M J Kreek

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Addictions and stress: clues for cocaine pharmacotherapies
    R Picetti
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Senior Physician, The Rockefeller University Hospital, 1230 York Avenue Box 171, New York, NY 10065
    Curr Pharm Des 19:7065-80. 2013
  2. pmc Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10065, USA
    J Clin Invest 122:3387-93. 2012
  3. pmc Extreme marginalization: addiction and other mental health disorders, stigma, and imprisonment
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, USA
    Ann N Y Acad Sci 1231:65-72. 2011
  4. ncbi request reprint Genes associated with addiction: alcoholism, opiate, and cocaine addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuromolecular Med 5:85-108. 2004
  5. pmc Opioids, dopamine, stress, and the addictions
    Mary Jeanne Kreek
    Laboratory of Biology of Addictive Diseases, Rockefeller University, New York, NY 10021, USA
    Dialogues Clin Neurosci 9:363-78. 2007
  6. pmc Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, NY 10021, USA
    Addiction 103:681-6. 2008
  7. ncbi request reprint Stress responsivity, addiction, and a functional variant of the human mu-opioid receptor gene
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Disease, The Rockefeller University, New York, NY 10021, USA
    Mol Interv 7:74-8. 2007
  8. pmc Bidirectional translational research: Progress in understanding addictive diseases
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 56:32-43. 2009
  9. pmc Opiate and cocaine addiction: from bench to clinic and back to the bench
    Mary Jeanne Kreek
    The Rockefeller University, Laboratory of the Biology of Addictive Diseases, 1230 York Avenue, Box 171, New York, NY 10065, United States
    Curr Opin Pharmacol 9:74-80. 2009
  10. ncbi request reprint Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    Nat Neurosci 8:1450-7. 2005

Collaborators

Detail Information

Publications156 found, 100 shown here

  1. ncbi request reprint Addictions and stress: clues for cocaine pharmacotherapies
    R Picetti
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Senior Physician, The Rockefeller University Hospital, 1230 York Avenue Box 171, New York, NY 10065
    Curr Pharm Des 19:7065-80. 2013
    ..Results from animal models and basic clinical research have shown important interactions between the dopaminergic and the opioid systems. Hence, compounds modulating the opioid system may be beneficial in treating cocaine addiction. ..
  2. pmc Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10065, USA
    J Clin Invest 122:3387-93. 2012
    ..Here, we review the molecular neurobiology and genetics of opiate addiction, including heroin and prescription opioids, and cocaine addiction...
  3. pmc Extreme marginalization: addiction and other mental health disorders, stigma, and imprisonment
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, USA
    Ann N Y Acad Sci 1231:65-72. 2011
    ..All of these are characterized by a lasting stigma that hauntingly continues to affect each person suffering from any of these problems...
  4. ncbi request reprint Genes associated with addiction: alcoholism, opiate, and cocaine addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuromolecular Med 5:85-108. 2004
    ..A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article...
  5. pmc Opioids, dopamine, stress, and the addictions
    Mary Jeanne Kreek
    Laboratory of Biology of Addictive Diseases, Rockefeller University, New York, NY 10021, USA
    Dialogues Clin Neurosci 9:363-78. 2007
    ....
  6. pmc Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, NY 10021, USA
    Addiction 103:681-6. 2008
    ..To determine the prevalence of hepatitis A, B and C viruses in patients attending a methadone maintenance clinic in New York City...
  7. ncbi request reprint Stress responsivity, addiction, and a functional variant of the human mu-opioid receptor gene
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Disease, The Rockefeller University, New York, NY 10021, USA
    Mol Interv 7:74-8. 2007
    ..Future research will further define the role of the A118G variant in addictive diseases and their treatment, in pain perception and opioid analgesia, and for a myriad of other responses mediated by the mu-opioid receptor...
  8. pmc Bidirectional translational research: Progress in understanding addictive diseases
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 56:32-43. 2009
    ....
  9. pmc Opiate and cocaine addiction: from bench to clinic and back to the bench
    Mary Jeanne Kreek
    The Rockefeller University, Laboratory of the Biology of Addictive Diseases, 1230 York Avenue, Box 171, New York, NY 10065, United States
    Curr Opin Pharmacol 9:74-80. 2009
    ....
  10. ncbi request reprint Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    Nat Neurosci 8:1450-7. 2005
    ..Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases...
