Research Topics
Genomes and Genes | George KoobSummaryAffiliation: The Scripps Research Institute Country: USA Publications
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Publications
ERK regulation in chronic ethanol exposure and withdrawalPietro Paolo Sanna
Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Brain Res 948:186-91. 2002..Thus the dysregulation of the ERK pathway could contribute to escalation of withdrawal symptoms induced by repeated withdrawal and possibly to the neuroadaptative changes believed to underlie progression towards addiction...
Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in ratsZhongqi Zhang
Department of Anesthesiology, UC San Diego School of Medicine and VA San Diego Healthcare System, San Diego, California 92161 5008, USA
Alcohol Clin Exp Res 31:1811-9. 2007..0 g/kg) is accompanied by elevations in brain reward thresholds, and that repeated intermittent treatment with this dose results in a significant potentiation of reward deficit (Schulteis and Liu, 2006)...- CRF(1) receptor antagonists attenuate escalated cocaine self-administration in ratsSheila E Specio
The Scripps Research Institute, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 196:473-82. 2008..However, the involvement of activation of CRF(1) receptors in rats self-administering cocaine with extended access is unknown... - Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in ratsPaul J Kenny
Department of Neuropharmacology, CVN-7, The Scripps Research Institute, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 179:247-54. 2005..Further, it is likely that blockade of mGlu5 receptors may attenuate cocaine consumption, at least in part, by decreasing the baseline activity of brain reward circuitries... - Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercleJohn R Walker
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
Neuropsychopharmacology 27:203-11. 2002..These results shed light on adaptations of endogenous opioid systems to conditioned cues, stress, and withdrawal, all factors that play a role in motivating drug intake... - Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorderGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
Curr Top Behav Neurosci 13:3-30. 2013.... - Genetical genomic determinants of alcohol consumption in rats and humansBoris Tabakoff
Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
BMC Biol 7:70. 2009.... - Plasticity of reward neurocircuitry and the 'dark side' of drug addictionGeorge F Koob
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, 92037, USA
Nat Neurosci 8:1442-4. 2005..Understanding the neuroplasticity of the dark side of this circuitry is the key to understanding vulnerability to addiction... - Review. Neurobiological mechanisms for opponent motivational processes in addictionGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Philos Trans R Soc Lond B Biol Sci 363:3113-23. 2008.... - A role for brain stress systems in addictionGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuron 59:11-34. 2008..Understanding the role of brain stress and antistress systems in addiction provides novel targets for treatment and prevention of addiction and insights into the organization and function of basic brain emotional circuitry... - Neuroadaptive mechanisms of addiction: studies on the extended amygdalaGeorge F Koob
Division of Psychopharmacology, Department of Neuropharmacology, The Scripps Research Institute, CVN 7, La Jolla, CA 92037, USA
Eur Neuropsychopharmacol 13:442-52. 2003.... - Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholismGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:8809-10. 2008 - Substance dependence as a compulsive behaviorG F Koob
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Psychopharmacol 12:39-48. 1998..Challenges for the future involve not only elucidation of the neurobiological substrates of the different behavioral components of addiction, but better animal models of these components with which to effect such studies... - Neurobiological mechanisms in the transition from drug use to drug dependenceGeorge F Koob
Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neurosci Biobehav Rev 27:739-49. 2004.... - Addiction and the brain antireward systemGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
Annu Rev Psychol 59:29-53. 2008..Vulnerability to addiction may involve genetic comorbidity and developmental factors at the molecular, cellular, or neurocircuitry levels that sensitize the brain antireward systems... - Stress, dysregulation of drug reward pathways, and the transition to drug dependenceGeorge Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Am J Psychiatry 164:1149-59. 2007..A model of the role of different levels of hormonal/brain stress activation in addiction is presented that has heuristic value for understanding individual vulnerability to drug dependence and novel treatments for the disorder... - Nicotine withdrawal in adolescent and adult ratsLaura E O'Dell
Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
Ann N Y Acad Sci 1021:167-74. 2004.... - A role for GABA mechanisms in the motivational effects of alcoholGeorge F Koob
Department of Neuropharmacology, The Scripps Research Institute, 1055 North Pines Road, La Jolla, CA 92037, USA
