Alexander J F Lazar

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation
    Jonathan A F Hannay
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 6:1650-60. 2007
  2. pmc The role of chemotherapy in advanced solitary fibrous tumors: a retrospective analysis
    Min S Park
    Department of Sarcoma Medical Oncology Unit 0450, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Sarcoma Res 3:7. 2013
  3. pmc Extensive adipocytic maturation can be seen in myxoid liposarcomas treated with neoadjuvant doxorubicin and ifosfamide and pre-operative radiation therapy
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, Houston, TX, 77030, USA
    Clin Sarcoma Res 2:25. 2012
  4. pmc Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma
    Daniela Katz
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Sarcoma Res 2:2. 2012
  5. ncbi request reprint Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin
    Alexander J F Lazar
    Department of Pathology, Division of Dermatopathology, Brigham and Women s Hospital, Boston, MA, USA
    J Cutan Pathol 32:148-57. 2005
  6. doi request reprint Desmoid tumor: from surgical extirpation to molecular dissection
    Alexander J F Lazar
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 5009, USA
    Curr Opin Oncol 21:352-9. 2009
  7. ncbi request reprint Sarcoma molecular testing: diagnosis and prognosis
    Alexander J F Lazar
    Department of Pathology and Sarcoma Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Curr Oncol Rep 9:309-15. 2007
  8. doi request reprint Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 21:1303-10. 2008
  9. doi request reprint A randomized, phase II study of preoperative plus postoperative imatinib in GIST: evidence of rapid radiographic response and temporal induction of tumor cell apoptosis
    John C McAuliffe
    The University of Texas Houston, Houston, TX, USA
    Ann Surg Oncol 16:910-9. 2009
  10. doi request reprint COL1A1:PDGFB chimeric transcripts are not present in indeterminate fibrohistiocytic lesions of the skin
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Am J Dermatopathol 32:149-53. 2010

Detail Information

Publications46

  1. ncbi request reprint Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation
    Jonathan A F Hannay
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 6:1650-60. 2007
    ..In light of the importance of Rad51 in modulating STS chemoresistance, these findings point to a potential novel strategy for molecular-based treatments that may be of relevance to patients burdened by STS...
  2. pmc The role of chemotherapy in advanced solitary fibrous tumors: a retrospective analysis
    Min S Park
    Department of Sarcoma Medical Oncology Unit 0450, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Sarcoma Res 3:7. 2013
    ..We thus sought to estimate the efficacy of conventional chemotherapy for SFTs by reviewing data on tumor response to therapy and progression-free survival from SFT patients who received this therapy...
  3. pmc Extensive adipocytic maturation can be seen in myxoid liposarcomas treated with neoadjuvant doxorubicin and ifosfamide and pre-operative radiation therapy
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, Houston, TX, 77030, USA
    Clin Sarcoma Res 2:25. 2012
    ..We examined the histological changes, including adipocytic maturation, associated with this treatment in patients with myxoid liposarcoma and evaluated for prognostic significance...
  4. pmc Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma
    Daniela Katz
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Sarcoma Res 2:2. 2012
    ..abstract:..
  5. ncbi request reprint Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin
    Alexander J F Lazar
    Department of Pathology, Division of Dermatopathology, Brigham and Women s Hospital, Boston, MA, USA
    J Cutan Pathol 32:148-57. 2005
    ..This implies a common initial pathogenesis and is compatible with the proposition that pilomatrix carcinomas may at least on occasion arise from their benign counterparts...
  6. doi request reprint Desmoid tumor: from surgical extirpation to molecular dissection
    Alexander J F Lazar
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 5009, USA
    Curr Opin Oncol 21:352-9. 2009
    ..Little is known regarding the molecular determinates of desmoid tumor behavior. Some recent work has focused on the role of beta-catenin in desmoid tumor biology...
  7. ncbi request reprint Sarcoma molecular testing: diagnosis and prognosis
    Alexander J F Lazar
    Department of Pathology and Sarcoma Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Curr Oncol Rep 9:309-15. 2007
    ..Analysis of activating KIT mutations in gastrointestinal stromal tumors is currently being used in management of patient therapy...
  8. doi request reprint Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 21:1303-10. 2008
    ..Fluorescence in situ hybridization is useful to support the diagnosis of extraskeletal myxoid chondrosarcomas and may help to differentiate it from mimics such as other myxoid sarcomas, particularly in limited biopsies...