  11. ncbi request reprint Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments
    Mary Jeanne Kreek
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, New York 10021, USA
    Pharmacol Rev 57:1-26. 2005
    ..Variants in genes encoding proteins involved in metabolism or biotransformation of drugs of abuse and also of treatment agents are reviewed...
  12. pmc Pharmacotherapy in the treatment of addiction: methadone
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    J Addict Dis 29:200-16. 2010
    ..Research shows that women have different substance abuse treatment needs in comparison to their male counterparts. One New York City MMT program that has attempted to address these differences is highlighted...
  13. pmc Role of a functional human gene polymorphism in stress responsivity and addictions
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    Clin Pharmacol Ther 83:615-8. 2008
    ....
  14. pmc Genetic susceptibility to heroin addiction: a candidate gene association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Genes Brain Behav 7:720-9. 2008
    ..0005). None of these associations remained significant after adjustment for multiple testing. This study suggests the involvement of several genes and variants in heroin addiction, which is worthy of future study...
  15. pmc Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuroscience 153:1225-34. 2008
    ....
  16. ncbi request reprint Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 147:73-80. 1999
    ..The dynorphins are endogenous opioid peptides with relative binding selectivity for kappa-receptors. It is unclear whether the dynorphins share the pharmacological profile observed with synthetic kappa-agonists in primates...
  17. ncbi request reprint Elevation of guinea pig brain preprodynorphin mRNA expression and hypothalamic-pituitary-adrenal axis activity by "binge" pattern cocaine administration
    V Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 55:65-70. 2001
    ..Thus, the ppDyn mRNA and HPA responses to cocaine in guinea pigs are similar to those observed in rats...
  18. ncbi request reprint Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 143:190-6. 1999
    ..E-2078 has been found to produce kappa-opioid agonist effects in vivo in rodents...
  19. ncbi request reprint Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32
    Y Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:2645-51. 2006
    ..Thus, phosphorylation states of Thr34- and Ser130-DARPP-32 play important roles in modulating the reinforcing effects of cocaine...
  20. pmc Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area
    A P Piras
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA
    Neuroscience 169:751-7. 2010
    ..01) of rats withdrawn for 24 h from chronic cocaine. Our results show a cocaine withdrawal induced increase of KOPr signaling in the VTA, and suggest that the KOPr may play a role in acute withdrawal from cocaine...
  21. ncbi request reprint Effects of the androgenic anabolic steroid, nandrolone decanoate, on adrenocorticotropin hormone, corticosterone and proopiomelanocortin, corticotropin releasing factor (CRF) and CRF receptor1 mRNA levels in the hypothalamus, pituitary and amygdala of the
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Neurosci Lett 284:190-4. 2000
    ..The same was found for hypothalamic POMC. No significant AAS effects were observed on: hypothalamic CRF mRNA; POMC mRNA in the amygdala or CRF R1 mRNA in the anterior pituitary...
  22. pmc Steady-state methadone effect on generalized arousal in male and female mice
    N Devidze
    Laboratory of Neurobiology and Behavior, Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:1248-56. 2008
    ..In summary, SSM had no effect on GA behaviors. In females, SSM blunted the GA stress-induced LH orexin gene expression...
  23. ncbi request reprint Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence
    Tanya J Williams
    The Laboratories of the Biology of Addictive Diseases and Statistical Genetics, The Rockefeller University, USA
    Addict Biol 12:496-502. 2007
    ....
  24. ncbi request reprint Neuroendocrine alterations in a high-dose, extended-access rat self-administration model of escalating cocaine use
    J R Mantsch
    Laboratory of the Biology of Addictive Diseases, Box 171, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6339, USA
    Psychoneuroendocrinology 28:836-62. 2003
    ..These findings indicate that the transition to escalating patterns of SA may be associated with altered levels of hormones and gene expression within neuroendocrine systems. Such changes may underlie the onset of human addictive disease...
  25. ncbi request reprint Ablation of pituitary pro-opiomelanocortin (POMC) cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 13:808-17. 2001
    ..In turn, the downregulation of central mu opioid receptors in this model may be mediated through a mechanism related to hypothalamic POMC overexpression...
  26. ncbi request reprint Acute "binge" cocaine increases mu-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system
    V Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 48:109-12. 1999
    ....
