M J Kreek

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Drug addictions. Molecular and cellular endpoints
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University Hospital, New York, New York 10021, USA
    Ann N Y Acad Sci 937:27-49. 2001
  2. pmc Genetic susceptibility to heroin addiction: a candidate gene association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Genes Brain Behav 7:720-9. 2008
  3. ncbi request reprint Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 143:190-6. 1999
  4. ncbi request reprint Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 147:73-80. 1999
  5. ncbi request reprint Effects of the androgenic anabolic steroid, nandrolone decanoate, on adrenocorticotropin hormone, corticosterone and proopiomelanocortin, corticotropin releasing factor (CRF) and CRF receptor1 mRNA levels in the hypothalamus, pituitary and amygdala of the
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Neurosci Lett 284:190-4. 2000
  6. pmc Bidirectional translational research: Progress in understanding addictive diseases
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 56:32-43. 2009
  7. pmc Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area
    A P Piras
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA
    Neuroscience 169:751-7. 2010
  8. ncbi request reprint Elevation of guinea pig brain preprodynorphin mRNA expression and hypothalamic-pituitary-adrenal axis activity by "binge" pattern cocaine administration
    V Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 55:65-70. 2001
  9. pmc Steady-state methadone effect on generalized arousal in male and female mice
    N Devidze
    Laboratory of Neurobiology and Behavior, Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:1248-56. 2008
  10. ncbi request reprint Acute "binge" cocaine increases mu-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system
    V Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 48:109-12. 1999

Detail Information

Publications57

  1. ncbi request reprint Drug addictions. Molecular and cellular endpoints
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University Hospital, New York, New York 10021, USA
    Ann N Y Acad Sci 937:27-49. 2001
    ..Such altered molecular, cellular, and neurophysiological "set points" in the brain, in turn, contribute to alterations in behavior with implications for the specific addictive diseases...
  2. pmc Genetic susceptibility to heroin addiction: a candidate gene association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Genes Brain Behav 7:720-9. 2008
    ..0005). None of these associations remained significant after adjustment for multiple testing. This study suggests the involvement of several genes and variants in heroin addiction, which is worthy of future study...
  3. ncbi request reprint Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 143:190-6. 1999
    ..E-2078 has been found to produce kappa-opioid agonist effects in vivo in rodents...
  4. ncbi request reprint Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 147:73-80. 1999
    ..The dynorphins are endogenous opioid peptides with relative binding selectivity for kappa-receptors. It is unclear whether the dynorphins share the pharmacological profile observed with synthetic kappa-agonists in primates...
  5. ncbi request reprint Effects of the androgenic anabolic steroid, nandrolone decanoate, on adrenocorticotropin hormone, corticosterone and proopiomelanocortin, corticotropin releasing factor (CRF) and CRF receptor1 mRNA levels in the hypothalamus, pituitary and amygdala of the
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Neurosci Lett 284:190-4. 2000
    ..The same was found for hypothalamic POMC. No significant AAS effects were observed on: hypothalamic CRF mRNA; POMC mRNA in the amygdala or CRF R1 mRNA in the anterior pituitary...
  6. pmc Bidirectional translational research: Progress in understanding addictive diseases
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 56:32-43. 2009
    ....
  7. pmc Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area
    A P Piras
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA
    Neuroscience 169:751-7. 2010
    ..01) of rats withdrawn for 24 h from chronic cocaine. Our results show a cocaine withdrawal induced increase of KOPr signaling in the VTA, and suggest that the KOPr may play a role in acute withdrawal from cocaine...
  8. ncbi request reprint Elevation of guinea pig brain preprodynorphin mRNA expression and hypothalamic-pituitary-adrenal axis activity by "binge" pattern cocaine administration
    V Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 55:65-70. 2001
    ..Thus, the ppDyn mRNA and HPA responses to cocaine in guinea pigs are similar to those observed in rats...
  9. pmc Steady-state methadone effect on generalized arousal in male and female mice
    N Devidze
    Laboratory of Neurobiology and Behavior, Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:1248-56. 2008
    ..In summary, SSM had no effect on GA behaviors. In females, SSM blunted the GA stress-induced LH orexin gene expression...
  10. ncbi request reprint Acute "binge" cocaine increases mu-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system
    V Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 48:109-12. 1999
    ....
  11. ncbi request reprint Effects of systemically administered dynorphin A(1-17) in rhesus monkeys
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, Rockefeller University, New York, USA
    J Pharmacol Exp Ther 290:678-86. 1999
    ..The present studies show that serum prolactin levels are a sensitive quantitative endpoint to study the systemic effects of the endogenous opioid peptide, dynorphin A(1-17), in primates...
