed between-study heterogeneity, chance could not be excluded...
  29. ncbi request reprint Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia
    D Li
    Department of Medicine Cardiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Genomics 74:396-401. 2001
    ..While the function of NAPOR remains to be elucidated, our current characterization of the NAPOR gene will be valuable for further clinical and functional study...
  30. ncbi request reprint Human protein tyrosine phosphatase-like gene: expression profile, genomic structure, and mutation analysis in families with ARVD
    D Li
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Gene 256:237-43. 2000
    ..The genomic structure and intragenic polymorphism of PTPLA should be useful for further clinical and genetic studies such as gene targeting of PTPLA...
  31. ncbi request reprint Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer
    D Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Carcinog 31:214-23. 2001
    ..In conclusion, normal breast tissues from cancer patients had a significantly higher level of oxidative DNA damage. The elevated level of 8-oxo-dG in cancer patients was not related to age or to deficiency of the hOGG1 repair gene...
  32. ncbi request reprint Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer
    Jijiang Zhu
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 12:830-7. 2003
    ..These data strongly support the hypothesis that HCA exposure contributes to human breast cancer among genetically susceptible individuals...
  33. pmc Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)-DNA adducts in human pancreatic tissues
    J Zhu
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biomarkers 11:319-28. 2006
    ..Although limited by the small sample size, these preliminary results suggest that PhIP exposure may contribute to human pancreatic cancer development...
  34. ncbi request reprint Structural characterization and topology of the second potential membrane anchor region in the thromboxane A2 synthase amino-terminal domain
    K H Ruan
    Department of Internal Medicine, University of Texas Health Science Center, Houston 77030, USA
    Biochemistry 37:822-30. 1998
    ....
  35. doi request reprint Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation
    Jinyun Chen
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Ann Surg Oncol 16:431-9. 2009
    ..13 (1.04-4.36), 3.18 (1.37-7.39), and 10.09 (3.17-32.05), respectively. These findings suggest these polymorphisms in the cell cycle genes are promising prognostic markers for patients with pancreatic cancer...
  36. ncbi request reprint Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
    Carcinogenesis 27:2209-16. 2006
    ..006). These findings suggest that NBS1 polymorphisms and haplotypes may contribute to the etiology of sporadic breast cancer in young non-Hispanic white women. Large studies are warranted to confirm these findings...
  37. pmc Selected polymorphisms of DNA repair genes and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Detect Prev 30:284-91. 2006
    ....
  38. ncbi request reprint Molecular epidemiology of pancreatic cancer
    D Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Cancer J 7:259-65. 2001
    ..The associations between these environmental factors and K-ras mutations suggest that the mortality of pancreatic cancer can be decreased by changing of behavior and reducing exposure to environmental carcinogens...
  39. pmc Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer
    Xiaoqun Dong
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Gastroenterology 139:464-73, 473.e1-3. 2010
    ..We examined whether IGF-axis gene variants are associated with clinical outcomes in pancreatic cancer...
  40. pmc The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Lett 245:61-8. 2007
    ..24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer...
  41. ncbi request reprint In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:5628-34. 2007
    ..In conclusion, we confirmed the previously reported association between in vitro BPDE-induced DNA adduct levels and SCCHN risk, and the assay may help identify individuals at high risk of developing smoking-related cancers...
  42. pmc XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Gastroenterol 103:360-7. 2008
    ..We hypothesized that the altered HR repair capacity conferred by single nucleotide polymorphisms (SNPs) would modify individual susceptibility to sporadic pancreatic cancer...
  43. pmc Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2379-86. 2007
    ..The NAT2*6A/any slow acetylation genotype may be a predisposing factor for pancreatic cancer among diabetics with smoking exposure. Our observations must be confirmed in larger independent studies...
  44. pmc Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer
    Taro Okazaki
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:2042-8. 2008
    ....
  45. pmc Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer
    Hideo Suzuki
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:3467-73. 2008
    ..07; 95% CI = 0.01-0.57; P = 0.013). The polymorphic variants of the IGF genes may serve as a susceptibility factor for pancreatic cancer...
  46. pmc Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians
    Jinyun Chen
    Department of Epidemiology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 13:3100-4. 2007
    ..The purpose of this study was to investigate the association of the Aurora-A (T91A), and p16 (C540G and C580T) polymorphisms with age at diagnosis of pancreatic cancer...
  47. pmc Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity
    Taro Okazaki
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:320-9. 2010
    ....
  48. pmc Risk factors for pancreatic cancer: case-control study
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Gastroenterol 102:2696-707. 2007
    ..We evaluated the independent effects of multiple risk factors for pancreatic cancer and determined whether the magnitude of cigarette smoking was modified by other risk factors in men and women...