  27. ncbi request reprint Amygdalar vasopressin mRNA increases in acute cocaine withdrawal: evidence for opioid receptor modulation
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuroscience 134:1391-7. 2005
    ..Our findings suggest a potential role for amygdalar arginine vasopressin in the aversive consequences of early cocaine withdrawal...
  28. doi request reprint Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin
    Y Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10065, USA
    Neuroscience 158:474-83. 2009
    ..Taken together, these studies demonstrate the utility of siRNA in the neurobiological study of specific components of the reward system and should contribute to the study of other complex behaviors...
  29. ncbi request reprint Effect of acute binge cocaine on levels of extracellular dopamine in the caudate putamen and nucleus accumbens in male C57BL/6J and 129/J mice
    Y Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Brain Res 923:172-7. 2001
    ..In the nucleus accumbens, administration of cocaine also significantly increased dopamine levels in both strains (1.32 nM in C57BL/6J and 1.43 nM in 129/J), but with no difference between strains...
  30. pmc Genotype patterns that contribute to increased risk for or protection from developing heroin addiction
    D A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Mol Psychiatry 13:417-28. 2008
    ..This approach has identified several new genes potentially associated with heroin addiction and has confirmed the role of OPRM1 in this disease...
  31. pmc Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1
    D Proudnikov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacogenomics J 10:232-42. 2010
    ..Also in Caucasians, the genotype pattern, 1359G>A and -6274A>T, was significantly associated with heroin addiction experiment wise (P=0.0244). No association of FAAH 385C>A with heroin addiction was found in any group studied...
  32. ncbi request reprint Effects of systemically administered dynorphin A(1-17) in rhesus monkeys
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, Rockefeller University, New York, USA
    J Pharmacol Exp Ther 290:678-86. 1999
    ..The present studies show that serum prolactin levels are a sensitive quantitative endpoint to study the systemic effects of the endogenous opioid peptide, dynorphin A(1-17), in primates...
  33. ncbi request reprint Steady-dose and escalating-dose "binge" administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats
    Stefan D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 67:169-75. 2005
    ..These data suggest that the ppDyn response to cocaine in the CPu is not dose-dependent or that it has reached a maximal level at the 45 mg/kg daily dose...
  34. pmc Cocaine place conditioning increases pro-opiomelanocortin gene expression in rat hypothalamus
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY, USA
    Neurosci Lett 530:59-63. 2012
    ..The increased POMC gene expression in the hypothalamus suggests that it is involved in the reward/learning process of cocaine-induced conditioning...
  35. ncbi request reprint Reduced hypothalamic POMC and anterior pituitary CRF1 receptor mRNA levels after acute, but not chronic, daily "binge" intragastric alcohol administration
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Alcohol Clin Exp Res 24:1575-82. 2000
    ..Endogenous corticotropin-releasing factor (CRF), its pituitary CRF1 receptor, and proopiomelanocortin (POMC) may be involved in the hypothalamic-pituitary-adrenal (HPA) responses to alcohol...
  36. pmc Differential glutamate AMPA-receptor plasticity in subpopulations of VTA neurons in the presence or absence of residual cocaine: implications for the development of addiction
    D A Lane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Neuropharmacology 61:1129-40. 2011
    ....
  37. ncbi request reprint Use of positron emission tomography to measure the effects of nalmefene on D1 and D2 dopamine receptors in rat brain
    E M Unterwald
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10021, USA
    Brain Res 775:183-8. 1997
    ..These results suggest that nalmefene administration produces transient changes in the binding potential of D1-receptors in the striatum that are normalized after 1 week of steady-state administration...
  38. pmc Heroin addiction in African Americans: a hypothesis-driven association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Genes Brain Behav 8:531-40. 2009
    ..Further studies will be necessary to replicate these associations and to elucidate the roles of these variants in drug addiction vulnerability...
  39. ncbi request reprint Estrous cycle differences in cocaine-induced stereotypic and locomotor behaviors in Fischer rats
    V Quinones-Jenab
    The Laboratory of the Biology of Addictive Disease, The Rockefeller University, NY, NY 10021, USA
    Behav Brain Res 101:15-20. 1999
    ..This in turn may have important implications in gender differences in behavioral responses to cocaine...
  40. pmc Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, New York 10065, USA
    Ann N Y Acad Sci 1187:184-207. 2010
    ..Finally, we describe the development and application of a novel technique: molecular haplotyping for studies in genetics of drug addiction...