Biochem Pharmacol 68:1515-25. 2004.... - The neurobiology of addiction: a neuroadaptational view relevant for diagnosisGeorge F Koob
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
Addiction 101:23-30. 2006..The purpose of this review is to provide a synthesis of our knowledge of the neurobiological bases of addiction relevant for the diagnosis of addiction... - Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memoryG F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
Pharmacopsychiatry 42:S32-41. 2009.... - Development of pharmacotherapies for drug addiction: a Rosetta stone approachGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400 La Jolla, California 92037, USA
Nat Rev Drug Discov 8:500-15. 2009..This approach will promote translational research and provide a heuristic framework for developing efficient and effective pharmacotherapies for addiction... - A role for corticotropin releasing factor and urocortin in behavioral responses to stressorsG F Koob
Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
Brain Res 848:141-52. 1999.... - Stress, corticotropin-releasing factor, and drug addictionG F Koob
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
Ann N Y Acad Sci 897:27-45. 1999..CRF is hypothesized to be part of an allostatic change leading to vulnerability to relapse during prolonged abstinence from drugs of abuse... - Neurobiology of addiction. Toward the development of new therapiesG F Koob
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
Ann N Y Acad Sci 909:170-85. 2000..Elucidation of the specific neuropharmacological changes contributing to this prolonged functional dysregulation will be the challenge of future research on the neurobiology of drug addiction... - Alcoholism, corticotropin-releasing factor, and molecular genetic allostasisGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
Biol Psychiatry 63:137-8. 2008 - Neurobiological mechanisms of addiction: focus on corticotropin-releasing factorGeorge F Koob
The Scripps Research Institute, Committee on the Neurobiology of Addictive Disorders, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
Curr Opin Investig Drugs 11:63-71. 2010.... - The role of CRF and CRF-related peptides in the dark side of addictionGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400 La Jolla, CA 92037, USA
Brain Res 1314:3-14. 2010.... - The role of the striatopallidal and extended amygdala systems in drug addictionG F Koob
Department of Neuropharmacology, CVN 7, Scripps Research Institute, La Jolla, California 92037, USA
Ann N Y Acad Sci 877:445-60. 1999.... - Brain stress systems in the amygdala and addictionGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
Brain Res 1293:61-75. 2009.... - Neurocircuitry of addictionGeorge F Koob
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropsychopharmacology 35:217-38. 2010.... - Alcoholism: allostasis and beyondGeorge F Koob
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
Alcohol Clin Exp Res 27:232-43. 2003.... - CRF system recruitment mediates dark side of compulsive eatingPietro Cottone
Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:20016-20. 2009.... - Unlimited access to heroin self-administration: independent motivational markers of opiate dependenceScott A Chen
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
Neuropsychopharmacology 31:2692-707. 2006..showed a dose-dependent reduction in heroin intake. Changes in the pattern of drug and food intake in the present unlimited heroin access model may serve as independent motivational markers for the transition to a drug-dependent state... - Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependenceHeather N Richardson
Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
Neurobiol Dis 36:1-10. 2009..Increased hippocampal apoptosis and neuronal degeneration following alcohol exposure suggest a loss in neuronal turnover and indicate that the hippocampal neurogenic niche is highly vulnerable to alcohol... - Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring ratsValentina Sabino
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 189:175-86. 2006..The role of positive vs negative ethanol reinforcement in ethanol intake of Sardinian alcohol-preferring (sP) rats is unclear... - MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonistHeather N Richardson
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, 92037 California, USA
Pharmacol Biochem Behav 88:497-510. 2008.... - Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal intervalEva M Fekete
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropsychopharmacology 32:1052-68. 2007..The results implicate the VMN and PVN of the hypothalamus as sites for Ucn 3-CRF(2) control of food intake... - Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factorEmanuela Izzo
Department of Neuropharmacology, CVN-12, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, California, CA 92037, USA
Pharmacol Biochem Behav 81:701-8. 2005.... - The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administrationThomas N Greenwell
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, United States