  9. doi request reprint A randomized, phase II study of preoperative plus postoperative imatinib in GIST: evidence of rapid radiographic response and temporal induction of tumor cell apoptosis
    John C McAuliffe
    The University of Texas Houston, Houston, TX, USA
    Ann Surg Oncol 16:910-9. 2009
    ..02). Imatinib appears to be safe and may be considered for patients undergoing surgical resection of their GIST. Radiographic response and tumor cell apoptosis occur within the first week of imatinib therapy...
  10. doi request reprint COL1A1:PDGFB chimeric transcripts are not present in indeterminate fibrohistiocytic lesions of the skin
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Am J Dermatopathol 32:149-53. 2010
    ..Although indeterminate fibrohistiocytic lesions share some features with DFSP, the lack of COL1A1-PDGFB chimeric transcripts suggests that they are distinct entities...
  11. pmc Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors
    Alexander J F Lazar
    Sarcoma Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4001, USA
    Am J Pathol 173:1518-27. 2008
    ..In conclusion, CTNNB1 mutations are highly common in desmoid tumors. Furthermore, patients harboring CTNNB1 (45F) mutations are at particular risk for recurrence and therefore may especially benefit from adjuvant therapeutic approaches...
  12. doi request reprint Cutaneous and subcutaneous metastases of gastrointestinal stromal tumors: a series of 5 cases with molecular analysis
    Wei Lien Wang
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Dermatopathol 31:297-300. 2009
    ..Cutaneous metastases seem to be a late complication of GIST, but their presence does not necessarily herald a rapid demise of the patient...
  13. doi request reprint Dermatofibrosarcoma protuberans with unusual sarcomatous transformation: a series of 4 cases with molecular confirmation
    Michael G Swaby
    Department of Pathology, The University of Texas Medical School, Houston, TX, USA
    Am J Dermatopathol 33:354-60. 2011
    ..Ancillary diagnostic testing may be helpful to confirm the diagnosis, especially in small biopsies...
  14. ncbi request reprint Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin
    Doina Ivan
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Cutan Pathol 34:474-80. 2007
    ..Metastases from adnexal carcinomas generally retain p63 expression similar to their associated primary tumors...
  15. doi request reprint MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement
    Leona A Doyle
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 36:1444-51. 2012
    ..SEF without MUC4 expression may represent a distinct group of tumors. MUC4 expression correlates with glandular epithelial differentiation in biphasic synovial sarcoma and is very limited in other epithelioid soft tissue tumors...
  16. ncbi request reprint Association of intratumoral vascular endothelial growth factor expression and clinical outcome for patients with gastrointestinal stromal tumors treated with imatinib mesylate
    John C McAuliffe
    Department of Sarcoma Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 13:6727-34. 2007
    ..Importantly, selected patients may be treated with an approach to target both Kit and vascular endothelial growth factor receptor (VEGFR) expression...
  17. ncbi request reprint Basal cell carcinoma with matrical differentiation: a case study with analysis of beta-catenin
    Henry D Haskell
    Department of Pathology, Division of Dermatopathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Cutan Pathol 32:245-50. 2005
    ..Immunohistochemical and molecular methods are used to differentiate this lesion from benign or malignant forms of pilomatrixoma. differentiation: a case study with analysis of beta-catenin...
  18. doi request reprint Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK
    Adrian Mariño-Enríquez
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:135-44. 2011
    ..We propose the designation "epithelioid inflammatory myofibroblastic sarcoma" to convey both the malignant behavior of these tumors and their close relationship with IMT...
  19. doi request reprint ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour
    Badreddin Edris
    Department of Pathology, Stanford University School of Medicine, CA, USA
    J Pathol 227:223-33. 2012
    ..Together, these results show that ROR2 is a useful prognostic indicator in the clinical management of these soft-tissue sarcomas and may represent a novel therapeutic target...
  20. ncbi request reprint Renal cell carcinoma marker (RCC-Ma) is specific for cutaneous metastasis of renal cell carcinoma
    Ashley G Perna
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cutan Pathol 34:381-5. 2007
    ..RCC-Ma expression is relatively specific for primary clear cell renal cell carcinoma. Its expression in cutaneous metastasis of renal cell carcinoma (MRCC) and other cutaneous clear cell lesions has not been studied...
