Jonathan Kurie

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 64:9027-34. 2004
  2. ncbi request reprint Drugging the bad "AKT-TOR" to overcome TKI-resistant lung cancer
    Jeffrey Settleman
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Cell 12:6-8. 2007
  3. pmc Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations
    Kuicheon Choi
    Department of Thoracic Head and Neck Medical Oncology, M D Anderson Cancer Center, The University of Texas, Houston, Texas, United States of America
    PLoS ONE 2:e1226. 2007
  4. pmc Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer
    Yanan Yang
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 3:e2220. 2008
  5. pmc Fibulin-2 is a driver of malignant progression in lung adenocarcinoma
    Brandi N Baird
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 8:e67054. 2013
  6. ncbi request reprint Role of protein kinase B-dependent signaling in lung tumorigenesis
    Jonathan M Kurie
    Department of Thoracic Head and Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Chest 125:141S-4S. 2004
  7. pmc Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
    Don L Gibbons
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 23:2140-51. 2009
  8. doi request reprint Impact of smoking cessation on global gene expression in the bronchial epithelium of chronic smokers
    Li Zhang
    Department of Bioinformatics The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 1:112-8. 2008
  9. ncbi request reprint Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
    Marie Wislez
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 65:3226-35. 2005
  10. pmc Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer
    Kentaro Iwanaga
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:1119-27. 2008

Research Grants

  1. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2007
  2. Inflammation in Oncogenic K-ras-induced Lung Tumorigenesis
    Jonathan M Kurie; Fiscal Year: 2010
  3. Mediators of Oncogenic KRAS in Lung Adenocarcinoma
    Jonathan M Kurie; Fiscal Year: 2010
  4. Mediators of Oncogenic KRAS in Lung Adenocarcinoma
    Jonathan Kurie; Fiscal Year: 2007
  5. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2007
  6. Inflammation in Oncogenic K-ras-induced Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2009
  7. Mediators of Oncogenic KRAS in Lung Adenocarcinoma
    Jonathan Kurie; Fiscal Year: 2009
  8. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2009
  9. Kinase Signaling in Lung Tumorigenesis
    Jonathan M Kurie; Fiscal Year: 2010
  10. Mediators of Oncogenic KRAS in Lung Adenocarcinoma
    Jonathan Kurie; Fiscal Year: 2006

Detail Information

Publications55

  1. ncbi request reprint Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 64:9027-34. 2004
    ..These HBEC lines are a valuable new tool for studying of the pathogenesis of lung cancer...
  2. ncbi request reprint Drugging the bad "AKT-TOR" to overcome TKI-resistant lung cancer
    Jeffrey Settleman
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Cell 12:6-8. 2007
    ..However, combining HKI-272 with rapamycin promoted rapid tumor regression, suggesting a therapeutic strategy to overcome drug resistance...
  3. pmc Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations
    Kuicheon Choi
    Department of Thoracic Head and Neck Medical Oncology, M D Anderson Cancer Center, The University of Texas, Houston, Texas, United States of America
    PLoS ONE 2:e1226. 2007
    ....
  4. pmc Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer
    Yanan Yang
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 3:e2220. 2008
    ..The signals activated by oncogenic K-ras that mediate BASC expansion have not been fully defined...
  5. pmc Fibulin-2 is a driver of malignant progression in lung adenocarcinoma
    Brandi N Baird
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 8:e67054. 2013
    ..We conclude that fibulin-2 is a driver of malignant progression in lung adenocarcinoma and plays an unexpected role in collagen cross-linking and tumor cell adherence to collagen...
  6. ncbi request reprint Role of protein kinase B-dependent signaling in lung tumorigenesis
    Jonathan M Kurie
    Department of Thoracic Head and Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Chest 125:141S-4S. 2004
    ....
  7. pmc Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
    Don L Gibbons
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 23:2140-51. 2009
    ..We conclude that tumor cell metastasis is regulated by miR-200 expression, which changes in response to contextual extracellular cues...
