V A Letts

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. ncbi The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit
    V A Letts
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 19:340-7. 1998
  2. ncbi A new spontaneous mouse mutation in the Kcne1 gene
    V A Letts
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 11:831-5. 2000
  3. ncbi A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice
    Verity A Letts
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:2123-8. 2005
  4. ncbi Phenotypic heterogeneity in the stargazin allelic series
    Verity A Letts
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 14:506-13. 2003
  5. ncbi Genetic and physical maps of the stargazer locus on mouse chromosome 15
    V A Letts
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 43:62-8. 1997
  6. ncbi The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development
    G A Cox
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Nat Genet 26:198-202. 2000
  7. ncbi A curly-tail modifier locus, mct1, on mouse chromosome 17
    V A Letts
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 29:719-24. 1995
  8. ncbi Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice
    Wayne N Frankel
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Neurosci 25:3452-8. 2005
  9. ncbi Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4
    Barbara Beyer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Hum Mol Genet 17:1738-49. 2008
  10. ncbi Sulfated glycoprotein-2 (Sgp-2) maps to mouse chromosome 14
    E H Birkenmeier
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 4:131-2. 1993

Collaborators

Detail Information

Publications11

  1. ncbi The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit
    V A Letts
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nat Genet 19:340-7. 1998
    ....
  2. ncbi A new spontaneous mouse mutation in the Kcne1 gene
    V A Letts
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 11:831-5. 2000
    ..The Kcne1(pkr) mutant represents the first spontaneous mouse model for the human disorder, Jervell and Lange-Nielsen syndrome, associated with mutations in the homologous KCNE1 gene on human Chr 21...
  3. ncbi A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice
    Verity A Letts
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:2123-8. 2005
    ..Our studies show that the CACNG4 protein has seizure suppressing activity, but this effect is revealed only when CACNG2 expression is also compromised, suggesting that CACNG subunits have in vivo overlapping functions...
  4. ncbi Phenotypic heterogeneity in the stargazin allelic series
    Verity A Letts
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 14:506-13. 2003
    ....
  5. ncbi Genetic and physical maps of the stargazer locus on mouse chromosome 15
    V A Letts
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 43:62-8. 1997
    ..A physical contig of YACs, BACs, and P1s stretching 1.1 Mb from D15Mit30 to the somatostatin receptor 3 gene is reported, and the DNA interval including the stargazer locus has been narrowed to 150 kb...
  6. ncbi The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development
    G A Cox
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Nat Genet 26:198-202. 2000
    ..Fidgetin is the first mutant AAA protein found in a mammalian developmental mutant, thus defining a new role for these proteins in embryonic development...
  7. ncbi A curly-tail modifier locus, mct1, on mouse chromosome 17
    V A Letts
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 29:719-24. 1995
    ..spretus cross and was the preferred model overall. No evidence was found for epistatic interaction between ct and mct1...
  8. ncbi Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice
    Wayne N Frankel
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Neurosci 25:3452-8. 2005
    ..Because C3H/He mice have no other brain abnormalities, they are an attractive alternative for studying idiopathic absence epilepsy...
  9. ncbi Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4
    Barbara Beyer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Hum Mol Genet 17:1738-49. 2008
    ..These results demonstrate for the first time an essential role for Gria4 in the brain, and suggest that abnormal AMPA receptor-dependent synaptic activity can be involved in the network hypersynchrony that underlies absence seizures...
  10. ncbi Sulfated glycoprotein-2 (Sgp-2) maps to mouse chromosome 14
    E H Birkenmeier
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 4:131-2. 1993
  11. ncbi Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold
    Yan Yang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Hum Mol Genet 12:975-84. 2003
    ..Our results provide a novel genetic model for epilepsy research and demonstrate that the approach of using ECT to study seizures in mice has the potential to lead to the identification of human epilepsy susceptibility genes...