Research Topics
Species | Jay H KramerSummaryAffiliation: The George Washington University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Cardiac tissue iron: effects on post-ischemic function and free radical production, and its possible role during preconditioningJ H Kramer
Department of Physiology and Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Cell Mol Biol (Noisy-le-grand) 46:1313-27. 2000..These preliminary findings suggest that cardioprotection resulting from IP may, in part, be related to IP-induced release of cardiovascular endothelial iron (redox-active) prior to imposing severe I/R stress...
Neurogenic inflammation and cardiac dysfunction due to hypomagnesemiaJay H Kramer
Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington DC 20037, USA
Am J Med Sci 338:22-7. 2009..In view of the clinical prevalence of hypomagnesemia, new treatments, beyond magnesium repletion, may be needed to diminish deleterious neurogenic and prooxidative components described in this article...- Antioxidant and lysosomotropic properties of acute D-propranolol underlies its cardioprotection of postischemic hearts from moderate iron-overloaded ratsJay H Kramer
Department of Biochemistry, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Exp Biol Med (Maywood) 231:473-84. 2006.... - Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stressJay H Kramer
Department of Physiology, George Washington University Medical Center, Washington, DC 20037, USA
Exp Biol Med (Maywood) 228:665-73. 2003..Our data suggest that varying dietary Mg intake directly influences the magnitude of the neurogenic/oxidative responses in vivo and the resultant myocardial tolerance to I/R stress... - Mg-gluconate provides superior protection against postischemic dysfunction and oxidative injury compared to Mg-sulfateSarah B Murthi
Department of Surgery, Division of Cardiothoracic Surgery, The George Washington University Medical Center, Washington, D.C. 20037, USA
Mol Cell Biochem 245:141-8. 2003..MgGl2 treated hearts exhibited less postischemic dysfunction and oxidative injury compared to MgSO4, suggesting the contribution of Gl(1-) to cardioprotection... - Cardiovascular and intestinal responses to oxidative and nitrosative stress during prolonged magnesium deficiencyWilliam B Weglicki
Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
Am J Med Sci 342:125-8. 2011..The neurogenic signal transduction pathways that we have identified in the pro-oxidant/pro-inflammatory processes found with prolonged hypomagnesemia are described in this report... - The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunctionWilliam B Weglicki
Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University, Washington, DC 20037, USA
Can J Physiol Pharmacol 90:1145-9. 2012..Since hypomagnesemia alone can trigger oxidative stress and cardiac injury, we suggest that inhibition of EGFR-TK caused magnesium wasting, which partly contributed to decreased cardiac contractility... - The role of magnesium deficiency in cardiovascular and intestinal inflammationWilliam B Weglicki
Division of Experimental Medicine, Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA
Magnes Res 23:S199-206. 2010.... - Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemiaWilliam B Weglicki
The Department of Biochemistry and Molecular Biology, 439 Ross Hall, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
Magnes Res 22:167S-173S. 2009..Thus, we submit that inhibition of NEP by pharmacological, genetic and dietary approaches (magnesium restriction), causes greater neurogenic inflammation that may result in increased intestinal and cardiac dysfunction... - d-Propranolol protects against oxidative stress and progressive cardiac dysfunction in iron overloaded ratsJay H Kramer
Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Can J Physiol Pharmacol 90:1257-68. 2012..Since d-Pro is an antioxidant and reduces cardiac Fe uptake as well as inflammation, these properties may preserve cardiac function during Fe overload... - Suppression of neutrophil and endothelial activation by substance P receptor blockade in the Mg-deficient ratI Tong Mak
The George Washington University Medical Center, Department of Physiology and Experimental Medicine, Washington, DC 20037, USA
Magnes Res 16:91-7. 2003.... - AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementationI Tong Mak
Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University Medical Center, 2300 Eye Street, N W Ross Hall, Rm 443, Washington, DC 20037, USA
Cardiovasc Toxicol 9:78-85. 2009..05) the weight gain loss due to AZT intake. It is concluded that high dietary Mg may provide beneficial effects against AZT toxicity due to its systemic antioxidative/anti-inflammatory properties... 
Loss of neutral endopeptidase activity contributes to neutrophil activation and cardiac dysfunction during chronic hypomagnesemia: Protection by substance P receptor blockadeI Tong Mak
Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University
Exp Clin Cardiol 16:121-4. 2011..The effects of chronic Hypo-Mg on neutrophil NEP activity, cell activation and the associated cardiac dysfunction were examined...