Jay H Kramer

Summary

Affiliation: The George Washington University
Country: USA

Publications

  1. ncbi request reprint Cardiac tissue iron: effects on post-ischemic function and free radical production, and its possible role during preconditioning
    J H Kramer
    Department of Physiology and Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Cell Mol Biol (Noisy-le-grand) 46:1313-27. 2000
  2. pmc Neurogenic inflammation and cardiac dysfunction due to hypomagnesemia
    Jay H Kramer
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington DC 20037, USA
    Am J Med Sci 338:22-7. 2009
  3. ncbi request reprint Antioxidant and lysosomotropic properties of acute D-propranolol underlies its cardioprotection of postischemic hearts from moderate iron-overloaded rats
    Jay H Kramer
    Department of Biochemistry, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Exp Biol Med (Maywood) 231:473-84. 2006
  4. ncbi request reprint Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress
    Jay H Kramer
    Department of Physiology, George Washington University Medical Center, Washington, DC 20037, USA
    Exp Biol Med (Maywood) 228:665-73. 2003
  5. pmc d-Propranolol protects against oxidative stress and progressive cardiac dysfunction in iron overloaded rats
    Jay H Kramer
    Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Can J Physiol Pharmacol 90:1257-68. 2012
  6. ncbi request reprint Mg-gluconate provides superior protection against postischemic dysfunction and oxidative injury compared to Mg-sulfate
    Sarah B Murthi
    Department of Surgery, Division of Cardiothoracic Surgery, The George Washington University Medical Center, Washington, D C 20037, USA
    Mol Cell Biochem 245:141-8. 2003
  7. doi request reprint Cardiovascular and intestinal responses to oxidative and nitrosative stress during prolonged magnesium deficiency
    William B Weglicki
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Am J Med Sci 342:125-8. 2011
  8. pmc The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction
    William B Weglicki
    Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University, Washington, DC 20037, USA
    Can J Physiol Pharmacol 90:1145-9. 2012
  9. pmc The role of magnesium deficiency in cardiovascular and intestinal inflammation
    William B Weglicki
    Division of Experimental Medicine, Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA
    Magnes Res 23:S199-206. 2010
  10. pmc Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia
    William B Weglicki
    The Department of Biochemistry and Molecular Biology, 439 Ross Hall, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    Magnes Res 22:167S-173S. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Cardiac tissue iron: effects on post-ischemic function and free radical production, and its possible role during preconditioning
    J H Kramer
    Department of Physiology and Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Cell Mol Biol (Noisy-le-grand) 46:1313-27. 2000
    ..These preliminary findings suggest that cardioprotection resulting from IP may, in part, be related to IP-induced release of cardiovascular endothelial iron (redox-active) prior to imposing severe I/R stress...
  2. pmc Neurogenic inflammation and cardiac dysfunction due to hypomagnesemia
    Jay H Kramer
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington DC 20037, USA
    Am J Med Sci 338:22-7. 2009
    ..In view of the clinical prevalence of hypomagnesemia, new treatments, beyond magnesium repletion, may be needed to diminish deleterious neurogenic and prooxidative components described in this article...
  3. ncbi request reprint Antioxidant and lysosomotropic properties of acute D-propranolol underlies its cardioprotection of postischemic hearts from moderate iron-overloaded rats
    Jay H Kramer
    Department of Biochemistry, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Exp Biol Med (Maywood) 231:473-84. 2006
    ....
  4. ncbi request reprint Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress
    Jay H Kramer
    Department of Physiology, George Washington University Medical Center, Washington, DC 20037, USA
    Exp Biol Med (Maywood) 228:665-73. 2003
    ..Our data suggest that varying dietary Mg intake directly influences the magnitude of the neurogenic/oxidative responses in vivo and the resultant myocardial tolerance to I/R stress...
  5. pmc d-Propranolol protects against oxidative stress and progressive cardiac dysfunction in iron overloaded rats
    Jay H Kramer
    Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Can J Physiol Pharmacol 90:1257-68. 2012
    ..Since d-Pro is an antioxidant and reduces cardiac Fe uptake as well as inflammation, these properties may preserve cardiac function during Fe overload...
  6. ncbi request reprint Mg-gluconate provides superior protection against postischemic dysfunction and oxidative injury compared to Mg-sulfate
    Sarah B Murthi
    Department of Surgery, Division of Cardiothoracic Surgery, The George Washington University Medical Center, Washington, D C 20037, USA
    Mol Cell Biochem 245:141-8. 2003
    ..MgGl2 treated hearts exhibited less postischemic dysfunction and oxidative injury compared to MgSO4, suggesting the contribution of Gl(1-) to cardioprotection...
  7. doi request reprint Cardiovascular and intestinal responses to oxidative and nitrosative stress during prolonged magnesium deficiency
    William B Weglicki
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Am J Med Sci 342:125-8. 2011
    ..The neurogenic signal transduction pathways that we have identified in the pro-oxidant/pro-inflammatory processes found with prolonged hypomagnesemia are described in this report...
  8. pmc The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction
    William B Weglicki
    Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University, Washington, DC 20037, USA
    Can J Physiol Pharmacol 90:1145-9. 2012
    ..Since hypomagnesemia alone can trigger oxidative stress and cardiac injury, we suggest that inhibition of EGFR-TK caused magnesium wasting, which partly contributed to decreased cardiac contractility...
  9. pmc The role of magnesium deficiency in cardiovascular and intestinal inflammation
    William B Weglicki
    Division of Experimental Medicine, Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA
    Magnes Res 23:S199-206. 2010
    ....
  10. pmc Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia
    William B Weglicki
    The Department of Biochemistry and Molecular Biology, 439 Ross Hall, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
    Magnes Res 22:167S-173S. 2009
    ..Thus, we submit that inhibition of NEP by pharmacological, genetic and dietary approaches (magnesium restriction), causes greater neurogenic inflammation that may result in increased intestinal and cardiac dysfunction...
  11. ncbi request reprint Suppression of neutrophil and endothelial activation by substance P receptor blockade in the Mg-deficient rat
    I Tong Mak
    The George Washington University Medical Center, Department of Physiology and Experimental Medicine, Washington, DC 20037, USA
    Magnes Res 16:91-7. 2003
    ....
  12. pmc AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation
    I Tong Mak
    Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University Medical Center, 2300 Eye Street, N W Ross Hall, Rm 443, Washington, DC 20037, USA
    Cardiovasc Toxicol 9:78-85. 2009
    ..05) the weight gain loss due to AZT intake. It is concluded that high dietary Mg may provide beneficial effects against AZT toxicity due to its systemic antioxidative/anti-inflammatory properties...
  13. pmc Loss of neutral endopeptidase activity contributes to neutrophil activation and cardiac dysfunction during chronic hypomagnesemia: Protection by substance P receptor blockade
    I Tong Mak
    Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University
    Exp Clin Cardiol 16:121-4. 2011
    ..The effects of chronic Hypo-Mg on neutrophil NEP activity, cell activation and the associated cardiac dysfunction were examined...