R Lai

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Establishment and characterization of a new mantle cell lymphoma cell line, Mino
    R Lai
    Department of Hematopathology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 72, Houston, TX 77030, USA
    Leuk Res 26:849-55. 2002
  2. ncbi request reprint A novel four-color PCR assay to assess T-cell receptor gamma gene rearrangements in lymphoproliferative lesions
    F Vega
    Division of Pathology and Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, 8515 Fannin, Houston, TX 77030-4095, USA
    Am J Clin Pathol 116:17-24. 2001
  3. ncbi request reprint Leukemic mantle cell lymphoma: clinical and pathologic spectrum of twenty-three cases
    E Schlette
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mod Pathol 14:1133-40. 2001
  4. ncbi request reprint Hepatosplenic gamma/delta T-cell lymphoma in bone marrow. A sinusoidal neoplasm with blastic cytologic features
    F Vega
    Dept of Hematopathology, Box 72, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 116:410-9. 2001
  5. ncbi request reprint Cytogenetic findings in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course
    A Mansoor
    Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 116:543-9. 2001
  6. ncbi request reprint Cytogenetic findings in mantle cell lymphoma cases with a high level of peripheral blood involvement have a distinct pattern of abnormalities
    M Onciu
    Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 116:886-92. 2001
  7. ncbi request reprint p53 gene mutations are uncommon but p53 is commonly expressed in anaplastic large-cell lymphoma
    G Z Rassidakis
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 19:1663-9. 2005
  8. ncbi request reprint Decreased expression level of SH2 domain-containing protein tyrosine phosphatase-1 (Shp1) is associated with progression of chronic myeloid leukaemia
    H M Amin
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Pathol 212:402-10. 2007
  9. ncbi request reprint STAT3 is activated in a subset of the Ewing sarcoma family of tumours
    R Lai
    Department of Pathology and Laboratory Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Pathol 208:624-32. 2006
  10. ncbi request reprint Different breakage-prone regions on chromosome 1 detected in t(11;14)-positive mantle cell lymphoma cell lines and multiple myeloma cell lines are associated with different tumor progression-related mechanisms
    C Rudolph
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Cytogenet Genome Res 112:213-21. 2006

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Establishment and characterization of a new mantle cell lymphoma cell line, Mino
    R Lai
    Department of Hematopathology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 72, Houston, TX 77030, USA
    Leuk Res 26:849-55. 2002
    ..Sequencing of the TP53 gene revealed a mutation (codon 147(valine-->glycine)) in exon 5. Epstein Barr virus was absent. In summary, Mino is a new MCL cell line that may be useful to study the pathogenesis of MCL...
  2. ncbi request reprint A novel four-color PCR assay to assess T-cell receptor gamma gene rearrangements in lymphoproliferative lesions
    F Vega
    Division of Pathology and Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, 8515 Fannin, Houston, TX 77030-4095, USA
    Am J Clin Pathol 116:17-24. 2001
    ....
  3. ncbi request reprint Leukemic mantle cell lymphoma: clinical and pathologic spectrum of twenty-three cases
    E Schlette
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mod Pathol 14:1133-40. 2001
    ..Chromosome 17 abnormalities are common in leukemic MCL, may be involved in pathogenesis, and are associated with p53 expression...
  4. ncbi request reprint Hepatosplenic gamma/delta T-cell lymphoma in bone marrow. A sinusoidal neoplasm with blastic cytologic features
    F Vega
    Dept of Hematopathology, Box 72, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 116:410-9. 2001
    ..HSTCL often can be recognized in bone marrow by its unique combination of a sinusoidal pattern in core biopsy specimens and blastic cytology in aspirate smears...
  5. ncbi request reprint Cytogenetic findings in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course
    A Mansoor
    Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 116:543-9. 2001
    ..We conclude that abnormal cytogenetic findings in LPL/WM correlate with the polymorphous subtype and poor prognosis...
  6. ncbi request reprint Cytogenetic findings in mantle cell lymphoma cases with a high level of peripheral blood involvement have a distinct pattern of abnormalities
    M Onciu
    Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 116:886-92. 2001
    ..2, 17q) in leukemic MCL but were only numeric in nodal MCL. Thus, leukemic MCL differs from nodal MCL in their cytogenetic profiles, which may contribute to the clinical presentation...
  7. ncbi request reprint p53 gene mutations are uncommon but p53 is commonly expressed in anaplastic large-cell lymphoma
    G Z Rassidakis
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 19:1663-9. 2005
    ..78 vs 0.91%, P = 0.0003). We conclude that the p53 gene is rarely mutated in ALK+ and ALK- ALCL tumors. Nevertheless, wild-type p53 gene product is commonly overexpressed in ALCL and may be functional in a subset of these tumors...
  8. ncbi request reprint Decreased expression level of SH2 domain-containing protein tyrosine phosphatase-1 (Shp1) is associated with progression of chronic myeloid leukaemia
    H M Amin
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Pathol 212:402-10. 2007
    ..Also, the decrease in Shp1 and subsequently its inhibitory effect on Bcr-Abl could provide an explanation for imatinib resistance seen in advanced stage CML patients...
  9. ncbi request reprint STAT3 is activated in a subset of the Ewing sarcoma family of tumours
    R Lai
    Department of Pathology and Laboratory Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Pathol 208:624-32. 2006
    ..In conclusion, STAT3 activation is present in approximately half of ESFT and correlates with clinical features. The role of STAT3 activation in ESFT pathogenesis seems to be independent of the type of EWS/Ets translocation...
  10. ncbi request reprint Different breakage-prone regions on chromosome 1 detected in t(11;14)-positive mantle cell lymphoma cell lines and multiple myeloma cell lines are associated with different tumor progression-related mechanisms
    C Rudolph
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Cytogenet Genome Res 112:213-21. 2006
    ..Our findings may indicate that different pathways of clonal evolution are involved in these morphologically distinct lymphomas harboring an identical primary chromosome aberration, t(11;14)...
  11. ncbi request reprint Megaprimer mutagenesis using very long primers
    R Lai
    University of Queensland, Brisbane, Queensland, Australia
    Biotechniques 34:52-4, 56. 2003
  12. ncbi request reprint Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma
    Y Han
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Leukemia 20:1602-9. 2006
    ..SHP1 appears to downregulate JAK3 by two mechanisms: tyrosine dephosphorylation and increased degradation via the proteasome pathway...
  13. ncbi request reprint High ZAP-70 expression correlates with worse clinical outcome in mantle cell lymphoma
    D Hui
    Leukemia 20:1905-8. 2006
  14. pmc Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma
    J Dien Bard
    Department of Laboratory Medicine and Pathology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada
    Leukemia 22:1595-603. 2008
    ..To conclude, for the first time, we demonstrate the importance of the IL-22 autocrine pathway in a lymphoid malignancy, and reveal yet another novel function of NPM-ALK...
  15. doi request reprint Quantitation of cytological parameters of malignant lymphocytes using computerized image analysis
    S A Hamid Jahanmehr
    Hematopathology, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Canada
    Int J Lab Hematol 30:278-85. 2008
    ..The results from image analysis may assist in defining morphological criteria and in developing quantitative cell morphology...