Mary Kreek

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. doi request reprint Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Brain Res 1523:49-58. 2013
  2. ncbi request reprint Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 909:186-216. 2000
  3. ncbi request reprint Evolving perspectives on neurobiological research on the addictions: celebration of the 30th anniversary of NIDA
    Mary Jeanne Kreek
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Neuropharmacology 47:324-44. 2004
  4. ncbi request reprint Pharmacotherapy of addictions
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Drug Discov 1:710-26. 2002
  5. ncbi request reprint Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice
    Yan Zhou
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 61:50-9. 2007
  6. ncbi request reprint Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    J Endocrinol 191:137-45. 2006
  7. pmc On blending practice and research: the search for commonalities in substance abuse treatment
    Scott Kellogg
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, New York, NY, USA
    Subst Abus 27:9-24. 2006
  8. ncbi request reprint Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York NY 10021, USA
    J Pharmacol Exp Ther 320:300-6. 2007
  9. ncbi request reprint Adolescent and young adult heroin patients: drug use and success in methadone maintenance treatment
    Scott Kellogg
    Rockefeller University, USA
    J Addict Dis 25:15-25. 2006
  10. ncbi request reprint The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking
    Alexander Kuzmin
    Department of Clinical Neuroscience, Division of Drug Dependence Research, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 32:902-10. 2007

Collaborators

Detail Information

Publications64

  1. doi request reprint Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Brain Res 1523:49-58. 2013
    ..These results may relate to our earlier behavioral finding that 129 mice are hyporesponsive to the rewarding effects of heroin...
  2. ncbi request reprint Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 909:186-216. 2000
    ....
  3. ncbi request reprint Evolving perspectives on neurobiological research on the addictions: celebration of the 30th anniversary of NIDA
    Mary Jeanne Kreek
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Neuropharmacology 47:324-44. 2004
    ..g., in the hypothalamic-pituitary-adrenal axis) plays a role in vulnerability and relapse to specific addictive diseases. This atypical responsivity may be drug-induced, environmentally acquired, and/or due to genetic variation...
  4. ncbi request reprint Pharmacotherapy of addictions
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Drug Discov 1:710-26. 2002
    ....
  5. ncbi request reprint Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice
    Yan Zhou
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 61:50-9. 2007
    ....
  6. ncbi request reprint Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    J Endocrinol 191:137-45. 2006
    ..hyp orexin activity plays a role in morphine-withdrawal-related behaviors...
  7. pmc On blending practice and research: the search for commonalities in substance abuse treatment
    Scott Kellogg
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, New York, NY, USA
    Subst Abus 27:9-24. 2006
    ..Examples from the research and treatment literature are provided...
  8. ncbi request reprint Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York NY 10021, USA
    J Pharmacol Exp Ther 320:300-6. 2007
    ..The present studies indicate that the hallucinogen salvinorin A acts as a high-efficacy kappa-agonist in nonhuman primates in a translationally viable neuroendocrine biomarker assay...
  9. ncbi request reprint Adolescent and young adult heroin patients: drug use and success in methadone maintenance treatment
    Scott Kellogg
    Rockefeller University, USA
    J Addict Dis 25:15-25. 2006
    ..There were no gender or ethnic differences between the two groups. Suggestions for interventions that might improve treatment outcome are presented...
  10. ncbi request reprint The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking
    Alexander Kuzmin
    Department of Clinical Neuroscience, Division of Drug Dependence Research, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 32:902-10. 2007
    ....
  11. ncbi request reprint Altered levels of basal cortisol in healthy subjects with a 118G allele in exon 1 of the Mu opioid receptor gene
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 31:2313-7. 2006
    ..Subjects with at least one copy of the 118G allele have increased basal levels of cortisol, which may influence the susceptibility to and treatment of the stress responsive dyscrasia...
  12. ncbi request reprint Antidepressant treatment patterns in a novel methadone maintenance clinic targeting young adults an observational study
    David W Galarneau
    Weill Medical College of Cornell University, New York, NY 10021, USA
    J Addict Dis 25:47-52. 2006
    ..e., general outpatient vs. methadone maintenance)...
