Affiliation: The Rockefeller University
- Phenotypic diversity, population growth, and information in fluctuating environmentsEdo Kussell
Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021 6399, USA
Science 309:2075-8. 2005..The optimal switching rates then mimic the statistics of environmental changes. We derive a relation between the long-term growth rate of the organism and the information available about its fluctuating environment...
- The designability hypothesis and protein evolutionEdo Kussell
Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Protein Pept Lett 12:111-6. 2005..It is argued that designability is one component of fold fitness, but most likely not a dominant one...
- Polymer-population mapping and localization in the space of phenotypesEdo Kussell
Laboratory of Living Matter and Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Avenue, Box 34, New York, New York 10021, USA
Phys Rev Lett 97:068101. 2006..Using this mapping, we develop a path integral formulation for populations and predict the existence of a biological counterpart for the well-known heteropolymer localization phase transition...
- Individual histories and selection in heterogeneous populationsStanislas Leibler
Center for Studies in Physics and Biology, and Laboratory of Living Matter, The Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021, USA
Proc Natl Acad Sci U S A 107:13183-8. 2010....
- Bacterial persistence: a model of survival in changing environmentsEdo Kussell
Rockefeller University, New York, New York 10021 6399, USA
Genetics 169:1807-14. 2005..In contrast to typical examples of adaptations to features of a single environment, persistence appears to constitute an adaptation that is tuned to the distribution of environmental change...
- Evolution in microbesEdo Kussell
Center for Genomics and Systems Biology, Department of Biology, Department of Physics, New York University, New York, New York 10003, USA
Annu Rev Biophys 42:493-514. 2013..Second, populations are viewed from a physiological perspective, and their nongenetic heterogeneity is examined. Bringing together these two viewpoints remains a major challenge for the future...
- Stochastic de-repression of Rhodopsins in single photoreceptors of the fly retinaPranidhi Sood
Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York, USA
PLoS Comput Biol 8:e1002357. 2012..Our results indicate that even in the absence of Dve, the Rhodopsin regulatory network can maintain highly stable states. We propose that the role of Dve in outer PRs is to buffer against rare fluctuations in this network...
- Side-chain dynamics and protein foldingEdo Kussell
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Proteins 52:303-21. 2003..The postnucleation processes by which side chains relax are characterized by very slow dynamics and many barrier crossings, and thus resemble the behavior of a glass...
- Glassy dynamics of side-chain ordering in a simple model of protein foldingEdo Kussell
Department of Biophysics, Harvard University, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Phys Rev Lett 89:168101. 2002..We find that as temperature is lowered, side-chain ordering becomes much slower than backbone folding. The presence of side chains leads to nonexponential kinetics and a broad distribution of relaxation times...
- A structure-based method for derivation of all-atom potentials for protein foldingEdo Kussell
Department of Biophysics, Harvard University, 240 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:5343-8. 2002....