  41. pmc Regional mRNA expression of the endogenous opioid and dopaminergic systems in brains of C57BL/6J and 129P3/J mice: strain and heroin effects
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacol Biochem Behav 100:8-16. 2011
    ..Heroin had dose-related effects on Drd1a mRNA in the hypothalamus and on Drd2 mRNA in the caudate putamen...
  42. ncbi request reprint Chronic 'binge' pattern cocaine alters the neuroendocrine profile of pregnant rats
    V Quinones-Jenab
    The Laboratory of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, USA
    Neurosci Lett 282:120-2. 2000
    ..Thus, cocaine's effect on progesterone and corticosterone may contribute to the series of behavioral alterations associated with cocaine exposure during pregnancy...
  43. ncbi request reprint Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats
    John R Mantsch
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Psychopharmacology (Berl) 175:26-36. 2004
    ..The investigation of rodent cocaine self-administration (SA) under conditions that promote escalating patterns of intake may provide insight into the loss of control over drug use that is central to human addiction...
  44. pmc Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women
    Bronson E Oosterhuis
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Am J Med Genet B Neuropsychiatr Genet 147:793-8. 2008
    ..05) after correction for multiple testing. No significant association was found with haplotypes of the three most common SNPs. Linkage disequilibrium patterns were similar for the three ethnic/cultural groups...
  45. doi request reprint Regional mRNA expression of GABAergic receptor subunits in brains of C57BL/6J and 129P3/J mice: strain and heroin effects
    S D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Brain Res 1523:49-58. 2013
    ..These results may relate to our earlier behavioral finding that 129 mice are hyporesponsive to the rewarding effects of heroin...
  46. ncbi request reprint Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, N Y, USA
    Neuroendocrinology 70:196-9. 1999
    ..The results indicate that DARPP-32 plays a role in mediating the stimulatory effects of cocaine on the HPA axis...
  47. pmc Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment
    O Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Pharmacogenomics J 12:319-27. 2012
    ..There was significant difference in methadone doses required by subjects with different genotypes of the NGFB intronic single-nucleotide polymorphism rs2239622 (P=0.0002). These results may have clinical importance...
  48. ncbi request reprint Effects of cocaine self-administration on plasma corticosterone and prolactin in rats
    J R Mantsch
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021 6399, USA
    J Pharmacol Exp Ther 294:239-47. 2000
    ..Alterations in neuroendocrine function associated with self-administration may be related to the development of cocaine dependence and could contribute to relapse in abstinent users...
  49. ncbi request reprint Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 909:186-216. 2000
    ....
  50. ncbi request reprint Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose-dependent
    J R Mantsch
    Laboratory of the Biology of Addictive Diseases, Box 171, The Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 157:31-9. 2001
    ..The characterization of self-administration (SA) under extended access conditions is necessary for the development of addiction models...
  51. ncbi request reprint Novelty-induced locomoter activity in Long-Evans rats pre- and post-chronic 'binge'-pattern cocaine treatment
    L R Lucas
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neurosci Lett 237:25-8. 1997
    ..These findings suggest that behavioral sensitization, as a result of CBP cocaine treatment, changes novelty-stress induced behavior which may reflect altered individual vulnerability to drugs of abuse...
  52. ncbi request reprint Cocaine abuse sharply reduced in an effective methadone maintenance program
    L Borg
    Rockefeller University, The Laboratory of the Biology of Addictive Diseases, New York, NY 10021, USA
    J Addict Dis 18:63-75. 1999
    ....
  53. ncbi request reprint Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction
    J H Schluger
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021-6399, USA
    Neuropsychopharmacology 24:568-75. 2001
    ....
  54. ncbi request reprint Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose "binge" cocaine-treated rats
    Alexis Bailey
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 57:160-6. 2005
    ..This upregulation was shown for the first time to persist at least 14 days into withdrawal after escalating "binge" cocaine...
  55. ncbi request reprint Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    J Endocrinol 191:137-45. 2006
    ..hyp orexin activity plays a role in morphine-withdrawal-related behaviors...
  56. pmc Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians
    Judith A Briant
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York 10065, USA
    Psychiatr Genet 20:65-72. 2010
    ..In this study, we examined five variants of OPRL1 and their role in determining vulnerability to develop opiate addiction...