  21. ncbi request reprint Molecular approaches to resolve diagnostic dilemmas: the case of gastrointestinal stromal tumor and leiomyosarcoma
    Jonathan C Trent
    The University of Texas, Department of Sarcoma Medical Oncology, The Sarcoma Research Center, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Suite FC11 3032, Unit 450, Houston, TX 77030, USA
    Future Oncol 3:629-37. 2007
    ..To aid in resolution of this clinical challenge, we performed a whole-genome gene expression study on 71 well-defined GIST and LMS samples with development of a robust, novel approach to molecular classification discussed herein...
  22. doi request reprint Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity
    A Hafeez Diwan
    Department of Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Cutan Pathol 35:647-50. 2008
    ..Twenty-three of 29 DFSP (79%) and 2 of 5 GCP (40%) expressed CD99. Comparison of CD99 and CD34 showed that the non-tumoral periphery of DFSP was less probable to be CD99 positive, but this finding was not statistically significant...
  23. pmc Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors
    Antti Ylipaa
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:380-9. 2011
    ....
  24. doi request reprint Pseudocystic dermatofibrosarcoma protuberans: report of two cases and demonstration of COL1A1-PDGFB rearrangement
    Marianna Shvartsbeyn
    Department of Pathology, New York University, New York, NY 10016, USA
    J Cutan Pathol 39:356-60. 2012
    ..Shvartsbeyn M, Lazar AJF, Lopez-Terrada D, Meehan SA. Pseudocystic dermatofibrosarcoma protuberans: report of two cases and demonstration of COL1A1-PDGFB rearrangement...
  25. pmc Integrated proteomics and genomics analysis reveals a novel mesenchymal to epithelial reverting transition in leiomyosarcoma through regulation of slug
    Jilong Yang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Proteomics 9:2405-13. 2010
    ..An increase in Slug expression by pCMV6-XL5-Slug transfection decreased E-cadherin and increased vimentin and N-cadherin. Thus, MErT, which is mediated through regulation of Slug, is a clinically significant phenotype in leiomyosarcoma...
  26. ncbi request reprint Angiogenesis-promoting gene patterns in alveolar soft part sarcoma
    Alexander J F Lazar
    Sarcoma Research Center, The University of Texas M D Anderson Cancer Center, and Department of Pathology, Texas Children s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Clin Cancer Res 13:7314-21. 2007
    ..Investigation of potential angiogenesis-modulating molecular determinants provided mechanistic and potentially therapeutically relevant insight into the enhanced vascularity characteristic of this unusual tumor...
  27. doi request reprint Impact of sentinel lymphadenectomy on survival in a murine model of melanoma
    Robert B Rebhun
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Exp Metastasis 25:191-9. 2008
    ..We found no difference in the incidence of lung metastases produced by B16-BL6 melanoma cells growing exclusively within regional lymph nodes and cells growing within the pinna...
  28. doi request reprint Metastatic basal cell carcinoma exhibits reduced actin expression
    Maria C Uzquiano
    Department of Pathology, UT MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 21:540-3. 2008
    ..Our results suggest that increased actin may contribute to local invasiveness, but it is lost in the metastatic phenotype. History of previous radiotherapy may contribute to development of the metastatic phenotype...
  29. ncbi request reprint Galectin-3 expression is associated with tumor progression and pattern of sun exposure in melanoma
    Victor G Prieto
    Department of Pathology, The University of Texas M D Anderson Cancer Center, The Methodist Hospital, Houston 77030, USA
    Clin Cancer Res 12:6709-15. 2006
    ....
  30. ncbi request reprint Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization
    Kayuri U Patel
    Department of Pathology at Texas Children s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
    Hum Pathol 39:184-93. 2008
    ..Its detection may be particularly helpful in the differential diagnosis of atypical, fibrosarcomatous, and metastatic DFSP...
  31. pmc Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications
    Sara C Shalin
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Histopathology 56:133-47. 2010
    ..This review focuses on the diagnostic and histological features of sebaceous lesions, the MTS, and recent insights into the molecular pathogenesis of sebaceous tumours...
  32. ncbi request reprint Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications
    Jason W Nash
    Departments of Pathology and Dermatology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Cutan Pathol 34:49-54. 2007
    ..In analogy to breast carcinoma, these findings suggest the applicability of trastuzumab for patients with metastatic adnexal carcinomas demonstrating Her-2/neu amplification...
