Philippe Krebs

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 113:6593-602. 2009
  2. pmc An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
    Michael Berger
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 11:335-43. 2010
  3. doi request reprint The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease
    Nengming Xiao
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 183:7975-83. 2009
  4. pmc Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
    Celine Eidenschenk
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:9759-64. 2010
  5. doi request reprint Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice
    Michael J Barnes
    Department of Genetics, Scripps Research Institute, La Jolla, CA, USA
    J Immunol 184:3743-54. 2010
  6. pmc ENU-induced phenovariance in mice: inferences from 587 mutations
    Carrie N Arnold
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    BMC Res Notes 5:577. 2012
  7. pmc Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice
    Gerhard Wingender
    La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Gastroenterology 143:418-28. 2012
  8. pmc Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency
    Gerhard Wingender
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 185:2721-9. 2010
  9. pmc Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 117:6582-8. 2011
  10. pmc A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:3046-51. 2010

Detail Information

Publications16

  1. pmc NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 113:6593-602. 2009
    ..We think that the recognition and killing of target cells by NK cells represents an important pathway for the generation of robust CD8+ T and humoral responses that may be exploited for vaccine development...
  2. pmc An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
    Michael Berger
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 11:335-43. 2010
    ..Our findings identify a physiological role for Slfn2 in the defense against pathogens through the regulation of quiescence in T cells and monocytes...
  3. doi request reprint The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease
    Nengming Xiao
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 183:7975-83. 2009
    ..Our data demonstrate that the encoded protein kinase Tpl2 plays an essential role in cell signaling in the immune response to certain pathogens...
  4. pmc Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
    Celine Eidenschenk
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:9759-64. 2010
    ..In the absence of Flt3 signaling, NK cell activation is delayed and survival during MCMV infection is markedly compromised...
  5. doi request reprint Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice
    Michael J Barnes
    Department of Genetics, Scripps Research Institute, La Jolla, CA, USA
    J Immunol 184:3743-54. 2010
    ..These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis...
  6. pmc ENU-induced phenovariance in mice: inferences from 587 mutations
    Carrie N Arnold
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    BMC Res Notes 5:577. 2012
    ....
  7. pmc Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice
    Gerhard Wingender
    La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Gastroenterology 143:418-28. 2012
    ..However, little is known about this process. We investigated whether symbiotic microbes can determine the activated phenotype and function of iNKT cells...
  8. pmc Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency
    Gerhard Wingender
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 185:2721-9. 2010
    ..Therefore, unlike NK cells, which rely mostly on perforin/granzyme-mediated mechanisms, the Ag-specific cytotoxicity of iNKT cells in vivo is largely restricted to the CD95/CD178 pathway...
  9. pmc Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 117:6582-8. 2011
    ..Our findings implicate MyD88 as the key initiator of myeloid and lymphoid proliferation in HLH, and suggest that blockade of this signaling molecule may reduce immunopathology in patients...
  10. pmc A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:3046-51. 2010
    ..This selective loss of function highlights the immunological importance of NEMO-regulated pathways beyond IkappaB alpha degradation, and offers a biochemical explanation for rare immune deficiencies in man...
  11. pmc Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection
    Amanda L Blasius
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    PLoS Pathog 8:e1002915. 2012
    ..Ultimately, infection persisted in feeble mice. We conclude that pDCs are likely required for efficient T cell priming and subsequent viral clearance. Our data suggest that reduced pDC functionality may lead to chronic infection...
  12. pmc Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice
    Lara Krieg
    Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA
    Blood 118:6418-25. 2011
    ..These findings establish the necessity of the gastric proton pump for iron absorption and effective erythropoiesis...
  13. pmc Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice
    Stefan Freigang
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 120:1873-84. 2010
    ..Our results suggest that the serum transport of lipid antigens directly shapes the quality of NKT cell responses, which could potentially be modulated in support of novel vaccination strategies...
  14. pmc Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:19678-82. 2011
    ..5 wk. Thus, we establish a mechanistic connection between Mediator and induction of a metabolic program for oxidative phosphorylation and fatty acid oxidation, in which lethal cardiomyopathy is mitigated by dietary intervention...
  15. pmc Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery
    Michael J Barnes
    Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA
    PLoS Biol 7:e51. 2009
    ..Furthermore, we show that peripheral T(reg) cells are a dynamic population that may expand to limit immunopathology or promote chronic infection...
  16. pmc Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
    Amanda L Blasius
    Departments of Genetics and Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:2706-11. 2009
    ..However, DOCK7 has non-redundant role(s) related to the distribution and function of dermal and follicular melanocytes...