  12. pmc Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuroscience 153:1225-34. 2008
    ....
  13. ncbi request reprint Effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male C57BL/6J and 129/J mice
    Y Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Brain Res 923:172-7. 2001
    ..In the nucleus accumbens, administration of cocaine also significantly increased dopamine levels in both strains (1.32 nM in C57BL/6J and 1.43 nM in 129/J), but with no difference between strains...
  14. pmc Cocaine place conditioning increases pro-opiomelanocortin gene expression in rat hypothalamus
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY, USA
    Neurosci Lett 530:59-63. 2012
    ..The increased POMC gene expression in the hypothalamus suggests that it is involved in the reward/learning process of cocaine-induced conditioning...
  15. pmc Differential glutamate AMPA-receptor plasticity in subpopulations of VTA neurons in the presence or absence of residual cocaine: implications for the development of addiction
    D A Lane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Neuropharmacology 61:1129-40. 2011
    ....
  16. ncbi request reprint Ablation of pituitary pro-opiomelanocortin (POMC) cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 13:808-17. 2001
    ..In turn, the downregulation of central mu opioid receptors in this model may be mediated through a mechanism related to hypothalamic POMC overexpression...
  17. pmc Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1
    D Proudnikov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacogenomics J 10:232-42. 2010
    ..Also in Caucasians, the genotype pattern, 1359G>A and -6274A>T, was significantly associated with heroin addiction experiment wise (P=0.0244). No association of FAAH 385C>A with heroin addiction was found in any group studied...
  18. ncbi request reprint Use of positron emission tomography to measure the effects of nalmefene on D1 and D2 dopamine receptors in rat brain
    E M Unterwald
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10021, USA
    Brain Res 775:183-8. 1997
    ..These results suggest that nalmefene administration produces transient changes in the binding potential of D1-receptors in the striatum that are normalized after 1 week of steady-state administration...
  19. pmc Regional mRNA expression of the endogenous opioid and dopaminergic systems in brains of C57BL/6J and 129P3/J mice: strain and heroin effects
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacol Biochem Behav 100:8-16. 2011
    ..Heroin had dose-related effects on Drd1a mRNA in the hypothalamus and on Drd2 mRNA in the caudate putamen...
  20. ncbi request reprint Chronic 'binge' pattern cocaine alters the neuroendocrine profile of pregnant rats
    V Quinones-Jenab
    The Laboratory of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, USA
    Neurosci Lett 282:120-2. 2000
    ..Thus, cocaine's effect on progesterone and corticosterone may contribute to the series of behavioral alterations associated with cocaine exposure during pregnancy...
  21. pmc Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin
    Y Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA
    Neuroscience 158:474-83. 2009
    ..Taken together, these studies demonstrate the utility of siRNA in the neurobiological study of specific components of the reward system and should contribute to the study of other complex behaviors...
  22. ncbi request reprint Reduced hypothalamic POMC and anterior pituitary CRF1 receptor mRNA levels after acute, but not chronic, daily "binge" intragastric alcohol administration
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Alcohol Clin Exp Res 24:1575-82. 2000
    ..Endogenous corticotropin-releasing factor (CRF), its pituitary CRF1 receptor, and proopiomelanocortin (POMC) may be involved in the hypothalamic-pituitary-adrenal (HPA) responses to alcohol...
  23. pmc Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Brain Res 1523:49-58. 2013
    ..These results may relate to our earlier behavioral finding that 129 mice are hyporesponsive to the rewarding effects of heroin...
  24. pmc Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment
    O Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacogenomics J 12:319-27. 2012
    ..There was significant difference in methadone doses required by subjects with different genotypes of the NGFB intronic single-nucleotide polymorphism rs2239622 (P=0.0002). These results may have clinical importance...
  25. ncbi request reprint Effects of cocaine self-administration on plasma corticosterone and prolactin in rats
    J R Mantsch
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021 6399, USA
    J Pharmacol Exp Ther 294:239-47. 2000
    ..Alterations in neuroendocrine function associated with self-administration may be related to the development of cocaine dependence and could contribute to relapse in abstinent users...
  26. ncbi request reprint Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 909:186-216. 2000
    ....
  27. ncbi request reprint Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose-dependent
    J R Mantsch
    Laboratory of the Biology of Addictive Diseases, Box 171, The Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 157:31-9. 2001
    ..The characterization of self-administration (SA) under extended access conditions is necessary for the development of addiction models...
