R J Krauzlis

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint Activity in the primate rostral superior colliculus during the "gap effect" for pursuit and saccades
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Ann N Y Acad Sci 956:409-13. 2002
  2. ncbi request reprint Activity of rostral superior colliculus neurons during passive and active viewing of motion
    Richard J Krauzlis
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurophysiol 92:949-58. 2004
  3. ncbi request reprint Neuronal activity in the rostral superior colliculus related to the initiation of pursuit and saccadic eye movements
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:4333-44. 2003
  4. ncbi request reprint Target selection and the superior colliculus: goals, choices and hypotheses
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Vision Res 44:1445-51. 2004
  5. ncbi request reprint The control of voluntary eye movements: new perspectives
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscientist 11:124-37. 2005
  6. ncbi request reprint Neural correlates of target choice for pursuit and saccades in the primate superior colliculus
    Richard Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 35:355-63. 2002
  7. ncbi request reprint Finding our way around the sensory-motor corner
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 54:852-4. 2007
  8. ncbi request reprint Extraretinal inputs to neurons in the rostral superior colliculus of the monkey during smooth-pursuit eye movements
    R J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurophysiol 86:2629-33. 2001
  9. ncbi request reprint Effects of directional expectations on motion perception and pursuit eye movements
    R J Krauzlis
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Vis Neurosci 18:365-76. 2001
  10. doi request reprint Walk this way
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 60:7-8. 2008

Research Grants

  1. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard J Krauzlis; Fiscal Year: 2010
  2. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard Krauzlis; Fiscal Year: 2009
  3. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard Krauzlis; Fiscal Year: 2007
  4. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard Krauzlis; Fiscal Year: 2005
  5. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard Krauzlis; Fiscal Year: 2002
  6. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard J Krauzlis; Fiscal Year: 2010