  8. doi request reprint Impact of smoking cessation on global gene expression in the bronchial epithelium of chronic smokers
    Li Zhang
    Department of Bioinformatics The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 1:112-8. 2008
    ....
  9. ncbi request reprint Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
    Marie Wislez
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 65:3226-35. 2005
    ....
  10. pmc Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer
    Kentaro Iwanaga
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:1119-27. 2008
    ..Thus, Pten inactivation cooperated with oncogenic K-ras in promoting lung tumorigenesis...
  11. ncbi request reprint Increased phospho-AKT (Ser(473)) expression in bronchial dysplasia: implications for lung cancer prevention studies
    Anne S Tsao
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 12:660-4. 2003
    ..Given its role as a mediator of malignant transformation, p-AKT should be investigated as a potential target in future lung cancer prevention studies...
  12. pmc Biological activity of celecoxib in the bronchial epithelium of current and former smokers
    Edward S Kim
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 3:148-59. 2010
    ..Celecoxib (400 mg twice daily) was biologically active in the bronchial epithelium of current and former smokers; additional studies on the efficacy of celecoxib in non-small cell lung cancer chemoprevention may be warranted...
  13. ncbi request reprint 9-cis-retinoic acid treatment increases serum concentrations of alpha-tocopherol in former smokers
    Ji Youn Han
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:2305-11. 2005
    ..Because hyperlipidemia is a known side effect of retinoids, we also evaluated the association between serum alpha-tocopherol and lipids in the same population...
  14. pmc Distinct biological roles for the notch ligands Jagged-1 and Jagged-2
    Kuicheon Choi
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:17766-74. 2009
    ..Our findings suggest that JAG1 and JAG2 have distinct biological roles including a previously undiscovered role for JAG2 in regulating the expression of cytokines that can promote antitumor immunity...
  15. ncbi request reprint Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer
    Ho Young Lee
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2970-5. 2002
    ..Here, we investigated gene delivery to lung tumors by aerosolization of adenoviral vectors incorporated into calcium phosphate precipitates...
  16. ncbi request reprint Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway
    Dianren Xia
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:3507-19. 2007
    ..Thus, MKK4 promotes cell survival by activating phosphatidylinositol 3-kinase through an NFkappaB/PTEN-dependent pathway...
  17. pmc Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma
    Don L Gibbons
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 4:e5401. 2009
    ..Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood...
  18. ncbi request reprint Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma
    Serap Hasturk
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 94:1023-31. 2002
    ..Cyclooxygenase (Cox) is the main target enzyme for the nonsteroidal antiinflammatory drugs that have been shown to suppress carcinogenesis in both experimental models and epidemiologic studies...
  19. ncbi request reprint In vivo respiratory-gated micro-CT imaging in small-animal oncology models
    Dawn Cavanaugh
    University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Imaging 3:55-62. 2004
    ..15 Gy for this respiratory-gated micro-CT imaging protocol. The combination of high-resolution CT imaging and respiratory-gated acquisitions appears well-suited to serial in vivo scanning...
  20. pmc Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells
    Jie Zhang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Cancer Prev Res (Phila) 1:201-7. 2008
    ....
  21. pmc Proliferative changes in the bronchial epithelium of former smokers treated with retinoids
    Walter N Hittelman
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Box 19, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 99:1603-12. 2007
    ....
  22. ncbi request reprint Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer
    Ho Young Lee
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 62:3530-7. 2002
    ....
  23. ncbi request reprint The novel and effective nonplatinum, nontaxane combination of gemcitabine and vinorelbine in advanced nonsmall cell lung carcinoma: potential for decreased toxicity and combination with biological therapy
    Roy S Herbst
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 95:340-53. 2002
    ..The authors conducted a formal Phase II trial to evaluate the efficacy of this combination in both untreated and previously treated patients with Stage IIIB (with pleural effusion) or Stage IV NSCLC...