  13. ncbi request reprint Glucocorticoid negative feedback in methadone-maintained former heroin addicts with ongoing cocaine dependence: dose-response to dexamethasone suppression
    Bruno Aouizerate
    Laboratory of Pathophysiology of Behavior, The Victor Segalen s University Bordeaux 2, France
    Addict Biol 11:84-96. 2006
    ..Thus, further studies are needed to know whether altered glucocorticoid negative feedback is related to chronic cocaine exposure, or is the result of former heroin addiction and/or its long-term treatment with methadone...
  14. ncbi request reprint Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06519, USA
    Arch Gen Psychiatry 63:324-31. 2006
    ..Stress and drug cue exposure are known to increase cocaine craving and stress arousal, but the association between these responses and cocaine relapse has not been previously studied...
  15. ncbi request reprint Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals
    Helen C Fox
    Substance Abuse Center, Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 185:348-57. 2006
    ..Extensive research suggests that gender may affect neuroendocrine and cardiovascular arousal mechanisms underlying biological responses to stress...
  16. ncbi request reprint Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    Nat Neurosci 8:1450-7. 2005
    ..Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases...
  17. ncbi request reprint Correlation between high methadone doses and methadone serum levels in methadone maintenance treatment (MMT) patients
    Miriam Adelson
    Tel Aviv Elias Sourasky Medical Center, 6, Weizman St, Tel Aviv, Israel
    J Addict Dis 26:15-26. 2007
    ..To evaluate the relation between high methadone doses and methadone serum levels in MMT patients...
  18. ncbi request reprint Involvement of arginine vasopressin and V1b receptor in heroin withdrawal and heroin seeking precipitated by stress and by heroin
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 33:226-36. 2008
    ....
  19. ncbi request reprint The BiolAD-DB system : an informatics system for clinical and genetic data
    David A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Mol Diagn Ther 11:15-9. 2007
    ..BiolAD-DB tools further provide functionalities for generating customized reports and views. The BiolAD-DB system schema, client, and installation instructions are freely available at http://www.rockefeller.edu/biolad-db/...
  20. pmc The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates
    Eduardo R Butelman
    The Rockefeller University, Box 171, 1230 York Ave, New York, NY 10065, USA
    J Pharmacol Exp Ther 327:154-60. 2008
    ..c.) caused approximately 70% reduction in the peak effect of herkinorin (0.32 mg/kg) in females, indicating that this effect of herkinorin is prominently mediated outside the blood-brain barrier...
  21. pmc Heroin-induced locomotor activity and conditioned place preference in C57BL/6J and 129P3/J mice
    Stefan D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10065, United States
    Neurosci Lett 440:284-8. 2008
    ..These studies indicate that 129P3/J mice are less sensitive to the rewarding effects of heroin than are age-matched C57BL/6J mice...
  22. pmc ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 17:2219-27. 2008
    ..026). These data suggest that specific ABCB1 variants may have clinical relevance by influencing the methadone dose required to prevent withdrawal symptoms and relapse in this population...
  23. pmc Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction
    Dmitri Proudnikov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neurosci Lett 435:234-9. 2008
    ..0014, experiment-wise p=0.0168), whereas another haplotype, AACT, consisting of the same variants, was associated with a protective effect from heroin addiction (p=0.0039, experiment-wise p=0.0468)...
  24. doi request reprint Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, NY 10021, USA
    Addiction 103:681-6. 2008
    ..To determine the prevalence of hepatitis A, B and C viruses in patients attending a methadone maintenance clinic in New York City...
  25. pmc Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation
    Sudie E Back
    Department of Psychiatry, Clinical Neuroscience Division, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC, USA
    Psychoneuroendocrinology 33:560-8. 2008
    ..In addition, there is some evidence for a more robust neuroendocrine and physiologic response to acute laboratory stress in women as compared to men...