Detail Information

Publications37

  1. ncbi request reprint Activity in the primate rostral superior colliculus during the "gap effect" for pursuit and saccades
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Ann N Y Acad Sci 956:409-13. 2002
  2. ncbi request reprint Activity of rostral superior colliculus neurons during passive and active viewing of motion
    Richard J Krauzlis
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurophysiol 92:949-58. 2004
    ....
  3. ncbi request reprint Neuronal activity in the rostral superior colliculus related to the initiation of pursuit and saccadic eye movements
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:4333-44. 2003
    ..These results suggest how SC neurons may coordinate the initiation of pursuit and saccades: buildup activity may gate the initiation of pursuit, whereas it indirectly triggers saccades by recruiting a saccade-related burst...
  4. ncbi request reprint Target selection and the superior colliculus: goals, choices and hypotheses
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Vision Res 44:1445-51. 2004
    ..In one version of this mechanism, the decision to select a new goal would occur each time the null hypothesis, represented by neurons in the rostral SC, was rejected in favor of an alternative represented elsewhere in the SC...
  5. ncbi request reprint The control of voluntary eye movements: new perspectives
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscientist 11:124-37. 2005
    ..These points of similarity may hold the key for understanding how neural circuits negotiate the links between the many higher order functions that can influence behavior and the singular and coordinated motor actions that follow...
  6. ncbi request reprint Neural correlates of target choice for pursuit and saccades in the primate superior colliculus
    Richard Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 35:355-63. 2002
    ..These results show that activity from the same set of neurons in the superior colliculus can predict target choices for both pursuit and saccades...
  7. ncbi request reprint Finding our way around the sensory-motor corner
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 54:852-4. 2007
    ..In this issue of Neuron, Wilmer and Nakayama use a novel analysis to show that the initial changes in smooth-pursuit eye speed are driven by low-level motion signals, whereas the later eye speed is determined by high-level signals...
  8. ncbi request reprint Extraretinal inputs to neurons in the rostral superior colliculus of the monkey during smooth-pursuit eye movements
    R J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurophysiol 86:2629-33. 2001
    ..These results indicate that discharge of rostral SC neurons during pursuit is not simply a visual response, but includes extraretinal signals...
  9. ncbi request reprint Effects of directional expectations on motion perception and pursuit eye movements
    R J Krauzlis
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Vis Neurosci 18:365-76. 2001
    ..Applying cognitive factors such as expectations at relatively early stages of visual processing could act to coordinate the metrics of eye movements with perceptual judgements...
  10. doi request reprint Walk this way
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 60:7-8. 2008
    ..In this issue of Neuron, Felsen and Mainen use an olfactory-guided orienting task to show that the superior colliculus is necessary in rodents for the normal execution of spatial locomotor choices...
  11. ncbi request reprint Discharge properties of neurons in the rostral superior colliculus of the monkey during smooth-pursuit eye movements
    R J Krauzlis
    Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland 20892, USA
    J Neurophysiol 84:876-91. 2000
    ..Thus the tonic activity of these rostral neurons provides a potential position-error signal rather than a motor command-a principle that may be applicable to buildup neurons elsewhere in the SC...
  12. ncbi request reprint Target selection for pursuit and saccadic eye movements in humans
    R J Krauzlis
    The Salk Institute SNL K, 10010 N Torrey Pines Road, La Jolla, CA 92037 1099, USA
    J Cogn Neurosci 11:641-9. 1999
    ..The differences in the details of the effects on pursuit and saccades suggest that the neural mechanisms that trigger these two movements can be independently regulated...
  13. ncbi request reprint Recasting the smooth pursuit eye movement system
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurophysiol 91:591-603. 2004
    ..Although the traditional view describes pursuit and saccades as two distinct neural systems, it may be more accurate to consider the two movements as different outcomes from a shared cascade of sensory-motor functions...
  14. ncbi request reprint Decreases in the latency of smooth pursuit and saccadic eye movements produced by the "gap paradigm" in the monkey
    R J Krauzlis
    Laboratory of Sensorimotor Research, National Institutes of Health, Bethesda, MD 20982, USA
    Vision Res 36:1973-85. 1996
    ..The gap paradigm did not produce "express" pursuit, even though express saccades could be elicited on interleaved trials...
  15. ncbi request reprint Activation and inactivation of rostral superior colliculus neurons during smooth-pursuit eye movements in monkeys
    M A Basso
    Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland 20892
    J Neurophysiol 84:892-908. 2000
    ....
  16. pmc Microsaccadic suppression of visual bursts in the primate superior colliculus
    Ziad M Hafed
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 30:9542-7. 2010
    ..These results provide evidence that the superior colliculus is part of the mechanism for suppressing self-generated visual signals during microsaccades that might otherwise disrupt perceptual stability...
  17. ncbi request reprint Spatial deployment of attention influences both saccadic and pursuit tracking
    Laurent Madelain
    Systems Neurobiology Laboratory, Salk Institute for Biological Research, La Jolla, CA 92037, USA
    Vision Res 45:2685-703. 2005
    ..small. We propose that the timing of the saccade decision process depends on both the size of the attended object and the magnitude of the perturbation...
  18. ncbi request reprint Reaching for answers
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Neuron 34:673-4. 2002
    ..In this issue of Neuron, present provocative data showing that microstimulation of the precentral cortex evokes complex movements, and conclude that the motor and premotor cortex together may form a single map of complex postures...
  19. pmc Inactivation of primate superior colliculus impairs covert selection of signals for perceptual judgments
    Lee P Lovejoy
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Neurosci 13:261-6. 2010
    ..When distracting stimuli contained no information, discrimination performance was largely unaffected. Thus, the superior colliculus is a bottleneck in the covert selection of signals for perceptual judgments...
  20. pmc Spatial allocation of attention during smooth pursuit eye movements
    Lee P Lovejoy
    Salk Institute for Biological Studies, La Jolla, CA 92037, United States
    Vision Res 49:1275-85. 2009
    ..Spatial cues were only partly effective in directing attention to other locations in our task, and these cueing effects were biased for locations ahead of the tracked target...
  21. pmc Saccade selection when reward probability is dynamically manipulated using Markov chains
    Samuel U Nummela