  28. ncbi request reprint Novelty-induced locomoter activity in Long-Evans rats pre- and post-chronic 'binge'-pattern cocaine treatment
    L R Lucas
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neurosci Lett 237:25-8. 1997
    ..These findings suggest that behavioral sensitization, as a result of CBP cocaine treatment, changes novelty-stress induced behavior which may reflect altered individual vulnerability to drugs of abuse...
  29. ncbi request reprint Cocaine abuse sharply reduced in an effective methadone maintenance program
    L Borg
    Rockefeller University, The Laboratory of the Biology of Addictive Diseases, New York, NY 10021, USA
    J Addict Dis 18:63-75. 1999
    ....
  30. pmc Genotype patterns that contribute to increased risk for or protection from developing heroin addiction
    D A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Mol Psychiatry 13:417-28. 2008
    ..This approach has identified several new genes potentially associated with heroin addiction and has confirmed the role of OPRM1 in this disease...
  31. ncbi request reprint Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32
    Y Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:2645-51. 2006
    ..Thus, phosphorylation states of Thr34- and Ser130-DARPP-32 play important roles in modulating the reinforcing effects of cocaine...
  32. pmc Self administration of oxycodone by adolescent and adult mice affects striatal neurotransmitter receptor gene expression
    B Mayer-Blackwell
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuroscience 258:280-91. 2014
    ..Overall, this study demonstrates that repeated oxycodone self administration alters neurotransmitter receptors gene expression in the dorsal striatum of adolescent and adult mice...
  33. pmc Chromatin alterations in response to forced swimming underlie increased prodynorphin transcription
    B Reed
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuroscience 220:109-18. 2012
    ..Epigenetic changes resulting in elevated dynorphin levels specifically in the caudate putamen may in part underlie the enduring effects of stress...
  34. ncbi request reprint Methadone-maintained former heroin addicts, including those who are anti-HIV-1 seropositive, comply with and respond to hepatitis B vaccination
    L Borg
    Rockefeller University, Laboratory on the Biology of Addictive Diseases, New York, NY 10021, USA
    Addiction 94:489-93. 1999
    ..To study the efficacy of standard hepatitis B (HB) vaccination in methadone-maintained former intravenous drug users...
  35. ncbi request reprint kappa-Opioid receptor agonist-induced prolactin release in primates is blocked by dopamine D(2)-like receptor agonists
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University Box 171, 1230 York Avenue, New York, NY 10021, USA
    Eur J Pharmacol 423:243-9. 2001
    ....
  36. pmc Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area
    D A Lane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Neuroscience 169:559-73. 2010
    ..These adaptations may contribute to increased cocaine seeking/relapse and decreased reward that is reported with chronic cocaine use...
  37. ncbi request reprint Distribution and polysome association of full-length and 3' truncated preproenkephalin mRNA in the guinea-pig brain
    K S LaForge
    Rockefeller University, New York, NY 10021, USA
    Brain Res Mol Brain Res 46:169-76. 1997
    ..This discontinuity in the amount of the two forms between polysomal and non-polysomal mRNA may suggest that the full-length form is more readily incorporated into polysomes...
  38. ncbi request reprint Neuroendocrine-related effects of long-term, 'binge' cocaine administration: diminished individual differences in stress-induced corticosterone response
    Z Sarnyai
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, N Y, 10021, USA
    Neuroendocrinology 68:334-44. 1998
    ..These results indicate that chronic binge cocaine administration leads to sustained activation of the HPA axis and alters processes underlying individual vulnerability to stress...
  39. ncbi request reprint Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized female rats
    V Quinones-Jenab
    The Laboratory of the Biology of Addictive Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Pharmacol Biochem Behav 67:417-22. 2000
    ..These effects may underlie reported sex and estrous cycle differences in cocaine-induced behavioral activity...
  40. ncbi request reprint Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction
    J H Schluger
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021-6399, USA
    Neuropsychopharmacology 24:568-75. 2001
    ....
  41. ncbi request reprint Amygdalar vasopressin mRNA increases in acute cocaine withdrawal: evidence for opioid receptor modulation
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuroscience 134:1391-7. 2005
    ..Our findings suggest a potential role for amygdalar arginine vasopressin in the aversive consequences of early cocaine withdrawal...