  33. ncbi request reprint Oral-cutaneous CD4-positive T-cell lymphoma: a study of two patients
    Steve A May
    Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Dermatopathol 29:62-7. 2007
    ..These cases are strikingly similar, and may represent an unusual clinicopathologic type of T-cell lymphoma that can hone to cutaneous and oral mucosal sites with a slowly progressive natural history...
  34. doi request reprint Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma
    Doina Ivan
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Cutan Pathol 37:231-6. 2010
    ....
  35. ncbi request reprint Clinical, histopathologic, molecular and therapeutic findings in a large kindred with gastrointestinal stromal tumor
    Eric P Kleinbaum
    Department of Sarcoma Medical Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 122:711-8. 2008
    ..Germ-line deletion of KIT codon 579 in GIST is associated with clinical benefit from imatinib, limited utility of mitoses to predict malignant potential, and a novel homozygous deletion of this codon in one individual...
  36. ncbi request reprint Primitive nonneural granular cell tumors of skin: clinicopathologic analysis of 13 cases
    Alexander J F Lazar
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:927-34. 2005
    ..These cutaneous granular tumors do not appear to be neural or Schwannian in nature, but their precise line of differentiation is unknown...
  37. ncbi request reprint Staging soft tissue sarcoma: evolution and change
    Dhanasekaran Kotilingam
    The University of TexasMD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 56:282-91; quiz 314-5. 2006
    ..Further opportunities to improve this process exist, particularly as molecular considerations become more apparent, and future evolution into an even more useful STS staging system can be anticipated...
  38. ncbi request reprint Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma
    Vikas K Goel
    Department of Medicine, Division of Hematology Oncology, Massachusetts General Hospital, Melanoma Center, Boston, Massachusetts, USA
    J Invest Dermatol 126:154-60. 2006
    ..0001). Mutations in NRAS were not coincident with reduced PTEN expression, and the concurrent mutation of NRAS and BRAF was rare...
  39. ncbi request reprint Distinctive dermal clear cell mesenchymal neoplasm: clinicopathologic analysis of five cases
    Alexander J F Lazar
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Dermatopathol 26:273-9. 2004
    ..These tumors appear to be mesenchymal in nature, but their precise line of differentiation is unknown. Recognition of these lesions is important to avoid confusion with better-known malignant neoplasms...
  40. pmc Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence
    Wilfredo Cosme-Blanco
    Department of Cancer Genetics, The MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    EMBO Rep 8:497-503. 2007
    ..These results indicate that suppression of spontaneous tumorigenesis by dysfunctional telomeres requires the activation of the p53-dependent cellular senescence pathway...
  41. pmc A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence
    Easwar Natarajan
    Department of Dermatology, Brigham and Women s Hospital and Harvard Skin Disease Research Center, Harvard Institutes of Medicine, Room 664, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Am J Pathol 168:1821-37. 2006
    ..These results reveal fundamental features of a keratinocyte hyper-motility/growth-arrest response that is activated in wound healing, tumor suppression, and during serial culture...
  42. ncbi request reprint Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF)
    Maina Lepourcelet
    Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Development 132:415-27. 2005
    ..Our findings also advance understanding of HDGF functions and implicate this developmentally regulated gene in RNA metabolic pathways that may influence malignant behaviors in colorectal cancer...
  43. doi request reprint The usefulness of p63 detection for differentiating primary from metastatic skin adenocarcinomas
    Doina Ivan
    J Cutan Pathol 35:880-1. 2008
  44. ncbi request reprint Human sebaceous tumors harbor inactivating mutations in LEF1
    Hikaru Takeda
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Med 12:395-7. 2006
    ..Mutant LEF1 not only inhibited expression of beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors...
  45. doi request reprint Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases
    Alistair Robson
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Am J Surg Pathol 32:682-90. 2008
    ..Furthermore, steroid receptor expression should be investigated in these tumors, particularly if a tumor is unlikely to be controlled by surgery alone...
  46. pmc Genetic aberrations of gastrointestinal stromal tumors
    Jilong Yang
    Department of Bone and Soft Tissue Tumors, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin, China
    Cancer 113:1532-43. 2008
    ..A new paradigm of classification, integrating the standard clinical and pathological criteria with molecular aberrations, may permit personalized prognosis and treatment...