  57. doi request reprint Self administration of oxycodone by adolescent and adult mice affects striatal neurotransmitter receptor gene expression
    B Mayer-Blackwell
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuroscience 258:280-91. 2014
    ..Overall, this study demonstrates that repeated oxycodone self administration alters neurotransmitter receptors gene expression in the dorsal striatum of adolescent and adult mice. ..
  58. pmc Structure and expression of the guinea pig preproenkephalin gene: site-specific cleavage in the 3' untranslated region yields truncated mRNA transcripts in specific brain regions
    K S LaForge
    Rockefeller University, New York, New York 10021
    Mol Cell Biol 15:2080-9. 1995
    ..This cleavage may serve as a preliminary step in RNA degradation and provide a mechanism for control of preproenkephalin mRNA abundance through selective degradation...
  59. pmc Chromatin alterations in response to forced swimming underlie increased prodynorphin transcription
    B Reed
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuroscience 220:109-18. 2012
    ..Epigenetic changes resulting in elevated dynorphin levels specifically in the caudate putamen may in part underlie the enduring effects of stress...
  60. ncbi request reprint Methadone-maintained former heroin addicts, including those who are anti-HIV-1 seropositive, comply with and respond to hepatitis B vaccination
    L Borg
    Rockefeller University, Laboratory on the Biology of Addictive Diseases, New York, NY 10021, USA
    Addiction 94:489-93. 1999
    ..To study the efficacy of standard hepatitis B (HB) vaccination in methadone-maintained former intravenous drug users...
  61. ncbi request reprint kappa-Opioid receptor agonist-induced prolactin release in primates is blocked by dopamine D(2)-like receptor agonists
    E R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University Box 171, 1230 York Avenue, New York, NY 10021, USA
    Eur J Pharmacol 423:243-9. 2001
    ....
  62. ncbi request reprint Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse
    Andrew C H Chen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021 6399, USA
    Am J Med Genet 114:429-35. 2002
    ....
  63. pmc Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts
    David A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York 10065, USA
    Hum Genet 127:639-49. 2010
    ..These changes in methylation of the OPRM1 promoter region may lead to altered expression of the mu-opioid receptor gene in the lymphocytes of former heroin addicts who are stabilized in methadone maintenance treatment...
  64. ncbi request reprint Antidepressant treatment patterns in a novel methadone maintenance clinic targeting young adults an observational study
    David W Galarneau
    Weill Medical College of Cornell University, New York, NY 10021, USA
    J Addict Dis 25:47-52. 2006
    ..e., general outpatient vs. methadone maintenance)...
  65. ncbi request reprint History and current status of opioid maintenance treatments: blending conference session
    Mary Jeanne Kreek
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University and The Rockefeller University Hospital, New York, NY 10021, USA
    J Subst Abuse Treat 23:93-105. 2002
    ..Future regulatory reform will likely involve the establishment of rules for "office based opioid treatment."..
  66. pmc Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid
    B Reed
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 20:606-16. 2008
    ....
  67. ncbi request reprint Nicotine addiction: insights from recent animal studies
    A M Mathieu-Kia
    Rockefeller University, Laboratory on the Biology of Addictive Diseases, Box 171, 1230 York Avenue, New York, NY 10021 6399, USA
    Psychopharmacology (Berl) 162:102-18. 2002
    ..Recent preclinical behavioral and neurobiological research has characterized important behavioral features and has identified neurobiological substrates that may underlie nicotine reinforcement and addiction...
  68. ncbi request reprint Distribution and polysome association of full-length and 3' truncated preproenkephalin mRNA in the guinea-pig brain
    K S LaForge
    Rockefeller University, New York, NY 10021, USA
    Brain Res Mol Brain Res 46:169-76. 1997
    ..This discontinuity in the amount of the two forms between polysomal and non-polysomal mRNA may suggest that the full-length form is more readily incorporated into polysomes...
  69. pmc Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area
    D A Lane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Neuroscience 169:559-73. 2010
    ..These adaptations may contribute to increased cocaine seeking/relapse and decreased reward that is reported with chronic cocaine use...
  70. ncbi request reprint Neuroendocrine-related effects of long-term, 'binge' cocaine administration: diminished individual differences in stress-induced corticosterone response
    Z Sarnyai
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, N Y, 10021, USA
    Neuroendocrinology 68:334-44. 1998
    ..These results indicate that chronic binge cocaine administration leads to sustained activation of the HPA axis and alters processes underlying individual vulnerability to stress...
