Research Topics
Species | Laura A KrestySummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patientsLaura A Kresty
Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
Nutr Cancer 54:148-56. 2006....
Cranberry proanthocyanidins induce apoptosis and inhibit acid-induced proliferation of human esophageal adenocarcinoma cellsLaura A Kresty
Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 56:676-80. 2008..These findings support that further mechanistic studies are warranted to more fully elucidate the inhibitory potential of PAC against esophageal cancer...
Protection against esophageal cancer in rodents with lyophilized berries: potential mechanismsGary D Stoner
Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
Nutr Cancer 54:33-46. 2006..Based upon the preclinical data on rodents, we have initiated prevention trials in humans to determine if berries might exhibit chemopreventive effects in the esophagus...- Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagusRashmeet K Reen
Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
Cancer Res 67:6484-92. 2007..Samples obtained from animals treated with PEITC alone or cotreated with PEITC + NMBA were more similar to controls than to samples treated with NMBA alone... - Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesisTong Chen
Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 64:3714-7. 2004..These observations suggest that iNOS plays a role in tumor development and that its selective inhibitor, PBIT, significantly inhibits esophageal tumor progression presumably through reducing the production of NO... - Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesionsBrian S Shumway
Department of Oral and Maxillofacial Surgery, Anesthesiology and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
Clin Cancer Res 14:2421-30. 2008..Previously, our laboratories have shown that FBRs are well tolerated and possess potent antioxidant, apoptotic, and differentiation-inducing properties... - Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancerJunan Li
Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
Anticancer Res 31:2683-92. 2011..In this study, the levels of gankyrin mRNA and protein expression were assessed in human oral epithelial cell lines, at-risk normal oral tissues, premalignant oral lesions, and primary oral squamous cell carcinomas (OSCCs)... - Chemoprevention of oral cancer by black raspberriesBruce C Casto
Division of Environmental Health Sciences, School of Public Health, Ohio State University, Columbus, OH 43210, USA
Anticancer Res 22:4005-15. 2002..These experiments support previous studies from our laboratories showing the chemopreventive activity of black raspberries and show, for the first time, that dietary black raspberries will inhibit tumor formation in the oral cavity... - The effects of reactive species on the tumorigenic phenotype of human head and neck squamous cell carcinoma (HNSCC) cellsJennifer E Bradburn
Integrated Biomedical Sciences Graduate Program, School of Biomedical Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Anticancer Res 27:3819-27. 2007.... - Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasiaLaura A Kresty
Division of Environmental Health Sciences, School of Public Health, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Cancer Res 62:5295-300. 2002..These data support that INK4a/ARF locus alterations are frequent events preceding the development of oral cancer and that p16(INK4a) inactivation occurs to a greater extent in oral dysplasia than does p14(ARF) inactivation... - In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometryKevin J Chalut
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Cancer Epidemiol Biomarkers Prev 16:223-7. 2007....
Research Grants
- Targeting Histone Deacetylation: A Tool for Chemopevention of Esophageal CancerLaura Kresty; Fiscal Year: 2007..a necessary early step toward the long-term goal of identifying and translating efficacious preventive agents into the clinic for evaluation in high risk human cohorts, including patients with long standing Barrett's esophagus or ..