O Levran

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Spectrum of sequence variation in the FANCG gene: an International Fanconi Anemia Registry (IFAR) study
    Arleen D Auerbach
    Laboratory of Human Genetics and Hematology, Rockefeller University, New York, New York 10021 6399, USA
    Hum Mutat 21:158-68. 2003
  2. ncbi request reprint Stress-related genes and heroin addiction: A role for a functional FKBP5 haplotype
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA Electronic address
    Psychoneuroendocrinology 45:67-76. 2014
  3. pmc CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Addict Biol 18:709-16. 2013
  4. pmc Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Pharmacogenomics 14:755-68. 2013
  5. pmc Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment
    O Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacogenomics J 12:319-27. 2012
  6. pmc The genetics of the opioid system and specific drug addictions
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Genet 131:823-42. 2012
  7. pmc ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 17:2219-27. 2008
  8. pmc Genetic susceptibility to heroin addiction: a candidate gene association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Genes Brain Behav 7:720-9. 2008
  9. pmc Haplotype block structure of the genomic region of the mu opioid receptor gene
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    J Hum Genet 56:147-55. 2011
  10. pmc Heroin addiction in African Americans: a hypothesis-driven association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Genes Brain Behav 8:531-40. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Spectrum of sequence variation in the FANCG gene: an International Fanconi Anemia Registry (IFAR) study
    Arleen D Auerbach
    Laboratory of Human Genetics and Hematology, Rockefeller University, New York, New York 10021 6399, USA
    Hum Mutat 21:158-68. 2003
    ..Our data suggest that the Portuguese-Brazilian, French-Acadian, and Korean/Japanese mutations were likely to have been present in a founding member of each of these populations...
  2. ncbi request reprint Stress-related genes and heroin addiction: A role for a functional FKBP5 haplotype
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA Electronic address
    Psychoneuroendocrinology 45:67-76. 2014
    ..Drug addictions are caused by genetic, environmental and drug-induced factors. The objective of this hypothesis-driven association study was to determine if genetic variants in stress-related genes are associated with heroin addiction...
  3. pmc CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Addict Biol 18:709-16. 2013
    ..Of these, 24 SNPs were polymorphic and none showed significant association with methadone dose. Further studies are necessary to replicate these preliminary findings in additional subjects and other populations...
  4. pmc Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Pharmacogenomics 14:755-68. 2013
    ..This study was conducted to identify some of these variants...
  5. pmc Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment
    O Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacogenomics J 12:319-27. 2012
    ..There was significant difference in methadone doses required by subjects with different genotypes of the NGFB intronic single-nucleotide polymorphism rs2239622 (P=0.0002). These results may have clinical importance...
  6. pmc The genetics of the opioid system and specific drug addictions
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Genet 131:823-42. 2012
    ..We will provide information on the sample populations and the size of each study, as well as a list of the variants implicated in association with addiction-related phenotypes, and with the effectiveness of pharmacotherapy for addiction...
  7. pmc ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 17:2219-27. 2008
    ..026). These data suggest that specific ABCB1 variants may have clinical relevance by influencing the methadone dose required to prevent withdrawal symptoms and relapse in this population...
  8. pmc Genetic susceptibility to heroin addiction: a candidate gene association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Genes Brain Behav 7:720-9. 2008
    ..0005). None of these associations remained significant after adjustment for multiple testing. This study suggests the involvement of several genes and variants in heroin addiction, which is worthy of future study...
  9. pmc Haplotype block structure of the genomic region of the mu opioid receptor gene
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    J Hum Genet 56:147-55. 2011
    ..These findings were corroborated by genotyping eight SNPs in a sample of European Americans and suggest an extended OPRM1 locus with potential new regulatory regions...
  10. pmc Heroin addiction in African Americans: a hypothesis-driven association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Genes Brain Behav 8:531-40. 2009
    ..Further studies will be necessary to replicate these associations and to elucidate the roles of these variants in drug addiction vulnerability...
  11. pmc Genotype patterns that contribute to increased risk for or protection from developing heroin addiction
    D A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Mol Psychiatry 13:417-28. 2008
    ..This approach has identified several new genes potentially associated with heroin addiction and has confirmed the role of OPRM1 in this disease...
  12. pmc Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, New York 10065, USA
    Ann N Y Acad Sci 1187:184-207. 2010
    ..Finally, we describe the development and application of a novel technique: molecular haplotyping for studies in genetics of drug addiction...
  13. pmc Regional mRNA expression of the endogenous opioid and dopaminergic systems in brains of C57BL/6J and 129P3/J mice: strain and heroin effects
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacol Biochem Behav 100:8-16. 2011
    ..Heroin had dose-related effects on Drd1a mRNA in the hypothalamus and on Drd2 mRNA in the caudate putamen...