  26. pmc Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens
    Michael J Glass
    Department of Neurology and Neuroscience, 411 East 69th Street, Well Medical College of Cornell University, NY, NY 10021, USA
    Exp Neurol 210:750-61. 2008
    ....
  27. pmc Opioids, dopamine, stress, and the addictions
    Mary Jeanne Kreek
    Laboratory of Biology of Addictive Diseases, Rockefeller University, New York, NY 10021, USA
    Dialogues Clin Neurosci 9:363-78. 2007
    ....
  28. doi request reprint TPH2 and TPH1: association of variants and interactions with heroin addiction
    David A Nielsen
    Laboratory of Biology of the Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10065, USA
    Behav Genet 38:133-50. 2008
    ..022), and with the TPH2 rs4290270 variant and heroin addiction (P=0.011). In the African-American group, a significant association of a specific TPH2 haplotype with heroin addiction also was found (SNPHAP, P=0.004; PHASE P=0.036)...
  29. pmc Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Psychoneuroendocrinology 33:292-304. 2008
    ..v. administration. Thus, the relative ineffectiveness of i.v. beta-endorphin in this assay does not appear to be principally due to rapid generation of non-opioid fragments of this neuropeptide...
  30. pmc Stress, dysregulation of drug reward pathways, and the transition to drug dependence
    George Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Am J Psychiatry 164:1149-59. 2007
    ..A model of the role of different levels of hormonal/brain stress activation in addiction is presented that has heuristic value for understanding individual vulnerability to drug dependence and novel treatments for the disorder...
  31. ncbi request reprint Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence
    Tanya J Williams
    The Laboratories of the Biology of Addictive Diseases and Statistical Genetics, The Rockefeller University, USA
    Addict Biol 12:496-502. 2007
    ....
  32. ncbi request reprint Stress responsivity, addiction, and a functional variant of the human mu-opioid receptor gene
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Disease, The Rockefeller University, New York, NY 10021, USA
    Mol Interv 7:74-8. 2007
    ..Future research will further define the role of the A118G variant in addictive diseases and their treatment, in pain perception and opioid analgesia, and for a myriad of other responses mediated by the mu-opioid receptor...
  33. ncbi request reprint Effects of high-dose methadone maintenance on cocaine place conditioning, cocaine self-administration, and mu-opioid receptor mRNA expression in the rat brain
    Francesco Leri
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Neuropsychopharmacology 31:1462-74. 2006
    ....
  34. ncbi request reprint Steady-dose and escalating-dose "binge" administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats
    Stefan D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 67:169-75. 2005
    ..These data suggest that the ppDyn response to cocaine in the CPu is not dose-dependent or that it has reached a maximal level at the 45 mg/kg daily dose...
  35. ncbi request reprint Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates
    Matthew D Schmidt
    Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, Iowa 52242
    Synapse 58:208-10. 2005
    ..Salvinorin B, the presumed major metabolite, is observed to accumulate ex vivo; however, in this study it never reached the limit of detection...
  36. ncbi request reprint Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, S 112 Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 170:62-72. 2003
    ..This study examined the response of brain stress circuits to environmental stimuli that are known to increase cocaine craving in cocaine dependent individuals...
  37. ncbi request reprint Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res Mol Brain Res 114:73-9. 2003
    ....
  38. ncbi request reprint Locomotion, stereotypy, and dopamine D1 receptors after chronic "binge" cocaine in C57BL/6J and 129/J mice
    Stefan D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Pharmacol Biochem Behav 75:123-31. 2003
    ..Thus, with chronic binge cocaine administration, behavioral differences persist between the C57BL/6J and 129/J mice, and cocaine-induced locomotor activity is not correlated with changes in dopamine D(1) receptor binding...
  39. ncbi request reprint Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice
    Stefan D Schlussman
    The Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 974:249-53. 2003
    ..05), but not in 129/J mice, with no differences in the NAc. Thus, 129/J mice are hyporesponsive to the preprodynorphin activating effects of acute 'binge' cocaine in the CPu...
