George Koob

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi ERK regulation in chronic ethanol exposure and withdrawal
    Pietro Paolo Sanna
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 948:186-91. 2002
  2. pmc Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats
    Zhongqi Zhang
    Department of Anesthesiology, UC San Diego School of Medicine and VA San Diego Healthcare System, San Diego, California 92161 5008, USA
    Alcohol Clin Exp Res 31:1811-9. 2007
  3. pmc CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats
    Sheila E Specio
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 196:473-82. 2008
  4. ncbi Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:247-54. 2005
  5. ncbi Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle
    John R Walker
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Neuropsychopharmacology 27:203-11. 2002
  6. pmc Addiction as a stress surfeit disorder
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA Electronic address
    Neuropharmacology 76:370-82. 2014
  7. doi Negative reinforcement in drug addiction: the darkness within
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Curr Opin Neurobiol 23:559-63. 2013
  8. pmc Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Curr Top Behav Neurosci 13:3-30. 2013
  9. pmc Genetical genomic determinants of alcohol consumption in rats and humans
    Boris Tabakoff
    Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
    BMC Biol 7:70. 2009
  10. pmc Review. Neurobiological mechanisms for opponent motivational processes in addiction
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 363:3113-23. 2008

Detail Information

Publications91

  1. ncbi ERK regulation in chronic ethanol exposure and withdrawal
    Pietro Paolo Sanna
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 948:186-91. 2002
    ..Thus the dysregulation of the ERK pathway could contribute to escalation of withdrawal symptoms induced by repeated withdrawal and possibly to the neuroadaptative changes believed to underlie progression towards addiction...
  2. pmc Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats
    Zhongqi Zhang
    Department of Anesthesiology, UC San Diego School of Medicine and VA San Diego Healthcare System, San Diego, California 92161 5008, USA
    Alcohol Clin Exp Res 31:1811-9. 2007
    ..0 g/kg) is accompanied by elevations in brain reward thresholds, and that repeated intermittent treatment with this dose results in a significant potentiation of reward deficit (Schulteis and Liu, 2006)...
  3. pmc CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats
    Sheila E Specio
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 196:473-82. 2008
    ..However, the involvement of activation of CRF(1) receptors in rats self-administering cocaine with extended access is unknown...
  4. ncbi Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:247-54. 2005
    ..Evidence is accumulating that metabotropic glutamate 5 (mGlu5) receptors play an important role in regulating the reinforcing actions of drugs of abuse...
  5. ncbi Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle
    John R Walker
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Neuropsychopharmacology 27:203-11. 2002
    ..These results shed light on adaptations of endogenous opioid systems to conditioned cues, stress, and withdrawal, all factors that play a role in motivating drug intake...
  6. pmc Addiction as a stress surfeit disorder
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA Electronic address
    Neuropharmacology 76:370-82. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  7. doi Negative reinforcement in drug addiction: the darkness within
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Curr Opin Neurobiol 23:559-63. 2013
    ....
  8. pmc Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Curr Top Behav Neurosci 13:3-30. 2013
    ....
  9. pmc Genetical genomic determinants of alcohol consumption in rats and humans
    Boris Tabakoff
    Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
    BMC Biol 7:70. 2009
    ....
  10. pmc Review. Neurobiological mechanisms for opponent motivational processes in addiction
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Philos Trans R Soc Lond B Biol Sci 363:3113-23. 2008
    ....
  11. ncbi Neurobiological mechanisms in the transition from drug use to drug dependence
    George F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurosci Biobehav Rev 27:739-49. 2004
    ....
  12. ncbi Neuroadaptive mechanisms of addiction: studies on the extended amygdala
    George F Koob
    Division of Psychopharmacology, Department of Neuropharmacology, The Scripps Research Institute, CVN 7, La Jolla, CA 92037, USA
    Eur Neuropsychopharmacol 13:442-52. 2003
    ....
  13. pmc A role for brain stress systems in addiction
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuron 59:11-34. 2008
    ..Understanding the role of brain stress and antistress systems in addiction provides novel targets for treatment and prevention of addiction and insights into the organization and function of basic brain emotional circuitry...