Pharmacol Biochem Behav 91:295-302. 2009..The data suggest that the alpha1 adrenergic system may contribute to mechanisms that promote dependence in rats with extended access... - Reduction of anxiety after restricted feeding in the rat: implication for eating disordersKoki Inoue
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
Biol Psychiatry 55:1075-81. 2004..The findings might have etiologic and pathophysiologic relevance for the restrained eating pattern in eating-disorder patients with comorbid anxious symptoms... - Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar ratsAnnika Thorsell
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road SP30 2400, La Jolla, CA 92037, USA
Brain 130:1330-7. 2007..Repeated withdrawal in combination with a history of alcohol consumption significantly elevated alcohol intake, and the amygdala may mediate the transition to high-drinking states in this model... - Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine stateHeather N Richardson
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Eur J Neurosci 28:1641-53. 2008.... - Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in ratsDong Ji
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California, USA
Behav Pharmacol 19:1-12. 2008..MPZP did not affect alcohol or supersac consumption. Different profiles for drugs that suppress binge-like alcohol drinking compared with dependence-induced drinking provide a heuristic foundation for future medications development... - Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behaviorTracy L Bale
Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
J Neurosci 22:193-9. 2002..These results indicate that both CRFR1 and CRFR2 have critical roles in gene regulation and the maintenance of homeostasis in response to stress... - Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addictionAdie W Bruijnzeel
Molecular and Integrative Neuroscience Department, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 186:612-9. 2006..Both the enhanced rewarding effects and the diminished nicotine withdrawal likely contribute to the rapid development of nicotine use during adolescence... - Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activationGlenn R Valdez
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
Alcohol Clin Exp Res 28:865-72. 2004.... - Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in ratsScott A Chen
Department of Molecular and Integrative Neurosciences, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
J Pharmacol Exp Ther 320:180-93. 2007..The results demonstrate that rats will self-administer nicotine to the point of producing dependence, as measured by somatic signs, resistance to extinction, and measures of food intake... - Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levelsSerge H Ahmed
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
J Neurochem 86:102-13. 2003..These findings show that changes in cocaine efficacy or pharmacokinetics do not play a critical role in cocaine intake escalation... - Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitizationEmanuela Izzo
Department of Neuropharmacology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, CVN12, La Jolla, California 92103, USA
Nat Neurosci 5:1263-4. 2002..Our results show that PI3K is required for the expression, but not the induction, of behavioral sensitization to cocaine... - Vapor inhalation of alcohol in ratsNicholas W Gilpin
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA
Curr Protoc Neurosci . 2008..This unit describes the options available to investigators using this procedure for dependence induction, when different options are more or less appropriate, and the implications of each... - A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent ratsCindy K Funk
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Brain Res 1155:172-8. 2007..These data demonstrate an opposing role of the CRF(2) receptor subtype within the CeA in mediating ethanol self-administration in withdrawn, dependent and nondependent rats... - Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in ratsPaul J Kenny
Department of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Eur J Neurosci 17:191-5. 2003.... - Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatementCristina Orsini
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Brain Res 925:133-40. 2002..These observations lend further support to the hypothesis of the involvement of nitric oxide in cocaine addiction and extend previous findings to components of the cocaine addictive cycle associated with relapse... - Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockoutKathleen Chu
Molecular and Integrative Neurosciences Department, SV 142, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92036, USA
Pharmacol Biochem Behav 86:813-21. 2007..In addition, a model is presented that may be useful for studies examining underlying mechanisms of the ethanol addiction process as well as for testing potential therapeutics... - Chronic opioid exposure produces increased heroin self-administration in ratsJohn R Walker