  40. ncbi request reprint Corticotropin-releasing factor testing reveals a dose-dependent difference in methadone maintained vs control subjects
    James H Schluger
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Neuropsychopharmacology 28:985-94. 2003
    ....
  41. ncbi request reprint 1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial
    Johan Kakko
    Division of Psychiatry, Neurotec, Karolinska Institute, Huddinge University Hospital, S 141 86, Stockholm, Sweden
    Lancet 361:662-8. 2003
    ..We aimed to assess the 1-year efficacy of buprenorphine in combination with intensive psychosocial therapy for treatment of heroin dependence...
  42. ncbi request reprint Optimizing primer--probe design for fluorescent PCR
    Dmitri Proudnikov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Neurosci Methods 123:31-45. 2003
    ..Cocaine-induced alterations in expression of c-fos and preprodynorphin mRNAs measured by TaqMan were confirmed by ribonuclease protection assay...
  43. ncbi request reprint The Personality Assessment Inventory Drug Problems Scale: a validity analysis
    Scott H Kellogg
    Laboratory of the Biology of the Addictive Diseases, Rockefeller University, New York, NY 10021 6399, USA
    J Pers Assess 79:73-84. 2002
    ..Overall, higher scores did reflect both more serious involvements with drug use and more serious problems as a consequence of their involvement...
  44. ncbi request reprint History and current status of opioid maintenance treatments: blending conference session
    Mary Jeanne Kreek
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University and The Rockefeller University Hospital, New York, NY 10021, USA
    J Subst Abuse Treat 23:93-105. 2002
    ..Future regulatory reform will likely involve the establishment of rules for "office based opioid treatment."..
  45. ncbi request reprint Conditioned place preference after single doses or "binge" cocaine in C57BL/6J and 129/J mice
    Yong Zhang
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Pharmacol Biochem Behav 73:655-62. 2002
    ....
  46. ncbi request reprint The use of levo-alpha-acetylmethadol (LAAM) in methadone patients who have not achieved heroin abstinence
    Lisa Borg
    The Rockefeller University, Laboratory of the Biology of Addictive Diseases, New York, NY 10021, USA
    J Addict Dis 21:13-22. 2002
    ..While subject acceptance of LAAM was high, subjects were not in a "steady-state," with evidence of ongoing illicit opioid abuse...
  47. ncbi request reprint Hypothalamic-pituitary-adrenocortical (HPA) axis response and biotransformation of oral naltrexone: preliminary examination of relationship to family history of alcoholism
    Andrea C King
    University of Chicago, Department of Psychiatry, Chicago, IL 60637, USA
    Neuropsychopharmacology 26:778-88. 2002
    ..166 words...
  48. ncbi request reprint Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse
    Andrew C H Chen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021 6399, USA
    Am J Med Genet 114:429-35. 2002
    ....
  49. ncbi request reprint Dynorphin A(1-17) biotransformation in striatum of freely moving rats using microdialysis and matrix-assisted laser desorption/ionization mass spectrometry
    Brian Reed
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    J Neurochem 86:815-23. 2003
    ..Additional modifications, of mass 42 and 113 Da, were also found on the N-terminus (Ile8 or Pro10) of these same C-terminal fragments. The role of these modifications of C-terminal fragments has not yet been characterized...
  50. ncbi request reprint Effect of chronic "binge cocaine" on basal levels and cocaine-induced increases of dopamine in the caudate putamen and nucleus accumbens of C57BL/6J and 129/J mice
    Yong Zhang
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 50:191-9. 2003
    ....
  51. ncbi request reprint Increased AMPA GluR1 receptor subunit labeling on the plasma membrane of dendrites in the basolateral amygdala of rats self-administering morphine
    Michael J Glass
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    Synapse 58:1-12. 2005
    ....
  52. ncbi request reprint Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuropsychopharmacology 30:2254-62. 2005
    ....
