MACUS KUO

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells
    Im Sook Song
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 3:1543-9. 2004
  2. ncbi request reprint The roles of copper transporters in cisplatin resistance
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Metastasis Rev 26:71-83. 2007
  3. pmc Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals
    Zheng Dong Liang
    Department of Translational Molecular Pathology Route 2951, The University of Texas MD Anderson Cancer Center, 2130 W Holcombe Blvd, Houston, TX, 77030, USA
    J Biol Inorg Chem 19:17-27. 2014
  4. pmc Overcoming platinum drug resistance with copper-lowering agents
    Helen H W Chen
    Department of Translational Molecular Pathology Unit 951, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Anticancer Res 33:4157-61. 2013
  5. pmc Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction
    Yan Long
    Corresponding Author Macus Tien Kuo, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 951, Houston, TX 77030
    Mol Cancer Ther 12:2581-90. 2013
  6. pmc Mechanistic basis for overcoming platinum resistance using copper chelating agents
    Zheng D Liang
    Department of Molecular Pathology, Unit 951, Room 2SCR4 3025, The University of Texas MD Anderson Cancer Center, 7435 Fannin Blvd, Houston, TX 77054, USA
    Mol Cancer Ther 11:2483-94. 2012
  7. pmc Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Res 72:4616-21. 2012
  8. pmc Specificity protein 1 (sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression
    Zheng D Liang
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Mol Pharmacol 81:455-64. 2012
  9. pmc Overcoming cisplatin resistance by mTOR inhibitor in lung cancer
    Chunjing Wu
    University of Miami School of Medicine, 1475 NW 12 Ave, Miami, FL 33136, USA
    Mol Cancer 4:25. 2005
  10. pmc Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Oncotarget 1:246-51. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells
    Im Sook Song
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 3:1543-9. 2004
    ..These results collectively show the importance of hCtr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant variants...
  2. ncbi request reprint The roles of copper transporters in cisplatin resistance
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Metastasis Rev 26:71-83. 2007
    ....
  3. pmc Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals
    Zheng Dong Liang
    Department of Translational Molecular Pathology Route 2951, The University of Texas MD Anderson Cancer Center, 2130 W Holcombe Blvd, Houston, TX, 77030, USA
    J Biol Inorg Chem 19:17-27. 2014
    ..In contrast, Cd(II), another inhibitor of copper transport, downregulates hCtr1 expression by suppressing Sp1 expression. Collectively, our results demonstrate diverse mechanisms of regulating copper metabolism by these heavy metals. ..
  4. pmc Overcoming platinum drug resistance with copper-lowering agents
    Helen H W Chen
    Department of Translational Molecular Pathology Unit 951, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Anticancer Res 33:4157-61. 2013
    ..This short review describes the perspectives of using Cu-lowering agents in overcoming Pt resistance in cancer chemotherapy...
  5. pmc Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction
    Yan Long
    Corresponding Author Macus Tien Kuo, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 951, Houston, TX 77030
    Mol Cancer Ther 12:2581-90. 2013
    ..This study identified multiple targets for overcoming ADI-PEG resistance in cancer chemotherapy using recombinant arginine-degrading enzymes...
  6. pmc Mechanistic basis for overcoming platinum resistance using copper chelating agents
    Zheng D Liang
    Department of Molecular Pathology, Unit 951, Room 2SCR4 3025, The University of Texas MD Anderson Cancer Center, 7435 Fannin Blvd, Houston, TX 77054, USA
    Mol Cancer Ther 11:2483-94. 2012
    ..This study reveals the mechanistic basis for using copper chelation to overcome cDDP resistance in clinical investigations...
  7. pmc Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Res 72:4616-21. 2012
    ....
  8. pmc Specificity protein 1 (sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression
    Zheng D Liang
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Mol Pharmacol 81:455-64. 2012
    ..These findings have important implications in mammalian copper physiology regulation...
  9. pmc Overcoming cisplatin resistance by mTOR inhibitor in lung cancer
    Chunjing Wu
    University of Miami School of Medicine, 1475 NW 12 Ave, Miami, FL 33136, USA
    Mol Cancer 4:25. 2005
    ..We have also determined the role of CCI-779 in P-gp1 and MRP1 mediated resistance...