  24. ncbi request reprint Murine lung tumor measurement using respiratory-gated micro-computed tomography
    Dianna D Cody
    Department of Imaging Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Invest Radiol 40:263-9. 2005
    ..The authors explored micro-computed tomography (micro-CT) to quantify lung tumor number and volume in a specific genetic mouse model for lung cancer...
  25. pmc A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras
    Yanan Yang
    Departments of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 7:952-60. 2008
    ..We conclude that PHA-665752 inhibited lung tumorigenesis in Kras(LA1) mice and may provide a novel therapeutic approach to the prevention of K-ras-mutant NSCLC...
  26. ncbi request reprint Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy
    Stephen G Swisher
    Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:93-101. 2003
    ..We designed a prospective single arm Phase II study to evaluate the feasibility and mechanisms of apoptosis induction after Ad-p53 (INGN 201) gene transfer and radiation therapy in patients with non-small cell lung cancer...
  27. pmc Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis
    Hongxia Sun
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 1:316-28. 2008
    ..We propose that targeting CREB or NF-kappaB using small-molecule inhibitors, such as KG-501, holds promise as a preventive and/or therapeutic approach for NSCLC...
  28. ncbi request reprint Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells
    Ho Young Lee
    Department of Thoracic Head and Neck Medical Oncology, Unit 432, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 10:1074-9. 2004
    ....
  29. pmc Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model
    Seyed Javad Moghaddam
    Department of Pulmonary Medicine, University of Texas M D Anderson Cancer Center, 2121 W Holcombe Boulevard, Suite 703F, Houston, TX 77030, USA
    Am J Respir Cell Mol Biol 40:443-53. 2009
    ..We conclude that COPD-like airway inflammation promotes lung carcinogenesis in a background of a G12D-activated K-ras allele in airway secretory cells...
  30. pmc A new method for respiratory gating during microcomputed tomography of lung in mice
    Evan M Johnson
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Am Assoc Lab Anim Sci 47:46-56. 2008
    ..A secondary experiment was performed to assess the stress placed on mice by the acquisition techniques...
  31. pmc Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment
    Li Zhong
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Cancer Res 68:7237-45. 2008
    ..Strategies to inhibit tumor/stromal cell interactions may be useful as therapeutic approaches in NSCLC patients...
  32. ncbi request reprint High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras
    Marie Wislez
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:4198-207. 2006
    ..Thus, high expression of CXCR2 ligands may contribute to the expansion of early alveolar neoplastic lesions induced by oncogenic KRAS...
  33. ncbi request reprint Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival
    Ho Young Lee
    Departments of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:23630-8. 2003
    ..Furthermore, LY294002 induced apoptosis of MKK4-null but not wild-type mouse embryo fibroblasts. Therefore, we propose that, in the setting of wild-type PTEN, PI3K- and MKK4/JNK-dependent pathways cooperate to maintain cell survival...
  34. doi request reprint Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs
    Manisha Bhutani
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Cancer Prev Res (Phila) 1:39-44. 2008
    ....
  35. ncbi request reprint High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor
    Nobukazu Fujimoto
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11478-85. 2005
    ..Thus, lung adenocarcinoma cells that depend on EGFR for survival constitutively activate the receptor through a combination of genetic mutations and overexpression of EGFR dimeric partners and their ligands...
  36. ncbi request reprint Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers
    Jean Charles Soria
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 95:165-8. 2003
    ....
  37. ncbi request reprint Loss of retinoic acid receptor beta gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines
    Young Ah Suh
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:3945-9. 2002
    ....
  38. pmc c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha
    Harish Srinivas
    Department of Thoracic Head and Neck Oncology Unit 432, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 25:1054-69. 2005
    ..These findings point to JNK as a key mediator of aberrant retinoid signaling in lung cancer cells...