  14. ncbi Nicotine withdrawal in adolescent and adult rats
    Laura E O'Dell
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1021:167-74. 2004
    ....
  15. ncbi A role for GABA mechanisms in the motivational effects of alcohol
    George F Koob
    Department of Neuropharmacology, The Scripps Research Institute, 1055 North Pines Road, La Jolla, CA 92037, USA
    Biochem Pharmacol 68:1515-25. 2004
    ....
  16. ncbi The neurobiology of addiction: a neuroadaptational view relevant for diagnosis
    George F Koob
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Addiction 101:23-30. 2006
    ..The purpose of this review is to provide a synthesis of our knowledge of the neurobiological bases of addiction relevant for the diagnosis of addiction...
  17. pmc Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:8809-10. 2008
  18. pmc Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 63:137-8. 2008
  19. ncbi Plasticity of reward neurocircuitry and the 'dark side' of drug addiction
    George F Koob
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, 92037, USA
    Nat Neurosci 8:1442-4. 2005
    ..Understanding the neuroplasticity of the dark side of this circuitry is the key to understanding vulnerability to addiction...
  20. ncbi Addiction and the brain antireward system
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Psychol 59:29-53. 2008
    ..Vulnerability to addiction may involve genetic comorbidity and developmental factors at the molecular, cellular, or neurocircuitry levels that sensitize the brain antireward systems...
  21. pmc Stress, dysregulation of drug reward pathways, and the transition to drug dependence
    George Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Am J Psychiatry 164:1149-59. 2007
    ..A model of the role of different levels of hormonal/brain stress activation in addiction is presented that has heuristic value for understanding individual vulnerability to drug dependence and novel treatments for the disorder...
  22. pmc Brain stress systems in the amygdala and addiction
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Brain Res 1293:61-75. 2009
    ....
  23. pmc Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory
    G F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Pharmacopsychiatry 42:S32-41. 2009
    ....
  24. pmc Development of pharmacotherapies for drug addiction: a Rosetta stone approach
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400 La Jolla, California 92037, USA
    Nat Rev Drug Discov 8:500-15. 2009
    ..This approach will promote translational research and provide a heuristic framework for developing efficient and effective pharmacotherapies for addiction...
  25. ncbi Substance dependence as a compulsive behavior
    G F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Psychopharmacol 12:39-48. 1998
    ..Challenges for the future involve not only elucidation of the neurobiological substrates of the different behavioral components of addiction, but better animal models of these components with which to effect such studies...
  26. ncbi The role of the striatopallidal and extended amygdala systems in drug addiction
    G F Koob
    Department of Neuropharmacology, CVN 7, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 877:445-60. 1999
    ....
  27. ncbi A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
    G F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 848:141-52. 1999
    ....
  28. ncbi Stress, corticotropin-releasing factor, and drug addiction
    G F Koob
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 897:27-45. 1999
    ..CRF is hypothesized to be part of an allostatic change leading to vulnerability to relapse during prolonged abstinence from drugs of abuse...
  29. ncbi Neurobiology of addiction. Toward the development of new therapies
    G F Koob
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 909:170-85. 2000
    ..Elucidation of the specific neuropharmacological changes contributing to this prolonged functional dysregulation will be the challenge of future research on the neurobiology of drug addiction...
  30. pmc Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor
    George F Koob
    The Scripps Research Institute, Committee on the Neurobiology of Addictive Disorders, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Curr Opin Investig Drugs 11:63-71. 2010
    ....
  31. pmc The role of CRF and CRF-related peptides in the dark side of addiction
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400 La Jolla, CA 92037, USA
    Brain Res 1314:3-14. 2010
    ....
  32. pmc Neurocircuitry of addiction
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 35:217-38. 2010
    ....
  33. ncbi Alcoholism: allostasis and beyond
    George F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 27:232-43. 2003
    ....
