C Dean Kurth

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Cerebral hemoglobin and optical pathlength influence near-infrared spectroscopy measurement of cerebral oxygen saturation
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Anesth Analg 84:1297-305. 1997
  2. ncbi request reprint Near-infrared spectroscopy cerebral oxygen saturation thresholds for hypoxia-ischemia in piglets
    C Dean Kurth
    Brain Research Laboratory, Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Cereb Blood Flow Metab 22:335-41. 2002
  3. ncbi request reprint Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, The Joseph Stokes Jr Research Institute, and The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 95:959-64. 2001
  4. ncbi request reprint Cerebral oxygen saturation before congenital heart surgery
    C D Kurth
    Department of Anesthesiology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Ann Thorac Surg 72:187-92. 2001
  5. ncbi request reprint Regional patterns of neuronal death after deep hypothermic circulatory arrest in newborn pigs
    C D Kurth
    Brain Research Laboratory, Joseph Stokes Research Institute, Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 118:1068-77. 1999
  6. ncbi request reprint A multiwavelength frequency-domain near-infrared cerebral oximeter
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Phys Med Biol 44:727-40. 1999
  7. ncbi request reprint Comparison of pH-stat and alpha-stat cardiopulmonary bypass on cerebral oxygenation and blood flow in relation to hypothermic circulatory arrest in piglets
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104, USA
    Anesthesiology 89:110-8. 1998
  8. ncbi request reprint Brain cooling efficiency with pH-stat and alpha-stat cardiopulmonary bypass in newborn pigs
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, PA 19104, USA
    Circulation 96:II-358-63. 1997
  9. doi request reprint Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets
    C Dean Kurth
    Department of Anesthesiology, Cincinnati Children s Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Anesth Analg 108:1268-77. 2009
  10. ncbi request reprint Apoptotic neuronal death following deep hypothermic circulatory arrest in piglets
    Dara Ditsworth
    Brain Research Laboratory, Department of Anesthesiology and Critical Care Medicine, The Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Anesthesiology 98:1119-27. 2003

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Cerebral hemoglobin and optical pathlength influence near-infrared spectroscopy measurement of cerebral oxygen saturation
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Anesth Analg 84:1297-305. 1997
    ..Instruments to account for these factors may improve NIRS cerebral oxygen saturation measurements...
  2. ncbi request reprint Near-infrared spectroscopy cerebral oxygen saturation thresholds for hypoxia-ischemia in piglets
    C Dean Kurth
    Brain Research Laboratory, Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Cereb Blood Flow Metab 22:335-41. 2002
    ....
  3. ncbi request reprint Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, The Joseph Stokes Jr Research Institute, and The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Anesthesiology 95:959-64. 2001
    ..Volatile anesthetics have neuroprotective properties against both global and focal ischemia at normothermia. The authors examined the hemodynamic and neuroprotective effects of desflurane in a piglet CPB-DHCA model...
  4. ncbi request reprint Cerebral oxygen saturation before congenital heart surgery
    C D Kurth
    Department of Anesthesiology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Ann Thorac Surg 72:187-92. 2001
    ..To evaluate preoperative cerebral oxygenation, this study determined cerebral O2 saturation (ScO2) in CHD and healthy children...
  5. ncbi request reprint Regional patterns of neuronal death after deep hypothermic circulatory arrest in newborn pigs
    C D Kurth
    Brain Research Laboratory, Joseph Stokes Research Institute, Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 118:1068-77. 1999
    ..In adult normothermic ischemia, brain cells in certain regions die, some by necrosis and others by apoptosis (programmed cell death). This study characterized regional brain cell death after DHCA in newborn pigs...
  6. ncbi request reprint A multiwavelength frequency-domain near-infrared cerebral oximeter
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Phys Med Biol 44:727-40. 1999
    ..In conclusion, fdNIRS accurately measures SO2 in an in vitro brain model, although low haemoglobin concentration and extracranial tissue of adult thickness influence accuracy...
  7. ncbi request reprint Comparison of pH-stat and alpha-stat cardiopulmonary bypass on cerebral oxygenation and blood flow in relation to hypothermic circulatory arrest in piglets
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104, USA
    Anesthesiology 89:110-8. 1998
    ..This study examined cortical oxygen saturation (ScO2), cortical blood flow (CBF), and cortical physiologic recovery in relation to deep hypothermic arrest with alpha-stat or pH-stat CPB...
  8. ncbi request reprint Brain cooling efficiency with pH-stat and alpha-stat cardiopulmonary bypass in newborn pigs
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, PA 19104, USA
    Circulation 96:II-358-63. 1997
    ..The pH-stat method is hypothesized to protect the brain through improved cooling and/or rewarming. We examined brain cooling and rewarming during pH-stat and alpha-stat cardiopulmonary bypass in 12 newborn pigs...