Department of Neuropharmacology, The Scripps Research Institute, CVN-7, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Pharmacol Biochem Behav 75:349-54. 2003..These results suggest that passive administration of morphine sufficient to produce and maintain dependence facilitates escalation in heroin intake... - Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access ratsThomas N Greenwell
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, USA
Addict Biol 14:130-43. 2009..The results demonstrate that blockade of the CRF-CRF(1) receptor system attenuates the increased heroin intake of rats with extended access to the drug... - Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the ratMichael E Hoefer
Molecular and Integrative Neurosciences Department, SP30-2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Pharmacol Biochem Behav 83:403-9. 2006.... - Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholismGlenn R Valdez
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Pharmacol Biochem Behav 79:671-89. 2004.... - Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the ratEric P Zorrilla
Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
Brain Res 952:188-99. 2002.... - Cellular and behavioral interactions of gabapentin with alcohol dependenceMarisa Roberto
Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 28:5762-71. 2008.... - Nibbling at CRF receptor control of feeding and gastrocolonic motilityEric P Zorrilla
Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Trends Pharmacol Sci 24:421-7. 2003..These findings have important physiological implications and suggest targeted approaches for the pharmacotherapy of obesity and stress-related functional gastrointestinal and eating disorders... - Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the ratEric P Zorrilla
Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 177:324-35. 2005..Many attempts to understand ingestion have sought to clarify the control of meals. Little is known about the effects of the anorexogenic hormone leptin on meal patterning... - Conditioned withdrawal drives heroin consumption and decreases reward sensitivityPaul J Kenny
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 26:5894-900. 2006..Thus, conditioned stimuli predicting the onset of heroin withdrawal, and hence the reward deficits coupled with this state, may play a critical role in provoking craving and relapse in human opiate addicts... - The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuseSunmee Wee
Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 210:121-35. 2010.... - Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependenceMarisa Roberto
Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
Biol Psychiatry 67:831-9. 2010..Ethanol augments CeA GABA release in ethanol-naive rats and mice... - Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinenceGlenn R Valdez
Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Alcohol 29:55-60. 2003..Results of the current experiment demonstrated that continuous exposure to ethanol over a 3-week period leads to an increased behavioral responsiveness to stress, which seems to be regulated by CRF... - Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacologyGeorge F Koob
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
Recent Dev Alcohol 16:263-81. 2003.... - Escalation of methamphetamine self-administration in rats: a dose-effect functionOsamu Kitamura
Molecular and Integrative Neurosciences Department, SP30-2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 186:48-53. 2006..Results suggest that the rapidity of escalation is dependent on dose and has an upper limit of intake over a period of 21 days... - alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanolBrendan M Walker
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Alcohol 42:91-7. 2008..None of the doses tested reliably affected concurrent water self-administration. These results suggest the involvement of the noradrenergic system in the excessive alcohol drinking seen during acute withdrawal in ethanol-dependent rats... - Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session durationSunmee Wee
Committee on Neurobiology of Addictive Disorder, The Scripps Research Institute, La Jolla, CA92037, USA
Neuropsychopharmacology 32:2238-47. 2007..However, mechanisms other than downregulation of D(2) DA receptors in the nucleus accumbens and the striatum may be responsible for the increased sensitivity of the dopaminergic function in LgA rats... - Effects of dose and session duration on cocaine self-administration in ratsSunmee Wee
Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
J Pharmacol Exp Ther 320:1134-43. 2007..Therefore, high doses or prolonged access to cocaine are more likely to result in a pattern of cocaine intake that reflects compulsive use... - Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged accessSunmee Wee
Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Eur Neuropsychopharmacol 18:303-11. 2008..The data suggest that activation of the alpha 1-noradrenergic system, perhaps in the BNST, is associated with increased motivation for cocaine in rats with extended access... - The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent ratsBrendan M Walker
