Julio A Kovacs

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Fast rotational matching
    Julio A Kovacs
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Acta Crystallogr D Biol Crystallogr 58:1282-6. 2002
  2. ncbi Predictions of protein flexibility: first-order measures
    Julio A Kovacs
    Department of Molecular Biology, The Scripps Research Institute La Jolla, California 92037, USA
    Proteins 56:661-8. 2004
  3. ncbi Computational prediction of atomic structures of helical membrane proteins aided by EM maps
    Julio A Kovacs
    Department of Molecular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Biophys J 93:1950-9. 2007
  4. ncbi Damped-dynamics flexible fitting
    Julio A Kovacs
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Biophys J 95:3192-207. 2008
  5. ncbi Molecular modeling and mutagenesis of gap junction channels
    Julio A Kovacs
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Prog Biophys Mol Biol 94:15-28. 2007
  6. ncbi 2D fast rotational matching for image processing of biophysical data
    Yao Cong
    School of Health Information Sciences and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 7000 Fannin St, Suite 600, Houston, TX 77030, USA
    J Struct Biol 144:51-60. 2003

Detail Information

Publications6

  1. ncbi Fast rotational matching
    Julio A Kovacs
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Acta Crystallogr D Biol Crystallogr 58:1282-6. 2002
    ..Applications to the docking of atomic structures into electron-microscopy maps and the molecular-replacement problem in X-ray crystallography are considered...
  2. ncbi Predictions of protein flexibility: first-order measures
    Julio A Kovacs
    Department of Molecular Biology, The Scripps Research Institute La Jolla, California 92037, USA
    Proteins 56:661-8. 2004
    ..Deformability calculations correlate well with experimental results and validate the applicability of this method to protein flexibility predictions...
  3. ncbi Computational prediction of atomic structures of helical membrane proteins aided by EM maps
    Julio A Kovacs
    Department of Molecular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Biophys J 93:1950-9. 2007
    ..In addition, our method implements a penalty term through a so-called tethering map, derived from the EM map, which restrains the positions of the alpha-helices. The protocol was validated on three test cases: GpA, KcsA, and MscL...
  4. ncbi Damped-dynamics flexible fitting
    Julio A Kovacs
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    Biophys J 95:3192-207. 2008
    ..Applications to the computation of transition pathways between known conformers, homology and loop modeling, as well as protein docking, are also discussed...
  5. ncbi Molecular modeling and mutagenesis of gap junction channels
    Julio A Kovacs
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Prog Biophys Mol Biol 94:15-28. 2007
    ..In spite of this substantial progress in understanding the structural biology of gap junction channels, an experimentally determined structure at atomic resolution will be essential to confirm these concepts...
  6. ncbi 2D fast rotational matching for image processing of biophysical data
    Yao Cong
    School of Health Information Sciences and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 7000 Fannin St, Suite 600, Houston, TX 77030, USA
    J Struct Biol 144:51-60. 2003
    ..FRM2D exhibits a comparable or higher robustness against noise and a significant gain in efficiency that depends on the fineness of the angular sampling and linear search range...