  39. pmc Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis
    Nili Jin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 136:3347-56. 2009
    ..These results demonstrate that Mig-6 is required for prenatal and perinatal lung development, in part through the regulation of EGF signaling, as well as for maintaining proper pulmonary vascularization...
  40. ncbi request reprint Phase I study of weekly alternating therapy with irinotecan/cisplatin and etoposide/cisplatin for patients with small-cell lung cancer
    Faye M Johnson
    Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, USA
    Clin Lung Cancer 5:40-5. 2003
    ..With the exception of the 2 deaths, the therapy was well tolerated and active. Phase II evaluation of the regimen in patients with extensive-stage SCLC is ongoing...
  41. pmc SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines
    Jie Zhang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Pathol 170:366-76. 2007
    ..We conclude that SFKs are activated in NSCLC biopsy samples, promote the survival of EGFR-dependent NSCLC cells, and should be investigated as therapeutic targets in NSCLC patients...
  42. ncbi request reprint A phase I study of topotecan/paclitaxel alternating with etoposide/cisplatin and thoracic irradiation in patients with limited small cell lung cancer
    Charles Lu
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:2085-91. 2003
    ..In an effort to integrate paclitaxel and topotecan into the treatment of limited disease (LD) SCLC, we conducted a Phase I study of these agents administered as initial induction therapy...
  43. ncbi request reprint Dose-dense therapy with a novel irinotecan regimen for small-cell lung cancer
    Faye M Johnson
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Oncology (Williston Park) 17:17-21. 2003
    ..Patients generally tolerated the weekly alternating chemotherapy with irinotecan/cisplatin and etoposide/cisplatin well, and this combination possessed significant antitumor activity in small-cell lung cancer...
  44. ncbi request reprint Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products
    Gautam Sethi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 179:1926-33. 2007
    ..Overall, our results indicate that MKK4 plays a central role in TNF-induced apoptosis through the regulation of NF-kappaB-regulated gene products...
  45. pmc Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor ╬│2 expression
    Young Ho Ahn
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell Biol 31:4270-85. 2011
    ..We conclude that Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing PPAR╬│2 levels...
  46. pmc miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1
    Jonathon D Roybal
    University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cancer Res 9:25-35. 2011
    ..Flt1 knockdown decreased the growth and metastasis of tumor cells in syngeneic mice. We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1...
  47. pmc MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch
    Young Ho Ahn
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:29399-404. 2009
    ..These data suggest that MKK4 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase Itch, which has a fundamental role in the mechanism that controls MKK4 protein levels...
  48. ncbi request reprint Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    Jean Charles Soria
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Cancer Res 8:1178-84. 2002
    ....
  49. ncbi request reprint Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: results from a randomized placebo-controlled trial
    Jonathan M Kurie
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 95:206-14. 2003
    ..This study was designed to investigate whether either of two retinoid-based regimens, 9-cis-retinoic acid (RA) or 13-cis-RA plus alpha-tocopherol (AT), could reverse RAR-beta expression loss in former smokers after 3 months of treatment...
  50. ncbi request reprint Cyclin D1 expression in the field of exposure: another piece in the molecular Auerbach puzzle
    Jonathan M Kurie
    J Clin Oncol 21:2056-8. 2003
  51. ncbi request reprint Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer
    Joseph Amann
    Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Cancer Res 65:226-35. 2005
    ..Thus, in addition to EGFR mutations, other factors in NSCLC cells, such as high expression of ErbB family members, may constitutively activate AKT and sensitize cells to EGFR inhibitors...
  52. ncbi request reprint Initial clinical trial of oral TAC-101, a novel retinoic acid receptor-alpha selective retinoid, in patients with advanced cancer
    Naiyer A Rizvi
    Developmental Therapeutics Program, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    J Clin Oncol 20:3522-32. 2002
    ..The goals of this study were to determine the safety, toxicity, and pharmacokinetics of TAC-101, a novel synthetic retinoic acid receptor-alpha (RAR-alpha) selective retinoid, in patients with advanced cancer...
