Marilisa Leone

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam
    Marilisa Leone
    Burnham Institute for Medical Research, La Jolla, California, USA
    BMC Struct Biol 9:59. 2009
  2. pmc NMR studies of a heterotypic Sam-Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor
    Marilisa Leone
    Burnham Institute for Medical Research, La Jolla, California, USA
    Biochemistry 47:12721-8. 2008
  3. pmc Structure-based discovery of a new class of Bcl-xL antagonists
    Michele F Rega
    Burnham Institute for Medical Research, Cancer Center and Infectious and Inflammatory Disease Center, La Jolla, CA 92037, USA
    Bioorg Chem 35:344-53. 2007
  4. ncbi Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules
    Barbara Becattini
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Chem Biol 11:1107-17. 2004
  5. ncbi Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins
    Marilisa Leone
    The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:8118-21. 2003
  6. ncbi Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L)
    Barbara Becattini
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 11:389-95. 2004
  7. ncbi The FRB domain of mTOR: NMR solution structure and inhibitor design
    Marilisa Leone
    Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:10294-302. 2006
  8. ncbi A structure-based approach to retinoid X receptor-alpha inhibition
    John L Stebbins
    Cancer Center, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 281:16643-8. 2006
  9. pmc NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH
    Marilisa Leone
    Infectious and Inflammatory Disease Center and Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Chem Biol Drug Des 76:10-6. 2010
  10. pmc Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid
    Barbara Becattini
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:12602-6. 2006

Collaborators

Detail Information

Publications18

  1. pmc The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam
    Marilisa Leone
    Burnham Institute for Medical Research, La Jolla, California, USA
    BMC Struct Biol 9:59. 2009
    ..Previous studies have demonstrated that the Sam domain of the lipid phosphatase Ship2 can hetero-dimerize with the Sam domain of the PI3K effector protein Arap3...
  2. pmc NMR studies of a heterotypic Sam-Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor
    Marilisa Leone
    Burnham Institute for Medical Research, La Jolla, California, USA
    Biochemistry 47:12721-8. 2008
    ..Hence, this peptide and the detection of key structural elements important for EphA2 receptor endocytosis provide possible ways for the development of novel small molecule antagonists with potential anticancer activity...
  3. pmc Structure-based discovery of a new class of Bcl-xL antagonists
    Michele F Rega
    Burnham Institute for Medical Research, Cancer Center and Infectious and Inflammatory Disease Center, La Jolla, CA 92037, USA
    Bioorg Chem 35:344-53. 2007
    ..The compounds were characterized in a number of assays including in vitro binding using 15N-labeled protein, a displacement DELFIA assay, and a cell-based viability assay with human cancer cells...
  4. ncbi Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules
    Barbara Becattini
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Chem Biol 11:1107-17. 2004
    ..These compounds represent the first antiapoptotic small molecules targeting a Bcl-2 protein as shown by their ability to inhibit tBid-induced SMAC release, caspase-3 activation, and cell death...
  5. ncbi Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins
    Marilisa Leone
    The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:8118-21. 2003
    ..These data suggest a strong link between the anticancer activities of these tea polyphenols and their inhibition of a crucial antiapoptotic pathway, which is implicated in the development of many human malignancies...
  6. ncbi Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L)
    Barbara Becattini
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 11:389-95. 2004
    ..Finally, preliminary data on cells freshly isolated from patients affected by chronic lymphocytic leukemia strongly suggest potential applications of Bcl-2 antagonists as chemosensitizers in cancer therapy...
  7. ncbi The FRB domain of mTOR: NMR solution structure and inhibitor design
    Marilisa Leone
    Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:10294-302. 2006
    ..As such, these ligands could be useful in deciphering the complex regulation of mTOR in the cell and in validating the FRB domain as a possible target for the development of novel therapeutic compounds...
  8. ncbi A structure-based approach to retinoid X receptor-alpha inhibition
    John L Stebbins
    Cancer Center, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 281:16643-8. 2006
    ..The inhibitory scaffolds discovered with this method form the basis for the development of novel RXRalpha ligands with potential therapeutic properties...
  9. pmc NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH
    Marilisa Leone
    Infectious and Inflammatory Disease Center and Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Chem Biol Drug Des 76:10-6. 2010
    ....
  10. pmc Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid
    Barbara Becattini
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:12602-6. 2006
    ..g., neurodegenerative diseases, cerebral ischemia, or brain trauma...
  11. ncbi The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies
    Marilisa Leone
    Cancer Center and Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, CA, USA
    Biopolymers 89:86-92. 2008
    ..Therefore, our studies suggest that capture of lipids by the PTB domain of tensin1 may play a role for the protein function at focal adhesions...
  12. pmc Design and NMR studies of cyclic peptides targeting the N-terminal domain of the protein tyrosine phosphatase YopH
    Marilisa Leone
    Infectious and Inflammatory Disease Center and Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol Drug Des 77:12-9. 2011
    ..These preliminary studies may pave the way for the discovery of more potent and selective peptide-based ligands of the YopH N-terminal domain which could be further investigated for their ability to inhibit Yersiniae infections...
  13. ncbi NMR assignment of the phosphotyrosine binding (PTB) domain of tensin
    Marilisa Leone
    Burnham Institute for Medical Research, Infectious and Inflammatory Disease Center and Cancer Center, 10901 North Torrey Pines Rd, La Jolla, California 92037, USA
    J Biomol NMR 36:40. 2006
  14. ncbi Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex
    Eugenio Santelli
    The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:34278-87. 2005
    ..The C-terminal domain of SIP, which binds to Skp1, protrudes from the lower surface of Siah1, and we propose that this surface provides the scaffold for bringing substrate and the E2 enzyme into apposition in the functional complex...
  15. ncbi The Nuclear Overhauser Effect in the lead identification process
    Marilisa Leone
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Drug Discov Technol 3:91-100. 2006
    ..We will report examples of each of the above mentioned strategies...
  16. pmc Luminescent silica nanobeads: characterization and evaluation as efficient cytoplasmatic transporters for T-lymphocytes
    Massimo Bottini
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 129:7814-23. 2007
    ..Since signs of cytotoxicity were not observed, the reported nanobeads could be an excellent and nontoxic building block for efficient intracellular transporters...
  17. ncbi Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
    Shinichi Kitada
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 46:4259-64. 2003
    ....
  18. ncbi Selective incorporation of 19F-labeled Trp side chains for NMR-spectroscopy-based ligand-protein interaction studies
    Marilisa Leone
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92103, USA
    Chembiochem 4:649-50. 2003