Genomes and Genes
Gabriel C Lander
Affiliation: The Scripps Research Institute
- The proteasome under the microscope: the regulatory particle in focusGabriel C Lander
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Curr Opin Struct Biol 23:243-51. 2013..We discuss the biological insights into substrate processing provided by these structures, and the technical hurdles ahead to achieve an atomic resolution structure of the 26 proteasome...
- Conformational switching of the 26S proteasome enables substrate degradationMary E Matyskiela
Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
Nat Struct Mol Biol 20:781-8. 2013..Notably, Rpn11 moves from an occluded position to directly above the central pore, thus facilitating substrate deubiquitination concomitant with translocation. ..
- High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysisGregory M Alushin
Biophysics Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA
Cell 157:1117-29. 2014..Lateral interactions are similar in all conditions we examined, suggesting that microtubule lattice stability is primarily modulated at longitudinal interfaces...
- Structures of the RNA-guided surveillance complex from a bacterial immune systemBlake Wiedenheft
Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA
Nature 477:486-9. 2011..This conformational rearrangement may serve as a signal that recruits a trans-acting nuclease (Cas3) for destruction of invading nucleic-acid sequences...
- Complete subunit architecture of the proteasome regulatory particleGabriel C Lander
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Nature 482:186-91. 2012..We provide a structural basis for the ability of the proteasome to degrade a diverse set of substrates and thus regulate vital cellular processes...
- Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22Jinghua Tang
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0378, USA
Structure 19:496-502. 2011....
- Go hybrid: EM, crystallography, and beyondGabriel C Lander
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Curr Opin Struct Biol 22:627-35. 2012..Since structural studies generally only provide snapshots of these dynamic machines as they accomplish their molecular functions, combining data from many methodologies is crucial to our understanding of molecular function...
- The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunitsBrooke M Gardner
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA Miller Institute for Basic Research in Science, University of California, Berkeley, Berkeley, CA 94720, USA
J Mol Biol 427:1375-88. 2015..ATP hydrolysis by Pex1 is highly coordinated with that of Pex6. Furthermore, Pex15, the membrane anchor required for Pex1/Pex6 recruitment to peroxisomes, inhibits the ATP-hydrolysis activity of Pex1/Pex6. ..
- Molecular architecture of human polycomb repressive complex 2Claudio Ciferri
Department of Molecular and Cell Biology, University of California, Berkeley, United States
elife 1:e00005. 2012..Regions in PRC2 that interact with modified histone tails are localized near the methyltransferase site, suggesting a molecular mechanism for the chromatin-based regulation of PRC2 activity.DOI:http://dx.doi.org/10.7554/eLife.00005.001...