  9. doi request reprint Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets
    C Dean Kurth
    Department of Anesthesiology, Cincinnati Children s Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Anesth Analg 108:1268-77. 2009
    ..We investigated the relationship between H-I duration at Sc(O2) 35%, a viability threshold which causes neurophysiological impairment, to neurological outcome...
  10. ncbi request reprint Apoptotic neuronal death following deep hypothermic circulatory arrest in piglets
    Dara Ditsworth
    Brain Research Laboratory, Department of Anesthesiology and Critical Care Medicine, The Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Anesthesiology 98:1119-27. 2003
    ..Caspases, cytochrome c, tumor necrosis factor (TNF), and Fas play a role in apoptosis in many ischemic models. This study examined the expression of these factors in a DHCA piglet model...
  11. ncbi request reprint Desflurane improves neurologic outcome after low-flow cardiopulmonary bypass in newborn pigs
    Andreas W Loepke
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Anesthesiology 97:1521-7. 2002
    ..Desflurane confers neuroprotection against ischemia at normothermia and for DHCA. This study compared neurologic outcome of a desflurane-based with a fentanyl-based anesthetic for LF-CPB...
  12. ncbi request reprint An MRI study of neurological injury before and after congenital heart surgery
    William T Mahle
    Department of Pediatrics, Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Penn, USA
    Circulation 106:I109-14. 2002
    ..To understand the impact of preoperative events and to characterize the evaluation of neurological injury, we performed serial magnetic resonance imaging (MRI) studies of the brain in a cohort of neonates undergoing open-heart surgery...
  13. ncbi request reprint The plasma pharmacokinetics and cerebral spinal fluid penetration of intravenous topiramate in newborn pigs
    Jeffrey L Galinkin
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biopharm Drug Dispos 25:265-71. 2004
    ..The plasma pharmacokinetics, cerebrospinal fluid (CSF) penetration and pharmacodynamics of intravenous topiramate were studied in an established piglet model of hypoxia-ischemia...
  14. ncbi request reprint Effects of inspired hypoxic and hypercapnic gas mixtures on cerebral oxygen saturation in neonates with univentricular heart defects
    Chandra Ramamoorthy
    Department of Anesthesiology Critical Care Medicine, and Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Anesthesiology 96:283-8. 2002
    ..This study examined the effect of these treatments on cerebral oxygen saturation and systemic hemodynamics...
  15. doi request reprint Quantification of serum fentanyl concentrations from umbilical cord blood during ex utero intrapartum therapy
    Kha M Tran
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Anesth Analg 114:1265-7. 2012
    ..The time between IM administration of fentanyl and collection of the sample was 37 minutes (5-86 minutes). Fentanyl was detected in all of the samples, with a median serum concentration of 14.0 ng/mL (4.3-64.0 ng/mL)...
  16. ncbi request reprint The physiologic effects of isoflurane anesthesia in neonatal mice
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Anesth Analg 102:75-80. 2006
    ..Use of 0.8 MAC isoflurane for evaluation of neuroprotection during hypoxia-ischemia requires mechanical ventilation and glucose supplementation in this model...
  17. ncbi request reprint Development and validation of a multiwavelength spatial domain near-infrared oximeter to detect cerebral hypoxia-ischemia
    Lindsey A Nelson
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Department of Anesthesia and Pediatrics, Institute of Pediatric Anesthesia, Cincinnati, Ohio 45229 3039, USA
    J Biomed Opt 11:064022. 2006
    ..In piglets, the device measures cerebral O(2) saturation with bias +/-4% and precision +/-8%. In conclusion, this NIRS device accurately detects cerebral hypoxia-ischemia and is of a design that is practical for clinical application...
  18. ncbi request reprint Injury pattern of the neonatal brain after hypothermic low-flow cardiopulmonary bypass in a piglet model
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Institute of Pediatric Anesthesia, Cincinnati Children s Hospital Research Foundation, Ohio 45229, USA
    Anesth Analg 101:340-8, table of contents. 2005
    ..Less hippocampal damage was associated with higher blood glucose levels. Less functional neurological impairment and basal ganglia damage correlated with higher postoperative hematocrit...
  19. ncbi request reprint Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion
    Catherine L Dent
    Department of Pediatrics, Division of Cardiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Thorac Cardiovasc Surg 130:1523-30. 2005
    ..To evaluate the effect of this technique on brain ischemia, we performed serial brain magnetic resonance imaging in a cohort of infants before and after the Norwood operation using regional cerebral perfusion...
  20. ncbi request reprint Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion
    Catherine L Dent
    Department of Pediatrics Division of Cardiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Thorac Cardiovasc Surg 131:190-7. 2006
    ..To evaluate the impact of this technique on brain ischemia, we performed serial brain magnetic resonance imaging in a cohort of infants before and after the Norwood operation using regional cerebral perfusion...
  21. ncbi request reprint Quality management in the delivery of pediatric anesthesia care
    Anna M Varughese
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Int Anesthesiol Clin 44:119-39. 2006