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Alcohol Clin Exp Res 31:11-8. 2007..However, little work has focused on the effects of GABA(B) receptor agonists on self-administration of ethanol in dependent animals... - Neurobiological evidence for hedonic allostasis associated with escalating cocaine useSerge H Ahmed
Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux 2, CNRS UMR 5541, 146 rue Leo Saignat, Bordeaux 33076, France
Nat Neurosci 5:625-6. 2002.... - Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behaviorBenjamin Boutrel
Center for Psychiatric Neuroscience and Service Universitaire de Psychiatrie de l Enfant et de l Adolescent, Centre Hospitalier Universitaire Vaudois Département de Psychiatrie, University of Lausanne, Prilly, Switzerland
Proc Natl Acad Sci U S A 102:19168-73. 2005..These findings reveal a previously unidentified role for hypocretins in driving drug seeking through activation of stress pathways in the brain... - Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in ratsKarine Guillem
, UMR CNRS 5541, , BP 31, , 33076 Bordeaux, Cedex, France
Eur J Neurosci 24:3532-40. 2006.... - A key role for corticotropin-releasing factor in alcohol dependenceMarkus Heilig
Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, NIH, 10 Center Dr, 1 5334, Bethesda, MD 20892, USA
Trends Neurosci 30:399-406. 2007..Therefore, the CRF system is emerging as a key element of the neuroadaptive changes driving alcoholism and as a major target for its treatment... - Kappa opioid control of seizures produced by a virus in an animal modelMarylou V Solbrig
Department of Neurology, University of California Irvine, Irvine, CA 92697 4292, USA
Brain 129:642-54. 2006.... - 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administrationLaura E O'Dell
Department of Psychology, The University of Texas at El Paso, El Paso, TX 79968, USA
Pharmacol Biochem Behav 86:346-53. 2007..In addition, intermittent access to increasing unit doses appears to produce higher levels of nicotine intake than continuous access to a constant unit nicotine dose... - Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversionKarine Guillem
Laboratoire de Neuropsychobiologie des Désadaptations UMR CNRS 5541, Universite de Bordeaux 2, Bordeaux, France
Biol Psychiatry 63:158-63. 2008.... - Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in ratsCharles J Heyser
Department of Psychology, Franklin and Marshall College, PO Box 3003, Lancaster, PA 17604, USA
Neuropsychopharmacology 28:1463-71. 2003..These results support the hypothesis that naltrexone and acamprosate are effective in modulating aspects of alcohol-seeking behavior, and under certain situations may be more effective in combination... - Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward functionSerge H Ahmed
Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, CNRS UMR 5541, 33076, Bordeaux, France
Psychopharmacology (Berl) 180:473-90. 2005..The transition from initial drug use to drug addiction has been proposed to result from an allostatic decrease in reward function driven by an overactivation of brain antireward processes... - Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in ratsKarine Guillem
, , Centre National de la Recherche Scientifique, , 33076 Bordeaux Cedex, France
J Neurosci 25:8593-600. 2005..The results suggest that the inhibition of MAO activity by compounds present in tobacco smoke may combine with nicotine to produce the intense reinforcing properties of cigarette smoking that lead to addiction... - Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neuronsScott C Steffensen
Department of Psychology 1050 SWKT, Brigham Young University, Provo, UT 84602, USA
Exp Neurol 202:139-51. 2006.... - Lack of self-administration of cocaine in dopamine D1 receptor knock-out miceS Barak Caine
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
J Neurosci 27:13140-50. 2007..We conclude that D1 receptor knock-out mice do not reliably self-administer cocaine and that the D1 receptor is critical for the reinforcing effects of cocaine and other dopamine agonists, but not food or opioids, in mice... - Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in ratsLuis Stinus
Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux II, Bordeaux, Cedex, France
Neuropsychopharmacology 30:90-8. 2005..In addition, these results suggest that CRF1 antagonists can block the aversive stimulus effects of opiate withdrawal and may be potential therapeutic targets for opiate dependence... - The transition from controlled to compulsive drug use is associated with a loss of sensitizationOsnat Ben-Shahar
Department of Psychology, University of California, Santa Barbara, CA 93106 9660, USA
Brain Res 995:46-54. 2004..These data suggest that the transition to escalating patterns of drug use is associated with neuroadaptive changes that counteract those initially associated with controlled stable patterns of drug use... - Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intakeSerge H Ahmed
Laboratoire de Neuropsychobiologie Desadaptations, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, Universite Victor Segalen Bordeaux 2, Bordeaux, France
Psychopharmacology (Berl) 172:450-4. 2004..CONCLUSIONS: These data support the hypothesis that alterations in dopamine neurotransmission contribute to escalation of cocaine self-administration...
