SARAH LEIBOWITZ

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia
    Katherine E Wortley
    The Rockefeller University, New York, New York 10021, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1454-65. 2003
  2. pmc Developmental changes in embryonic hypothalamic neurons during prenatal fat exposure
    Kinning Poon
    The Rockefeller University, Laboratory of Behavioral Neurobiology, New York, NY 10065, USA
    Am J Physiol Endocrinol Metab 303:E432-41. 2012
  3. ncbi request reprint Function of neuropeptide Y and agouti-related protein at weaning: relation to corticosterone, dietary carbohydrate and body weight
    Sarah F Leibowitz
    Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1036:180-91. 2005
  4. ncbi request reprint Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis
    Sarah F Leibowitz
    Department of Neuropharmacology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuropeptides 39:327-32. 2005
  5. ncbi request reprint Leptin secretion after a high-fat meal in normal-weight rats: strong predictor of long-term body fat accrual on a high-fat diet
    S F Leibowitz
    The Rockefeller University, 1230 York Ave, New York, NY, USA
    Am J Physiol Endocrinol Metab 290:E258-67. 2006
  6. ncbi request reprint Weight gain model in prepubertal rats: prediction and phenotyping of obesity-prone animals at normal body weight
    K L Leibowitz
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Int J Obes (Lond) 31:1210-21. 2007
  7. ncbi request reprint Hypothalamic control of energy balance: different peptides, different functions
    Sarah F Leibowitz
    Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Peptides 25:473-504. 2004
  8. pmc Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides
    Sarah F Leibowitz
    The Rockefeller University, New York, NY 10021, USA
    Physiol Behav 91:513-21. 2007
  9. ncbi request reprint Increased caloric intake on a fat-rich diet: role of ovarian steroids and galanin in the medial preoptic and paraventricular nuclei and anterior pituitary of female rats
    S F Leibowitz
    The Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 19:753-66. 2007
  10. pmc Puberty onset in female rats: relationship with fat intake, ovarian steroids and the peptides, galanin and enkephalin, in the paraventricular and medial preoptic nuclei
    S F Leibowitz
    Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 21:538-49. 2009

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia
    Katherine E Wortley
    The Rockefeller University, New York, New York 10021, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1454-65. 2003
    ..This evidence suggests that the orexins, like galanin, are "fat-responsive" peptides that respond to circulating lipids...
  2. pmc Developmental changes in embryonic hypothalamic neurons during prenatal fat exposure
    Kinning Poon
    The Rockefeller University, Laboratory of Behavioral Neurobiology, New York, NY 10065, USA
    Am J Physiol Endocrinol Metab 303:E432-41. 2012
    ..These changes may contribute to the increase in HFD intake and body weight observed in offspring...
  3. ncbi request reprint Function of neuropeptide Y and agouti-related protein at weaning: relation to corticosterone, dietary carbohydrate and body weight
    Sarah F Leibowitz
    Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1036:180-91. 2005
    ....
  4. ncbi request reprint Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis
    Sarah F Leibowitz
    Department of Neuropharmacology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuropeptides 39:327-32. 2005
    ..These circuits are believed to contribute to the large meal size, over-consumption of alcohol, and obesity which are generally associated with fat-rich foods...
  5. ncbi request reprint Leptin secretion after a high-fat meal in normal-weight rats: strong predictor of long-term body fat accrual on a high-fat diet
    S F Leibowitz
    The Rockefeller University, 1230 York Ave, New York, NY, USA
    Am J Physiol Endocrinol Metab 290:E258-67. 2006
    ..Thus, with this HFM-induced leptin measurement, OP rats can be identified while still at normal weight and then investigated for mechanisms that contribute to their excessive body fat accrual on a high-fat diet...
  6. ncbi request reprint Weight gain model in prepubertal rats: prediction and phenotyping of obesity-prone animals at normal body weight
    K L Leibowitz
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Int J Obes (Lond) 31:1210-21. 2007
    ....
  7. ncbi request reprint Hypothalamic control of energy balance: different peptides, different functions
    Sarah F Leibowitz
    Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Peptides 25:473-504. 2004
    ....
  8. pmc Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides
    Sarah F Leibowitz
    The Rockefeller University, New York, NY 10021, USA
    Physiol Behav 91:513-21. 2007
    ....