  49. pmc Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:840-8. 2007
    ..The authors hypothesized that genetic variants of glutathione S-transferase (GST) affect detoxification of carcinogens and anticancer agents in the human pancreas and, thus, the risk and survival of pancreatic cancer...
  50. pmc Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer
    Hongwei Tang
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1550 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Carcinogenesis 31:607-13. 2010
    ..These data suggest that genetic variations in antioxidant defenses modify the risk of pancreatic cancer in diabetics or individuals with a low dietary vitamin E intake...
  51. pmc Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis
    Hui Zhao
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1560-6. 2008
    ..Our findings suggest that the genotypes and haplotypes of ERCC1 and ERCC2/XPD may have an effect on in vitro BPDE-induced DNA adduct levels...
  52. pmc Association between hepatitis B virus and pancreatic cancer
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 26:4557-62. 2008
    ..However, little is known about the role of HBV and HCV infection in other malignancies. This study aimed to determine whether HBV and HCV infections increase the risk for pancreatic cancer development...
  53. ncbi request reprint WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases
    D Li
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Mol Life Sci 58:2085-97. 2001
    ....
  54. ncbi request reprint 3-Methylcholanthrene-inducible liver cytochrome(s) P450 in female Sprague-Dawley rats: possible link between P450 turnover and formation of DNA adducts and I-compounds
    B Moorthy
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030
    Carcinogenesis 14:879-86. 1993
    ..Level of most I-compounds returned to normal at 45 days, and this paralleled the return of P450-related activities to normal. These results suggest a possible link between P450 turnover, DNA adduct formation, and I-compound depletion...
  55. ncbi request reprint Identification of the substrate interaction site in the N-terminal membrane anchor segment of thromboxane A2 synthase by determination of its substrate analog conformational changes using high resolution NMR technique
    S P So
    Vascular Biology Research Center and Division of Hematology, The Department of Internal Medicine, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 275:40679-85. 2000
    ..The combination of the structural information of and was able to simulate a solution structure of the unstable TXAS and PGIS substrate, PGH(2)...
  56. ncbi request reprint Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Hepatology 36:1206-13. 2002
    ..Exploring the underlying mechanisms for such synergisms may indicate new HCC prevention strategies in high-risk individuals...
  57. ncbi request reprint Elevated luteinizing hormone in serum, breast cancer tissue, and normal breast tissue from breast cancer patients
    Elvio G Silva
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Breast Cancer Res Treat 76:125-30. 2002
    ..Hormones are known to be important in breast cancer, but studies have focused on steroid hormones and their cognate receptors. We report here an analysis of luteinizing hormone (LH) concentration in serum and breast tissue samples...
  58. pmc Association between hypothyroidism and hepatocellular carcinoma: a case-control study in the United States
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hepatology 49:1563-70. 2009
    ..Experimental investigations are necessary for thorough assessment of the relationship between thyroid disorders and HCC...
  59. pmc The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 426, Houston, TX 77030, USA
    J Hepatol 50:334-41. 2009
    ..The study aimed at addressing the connection between positive family history of liver cancer and hepatocellular carcinoma (HCC) development in the USA...
  60. ncbi request reprint Risk factors associated with neuroendocrine tumors: A U.S.-based case-control study
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 123:867-73. 2008
    ..The increased risk of gastric NETs in women with both diabetes and a positive family history of cancer suggest that women may have a greater genetic susceptibility to NETs than men...
  61. ncbi request reprint Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer
    Kenji Yokoi
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 27:1361-9. 2005
    ..Although SAA is not specific for pancreatic cancer and not sensitive enough to detect stage I patients, it may be a candidate biomarker for detecting and monitoring the progressive growth of pancreatic cancer...
  62. pmc Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 123:1883-91. 2008
    ..Controlling for smoking exposure might be a prudent approach to the prevention of HCC, especially in patients with chronic viral hepatitis infections...
  63. pmc K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Pancreas 34:55-62. 2007
    ..To examine the profiles of K-ras mutations and p16 and preproenkephalin (ppENK) promoter hypermethylation and their associations with cigarette smoking in pancreatic cancer patients...
  64. pmc Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:1938-46. 2010
    ..This objective of the current study was to determine the association between HCC risk and diabetes duration and type of diabetes treatment...
  65. ncbi request reprint Studies on the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl)formyl-CoA: elucidation of the inactivation mechanism and identification of cysteine-114 as the entrapped nucleophile
    S Dakoji
    Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, 78712, USA
    J Am Chem Soc 123:9749-59. 2001
    ..In addition, these studies provide important clues for future design of more efficient and selective inhibitors to control and/or regulate fatty acid metabolism...
  66. ncbi request reprint Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity protein-1 and its coactivator DRIP-130
    D C Mitchell
    Institute of Biosciences and Technology, and Department of Molecular and Cellular Medicine, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Oncogene 26:1739-47. 2007
    ..3-q23, provokes increased tumor metastasis...
