Gabriel C Lander

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc The proteasome under the microscope: the regulatory particle in focus
    Gabriel C Lander
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Struct Biol 23:243-51. 2013
  2. pmc Conformational switching of the 26S proteasome enables substrate degradation
    Mary E Matyskiela
    Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Nat Struct Mol Biol 20:781-8. 2013
  3. pmc Complete subunit architecture of the proteasome regulatory particle
    Gabriel C Lander
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Nature 482:186-91. 2012
  4. pmc Go hybrid: EM, crystallography, and beyond
    Gabriel C Lander
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Struct Biol 22:627-35. 2012

Collaborators

  • Mary E Matyskiela
  • Andreas Martin

Detail Information

Publications4

  1. pmc The proteasome under the microscope: the regulatory particle in focus
    Gabriel C Lander
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Struct Biol 23:243-51. 2013
    ..We discuss the biological insights into substrate processing provided by these structures, and the technical hurdles ahead to achieve an atomic resolution structure of the 26 proteasome...
  2. pmc Conformational switching of the 26S proteasome enables substrate degradation
    Mary E Matyskiela
    Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Nat Struct Mol Biol 20:781-8. 2013
    ..Notably, Rpn11 moves from an occluded position to directly above the central pore, thus facilitating substrate deubiquitination concomitant with translocation. ..
  3. pmc Complete subunit architecture of the proteasome regulatory particle
    Gabriel C Lander
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Nature 482:186-91. 2012
    ..We provide a structural basis for the ability of the proteasome to degrade a diverse set of substrates and thus regulate vital cellular processes...
  4. pmc Go hybrid: EM, crystallography, and beyond
    Gabriel C Lander
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Struct Biol 22:627-35. 2012
    ..Since structural studies generally only provide snapshots of these dynamic machines as they accomplish their molecular functions, combining data from many methodologies is crucial to our understanding of molecular function...