  9. ncbi request reprint Increased caloric intake on a fat-rich diet: role of ovarian steroids and galanin in the medial preoptic and paraventricular nuclei and anterior pituitary of female rats
    S F Leibowitz
    The Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 19:753-66. 2007
    ....
  10. pmc Puberty onset in female rats: relationship with fat intake, ovarian steroids and the peptides, galanin and enkephalin, in the paraventricular and medial preoptic nuclei
    S F Leibowitz
    Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 21:538-49. 2009
    ....
  11. pmc Hypothalamic injection of non-opioid peptides increases gene expression of the opioid enkephalin in hypothalamic and mesolimbic nuclei: Possible mechanism underlying their behavioral effects
    Olga Karatayev
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Peptides 30:2423-31. 2009
    ..In light of published findings showing an opioid antagonist to block GAL- and OX-induced feeding, these results provide additional evidence that ENK is involved in mediating the common behavioral effects of these peptides...
  12. ncbi request reprint Glucose injection reduces neuropeptide Y and agouti-related protein expression in the arcuate nucleus: a possible physiological role in eating behavior
    Guo Qing Chang
    Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res Mol Brain Res 135:69-80. 2005
    ....
  13. ncbi request reprint Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: relationship with circulating triglycerides
    Guo Qing Chang
    Laboratory of Behavioral Neurobiology, The Rockefeller University, New York, New York 10021, USA
    Alcohol Clin Exp Res 31:249-59. 2007
    ..To test the hypothesis that other feeding-related systems are involved in ethanol intake, this study examined the effect of ethanol on the hypothalamic opioid peptides, enkephalin (ENK), and dynorphin (DYN)...
  14. pmc Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity
    Guo Qing Chang
    The Rockefeller University, New York, New York 10065, USA
    J Neurosci 28:12107-19. 2008
    ....
  15. ncbi request reprint Cocaine- and amphetamine-regulated transcript in the arcuate nucleus stimulates lipid metabolism to control body fat accrual on a high-fat diet
    Katherine E Wortley
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Regul Pept 117:89-99. 2004
    ..These results suggest that, on a fat-rich diet, this leptin-CART pathway originating in the ARC inhibits excessive body fat accrual by causing a shift from lipid storage toward lipid mobilization...
  16. pmc Increased intake of ethanol and dietary fat in galanin overexpressing mice
    Olga Karatayev
    Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Alcohol 43:571-80. 2009
    ..They reveal gender differences in the behavioral phenotype, which may reflect GAL's functional relationship to reproductive hormones in the stimulation of consummatory behavior...
  17. ncbi request reprint Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it
    Sarah F Leibowitz
    Laboratory of Behavioral Neurobiology, Rockefeller University, New York, NY 10021, USA
    Physiol Behav 79:103-11. 2003
    ..These studies suggest a possible role for hypothalamic GAL in alcohol abuse...
  18. ncbi request reprint Elevated D3 dopamine receptor mRNA in dopaminergic and dopaminoceptive regions of the rat brain in response to morphine
    Rudolph Spangler
    Laboratory of Behavioral Neuroscience, The Rockefeller University, Box 278, 1230 York Avenue, New York, NY 10021, USA
    Brain Res Mol Brain Res 111:74-83. 2003
    ..The finding that chronic, intermittent injections of morphine caused an increase in D3R mRNA extends our understanding of the ability of D3R agonists to reduce the effects of morphine...
  19. ncbi request reprint Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus
    Guo Qing Chang
    Laboratory of Behavioral Neurobiology, Rockefeller University, New York, New York 10021, USA
    Endocrinology 145:3904-12. 2004
    ....
  20. ncbi request reprint Opiate-like effects of sugar on gene expression in reward areas of the rat brain
    Rudolph Spangler
    Laboratory of Behavioral Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res Mol Brain Res 124:134-42. 2004
    ..These findings support a major role for the nucleus accumbens in mediating the effects of naturally rewarding substances and extend an animal model for studying the common substrates of drug addiction and eating disorders...
  21. ncbi request reprint Acute high-fat diet paradigms link galanin to triglycerides and their transport and metabolism in muscle
    Sarah F Leibowitz
    Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1008:168-78. 2004
    ....
