Research Topics
Genomes and Genes
| Philippe KrebsSummaryAffiliation: The Scripps Research Institute Country: USA Publications
| Collaborators
|
Detail Information
Publications
NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responsesPhilippe Krebs
Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Blood 113:6593-602. 2009..We think that the recognition and killing of target cells by NK cells represents an important pathway for the generation of robust CD8+ T and humoral responses that may be exploited for vaccine development...- An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescenceMichael Berger
Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
Nat Immunol 11:335-43. 2010..Our findings identify a physiological role for Slfn2 in the defense against pathogens through the regulation of quiescence in T cells and monocytes... 
The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal diseaseNengming Xiao
Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 183:7975-83. 2009..Our data demonstrate that the encoded protein kinase Tpl2 plays an essential role in cell signaling in the immune response to certain pathogens...- Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cellsCeline Eidenschenk
Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 107:9759-64. 2010..In the absence of Flt3 signaling, NK cell activation is delayed and survival during MCMV infection is markedly compromised... - Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient miceMichael J Barnes
Department of Genetics, Scripps Research Institute, La Jolla, CA, USA
J Immunol 184:3743-54. 2010..These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis... - Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in miceGerhard Wingender
La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Gastroenterology 143:418-28. 2012..However, little is known about this process. We investigated whether symbiotic microbes can determine the activated phenotype and function of iNKT cells... - ENU-induced phenovariance in mice: inferences from 587 mutationsCarrie N Arnold
Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
BMC Res Notes 5:577. 2012.... - Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potencyGerhard Wingender
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 185:2721-9. 2010..Therefore, unlike NK cells, which rely mostly on perforin/granzyme-mediated mechanisms, the Ag-specific cytotoxicity of iNKT cells in vivo is largely restricted to the CD95/CD178 pathway... - Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in micePhilippe Krebs
Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Blood 117:6582-8. 2011..Our findings implicate MyD88 as the key initiator of myeloid and lymphoid proliferation in HLH, and suggest that blockade of this signaling molecule may reduce immunopathology in patients... - A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alphaOwen M Siggs
Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 107:3046-51. 2010..This selective loss of function highlights the immunological importance of NEMO-regulated pathways beyond IkappaB alpha degradation, and offers a biochemical explanation for rare immune deficiencies in man... - Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infectionAmanda L Blasius
Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
PLoS Pathog 8:e1002915. 2012..Ultimately, infection persisted in feeble mice. We conclude that pDCs are likely required for efficient T cell priming and subsequent viral clearance. Our data suggest that reduced pDC functionality may lead to chronic infection... - Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in miceLara Krieg
Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA
Blood 118:6418-25. 2011..These findings establish the necessity of the gastric proton pump for iron absorption and effective erythropoiesis... - Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in miceStefan Freigang
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Clin Invest 120:1873-84. 2010..Our results suggest that the serum transport of lipid antigens directly shapes the quality of NKT cell responses, which could potentially be modulated in support of novel vaccination strategies... - Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic dietPhilippe Krebs
Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 108:19678-82. 2011..5 wk. Thus, we establish a mechanistic connection between Mediator and induction of a metabolic program for oxidative phosphorylation and fatty acid oxidation, in which lethal cardiomyopathy is mitigated by dietary intervention... - Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the peripheryMichael J Barnes
Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA
PLoS Biol 7:e51. 2009..Furthermore, we show that peripheral T(reg) cells are a dynamic population that may expand to limit immunopathology or promote chronic infection... - Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological functionAmanda L Blasius
Departments of Genetics and Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:2706-11. 2009..However, DOCK7 has non-redundant role(s) related to the distribution and function of dermal and follicular melanocytes...