  34. ncbi Unlimited access to heroin self-administration: independent motivational markers of opiate dependence
    Scott A Chen
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Neuropsychopharmacology 31:2692-707. 2006
    ..showed a dose-dependent reduction in heroin intake. Changes in the pattern of drug and food intake in the present unlimited heroin access model may serve as independent motivational markers for the transition to a drug-dependent state...
  35. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
    ....
  36. pmc Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence
    Heather N Richardson
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Neurobiol Dis 36:1-10. 2009
    ..Increased hippocampal apoptosis and neuronal degeneration following alcohol exposure suggest a loss in neuronal turnover and indicate that the hippocampal neurogenic niche is highly vulnerable to alcohol...
  37. ncbi Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
    Valentina Sabino
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 189:175-86. 2006
    ..The role of positive vs negative ethanol reinforcement in ethanol intake of Sardinian alcohol-preferring (sP) rats is unclear...
  38. pmc MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist
    Heather N Richardson
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, 92037 California, USA
    Pharmacol Biochem Behav 88:497-510. 2008
    ....
  39. pmc The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
    Thomas N Greenwell
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, United States
    Pharmacol Biochem Behav 91:295-302. 2009
    ..The data suggest that the alpha1 adrenergic system may contribute to mechanisms that promote dependence in rats with extended access...
  40. pmc Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval
    Eva M Fekete
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1052-68. 2007
    ..The results implicate the VMN and PVN of the hypothalamus as sites for Ucn 3-CRF(2) control of food intake...
  41. ncbi Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor
    Emanuela Izzo
    Department of Neuropharmacology, CVN 12, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, California, CA 92037, USA
    Pharmacol Biochem Behav 81:701-8. 2005
    ....
  42. ncbi Reduction of anxiety after restricted feeding in the rat: implication for eating disorders
    Koki Inoue
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Biol Psychiatry 55:1075-81. 2004
    ..Eating-disorder patients exhibit not only abnormal eating attitudes but also pathologic anxiety-like behaviors. The specific nature of the relationship between dieting and anxiety-like behavior is unknown...
  43. pmc Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats
    Annika Thorsell
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road SP30 2400, La Jolla, CA 92037, USA
    Brain 130:1330-7. 2007
    ..Repeated withdrawal in combination with a history of alcohol consumption significantly elevated alcohol intake, and the amygdala may mediate the transition to high-drinking states in this model...
  44. pmc Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state
    Heather N Richardson
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Neurosci 28:1641-53. 2008
    ....
  45. pmc Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats
    Dong Ji
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California, USA
    Behav Pharmacol 19:1-12. 2008
    ..MPZP did not affect alcohol or supersac consumption. Different profiles for drugs that suppress binge-like alcohol drinking compared with dependence-induced drinking provide a heuristic foundation for future medications development...
  46. ncbi Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior
    Tracy L Bale
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 22:193-9. 2002
    ..These results indicate that both CRFR1 and CRFR2 have critical roles in gene regulation and the maintenance of homeostasis in response to stress...
  47. ncbi Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction
    Laura E O'Dell
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 186:612-9. 2006
    ..Enhanced reinforcing effects of nicotine during adolescence appear to contribute to the rapid development of dependence in this age group. However, the contribution of nicotine withdrawal to dependence in adolescents is unclear...
  48. ncbi Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats
    Scott A Chen
    Department of Molecular and Integrative Neurosciences, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:180-93. 2007
    ..The results demonstrate that rats will self-administer nicotine to the point of producing dependence, as measured by somatic signs, resistance to extinction, and measures of food intake...
  49. ncbi Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization
    Emanuela Izzo
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Rd, CVN12, La Jolla, California 92103, USA
    Nat Neurosci 5:1263-4. 2002
    ..Our results show that PI3K is required for the expression, but not the induction, of behavioral sensitization to cocaine...
  50. ncbi Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation
    Glenn R Valdez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 28:865-72. 2004
    ....
  51. ncbi Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels
    Serge H Ahmed
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 86:102-13. 2003
    ..These findings show that changes in cocaine efficacy or pharmacokinetics do not play a critical role in cocaine intake escalation...