  42. pmc Proopiomelanocortin (POMC) expression and conditioned place aversion during protracted withdrawal from chronic intermittent escalating-dose heroin in POMC-EGFP promoter transgenic mice
    K Niikura
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuroscience 236:220-32. 2013
    ..Our results show dynamic changes in POMC in hypothalamic and extra-hypothalamic regions that may contribute to the negative affective/emotional state of heroin withdrawal shown by CPA from acute to extended periods of heroin withdrawal...
  43. pmc Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid
    B Reed
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 20:606-16. 2008
    ....
  44. ncbi request reprint Opioid receptor and peptide gene polymorphisms: potential implications for addictions
    K S LaForge
    Laboratory Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10021, USA
    Eur J Pharmacol 410:249-268. 2000
    ..A number of recent genetic association studies and a few studies of potential function provide clues as to which genes and which alleles may have implications for human physiology and pathophysiology, including the addictions...
  45. ncbi request reprint Neuroendocrine alterations in a high-dose, extended-access rat self-administration model of escalating cocaine use
    J R Mantsch
    Laboratory of the Biology of Addictive Diseases, Box 171, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6339, USA
    Psychoneuroendocrinology 28:836-62. 2003
    ..These findings indicate that the transition to escalating patterns of SA may be associated with altered levels of hormones and gene expression within neuroendocrine systems. Such changes may underlie the onset of human addictive disease...
  46. pmc Structure and expression of the guinea pig preproenkephalin gene: site-specific cleavage in the 3' untranslated region yields truncated mRNA transcripts in specific brain regions
    K S LaForge
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 15:2080-9. 1995
    ..This cleavage may serve as a preliminary step in RNA degradation and provide a mechanism for control of preproenkephalin mRNA abundance through selective degradation...
  47. pmc Heroin addiction in African Americans: a hypothesis-driven association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Genes Brain Behav 8:531-40. 2009
    ..Further studies will be necessary to replicate these associations and to elucidate the roles of these variants in drug addiction vulnerability...
  48. ncbi request reprint GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    J Pharmacol Exp Ther 298:1049-59. 2001
    ..GR89,696 was less sensitive than U50,488 and U69,593 to naltrexone or nor-BNI antagonism, consistent with an action through the proposed kappa(2) receptor subtype...
  49. pmc Role of a functional human gene polymorphism in stress responsivity and addictions
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    Clin Pharmacol Ther 83:615-8. 2008
    ....
  50. ncbi request reprint Nicotine addiction: insights from recent animal studies
    A M Mathieu-Kia
    Rockefeller University, Laboratory on the Biology of Addictive Diseases, Box 171, 1230 York Avenue, New York, NY 10021 6399, USA
    Psychopharmacology (Berl) 162:102-18. 2002
    ..Recent preclinical behavioral and neurobiological research has characterized important behavioral features and has identified neurobiological substrates that may underlie nicotine reinforcement and addiction...
  51. ncbi request reprint Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, N Y, USA
    Neuroendocrinology 70:196-9. 1999
    ..The results indicate that DARPP-32 plays a role in mediating the stimulatory effects of cocaine on the HPA axis...
  52. ncbi request reprint Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden
    G Bart
    Mol Psychiatry 9:547-9. 2004
  53. ncbi request reprint Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence
    T Cigler
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Am J Med Genet 105:489-97. 2001
    ..No significant differences between cases and controls were found...
  54. ncbi request reprint Guinea pig preprodynorphin mRNA: primary structure and regional quantitation in the brain
    V P Yuferov
    The Rockefeller University, New York, NY 10021, USA
    DNA Cell Biol 15:1105-12. 1996
    ..The nucleus accumbens was found to have the greatest abundance of ppDyn mRNA, followed by caudate putamen, hippocampus, hypothalamus, amygdala, frontal cortex, olfactory bulb, and pons/medulla...
  55. pmc Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction
    C Bond
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Proc Natl Acad Sci U S A 95:9608-13. 1998
    ....
  56. ncbi request reprint Subject-regulated dosing alters morphine self-administration behavior and morphine-stimulated [35S]GTPgammaS binding
    P J Kruzich
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 47:243-9. 2003
    ..These results suggest subject-regulated dosing is a useful approach for modeling dose escalation associated with opioid dependence...
  57. ncbi request reprint Reliability of salivary cortisol assessments in cocaine dependent individuals
    H C Fox
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    J Psychopharmacol 20:650-5. 2006
    ..These moderately significant correlations suggest that salivary measurements represent a stable, non-invasive and broad indicator of HPA axis functioning in cocaine dependent individuals...