  10. pmc Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Oncotarget 1:246-51. 2010
    ....
  11. pmc Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities
    Macus Tien Kuo
    Department of Molecular Pathology Unit 951, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Antioxid Redox Signal 11:99-133. 2009
    ..Finally, the roles of redox signaling in the maintenance and evolution of cancer stem cells and their implications in the development of intrinsic and acquired multidrug resistance in cancer chemotherapy are discussed...
  12. ncbi request reprint Association of fragile site-associated (FSA) gene expression with epithelial differentiation and tumor development
    M Tien Kuo
    Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Street, Houston, TX 77030, USA
    Biochem Biophys Res Commun 340:887-93. 2006
    ..Moreover, levels of FSA expression are downregulated in tumors of these tissue origins. These results suggest that FSA also plays important roles in regulating mammalian epithelial growth and differentiation and tumor development...
  13. ncbi request reprint Roles of multidrug resistance genes in breast cancer chemoresistance
    M Tien Kuo
    Department of Molecular Pathology, Unit 89, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Adv Exp Med Biol 608:23-30. 2007
    ..These studies may lead to novel strategies for improving chemotherapeutic efficacies through targeted interventions of these ABC transporters...
  14. pmc Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1
    Helen H W Chen
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Pharmacol 74:697-704. 2008
    ..These findings also have important implications in that modulation of the intracellular copper pool may be a novel strategy for improving chemotherapeutic efficacy of platinum-based antitumor agents...
  15. ncbi request reprint Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:1945-54. 2002
    ..These results demonstrated that 2-AAF up-regulates MDR1 expression is mediated by the multiple effectors of the PI3K signaling pathway...
  16. pmc Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells
    Im Sook Song
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Pharmacol 74:705-13. 2008
    ..Our results demonstrate that mammalian copper homeostasis is maintained at the hCtr1 mRNA level, which is regulated by the Sp1 transcription factor...
  17. pmc Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4
    Wen Bin Tsai
    Department of Molecular Pathology, Unit 951, The University of Texas M D Anderson Cancer Center, 7435 Fannin Street, Houston, Texas 77030, USA
    Mol Cancer Ther 8:3223-33. 2009
    ..Inability of AS induction in A375 cells under arginine depletion conditions was correlated by the failure of c-Myc to interact with the AS promoter...
  18. pmc Elevated GSH level increases cadmium resistance through down-regulation of Sp1-dependent expression of the cadmium transporter ZIP8
    Isamu Aiba
    Department of Molecular Pathology, M D Anderson Cancer Center, Houston, TX 77054, USA
    Mol Pharmacol 74:823-33. 2008
    ..More important, our results reveal a new mechanism by which elevated GSH levels confer cadmium resistance by down-regulation of ZIP8 expression through the suppression of Sp1...
  19. ncbi request reprint Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine
    Niramol Savaraj
    Hematology Oncology, VA Medical Center, Room D1010, 1201 NW 16th Street, Miami, FL 33125, USA
    Int J Oncol 23:173-9. 2003
    ..These findings are most likely due to the inhibitory effects of telomere catalytic subunit by AZT. Thus, certain biochemical changes induced by CDDP can be explored for future treatment to overcome this form of resistance...

Research Grants25

  1. Redox Regulation of Multidrug Resistance Gene Expression
    MACUS KUO; Fiscal Year: 2009
    ..We hope from these studies to learn the molecular bases of redox conditions that affect drug sensitivity through the regulation of their respective drug resistance gene expression. ..
  2. Redox Regulation of Multidrug Resistance Gene Expression
    MACUS KUO; Fiscal Year: 2007
    ..We hope from these studies to learn the molecular bases of redox conditions that affect drug sensitivity through the regulation of their respective drug resistance gene expression. ..
  3. Genomic Instability and Evolution of Drug Resistance
    MACUS KUO; Fiscal Year: 2007
    ..We anticipate from these studies to gain important insights into the function of FSA in the regulation of cell growth and differentiation in normal and malignant epithelial cells. ..
  4. REGULATION OF MDR GENE EXPRESSION IN LIVER CANCERS
    MACUS KUO; Fiscal Year: 2004
    ..We hope from this research, which includes in vitro cell culture and in vivo animal and tumor models, to gain important molecular insights into the genetic resolution of drug resistance and hepatocarcinogenesis. ..