  52. ncbi Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 17:191-5. 2003
    ....
  53. pmc Vapor inhalation of alcohol in rats
    Nicholas W Gilpin
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA
    Curr Protoc Neurosci . 2008
    ..This unit describes the options available to investigators using this procedure for dependence induction, when different options are more or less appropriate, and the implications of each...
  54. pmc A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats
    Cindy K Funk
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1155:172-8. 2007
    ..These data demonstrate an opposing role of the CRF(2) receptor subtype within the CeA in mediating ethanol self-administration in withdrawn, dependent and nondependent rats...
  55. pmc Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout
    Kathleen Chu
    Molecular and Integrative Neurosciences Department, SV 142, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92036, USA
    Pharmacol Biochem Behav 86:813-21. 2007
    ..In addition, a model is presented that may be useful for studies examining underlying mechanisms of the ethanol addiction process as well as for testing potential therapeutics...
  56. pmc Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats
    Thomas N Greenwell
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, USA
    Addict Biol 14:130-43. 2009
    ..The results demonstrate that blockade of the CRF-CRF(1) receptor system attenuates the increased heroin intake of rats with extended access to the drug...
  57. ncbi Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement
    Cristina Orsini
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 925:133-40. 2002
    ..These observations lend further support to the hypothesis of the involvement of nitric oxide in cocaine addiction and extend previous findings to components of the cocaine addictive cycle associated with relapse...
  58. ncbi Chronic opioid exposure produces increased heroin self-administration in rats
    John R Walker
    Department of Neuropharmacology, The Scripps Research Institute, CVN 7, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 75:349-54. 2003
    ..These results suggest that passive administration of morphine sufficient to produce and maintain dependence facilitates escalation in heroin intake...
  59. ncbi Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat
    Michael E Hoefer
    Molecular and Integrative Neurosciences Department, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 83:403-9. 2006
    ....
  60. ncbi Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism
    Glenn R Valdez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 79:671-89. 2004
    ....
  61. pmc Cellular and behavioral interactions of gabapentin with alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:5762-71. 2008
    ....
  62. ncbi Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence
    Glenn R Valdez
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol 29:55-60. 2003
    ..Results of the current experiment demonstrated that continuous exposure to ethanol over a 3-week period leads to an increased behavioral responsiveness to stress, which seems to be regulated by CRF...
  63. ncbi Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology
    George F Koob
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Recent Dev Alcohol 16:263-81. 2003
    ....
  64. pmc alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Alcohol 42:91-7. 2008
    ..None of the doses tested reliably affected concurrent water self-administration. These results suggest the involvement of the noradrenergic system in the excessive alcohol drinking seen during acute withdrawal in ethanol-dependent rats...
  65. ncbi Nibbling at CRF receptor control of feeding and gastrocolonic motility
    Eric P Zorrilla
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 24:421-7. 2003
    ..These findings have important physiological implications and suggest targeted approaches for the pharmacotherapy of obesity and stress-related functional gastrointestinal and eating disorders...
  66. ncbi Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat
    Eric P Zorrilla
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 177:324-35. 2005
    ..Many attempts to understand ingestion have sought to clarify the control of meals. Little is known about the effects of the anorexogenic hormone leptin on meal patterning...
  67. pmc The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 31:11-8. 2007
    ..However, little work has focused on the effects of GABA(B) receptor agonists on self-administration of ethanol in dependent animals...
  68. pmc Effects of dose and session duration on cocaine self-administration in rats
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:1134-43. 2007
    ..Therefore, high doses or prolonged access to cocaine are more likely to result in a pattern of cocaine intake that reflects compulsive use...
  69. ncbi Escalation of methamphetamine self-administration in rats: a dose-effect function
    Osamu Kitamura
    Molecular and Integrative Neurosciences Department, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 186:48-53. 2006
    ..The transition from stable to escalated drug intake has been demonstrated in rats self-administrating cocaine and heroin using a single dose of drug...