  71. ncbi request reprint Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized female rats
    V Quinones-Jenab
    The Laboratory of the Biology of Addictive Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Pharmacol Biochem Behav 67:417-22. 2000
    ..These effects may underlie reported sex and estrous cycle differences in cocaine-induced behavioral activity...
  72. pmc Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases
    Yan Zhou
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Brain Res 1314:235-52. 2010
    ..Several of these stress-responsive systems and components, primarily based on our laboratory-based and human molecular genetics research of addictive diseases, will be briefly discussed in this review...
  73. pmc Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction
    David A Nielsen
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York 10065, USA
    Psychiatr Genet 20:207-14. 2010
    ..We have used genome-wide association studies to identify variants that are associated with vulnerability to develop heroin addiction...
  74. pmc Tissue plasminogen activator modulates the cellular and behavioral response to cocaine
    Rajani Maiya
    Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:1983-8. 2009
    ..Cocaine exposure also had an anxiolytic effect in tPA-/- but not WT mice. These results identify tPA as an important and novel component of the signaling pathway that modulates cocaine-induced changes in neuroadaptation and behavior...
  75. pmc Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens
    Michael J Glass
    Department of Neurology and Neuroscience, 411 East 69th Street, Well Medical College of Cornell University, NY, NY 10021, USA
    Exp Neurol 210:750-61. 2008
    ....
  76. ncbi request reprint Involvement of arginine vasopressin and V1b receptor in heroin withdrawal and heroin seeking precipitated by stress and by heroin
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 33:226-36. 2008
    ....
  77. pmc Proopiomelanocortin (POMC) expression and conditioned place aversion during protracted withdrawal from chronic intermittent escalating-dose heroin in POMC-EGFP promoter transgenic mice
    K Niikura
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuroscience 236:220-32. 2013
    ..Our results show dynamic changes in POMC in hypothalamic and extra-hypothalamic regions that may contribute to the negative affective/emotional state of heroin withdrawal shown by CPA from acute to extended periods of heroin withdrawal...
  78. ncbi request reprint Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence
    T Cigler
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Am J Med Genet 105:489-97. 2001
    ..No significant differences between cases and controls were found...
  79. ncbi request reprint Opioid receptor and peptide gene polymorphisms: potential implications for addictions
    K S LaForge
    Laboratory Biology of Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10021, USA
    Eur J Pharmacol 410:249-268. 2000
    ..A number of recent genetic association studies and a few studies of potential function provide clues as to which genes and which alleles may have implications for human physiology and pathophysiology, including the addictions...
  80. ncbi request reprint Drug addictions. Molecular and cellular endpoints
    M J Kreek
    Laboratory of the Biology of Addictive Diseases, Rockefeller University Hospital, New York, New York 10021, USA
    Ann N Y Acad Sci 937:27-49. 2001
    ..Such altered molecular, cellular, and neurophysiological "set points" in the brain, in turn, contribute to alterations in behavior with implications for the specific addictive diseases...
  81. pmc A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:1185-97. 2009
    ....
  82. ncbi request reprint Corticotropin-releasing factor testing reveals a dose-dependent difference in methadone maintained vs control subjects
    James H Schluger
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Neuropsychopharmacology 28:985-94. 2003
    ....
  83. ncbi request reprint Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice
    Yong Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Psychopharmacology (Berl) 173:146-52. 2004
    ....
  84. ncbi request reprint Primary structure of guinea pig preprodynorphin and preproenkephalin mRNAs: multiple transcription initiation sites for preprodynorphin
    K Steven LaForge
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 63:119-26. 2004
    ..These studies confirmed that the primary transcription start site is 28 nucleotides downstream from the TATAA site, and that intron A sequences are not present in significant amounts in these tissues...
  85. pmc The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, Box 171, New York, NY 10065, USA
    Psychopharmacology (Berl) 210:253-62. 2010
    ....
  86. ncbi request reprint Evolving perspectives on neurobiological research on the addictions: celebration of the 30th anniversary of NIDA
    Mary Jeanne Kreek
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY 10021, USA
    Neuropharmacology 47:324-44. 2004
    ..g., in the hypothalamic-pituitary-adrenal axis) plays a role in vulnerability and relapse to specific addictive diseases. This atypical responsivity may be drug-induced, environmentally acquired, and/or due to genetic variation...