  5. Targeted Prodrug Therapy of Liver Cancers
    MACUS KUO; Fiscal Year: 2003
    ....
  6. REGULATION OF MDR GENE EXPRESSION IN LIVER CANCERS
    MACUS KUO; Fiscal Year: 2002
    ..We hope from this research, which includes in vitro cell culture and in vivo animal and tumor models, to gain important molecular insights into the genetic resolution of drug resistance and hepatocarcinogenesis. ..
  7. REGULATION OF MDR GENE EXPRESSION IN LIVER CANCERS
    MACUS KUO; Fiscal Year: 2001
    ....
  8. REGULATION OF MDR GENE EXPRESSION IN LIVER CANCERS
    MACUS KUO; Fiscal Year: 1999
    ....
  9. REDOX REGULATION OF MULTIDRUG RESISTANCE GENE EXPESSION
    MACUS KUO; Fiscal Year: 2000
    ..The applicant anticipates from these studies to learn the molecular mechanisms that control multidrug resistance gene expression in cancer cells, and thus to improve the efficacy of cancer chemotherapy. ..
  10. REDOX REGULATION OF MULTIDRUG RESISTANCE GENE EXPESSION
    MACUS KUO; Fiscal Year: 2001
    ..The applicant anticipates from these studies to learn the molecular mechanisms that control multidrug resistance gene expression in cancer cells, and thus to improve the efficacy of cancer chemotherapy. ..
  11. Targeted Prodrug Therapy of Liver Cancers
    MACUS KUO; Fiscal Year: 2002
    ....
  12. Mechanism of Resistance to Arginine Deiminase Therapy in Advance Melanoma
    Macus T Kuo; Fiscal Year: 2010
    ..We propose approaches to circumvent the development of resistance, thereby to enhance the treatment efficacy of human malignant melanoma with ADI-PEG20. ..
  13. REGULATION OF MDR GENE EXPRESSION IN LIVER CANCERS
    MACUS KUO; Fiscal Year: 2001
    ..We hope from this research, which includes in vitro cell culture and in vivo animal and tumor models, to gain important molecular insights into the genetic resolution of drug resistance and hepatocarcinogenesis. ..
  14. Redox Regulation of Multidrug Resistance Gene Expression
    MACUS KUO; Fiscal Year: 2006
    ..We hope from these studies to learn the molecular bases of redox conditions that affect drug sensitivity through the regulation of their respective drug resistance gene expression. ..
  15. Genomic Instability and Evolution of Drug Resistance
    MACUS KUO; Fiscal Year: 2006
    ..We anticipate from these studies to gain important insights into the function of FSA in the regulation of cell growth and differentiation in normal and malignant epithelial cells. ..
  16. Targeted Prodrug Therapy of Liver Cancers
    MACUS KUO; Fiscal Year: 2005
    ....
  17. Genomic Instability and Evolution of Drug Resistance
    MACUS KUO; Fiscal Year: 2005
    ..We anticipate from these studies to gain important insights into the function of FSA in the regulation of cell growth and differentiation in normal and malignant epithelial cells. ..
  18. Targeted Prodrug Therapy of Liver Cancers
    MACUS KUO; Fiscal Year: 2004
    ....
  19. Genomic Instability and Evolution of Drug Resistance
    MACUS KUO; Fiscal Year: 2004
    ..We anticipate from these studies to gain important insights into the function of FSA in the regulation of cell growth and differentiation in normal and malignant epithelial cells. ..
  20. REGULATION OF MDR GENE EXPRESSION IN LIVER CANCERS
    MACUS KUO; Fiscal Year: 2003
    ..We hope from this research, which includes in vitro cell culture and in vivo animal and tumor models, to gain important molecular insights into the genetic resolution of drug resistance and hepatocarcinogenesis. ..
  21. Improving the Efficacy of Cisplatin-Based Cancer Chemotherapy
    Macus T Kuo; Fiscal Year: 2010
    ..We also propose to elucidate the mechanisms by which anti- copper drugs can regulate the transport of cisplatin into cancer cells. ..