  53. ncbi request reprint Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question
    Kevin M Haigis
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Genes Dev 21:361-6. 2007
  54. pmc Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation
    Koren K Mann
    Montreal Centre for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Clin Invest 115:2924-33. 2005
    ..These data may provide some insight into the rational development of chemotherapeutic combinations involving As2O3 as well as into molecular mechanisms of arsenic-induced carcinogenesis resulting from environmental exposure...
  55. ncbi request reprint A big step in the study of small cell lung cancer
    John D Minna
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Cell 4:163-6. 2003
    ....

Research Grants28

  1. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2007
    ....
  2. Inflammation in Oncogenic K-ras-induced Lung Tumorigenesis
    Jonathan M Kurie; Fiscal Year: 2010
    ..We hope to better understand the mechanisms by which tumor/stromal cell interactions promote lung tumorigenesis and to build a rationale to test CXCR2 as a target for lung cancer prevention and therapy. ..
  3. Mediators of Oncogenic KRAS in Lung Adenocarcinoma
    Jonathan M Kurie; Fiscal Year: 2010
    ....
  4. Mediators of Oncogenic KRAS in Lung Adenocarcinoma
    Jonathan Kurie; Fiscal Year: 2007
    ....
  5. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2007
    ..abstract_text> ..
  6. Inflammation in Oncogenic K-ras-induced Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2009
    ..We hope to better understand the mechanisms by which tumor/stromal cell interactions promote lung tumorigenesis and to build a rationale to test CXCR2 as a target for lung cancer prevention and therapy. ..
  7. Mediators of Oncogenic KRAS in Lung Adenocarcinoma
    Jonathan Kurie; Fiscal Year: 2009
    ....
  8. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2009
    ....
  9. Kinase Signaling in Lung Tumorigenesis
    Jonathan M Kurie; Fiscal Year: 2010
    ....
  10. Mediators of Oncogenic KRAS in Lung Adenocarcinoma
    Jonathan Kurie; Fiscal Year: 2006
    ....
  11. IGFBP 6--A Target in Lung Cancer Prevention
    Jonathan Kurie; Fiscal Year: 2001
    ..Aim 4) To investigate whether IGFBP-6 expression increases in the bronchial epithelium of patients treated with retinoids. ..
  12. IGFBP 6--A Target in Lung Cancer Prevention
    Jonathan Kurie; Fiscal Year: 2002
    ..Aim 4) To investigate whether IGFBP-6 expression increases in the bronchial epithelium of patients treated with retinoids. ..
  13. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2004
    ....
  14. IGFBP 6--A Target in Lung Cancer Prevention
    Jonathan Kurie; Fiscal Year: 2004
    ..Aim 4) To investigate whether IGFBP-6 expression increases in the bronchial epithelium of patients treated with retinoids. ..
  15. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2005
    ....
  16. IGFBP 6--A Target in Lung Cancer Prevention
    Jonathan Kurie; Fiscal Year: 2005
    ..Aim 4) To investigate whether IGFBP-6 expression increases in the bronchial epithelium of patients treated with retinoids. ..
  17. Kinase Signaling in Lung Tumorigenesis
    Jonathan Kurie; Fiscal Year: 2006
    ....
  18. IGFBP 6--A Target in Lung Cancer Prevention
    Jonathan Kurie; Fiscal Year: 2006
    ..Aim 4) To investigate whether IGFBP-6 expression increases in the bronchial epithelium of patients treated with retinoids. ..
  19. Inflammation in Oncogenic K-ras-induced Lung Tumorigenesis
    Jonathan M Kurie; Fiscal Year: 2010
    ..We hope to better understand the mechanisms by which tumor/stromal cell interactions promote lung tumorigenesis and to build a rationale to test CXCR2 as a target for lung cancer prevention and therapy. ..