  67. ncbi request reprint Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene
    D Li
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 274:117-23. 2000
    ..All of them have been defined as WD-repeat proteins. Therefore, WDR6 is a novel protein and probably belongs to a highly conserved subfamily of WD-repeat proteins in which T7B11.12 and YPL183c are its distantly related members...
  68. ncbi request reprint MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease
    Jin Wang
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Canter, Houston, Texas, 77054, USA
    Cancer Prev Res (Phila) 2:807-13. 2009
    ....
  69. pmc Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:2547-56. 2007
    ..The associations between passive smoking and the use of noncigarette tobacco products with pancreatic cancer are not clear...
  70. ncbi request reprint AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells
    Jijiang Zhu
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Genet Cytogenet 159:10-7. 2005
    ..These associations support our hypothesis that AURKA amplification contributes to pancreatic carcinogenesis by increasing chromosome instability and centrosome abnormality...
  71. pmc The locus of a novel gene responsible for arrhythmogenic right-ventricular dysplasia characterized by early onset and high penetrance maps to chromosome 10p12-p14
    D Li
    Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 66:148-56. 2000
    ..Chromosomal localization of the ARVD gene is the first step in identification of the genetic defect and the unraveling of the molecular basis responsible for the pathogenesis of the disease...
  72. ncbi request reprint Solution structure of the second extracellular loop of human thromboxane A2 receptor
    K H Ruan
    Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Biochemistry 40:275-80. 2001
    ..This approach may also be useful in structural studies of the extramembrane loops of other G protein-coupled receptors...
  73. pmc Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer
    Xiaoqun Dong
    Department of Gastrointestinal Medical Oncology, Surgical Oncology, Pathology, and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 27:1592-9. 2009
    ..DNA mismatch repair (MMR) is critical in maintaining genomic stability and may modulate the cellular response to gemcitabine. We hypothesized that genetic variations in MMR may affect the clinical outcome of patients with pancreatic cancer...
  74. ncbi request reprint Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:2245-53. 2006
    ..Most breast cancers develop from mammary epithelial cells; therefore, NO may play a role in their development. It was hypothesized that eNOS polymorphisms are associated with risk of breast cancer...
  75. ncbi request reprint The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells
    Takayuki Asano
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:8571-80. 2004
    ..Taken together, these data indicate that the aberrant expression of MMAC/PTEN contributes to the activation of the PI 3-kinase/Akt pathway and its transcription factor mediators in pancreatic cancer...
  76. pmc Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mutat Res 627:146-57. 2007
    ..Results from this exploratory study need to be confirmed in other experimental systems...
  77. ncbi request reprint Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis
    Behnam Ebrahimi
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:2727-36. 2004
    ..The objective of this study was to examine the association between serum levels of proinflammatory and antiinflammatory or angiogenic cytokines and the outcomes of patients with pancreatic carcinoma...
  78. ncbi request reprint Diagnostic protein discovery using proteolytic peptide targeting and identification
    John M Koomen
    Molecular Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Rapid Commun Mass Spectrom 18:2537-48. 2004
    ..These initial results are consistent with the known biology of pancreatic cancer or pancreatitis, but are not specific to those diseases...
  79. ncbi request reprint The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation
    Takayuki Asano
    Department of Gastrointestinal Medical Oncology, Unit 426, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Biochem Biophys Res Commun 331:295-302. 2005
    ..Together, these results indicate a complex role for c-Jun in cellular responses to CCI-779 and provide an important basis for investigating CCI-779 further as a potential therapeutic agent for pancreatic tumors...
  80. ncbi request reprint Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins
    John M Koomen
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:1110-8. 2005
    ..The identifications reveal only common serum proteins and components of the acute phase response, including serum amyloid A, alpha-1-antitrypsin, alpha-1-antichymotrypsin, and inter-alpha-trypsin inhibitor...
  81. ncbi request reprint Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery
    John M Koomen
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, 0089, UT M D, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    J Proteome Res 4:972-81. 2005
    ..On the basis of these data, we discuss limitations in biomarker discovery in the low molecular weight plasma or serum proteome using crude fractionation coupled to MALDI-MS profiling...
  82. pmc Pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 426, Houston, TX 77030, USA
    Lancet 363:1049-57. 2004
    ..However, new therapeutic strategies based on the molecular biology of pancreatic cancer seem to hold the greatest promise...
  83. pmc DNA mismatch repair gene polymorphisms affect survival in pancreatic cancer
    Xiaoqun Dong
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1550 Holcombe Boulevard, Houston, Texas 77030 4009, USA
    Oncologist 16:61-70. 2011
    ..DNA mismatch repair (MMR) maintains genomic stability and mediates cellular response to DNA damage. We aim to demonstrate whether MMR genetic variants affect overall survival (OS) in pancreatic cancer...