  53. ncbi request reprint Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex
    Alexis Bailey
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Mol Brain Res 137:258-62. 2005
    ..Naloxone had no effect on the increase of MOP or ppdyn mRNA levels. The results indicate that the opioid system is altered during early withdrawal from chronic cocaine administration...
  54. ncbi request reprint Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose "binge" cocaine-treated rats
    Alexis Bailey
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 57:160-6. 2005
    ..This upregulation was shown for the first time to persist at least 14 days into withdrawal after escalating "binge" cocaine...
  55. ncbi request reprint Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments
    Mary Jeanne Kreek
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, New York 10021, USA
    Pharmacol Rev 57:1-26. 2005
    ..Variants in genes encoding proteins involved in metabolism or biotransformation of drugs of abuse and also of treatment agents are reviewed...
  56. ncbi request reprint Something of value: the introduction of contingency management interventions into the New York City Health and Hospital Addiction Treatment Service
    Scott H Kellogg
    The Rockefeller University, New York, NY 10021 6399, USA
    J Subst Abuse Treat 28:57-65. 2005
    ....
  57. ncbi request reprint Clock reset for alcoholism
    Vadim Yuferov
    Nat Med 11:23-4. 2005
  58. ncbi request reprint Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction
    Vadim Yuferov
    aLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Pharmacogenetics 14:793-804. 2004
    ..0742, 0.1015 and 0.0041. Combining ethnicities by Fisher's method yields an empirical significance level of P = 0.0020...
  59. ncbi request reprint Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 30:417-22. 2005
    ..1%. There was no difference in A118G genotype between type 1 and type 2 alcoholics. In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased attributable risk for alcohol dependence...
  60. ncbi request reprint Primary structure of guinea pig preprodynorphin and preproenkephalin mRNAs: multiple transcription initiation sites for preprodynorphin
    K Steven LaForge
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 63:119-26. 2004
    ..These studies confirmed that the primary transcription start site is 28 nucleotides downstream from the TATAA site, and that intron A sequences are not present in significant amounts in these tissues...
  61. ncbi request reprint Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats
    John R Mantsch
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Psychopharmacology (Berl) 175:26-36. 2004
    ..The investigation of rodent cocaine self-administration (SA) under conditions that promote escalating patterns of intake may provide insight into the loss of control over drug use that is central to human addiction...
  62. ncbi request reprint Genes associated with addiction: alcoholism, opiate, and cocaine addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuromolecular Med 5:85-108. 2004
    ..A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article...
  63. ncbi request reprint Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice
    Yong Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Psychopharmacology (Berl) 173:146-52. 2004
    ....
  64. ncbi request reprint Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis
    STEPHANIE S O'MALLEY
    Yale University School of Medicine, Connecticut Mental Health Center, Substance Abuse Center S202, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 160:19-29. 2002
    ..This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of relapse to heavy drinking in individuals with alcohol dependence...

Research Grants14

  1. TREATMENT OF ADDICTIONS-BIOLOGICAL CORRELATES
    Mary Kreek; Fiscal Year: 2007
    ..Thematic integration and scientific interaction fosters synergism, which only a multidisciplinary center can provide. CENTER CHARACTERISTICS ..
  2. HIV and Psychiatric Comorbidity: Selected Genetic and Epigenetic Factors
    Mary Kreek; Fiscal Year: 2007
    ..The information gained from this research should help to alleviate the suffering of HIV-1 infection with comorbid psychiatric diseases. ..
  3. Addictive Drugs-Pharmacology & Physiology
    Mary Kreek; Fiscal Year: 2007
    ....
  4. ADDICTIONS: GENOTYPES, POLYMOPHISMS, AND FUNCTION
    Mary Kreek; Fiscal Year: 2003
    ..abstract_text> ..
  5. HIV and Psychiatric Comorbidity: Selected Genetic and Epigenetic Factors
    Mary J Kreek; Fiscal Year: 2010
    ..The information gained from this research should help to alleviate the suffering of HIV-1 infection with comorbid psychiatric diseases. ..