Research Grants
- Central mechanisms of nicotine reinforcement and dependenceGeorge Koob; Fiscal Year: 2009..abstract_text> ..
- DOPAMINE PARTIAL AGONISTS AND COCAINE DEPENDENCEGeorge Koob; Fiscal Year: 1999..These studies will help elucidate the effectiveness of dopamine partial agonists with a wide range of intrinsic efficacies in modifying various phases of the natural history of psychostimulant dependence. ..
- CENTRAL MECHANISMS OF OPIATE REINFORCEMENT & DEPENDENCEGeorge Koob; Fiscal Year: 1993..These studies have important implications for our understanding of the neural substrates involved in opiate seeking behavior and the drug abuse process...
- NEURONAL SUBSTRATES OF COCAINE REWARDGeorge Koob; Fiscal Year: 1993..The results obtained will go far to identify the neuropharmacological mechanism of action for cocaine reinforcement and thus should provide important clues to neuropharmacological basis of cocaine dependence and abuse...
- CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENCGeorge Koob; Fiscal Year: 2003....
- DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCEGeorge Koob; Fiscal Year: 2009....
- Central Mechanisms of Opiate Reinforcement and DependenceGeorge Koob; Fiscal Year: 2007....
- Neurpsychopharmacology-Multidisciplinary TrainingGeorge Koob; Fiscal Year: 2007..In summary, the training program discussed herein provides a dynamic environment for fellows to develop a strong foundation to pursue a career in the neuropsychopharmacology of alcoholism. ..
- CNS EFFECTS OF ALCOHOL: CELLULAR NEUROBIOLOGYGeorge Koob; Fiscal Year: 2007..Training and information dissemination to the San Diego community will be effected by the training opportunities of the Center including an NIAAA training grant and the Education Component. ..
- NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENTGeorge Koob; Fiscal Year: 2007..data to understand the neurobiologic changes in reward and stress systems in the extended amygdala associated with ethanol dependence and provide a framework for future diagnostic and medications development for alcoholism treatment ..
- DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCEGeorge Koob; Fiscal Year: 2004..Specific Aim 4 will then characterize the transition from moderate to excessive methamphetamine-seeking behavior and investigate whether partial dopamine agonists modify drug intake in rats with a history of drug escalation. ..
- Integrative Neuroscience Initiative on AlcoholismGeorge Koob; Fiscal Year: 2007..The INIA program will be directed by an Administrative Core in close cooperation with the Executive Committee, Steering Committee, and with the continual advice of the Scientific Advisory Board. ..
- NEURONAL SUBSTRATES OF COCAINE REWARDGeorge Koob; Fiscal Year: 2009..Such information is critical for the development of new treatments for cocaine addiction as well as for the development of strategies to identify individuals vulnerable for the development of cocaine addiction. ..
- NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENTGeorge F Koob; Fiscal Year: 2010....
- DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCEGeorge F Koob; Fiscal Year: 2010....
- NEURONAL SUBSTRATES OF COCAINE REWARDGeorge F Koob; Fiscal Year: 2010....
- Central mechanisms of nicotine reinforcement and dependenceGeorge F Koob; Fiscal Year: 2010....
- NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENTGeorge Koob; Fiscal Year: 1991..These results should have important implications not only for our understanding of the neurobiology of ethanol intoxication but may lead to the development of viable pharmacological intervention in alcoholism...
- NEURONAL SUBSTRATES OF COCAINE REWARDGeorge Koob; Fiscal Year: 2003..Such information is essential for the development of new treatments for drug addiction as well as for the development of strategies to identify vulnerability to the development of addiction. ..