  14. ncbi request reprint Spectrum of sequence variations in the FANCA gene: an International Fanconi Anemia Registry (IFAR) study
    Orna Levran
    Laboratory of Human Genetics and Hematology, Rockefeller University, New York, New York 10021 6399, USA
    Hum Mutat 25:142-9. 2005
    ..In addition, a conserved SNP haplotype block spanning at least 60 kb of the FANCA gene was identified in individuals from various ethnic groups...
  15. pmc Opiate and cocaine addiction: from bench to clinic and back to the bench
    Mary Jeanne Kreek
    The Rockefeller University, Laboratory of the Biology of Addictive Diseases, 1230 York Avenue, Box 171, New York, NY 10065, United States
    Curr Opin Pharmacol 9:74-80. 2009
    ....
  16. pmc A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:1185-97. 2009
    ....
  17. pmc Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs
    Vadim Yuferov
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10065, USA
    Pharmacogenet Genomics 21:185-96. 2011
    ..Expression of the prodynorphin gene (PDYN) is critical for rewarding properties of drugs of abuse and stress-induced responses. Epigenetic factors, such as DNA methylation, play an important role in modulation of gene expression...
  18. ncbi request reprint Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia
    Kenneth Offit
    Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 95:1548-51. 2003
    ..Individuals who carry a germline BRCA2 mutation and who plan to have children with a partner of Ashkenazi Jewish descent should consider undergoing genetic counseling...
  19. pmc Relative expression of mRNA for the somatostatin receptors in the caudate putamen of C57BL/6J and 129P3/J mice: strain and heroin effects
    Stefan D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Brain Res 1345:206-12. 2010
    ..These results demonstrate strain differences in the expression of specific mRNAs and a heroin-induced dose-dependent elevation of SSTR-1 and -3 mRNAs in the mouse caudate putamen...
  20. pmc Somatic mosaicism in Fanconi anemia: evidence of genotypic reversion in lymphohematopoietic stem cells
    J J Gregory
    Laboratory of Human Genetics and Hematology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:2532-7. 2001
    ....
  21. pmc Bidirectional translational research: Progress in understanding addictive diseases
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 56:32-43. 2009
    ....
  22. ncbi request reprint The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
    Orna Levran
    Laboratory for Human Genetics and Hematology, The Rockefeller University, New York, New York, USA
    Nat Genet 37:931-3. 2005
    ..Using genetic mapping, mutation identification and western-blot data, we identify the defective protein in FA-J cells as BRIP1 (also called BACH1), a DNA helicase that is a binding partner of the breast cancer tumor suppressor BRCA1...
  23. ncbi request reprint Identification of Alu-mediated deletions in the Fanconi anemia gene FAA
    O Levran
    Laboratory of Human Genetics and Hematology, Rockefeller University, New York, New York 10021, USA
    Hum Mutat 12:145-52. 1998
    ..Numerous Alu repeats are present in FAA, suggesting that Alu-mediated recombination might be an important mechanism for the generation of FAA mutations...
  24. pmc Sequence variation in the Fanconi anemia gene FAA
    O Levran
    Laboratory of Human Genetics and Hematology, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 94:13051-6. 1997
    ....
  25. ncbi request reprint Human papillomavirus DNA and p53 polymorphisms in squamous cell carcinomas from Fanconi anemia patients
    David I Kutler
    Laboratory of Epithelial Cancer Biology, Division of Head and Neck Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 95:1718-21. 2003
    ..05). These data suggest that Fanconi anemia is associated with increased susceptibility to HPV-induced carcinogenesis...
  26. pmc Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer
    Marianne Berwick
    Cancer Research and Treatment Center Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA
    Cancer Res 67:9591-6. 2007
    ..4; 95% CI, 1.1-5.2). Overall, there was no increased risk for cancer among FA heterozygotes in this study of Fanconi relatives, although there is some evidence that FANCC mutations are possibly breast cancer susceptibility alleles...
  27. ncbi request reprint GST genotype may modify clinical phenotype in patients with Fanconi anaemia
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45329, USA
    Br J Haematol 131:118-22. 2005
    ..GSTM1 genotype significantly influenced time to bone marrow failure in complementation group FA-C, (median age 3.0 years vs. 7.0 years, P < 0.01). GSTP1 genotype did not influence FA phenotype...
  28. ncbi request reprint A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients
    Saurabh Chandra
    Division of Experimental Hematology and Fanconi Anemia Comprehensive Care Center, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Ther 12:976-84. 2005
    ..This assay has now been established in a standardized fashion for complementation assignments in FA patients and the subsequent directing of rapid mutation analysis in those patients...
  29. ncbi request reprint Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia
    John E Wagner
    Division of Pediatric Hematology, Oncology, and Blood Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA
    Blood 103:3226-9. 2004
    ..Our results suggest that BRCA2 testing should be considered in all patients with FA in whom the complementation group cannot be defined or in whom leukemia is diagnosed at or before 5 years of age...