GREG E LEMKE

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. pmc Immunobiology of the TAM receptors
    Greg Lemke
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 8:327-36. 2008
  2. ncbi request reprint Schwann cell differentiation
    T S Zorick
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 8:870-6. 1996
  3. ncbi request reprint Neuregulin-1 and myelination
    Greg Lemke
    The Salk Institute, La Jolla, CA 92037, USA
    Sci STKE 2006:pe11. 2006
  4. ncbi request reprint Retinotectal mapping: new insights from molecular genetics
    Greg Lemke
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Cell Dev Biol 21:551-80. 2005
  5. pmc TAM receptors and the clearance of apoptotic cells
    Greg Lemke
    The Salk Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1209:23-9. 2010
  6. ncbi request reprint Glial control of neuronal development
    G Lemke
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Neurosci 24:87-105. 2001
  7. ncbi request reprint Macrophage regulation by Tyro 3 family receptors
    Greg Lemke
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 15:31-6. 2003
  8. ncbi request reprint TAM receptors are pleiotropic inhibitors of the innate immune response
    Carla V Rothlin
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cell 131:1124-36. 2007
  9. pmc Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling
    Benjamin W Gallarda
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 320:233-6. 2008
  10. ncbi request reprint A relative signalling model for the formation of a topographic neural map
    Michael Reber
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Nature 431:847-53. 2004

Research Grants

  1. TAM Receptor Regulation of Innate Immunity
    GREG E LEMKE; Fiscal Year: 2010
  2. FUNCTIONAL STUDIES OF TYRO 3 FAMILY RECEPTORS
    Greg Lemke; Fiscal Year: 2004
  3. Glial-Neuron Interactions: Genetic Studies
    Greg Lemke; Fiscal Year: 2005
  4. MOLECULAR DETERMINANTS OF NEURAL DEVELOPMENT
    Greg Lemke; Fiscal Year: 2007
  5. Eye Development: Genetic Studies
    Greg Lemke; Fiscal Year: 2007
  6. Eye Development: Genetic Studies
    GREG E LEMKE; Fiscal Year: 2010
  7. MYELINATION GENES-STRUCTURE, FUNCTION AND REGULATION
    Greg Lemke; Fiscal Year: 1993
  8. MYELINATION GENES--STRUCTURE, FUNCTION AND REGULATION
    Greg Lemke; Fiscal Year: 2000
  9. TAM Receptor Regulation of Innate Immunity
    GREG E LEMKE; Fiscal Year: 2011