  84. pmc Glucose metabolism gene variants modulate the risk of pancreatic cancer
    Xiaoqun Dong
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Cancer Prev Res (Phila) 4:758-66. 2011
    ..No significant main effect of other genes or significant interaction of genotype with other risk factors was observed. The findings show a potential role of HK2 gene, alone or in interaction with diabetes, in modifying the risk of PC...
  85. pmc Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer
    Hongwei Tang
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 20:779-92. 2011
    ..The genetic factors predisposing individuals with obesity or diabetes to pancreatic cancer have not been identified...
  86. doi request reprint Family history of cancer and associated risk of developing neuroendocrine tumors: a case-control study
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:959-65. 2008
    ..We evaluated the effect of positive family history of NET as well as other cancers on the development of NETs arising at five different locations...
  87. ncbi request reprint Diagnostic protein discovery using liquid chromatography/mass spectrometry for proteolytic peptide targeting
    John M Koomen
    Molecular Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Rapid Commun Mass Spectrom 19:1624-36. 2005
    ..This profiling method was superior to previous experiments using single sample MALDI analysis for protein profiling or proteolytic peptide profiling, because more potential protein markers were identified...
  88. ncbi request reprint Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer
    Marina S Touillaud
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nutr Cancer 51:162-9. 2005
    ..Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment...
  89. ncbi request reprint Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry
    Jianjun Shen
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas, USA
    Cancer Res 64:9018-26. 2004
    ..The newly identified proteins in pancreatic tumors may eventually serve as diagnostic markers or therapeutic targets...
  90. ncbi request reprint Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review
    Valentina Paracchini
    Scientific Direction, Ospedale Maggiore, Milan, Italy
    Am J Epidemiol 165:115-25. 2007
    ..The observed effect of age on the association in Caucasians indicates that further studies are needed on the role of CYP1B1 Val432Leu in estrogen metabolism according to age, ethnicity, and menopausal status...
  91. ncbi request reprint PAH-DNA adducts in a Chinese population: relationship to PAH exposure, smoking and polymorphisms of metabolic and DNA repair genes
    Yu Hu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Biomarkers 13:27-40. 2008
    ..The study suggests that PAH-DNA adducts may serve as a reliable biomarker of PAH exposure in occupational settings but may not be sensitive enough to be used in populations with environmental exposures to PAHs...
  92. ncbi request reprint High levels of oxidative DNA damage in lymphocyte DNA of premenopausal breast cancer patients from Egypt
    Amr S Soliman
    Department of Epidemiology, The University of Michigan School of Public Health, Ann Arbor 48109, USA
    Int J Environ Health Res 14:121-34. 2004
    ....
  93. ncbi request reprint Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat
    Samy L Habib
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712 1074, USA
    Carcinogenesis 24:573-82. 2003
    ..In keeping with this view, acute TGHQ-induced cytotoxicity was greater in Tsc-2(EK/+) rats than in Tsc-2(+/+) rats. The mechanism(s) coupling tuberin expression to the regulation of OGG1 are not known and are under investigation...
  94. ncbi request reprint Determination of nucleic acids based on shifting the association equilibrium between tetracarboxy aluminum phthalocyanine and poly-lysine
    Changqing Zhu
    The Key Laboratory of Analytical Science of MOE, Department of Chemistry, Xiamen University, Xiamen 361005, China
    Spectrochim Acta A Mol Biomol Spectrosc 61:743-8. 2005
    ..The relative standard deviation (n = 6) was 1.9 and 1.3% for 50 ng mL(-1) ctDNA and fsDNA, respectively. The proposed method was applied to the determination of nucleic acids in synthetic samples with satisfactory results...
  95. pmc Molecular basis for the RIN4 negative regulation of RPS2 disease resistance
    Brad Day
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94270, USA
    Plant Cell 17:1292-305. 2005
    ..To this end, we have identified specific amino acids within the C-terminal half of RIN4 that are required for RPS2 regulation and association...
  96. ncbi request reprint Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence
    Edward H Lin
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 110:534-42. 2007
    ..In this study, the authors examined whether increased levels of expression of CD133 messenger RNA (mRNA) in peripheral blood predicted disease recurrence in patients with colon cancer...
  97. pmc Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17
    Donghui Li
    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332 0230, USA
    Mol Cell Biol 27:6669-85. 2007
    ..We conclude that ACTH/cAMP stimulates PA production in the nucleus of H295R cells and that this increase in PA concentrations facilitates CYP17 induction...

Research Grants6

  1. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2004
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  2. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2005
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  3. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2006
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  4. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2007
    ..Such information will be valuable for the primary prevention of this deadly disease. ..