  87. doi request reprint TPH2 and TPH1: association of variants and interactions with heroin addiction
    David A Nielsen
    Laboratory of Biology of the Addictive Diseases, The Rockefeller University, Box 171, 1230 York Avenue, New York, NY 10065, USA
    Behav Genet 38:133-50. 2008
    ..022), and with the TPH2 rs4290270 variant and heroin addiction (P=0.011). In the African-American group, a significant association of a specific TPH2 haplotype with heroin addiction also was found (SNPHAP, P=0.004; PHASE P=0.036)...
  88. pmc Limited effects of beta-endorphin compared to loperamide or fentanyl in a neuroendocrine biomarker assay in non-human primates
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Psychoneuroendocrinology 33:292-304. 2008
    ..v. administration. Thus, the relative ineffectiveness of i.v. beta-endorphin in this assay does not appear to be principally due to rapid generation of non-opioid fragments of this neuropeptide...
  89. ncbi request reprint Optimizing primer--probe design for fluorescent PCR
    Dmitri Proudnikov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Neurosci Methods 123:31-45. 2003
    ..Cocaine-induced alterations in expression of c-fos and preprodynorphin mRNAs measured by TaqMan were confirmed by ribonuclease protection assay...
  90. ncbi request reprint Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice
    Yan Zhou
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 61:50-9. 2007
    ....
  91. pmc Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction
    Dmitri Proudnikov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neurosci Lett 435:234-9. 2008
    ..0014, experiment-wise p=0.0168), whereas another haplotype, AACT, consisting of the same variants, was associated with a protective effect from heroin addiction (p=0.0039, experiment-wise p=0.0468)...
  92. ncbi request reprint Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res Mol Brain Res 114:73-9. 2003
    ....
  93. ncbi request reprint Locomotion, stereotypy, and dopamine D1 receptors after chronic "binge" cocaine in C57BL/6J and 129/J mice
    Stefan D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Pharmacol Biochem Behav 75:123-31. 2003
    ..Thus, with chronic binge cocaine administration, behavioral differences persist between the C57BL/6J and 129/J mice, and cocaine-induced locomotor activity is not correlated with changes in dopamine D(1) receptor binding...
  94. pmc Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts
    David A Nielsen
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:867-73. 2009
    ..080). Both the -18 and the +84 CpG sites are located in potential Sp1 transcription factor-binding sites. Methylation of these CpG sites may lead to reduced OPRM1 expression in the lymphocytes of these former heroin addicts...
  95. pmc The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates
    Eduardo R Butelman
    The Rockefeller University, Box 171, 1230 York Ave, New York, NY 10065, USA
    J Pharmacol Exp Ther 327:154-60. 2008
    ..c.) caused approximately 70% reduction in the peak effect of herkinorin (0.32 mg/kg) in females, indicating that this effect of herkinorin is prominently mediated outside the blood-brain barrier...
  96. pmc Carbon dioxide-induced anesthesia results in a rapid increase in plasma levels of vasopressin
    Brian Reed
    Laboratories of the Biology of Addictive Diseases, Gaseous Ion Chemistry and MassSpectrometry, The Rockefeller University, New York, New York 10065, USA
    Endocrinology 150:2934-9. 2009
    ....
  97. ncbi request reprint Effect of chronic "binge cocaine" on basal levels and cocaine-induced increases of dopamine in the caudate putamen and nucleus accumbens of C57BL/6J and 129/J mice
    Yong Zhang
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 50:191-9. 2003
    ....
  98. pmc ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 17:2219-27. 2008
    ..026). These data suggest that specific ABCB1 variants may have clinical relevance by influencing the methadone dose required to prevent withdrawal symptoms and relapse in this population...
  99. pmc Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid
    Eduardo R Butelman
    Laboratory on the Biology of Addictive Diseases, Rockefeller University Box 171, 1230 York Ave, New York, NY 1006, USA
    J Pharmacol Exp Ther 328:588-97. 2009
    ..These are the first studies documenting rapid unconditioned effects of salvinorin A in a primate species, consistent with descriptive reports of rapid and robust effects of this powerful hallucinogen in humans...
  100. ncbi request reprint Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuropsychopharmacology 30:2254-62. 2005
    ....
  101. ncbi request reprint Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Neuropsychopharmacology 30:417-22. 2005
    ..1%. There was no difference in A118G genotype between type 1 and type 2 alcoholics. In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased attributable risk for alcohol dependence...