Gabriel C Lander

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Conformational switching of the 26S proteasome enables substrate degradation
    Mary E Matyskiela
    Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Nat Struct Mol Biol 20:781-8. 2013
  2. pmc The proteasome under the microscope: the regulatory particle in focus
    Gabriel C Lander
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Struct Biol 23:243-51. 2013
  3. pmc Complete subunit architecture of the proteasome regulatory particle
    Gabriel C Lander
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Nature 482:186-91. 2012
  4. doi request reprint Structures of the RNA-guided surveillance complex from a bacterial immune system
    Blake Wiedenheft
    Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA
    Nature 477:486-9. 2011
  5. pmc Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22
    Jinghua Tang
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0378, USA
    Structure 19:496-502. 2011
  6. pmc Go hybrid: EM, crystallography, and beyond
    Gabriel C Lander
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Struct Biol 22:627-35. 2012
  7. pmc High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis
    Gregory M Alushin
    Biophysics Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 157:1117-29. 2014
  8. pmc Molecular architecture of human polycomb repressive complex 2
    Claudio Ciferri
    Department of Molecular and Cell Biology, University of California, Berkeley, United States
    elife 1:e00005. 2012

Collaborators

Detail Information

Publications8

  1. pmc Conformational switching of the 26S proteasome enables substrate degradation
    Mary E Matyskiela
    Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Nat Struct Mol Biol 20:781-8. 2013
    ..Notably, Rpn11 moves from an occluded position to directly above the central pore, thus facilitating substrate deubiquitination concomitant with translocation. ..
  2. pmc The proteasome under the microscope: the regulatory particle in focus
    Gabriel C Lander
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Struct Biol 23:243-51. 2013
    ..We discuss the biological insights into substrate processing provided by these structures, and the technical hurdles ahead to achieve an atomic resolution structure of the 26 proteasome...
  3. pmc Complete subunit architecture of the proteasome regulatory particle
    Gabriel C Lander
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Nature 482:186-91. 2012
    ..We provide a structural basis for the ability of the proteasome to degrade a diverse set of substrates and thus regulate vital cellular processes...
  4. doi request reprint Structures of the RNA-guided surveillance complex from a bacterial immune system
    Blake Wiedenheft
    Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA
    Nature 477:486-9. 2011
    ..This conformational rearrangement may serve as a signal that recruits a trans-acting nuclease (Cas3) for destruction of invading nucleic-acid sequences...
  5. pmc Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22
    Jinghua Tang
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0378, USA
    Structure 19:496-502. 2011
    ....
  6. pmc Go hybrid: EM, crystallography, and beyond
    Gabriel C Lander
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Opin Struct Biol 22:627-35. 2012
    ..Since structural studies generally only provide snapshots of these dynamic machines as they accomplish their molecular functions, combining data from many methodologies is crucial to our understanding of molecular function...
  7. pmc High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis
    Gregory M Alushin
    Biophysics Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 157:1117-29. 2014
    ..Lateral interactions are similar in all conditions we examined, suggesting that microtubule lattice stability is primarily modulated at longitudinal interfaces...
  8. pmc Molecular architecture of human polycomb repressive complex 2
    Claudio Ciferri
    Department of Molecular and Cell Biology, University of California, Berkeley, United States
    elife 1:e00005. 2012
    ..Regions in PRC2 that interact with modified histone tails are localized near the methyltransferase site, suggesting a molecular mechanism for the chromatin-based regulation of PRC2 activity.DOI:http://dx.doi.org/10.7554/eLife.00005.001...