S M Leal

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9
    S M Leal
    Laboratory of Statistical Genetics, Rockefeller University, New York, USA
    Eur J Hum Genet 6:341-4. 1998
  2. pmc Effects of stratification in the analysis of affected-sib-pair data: benefits and costs
    S M Leal
    The Rockefeller University, 1230 York Avenue, Box 192, New York, NY 10021 6399, USA
    Am J Hum Genet 66:567-75. 2000
  3. ncbi request reprint Phenotypes and genetic analysis of psychiatric and neuropsychiatric traits
    S M Leal
    The Rockefeller University, Laboratory of Statistical Genetics, New York, New York 10021, USA
    Am J Med Genet 105:4-7. 2001
  4. pmc A novel locus (DFNA23) for prelingual autosomal dominant nonsyndromic hearing loss maps to 14q21-q22 in a Swiss German kindred
    A A Salam
    Laboratory of Statistical Genetics, The Rockefeller University, New York, NY 10021, USA
    Am J Hum Genet 66:1984-8. 2000
  5. ncbi request reprint Novel selection criteria for genome scans of complex traits
    A Wille
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, Box 192, New York, NY 10021, USA
    Genet Epidemiol 21:S800-4. 2001
  6. pmc Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women
    Bronson E Oosterhuis
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Am J Med Genet B Neuropsychiatr Genet 147:793-8. 2008
  7. ncbi request reprint A second kindred linked to DFNA20 (17q25.3) reduces the genetic interval
    A T DeWan
    The Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, USA
    Clin Genet 63:39-45. 2003
  8. ncbi request reprint Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction
    Vadim Yuferov
    aLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Pharmacogenetics 14:793-804. 2004
  9. ncbi request reprint Genetic and physical mapping of the progressive epilepsy with mental retardation (EPMR) locus on chromosome 8p
    S Ranta
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genome Res 6:351-60. 1996
  10. ncbi request reprint Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence
    T Cigler
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Am J Med Genet 105:489-97. 2001

