Genomes and Genes
Gabriel C Lander
Affiliation: The Scripps Research Institute
- The proteasome under the microscope: the regulatory particle in focusGabriel C Lander
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Curr Opin Struct Biol 23:243-51. 2013..We discuss the biological insights into substrate processing provided by these structures, and the technical hurdles ahead to achieve an atomic resolution structure of the 26 proteasome...
- Conformational switching of the 26S proteasome enables substrate degradationMary E Matyskiela
Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
Nat Struct Mol Biol 20:781-8. 2013..Notably, Rpn11 moves from an occluded position to directly above the central pore, thus facilitating substrate deubiquitination concomitant with translocation. ..
- Complete subunit architecture of the proteasome regulatory particleGabriel C Lander
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Nature 482:186-91. 2012..We provide a structural basis for the ability of the proteasome to degrade a diverse set of substrates and thus regulate vital cellular processes...
- Go hybrid: EM, crystallography, and beyondGabriel C Lander
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Curr Opin Struct Biol 22:627-35. 2012..Since structural studies generally only provide snapshots of these dynamic machines as they accomplish their molecular functions, combining data from many methodologies is crucial to our understanding of molecular function...