    Systems Neurobiology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Exp Brain Res 187:321-30. 2008
    ..These results demonstrate that Markov chains can be used to dynamically assign probabilities that are rapidly exploited by human subjects during saccade target selection...
  22. pmc Superior colliculus inactivation causes stable offsets in eye position during tracking
    Ziad M Hafed
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 28:8124-37. 2008
    ....
  23. pmc Goal representations dominate superior colliculus activity during extrafoveal tracking
    Ziad M Hafed
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 28:9426-39. 2008
    ..These results demonstrate the flexibility with which activity across the SC represents the location, as well as the spatial precision, of behaviorally relevant goals for multiple eye movements...
  24. ncbi request reprint Ongoing eye movements constrain visual perception
    Ziad M Hafed
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 9:1449-57. 2006
    ..We found that eye movements significantly promoted perceptual coherence compared to fixation. These results indicate that eye movement information constrains the perceptual interpretation of visual inputs...
  25. ncbi request reprint Shared decision signal explains performance and timing of pursuit and saccadic eye movements
    Dorion Liston
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Vis 5:678-89. 2005
    ..We argue that this pattern occurs because pursuit and saccades share a decision signal, but utilize different response thresholds and are subject to different motor processing delays...
  26. ncbi request reprint Primacy of spatial information in guiding target selection for pursuit and saccades
    Scott A Adler
    Salk Institute for Biological Studies, La Jolla, CA, USA
    J Vis 2:627-44. 2002
    ..We suggest that the primacy of spatial information for both pursuit and saccades reflects the importance of spatial attention in selecting the stimulus target for both eye movements...
  27. ncbi request reprint Cancelling of pursuit and saccadic eye movements in humans and monkeys
    Krista Kornylo
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurophysiol 89:2984-99. 2003
    ..Together, these results suggest that a common inhibitory mechanism regulates the initiation of pursuit and saccades...
  28. pmc Inactivation of primate superior colliculus biases target choice for smooth pursuit, saccades, and button press responses
    Samuel U Nummela
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA, 92037, USA
    J Neurophysiol 104:1538-48. 2010
    ..The inactivation-induced bias for smooth pursuit and button press responses indicates SC activity is important for selecting the target, independent of any role in saccade preparation...
  29. ncbi request reprint Effects of learning on smooth pursuit during transient disappearance of a visual target
    Laurent Madelain
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurophysiol 90:972-82. 2003
    ..Our results demonstrate that learned contingencies can increase eye velocity in the absence of visual signals and support the view that pursuit is regulated by extra-retinal signals that can undergo long-term plasticity...
  30. pmc A neural mechanism for microsaccade generation in the primate superior colliculus
    Ziad M Hafed
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 323:940-3. 2009
    ..These results, coupled with computational modeling of SC activity, demonstrate that microsaccades are controlled by the SC and explain the link between microsaccades and visual attention...
  31. ncbi request reprint Manipulating intent: evidence for a causal role of the superior colliculus in target selection
    Christopher D Carello
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, University of California, San Diego, La Jolla, California 92037, USA
    Neuron 43:575-83. 2004
    ..These results show that the SC helps decide the object of the next movement, beyond its traditional responsibility of saccade production...
  32. ncbi request reprint Pursuit of the ineffable: perceptual and motor reversals during the tracking of apparent motion
    Laurent Madelain
    Systems Neurobiology Lab, Salk Institute for Biological Studies, La Jolla, CA, USA
    J Vis 3:642-53. 2003
    ..Smooth pursuit and the perception of motion direction were in temporal register and highly correlated, suggesting that pursuit can provide a real-time readout for the state of motion perception...
  33. ncbi request reprint Shared response preparation for pursuit and saccadic eye movements
    Dorion Liston
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:11305-14. 2003
    ..This shared processing may help ensure the coordination of pursuit and saccadic eye movements in selecting a single target...
  34. pmc Inactivation and stimulation of the frontal pursuit area change pursuit metrics without affecting pursuit target selection
    Shaun Mahaffy
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Neurophysiol 106:347-60. 2011
    ..Despite these changes, both manipulations failed to significantly alter choice behavior. These results show that FPA activity is not necessary for pursuit target selection...
  35. pmc The spatial scale of attention strongly modulates saccade latencies
    Mark R Harwood
    Department of Biology, City College of New York, City University of New York, Convent Avenue at 138th St, New York, NY 10031, USA
    J Neurophysiol 99:1743-57. 2008
    ....
  36. ncbi request reprint Going for the goal
    Richard J Krauzlis
    Nat Neurosci 6:332-3. 2003
  37. ncbi request reprint Shared motion signals for human perceptual decisions and oculomotor actions
    Leland S Stone
    Human Factors Research and Technology Division, NASA Ames Research Center, Moffett Field, CA, USA
    J Vis 3:725-36. 2003
    ..We conclude that the neural signal encoding the direction of target motion that drives steady-state pursuit and supports concurrent perceptual judgments emanates from a shared ensemble of cortical neurons...

Research Grants13

  1. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard J Krauzlis; Fiscal Year: 2010
    ..Understanding how these systems interact will also help us understand how and why these circuits malfunction in a variety of developmental disorders. ..
  2. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard Krauzlis; Fiscal Year: 2009
    ..Understanding how these systems interact will also help us understand how and why these circuits malfunction in a variety of developmental disorders. ..
  3. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard Krauzlis; Fiscal Year: 2007
    ..Understanding how these systems interact will also help us understand how and why these circuits malfunction in a variety of developmental disorders. ..
  4. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard Krauzlis; Fiscal Year: 2005
    ..The results from these studies will therefore help refine clinical descriptions of the oculomotor system that are used to diagnose eye movement disorders in humans. ..
  5. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard Krauzlis; Fiscal Year: 2002
    ..These studies will therefore help refine clinical descriptions of the oculomotor system that are used to diagnose eye movement disorders in humans. ..
  6. COORDINATION OF VOLUNTARY EYE MOVEMENTS
    Richard J Krauzlis; Fiscal Year: 2010
    ..Understanding how these systems interact will also help us understand how and why these circuits malfunction in a variety of developmental disorders. ..