Collaborators

Detail Information

Publications29

  1. ncbi request reprint A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9
    S M Leal
    Laboratory of Statistical Genetics, Rockefeller University, New York, USA
    Eur J Hum Genet 6:341-4. 1998
    ..All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0-2.59 cM)...
  2. pmc Effects of stratification in the analysis of affected-sib-pair data: benefits and costs
    S M Leal
    The Rockefeller University, 1230 York Avenue, Box 192, New York, NY 10021 6399, USA
    Am J Hum Genet 66:567-75. 2000
    ..Even for values of the relative risk that diverge sufficiently from 1, with adequate sample sizes and IBD allele sharing, the benefits of stratifying ASP data are minimal...
  3. ncbi request reprint Phenotypes and genetic analysis of psychiatric and neuropsychiatric traits
    S M Leal
    The Rockefeller University, Laboratory of Statistical Genetics, New York, New York 10021, USA
    Am J Med Genet 105:4-7. 2001
    ..An overview of topics that were addressed and discussed at the workshop is presented in this article...
  4. pmc A novel locus (DFNA23) for prelingual autosomal dominant nonsyndromic hearing loss maps to 14q21-q22 in a Swiss German kindred
    A A Salam
    Laboratory of Statistical Genetics, The Rockefeller University, New York, NY 10021, USA
    Am J Hum Genet 66:1984-8. 2000
    ..A maximum multipoint LOD score of 5.1 occurred at Marker D14S290. The 3.0-LOD unit support interval is 9.4 cM and ranged from marker D14S980 to marker D14S1046...
  5. ncbi request reprint Novel selection criteria for genome scans of complex traits
    A Wille
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, Box 192, New York, NY 10021, USA
    Genet Epidemiol 21:S800-4. 2001
    ..Using the described novel selection criteria resulted in an increase of power, however, a rejection of the null hypothesis has to be interpreted with care...
  6. pmc Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women
    Bronson E Oosterhuis
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Am J Med Genet B Neuropsychiatr Genet 147:793-8. 2008
    ..05) after correction for multiple testing. No significant association was found with haplotypes of the three most common SNPs. Linkage disequilibrium patterns were similar for the three ethnic/cultural groups...
  7. ncbi request reprint A second kindred linked to DFNA20 (17q25.3) reduces the genetic interval
    A T DeWan
    The Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, USA
    Clin Genet 63:39-45. 2003
    ..The mean age of onset of hearing impairment is 13.2 years of age (standard deviation: 4.6 years)...
  8. ncbi request reprint Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction
    Vadim Yuferov
    aLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Pharmacogenetics 14:793-804. 2004
    ..0742, 0.1015 and 0.0041. Combining ethnicities by Fisher's method yields an empirical significance level of P = 0.0020...
  9. ncbi request reprint Genetic and physical mapping of the progressive epilepsy with mental retardation (EPMR) locus on chromosome 8p
    S Ranta
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genome Res 6:351-60. 1996
    ..Moreover, the distal end of the contig contains a subtelomeric YAC yRM2205 that anchors the contig to the telomere. Construction of a YAC contig across the disease gene region is an essential step toward the isolation of the EPMR gene...
  10. ncbi request reprint Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence
    T Cigler
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Am J Med Genet 105:489-97. 2001
    ..No significant differences between cases and controls were found...
  11. pmc Homozygosity mapping of the Achromatopsia locus in the Pingelapese
    J D Winick
    The Rockefeller University, New York, USA
    Am J Hum Genet 64:1679-85. 1999
    ..5cm...
  12. ncbi request reprint Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse
    Andrew C H Chen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021 6399, USA
    Am J Med Genet 114:429-35. 2002
    ....
  13. pmc Sequence variants in host cell factor C1 are associated with Ménière's disease
    Jeffrey T Vrabec
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U S A
    Otol Neurotol 29:561-6. 2008
    ..There is a genetic basis for the development of Ménière's (MD) disease...
  14. pmc Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data
    Bingshan Li
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 83:311-21. 2008
    ..The CMC method can be applied to either candidate-gene or whole-genome sequence data...
  15. pmc Genome-wide detection and characterization of positive selection in human populations
    Pardis C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 449:913-8. 2007
    ....
  16. ncbi request reprint Detection of genotyping errors and pseudo-SNPs via deviations from Hardy-Weinberg equilibrium
    Suzanne M Leal
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genet Epidemiol 29:204-14. 2005
    ..05. On the other hand, the detection of deviations from HWE for pseudo-SNPs (paralogous and ectopic sequence variants) for the majority of models examined produces a power of >0.8 for sample sizes as small as 50 individuals...
  17. pmc Positive selection of a pre-expansion CAG repeat of the human SCA2 gene
    Fuli Yu
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 1:e41. 2005
    ..These results suggest that a recent positive selection of the pre-expansion SCA2 CAG repeat has occurred in Utah residents with European ancestry...
  18. pmc A second generation human haplotype map of over 3.1 million SNPs
    Kelly A Frazer
    The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA
    Nature 449:851-61. 2007
    ..Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations...
  19. pmc Ignoring intermarker linkage disequilibrium induces false-positive evidence of linkage for consanguineous pedigrees when genotype data is missing for any pedigree member
    Bingshan Li
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Hered 65:199-208. 2008
    ....
  20. ncbi request reprint Mitochondrial genetic background modifies breast cancer risk
    Ren Kui Bai
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 67:4687-94. 2007
    ..37; 95% CI, 0.19-0.73; P = 0.0023, adjusted P = 0.03). Our results suggest that mitochondrial genetic background plays a role in modifying an individual's risk to breast cancer...
  21. ncbi request reprint Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women
    Martha P Mims
    Cancer Res 66:1880; author reply 1880-1. 2006
  22. pmc Novel sequence variants in the TMIE gene in families with autosomal recessive nonsyndromic hearing impairment
    Regie Lyn P Santos
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Alkek N1619 01, Houston, TX 77030, USA
    J Mol Med (Berl) 84:226-31. 2006
    ..3-4.8]. Further studies on the spectrum, prevalence rates, and functional effect of sequence variants in the TMIE gene in other populations should demonstrate the true importance of this gene as a cause of hearing impairment...
  23. pmc SimPed: a simulation program to generate haplotype and genotype data for pedigree structures
    Suzanne M Leal
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, N1619 01, Houston, TX 77025, USA
    Hum Hered 60:119-22. 2005
    ....
  24. ncbi request reprint High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes
    Eugene Sobngwi
    Department of Endocrinology and Diabetes, St Louis Hospital, University of Paris VII School of Medicine, France
    J Clin Endocrinol Metab 90:4446-51. 2005
    ..Ketosis-prone diabetes (KPD) is mostly observed in males of West African descent and is characterized by phasic or permanent insulin dependence without apparent autoimmune process...
  25. ncbi request reprint Mapping genes of complex psychiatric diseases in Daghestan genetic isolates
    Kazima B Bulayeva
    Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 117809 Russia
    Am J Med Genet B Neuropsychiatr Genet 132:76-84. 2005
    ..While the analyses are ongoing, the most positive findings were made in different isolated pedigrees on chromosomes 17p11, 3q24, and 22q for schizophrenia and on chromosome 12q for nonspecific mental retardation...
  26. ncbi request reprint Multicenter initiative seeking critical genes in respiratory papillomatosis
    Farrel J Buchinsky
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212 4772, USA
    Laryngoscope 114:349-57. 2004
    ..Genetically encoded host susceptibility is postulated. Determining the host genes that govern susceptibility will enhance our understanding not only of RRP but also of host-viral interaction in general...
  27. pmc DFNB39, a recessive form of sensorineural hearing impairment, maps to chromosome 7q11.22-q21.12
    Muhammad Wajid
    Department of Biological Sciences, Quaid i Azam University Islamabad, Pakistan
    Eur J Hum Genet 11:812-5. 2003
    ..Linkage was established to microsatellite markers located on chromosome 7q with a maximum multipoint lod score of 3.8. The region of homozygosity spans a 19 cM region that is bounded by markers D7S3046 and D7S644...
  28. ncbi request reprint Genetic maps of microsatellite and single-nucleotide polymorphism markers: are the distances accurate?
    Suzanne M Leal
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genet Epidemiol 24:243-52. 2003
    ....
  29. pmc Mitochondrial DNA variant interactions modify breast cancer risk
    Daniel Covarrubias
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA
    J Hum Genet 53:924-8. 2008
    ....