Pawan Kumar

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Dysregulation of microRNA-34a expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e37601. 2012
  2. pmc YM155 reverses cisplatin resistance in head and neck cancer by decreasing cytoplasmic survivin levels
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cancer Ther 11:1988-98. 2012
  3. pmc Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
    Pawan Kumar
    Department of Otolaryngology Head and Neck Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Mol Cancer 9:206. 2010
  4. pmc Sorafenib enhances the antitumor effects of chemoradiation treatment by downregulating ERCC-1 and XRCC-1 DNA repair proteins
    Arti Yadav
    The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Mol Cancer Ther 10:1241-51. 2011
  5. pmc IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway
    Arti Yadav
    The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    Mol Cancer Res 9:1658-67. 2011
  6. pmc MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib
    Shoumei Bai
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 284:32015-27. 2009
  7. pmc RhoC expression and head and neck cancer metastasis
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, Ohio State University, Columbus, OH 43210, USA
    Mol Cancer Res 7:1771-80. 2009
  8. pmc Highly aggressive human papillomavirus-related oropharyngeal cancer: clinical, radiologic, and pathologic characteristics
    Azeem S Kaka
    Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, OH 43212, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol 116:327-35. 2013
  9. pmc A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 9:e93208. 2014
  10. ncbi request reprint Biomarkers in advanced larynx cancer
    Carol R Bradford
    Department of Otolaryngology Head and Neck Surgery, Medical School, Ohio State University, Columbus, Ohio
    Laryngoscope 124:179-87. 2014

Collaborators

Detail Information

Publications10

  1. pmc Dysregulation of microRNA-34a expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e37601. 2012
    ..miR-34a is a tumor-suppressor that is frequently downregulated in a number of tumor types. However, little is known about the role of miR-34a in head and neck squamous cell carcinoma (HNSCC)...
  2. pmc YM155 reverses cisplatin resistance in head and neck cancer by decreasing cytoplasmic survivin levels
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cancer Ther 11:1988-98. 2012
    ..Taken together, our results suggest a potentially novel strategy to use YM155 to overcome the resistance in tumor cells, thereby enhancing the effectiveness of the chemotherapy in HNSCC...
  3. pmc Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
    Pawan Kumar
    Department of Otolaryngology Head and Neck Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Mol Cancer 9:206. 2010
    ..However, very little is known about the effect of TM on tumor cell function and tumor metastasis. In this study, we explored the mechanisms underlying TM-mediated inhibition of tumor metastasis...
  4. pmc Sorafenib enhances the antitumor effects of chemoradiation treatment by downregulating ERCC-1 and XRCC-1 DNA repair proteins
    Arti Yadav
    The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Mol Cancer Ther 10:1241-51. 2011
    ..Taken together, our results suggest a potentially novel strategy to use sorafenib to overcome chemo- and radioresistance in tumor and tumor-associated endothelial to enhance the effectiveness of the chemoradiation therapy...
  5. pmc IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway
    Arti Yadav
    The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    Mol Cancer Res 9:1658-67. 2011
    ..Taken together, these results show a novel function for IL-6 in mediating EMT in head and neck tumor cells and increasing their metastatic potential...
  6. pmc MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib
    Shoumei Bai
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 284:32015-27. 2009
    ....
  7. pmc RhoC expression and head and neck cancer metastasis
    Mozaffarul Islam
    Department of Otolaryngology Head and Neck Surgery, Ohio State University, Columbus, OH 43210, USA
    Mol Cancer Res 7:1771-80. 2009
    ..These findings suggest that RhoC warrants further investigation to delineate its robustness as a novel potentially therapeutic target...
  8. pmc Highly aggressive human papillomavirus-related oropharyngeal cancer: clinical, radiologic, and pathologic characteristics
    Azeem S Kaka
    Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, OH 43212, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol 116:327-35. 2013
    ..Although the majority of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas have a favorable prognosis, we search for markers of poor prognosis by carefully examining a subset of highly aggressive cases...
  9. pmc A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 9:e93208. 2014
    ..Taken together, our results suggest that H-4073 is a potent anti-tumor agent and it can be used to overcome chemotherapy resistance in HNSCC. ..
  10. ncbi request reprint Biomarkers in advanced larynx cancer
    Carol R Bradford
    Department of Otolaryngology Head and Neck Surgery, Medical School, Ohio State University, Columbus, Ohio
    Laryngoscope 124:179-87. 2014
    ..To determine if tumor biomarkers were predictive of outcome in a prospective cohort of patients with advanced larynx cancer treated in a phase II clinical trial...