Collaborators

Detail Information

Publications16

  1. pmc Immunobiology of the TAM receptors
    Greg Lemke
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 8:327-36. 2008
    ..Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation...
  2. ncbi request reprint Schwann cell differentiation
    T S Zorick
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 8:870-6. 1996
    ..Our understanding of the transcriptional control of Schwann cell development, particularly by the POU protein SCIP and the zinc-finger protein Krox-20, has been advanced by transgenic, knockout, and expression studies...
  3. ncbi request reprint Neuregulin-1 and myelination
    Greg Lemke
    The Salk Institute, La Jolla, CA 92037, USA
    Sci STKE 2006:pe11. 2006
    ..Recent studies suggest that this trigger is the growth factor neuregulin-1, expressed on the surface of axons, which signals through ErbB2 and ErbB3 receptors expressed on the surface of myelin-forming glia...
  4. ncbi request reprint Retinotectal mapping: new insights from molecular genetics
    Greg Lemke
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Cell Dev Biol 21:551-80. 2005
    ..They further suggest that order in the retinotectal map is determined by ratiometric rather than absolute difference comparisons in Eph signaling along the temporal-nasal and dorsal-ventral axes of the eye...
  5. pmc TAM receptors and the clearance of apoptotic cells
    Greg Lemke
    The Salk Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1209:23-9. 2010
    ..The TAM system appears to interact and cooperate with several other phagocytic networks, including scavenger receptor and integrin-based systems, and may serve as a signaling hub that integrates these systems...
  6. ncbi request reprint Glial control of neuronal development
    G Lemke
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Neurosci 24:87-105. 2001
    ..In these and related events, the defining principle is one of mutually reinforced and mutually dependent signaling that occurs in a network of developing neurons and glia...
  7. ncbi request reprint Macrophage regulation by Tyro 3 family receptors
    Greg Lemke
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Immunol 15:31-6. 2003
  8. ncbi request reprint TAM receptors are pleiotropic inhibitors of the innate immune response
    Carla V Rothlin
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cell 131:1124-36. 2007
    ....
  9. pmc Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling
    Benjamin W Gallarda
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 320:233-6. 2008
    ..Effective assembly of a key circuit underlying motor behaviors thus critically depends on trans-axonal signaling interactions resolving motor and sensory projections into discrete pathways...
  10. ncbi request reprint A relative signalling model for the formation of a topographic neural map
    Michael Reber
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Nature 431:847-53. 2004
    ..Molecular genetic experiments, exploiting a combinatorial series of EphA receptor knock-in and knockout mice, confirm the salient predictions of the model, and show that it both describes and predicts topographic mapping...
  11. ncbi request reprint TAM receptor function in the retinal pigment epithelium
    Dipti Prasad
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Neurosci 33:96-108. 2006
    ..These observations indicate that both Mer and Tyro 3 act in mouse RPE cells and suggest that their biologically relevant ligand in these cells is Protein S...
  12. ncbi request reprint The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye
    Stina H Mui
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037 USA
    Development 129:797-804. 2002
    ..Vax2 mutants also exhibit flattened DV and NT gradients of the EphA5, EphB2, EphB3, ephrin-B1 and ephrin-B2 axon guidance cues. Together, these data identify Vax2 as a fundamental regulator of axial polarization in the mammalian retina...
  13. pmc Vax genes ventralize the embryonic eye
    Stina H Mui
    Molecular Neurobiology Laboratory, The Salk Institute La Jolla, California 92037, USA
    Genes Dev 19:1249-59. 2005
    ....
  14. pmc Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis
    Tal Burstyn-Cohen
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California, USA
    J Clin Invest 119:2942-53. 2009
    ..These results demonstrate that ProS is a pleiotropic anticoagulant with aPC-independent activities and highlight new roles for ProS in vascular development and homeostasis...
  15. pmc Hedgehog-regulated localization of Vax2 controls eye development
    Jin Woo Kim
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Genes Dev 20:2833-47. 2006
    ..These results indicate that regulated changes in Vax2 localization modify the developmental competence of the optic neuroepithelium over time and thereby provide a mechanism for the sequential staging of eye development...
  16. pmc Local regulation of fat metabolism in peripheral nerves
    Mark H G Verheijen
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Genes Dev 17:2450-64. 2003
    ....

Research Grants36

  1. TAM Receptor Regulation of Innate Immunity
    GREG E LEMKE; Fiscal Year: 2010
    ..This receptor system is therefore a novel and attractive target for therapeutic modulation and intervention in disease treatment. ..
  2. FUNCTIONAL STUDIES OF TYRO 3 FAMILY RECEPTORS
    Greg Lemke; Fiscal Year: 2004
    ..Together, these studies will reveal the basics of cell-to-cell signaling through Tyro 3, Axl, and Mer -- three receptors of genuine biological importance. ..
  3. Glial-Neuron Interactions: Genetic Studies
    Greg Lemke; Fiscal Year: 2005
    ..Together, these studies will yield fundamental new insights into the transcriptional regulation of glial-neuron interactions in the developing central and peripheral nervous systems. ..
  4. MOLECULAR DETERMINANTS OF NEURAL DEVELOPMENT
    Greg Lemke; Fiscal Year: 2007
    ..Together, these experiments will provide us with fundamental new insights into the cellular interactions that mediate neural development, as well as a detailed understanding of their molecular basis. ..
  5. Eye Development: Genetic Studies
    Greg Lemke; Fiscal Year: 2007
    ..The experiments of this proposal are designed to provide fundamental insights into the genetic and biochemical mechanisms through which these axes are organized - from top to bottom and from side to side - during development. ..
  6. Eye Development: Genetic Studies
    GREG E LEMKE; Fiscal Year: 2010
    ..The experiments of this proposal are designed to provide fundamental insights into the genetic and biochemical mechanisms through which these axes are organized - from top to bottom and from side to side - during development. ..
  7. MYELINATION GENES-STRUCTURE, FUNCTION AND REGULATION
    Greg Lemke; Fiscal Year: 1993
    ....
  8. MYELINATION GENES--STRUCTURE, FUNCTION AND REGULATION
    Greg Lemke; Fiscal Year: 2000
    ....
  9. TAM Receptor Regulation of Innate Immunity
    GREG E LEMKE; Fiscal Year: 2011
    ..Together, these studies will provide basic insights into a new signaling system of critical importance to the regulation of immune responses and the development of autoimmunity. ..