  22. ncbi request reprint Phenotypic profile of SWR/J and A/J mice compared to control strains: possible mechanisms underlying resistance to obesity on a high-fat diet
    Sarah F Leibowitz
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1047:137-47. 2005
    ....
  23. pmc Increased orexin and melanin-concentrating hormone expression in the perifornical lateral hypothalamus of rats prone to overconsuming a fat-rich diet
    Irene Morganstern
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Pharmacol Biochem Behav 96:413-22. 2010
    ....
  24. pmc Galanin knockout mice show disturbances in ethanol consumption and expression of hypothalamic peptides that stimulate ethanol intake
    Olga Karatayev
    Laboratory of Behavioral Neurobiology, Rockefeller University, New York, New York, USA
    Alcohol Clin Exp Res 34:72-80. 2010
    ..The present study further examined this possibility in GAL knockout (GALKO) mice...
  25. ncbi request reprint A high-fat meal or injection of lipids stimulates ethanol intake
    Carmen A Carrillo
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Alcohol 34:197-202. 2004
    ..These findings provide new evidence to support a positive relation between dietary fat and the consumption of ethanol...
  26. ncbi request reprint Overlapping peptide control of alcohol self-administration and feeding
    Todd E Thiele
    Department of Psychology and the Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Alcohol Clin Exp Res 28:288-94. 2004
    ..Leibowitz and Bartley G. Hoebel...
  27. ncbi request reprint Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin
    Eve R Schneider
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Alcohol Clin Exp Res 31:1858-65. 2007
    ..The peptide orexin was found to exhibit similar properties to galanin in its relation to dietary fat and may therefore be similar to galanin in having a stimulatory effect on alcohol intake...
  28. ncbi request reprint Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior
    Guoqing Sheng
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, USA
    Nat Med 12:526-33. 2006
    ..These findings provide evidence linking hypothalamic Hap1 to GABA in the stimulation of feeding and suggest that this mechanism is involved in the feeding-inhibitory actions of insulin in the brain...
  29. ncbi request reprint Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist
    Pedro Rada
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Alcohol 33:91-7. 2004
    ..Because ethanol can increase expression of galanin mRNA in the paraventricular nucleus, this could set the stage for a positive feedback loop between galanin and ethanol intake...
  30. ncbi request reprint Galanin microinjection in the third ventricle increases voluntary ethanol intake
    Michael J Lewis
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Alcohol Clin Exp Res 28:1822-8. 2004
    ..Chronic ethanol (EtOH) increases the expression of galanin in the hypothalamus. The research presented here examines the effects of microinjection of galanin in the third ventricle on voluntary alcohol intake...
  31. ncbi request reprint Sugar-dependent rats show enhanced intake of unsweetened ethanol
    Nicole M Avena
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Alcohol 34:203-9. 2004
    ..In conclusion, bingeing on either ethanol or sugar fosters intake of the other...

Research Grants22

  1. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 2004
    ....
  2. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 2007
    ..In summary, this grant tests the novel hypothesis that a high-fat diet itself can promote overeating and ultimately dietary obesity through a positive feedback loop involving circulating lipids, hypothalamic peptides and accumbens DA. ..
  3. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 2009
    ..In summary, this grant tests the novel hypothesis that a high-fat diet itself can promote overeating and ultimately dietary obesity through a positive feedback loop involving circulating lipids, hypothalamic peptides and accumbens DA. ..
  4. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    Sarah F Leibowitz; Fiscal Year: 2010
    ..In summary, this grant tests the novel hypothesis that a high-fat diet itself can promote overeating and ultimately dietary obesity through a positive feedback loop involving circulating lipids, hypothalamic peptides and accumbens DA. ..
  5. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 1999
    ....
  6. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 1993
    ....
  7. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 1992
    ....
  8. HYPOTHALAMIC PEPTIDES IN THE CONTROL OF ALCOHOL INTAKE
    Sarah F Leibowitz; Fiscal Year: 2011
    ..These studies of neural mechanisms in animals will provide useful information on how to predict and prevent overconsumption of alcohol and may help in designing drugs that can be used in the treatment of alcohol-use disorder. ..