  70. pmc Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur Neuropsychopharmacol 18:303-11. 2008
    ..The data suggest that activation of the alpha 1-noradrenergic system, perhaps in the BNST, is associated with increased motivation for cocaine in rats with extended access...
  71. pmc The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 210:121-35. 2010
    ....
  72. ncbi Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
    Eric P Zorrilla
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res 952:188-99. 2002
    ....
  73. pmc Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 67:831-9. 2010
    ..Ethanol augments CeA GABA release in ethanol-naive rats and mice...
  74. pmc Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration
    Sunmee Wee
    Committee on Neurobiology of Addictive Disorder, The Scripps Research Institute, La Jolla, CA92037, USA
    Neuropsychopharmacology 32:2238-47. 2007
    ..However, mechanisms other than downregulation of D(2) DA receptors in the nucleus accumbens and the striatum may be responsible for the increased sensitivity of the dopaminergic function in LgA rats...
  75. ncbi Conditioned withdrawal drives heroin consumption and decreases reward sensitivity
    Paul J Kenny
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:5894-900. 2006
    ..Thus, conditioned stimuli predicting the onset of heroin withdrawal, and hence the reward deficits coupled with this state, may play a critical role in provoking craving and relapse in human opiate addicts...
  76. ncbi Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats
    Karine Guillem
    Laboratoire de Neuropsychobiologie des Desadaptations, Unite Mixte de Recherche 5541, Centre National de la Recherche Scientifique, Universite de Bordeaux 2, 33076 Bordeaux Cedex, France
    J Neurosci 25:8593-600. 2005
    ..The results suggest that the inhibition of MAO activity by compounds present in tobacco smoke may combine with nicotine to produce the intense reinforcing properties of cigarette smoking that lead to addiction...
  77. ncbi Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux 2, CNRS UMR 5541, 146 rue Leo Saignat, Bordeaux 33076, France
    Nat Neurosci 5:625-6. 2002
    ....
  78. ncbi Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats
    Charles J Heyser
    Department of Psychology, Franklin and Marshall College, PO Box 3003, Lancaster, PA 17604, USA
    Neuropsychopharmacology 28:1463-71. 2003
    ..These results support the hypothesis that naltrexone and acamprosate are effective in modulating aspects of alcohol-seeking behavior, and under certain situations may be more effective in combination...
  79. pmc 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration
    Laura E O'Dell
    Department of Psychology, The University of Texas at El Paso, El Paso, TX 79968, USA
    Pharmacol Biochem Behav 86:346-53. 2007
    ..In addition, intermittent access to increasing unit doses appears to produce higher levels of nicotine intake than continuous access to a constant unit nicotine dose...
  80. ncbi The transition from controlled to compulsive drug use is associated with a loss of sensitization
    Osnat Ben-Shahar
    Department of Psychology, University of California, Santa Barbara, CA 93106 9660, USA
    Brain Res 995:46-54. 2004
    ..These data suggest that the transition to escalating patterns of drug use is associated with neuroadaptive changes that counteract those initially associated with controlled stable patterns of drug use...
  81. ncbi Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats
    Karine Guillem
    Laboratoire de Neuropsychobiologie des Desadaptations, UMR CNRS 5541, Universite de Bordeaux 2, BP 31, 146 rue Leo Saignat, 33076 Bordeaux, Cedex, France
    Eur J Neurosci 24:3532-40. 2006
    ....
  82. pmc A key role for corticotropin-releasing factor in alcohol dependence
    Markus Heilig
    Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism NIAAA, NIH, 10 Center Dr, 1 5334, Bethesda, MD 20892, USA
    Trends Neurosci 30:399-406. 2007
    ..Therefore, the CRF system is emerging as a key element of the neuroadaptive changes driving alcoholism and as a major target for its treatment...
  83. ncbi Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion
    Karine Guillem
    Laboratoire de Neuropsychobiologie des Désadaptations UMR CNRS 5541, Universite de Bordeaux 2, Bordeaux, France
    Biol Psychiatry 63:158-63. 2008
    ....
  84. ncbi Kappa opioid control of seizures produced by a virus in an animal model
    Marylou V Solbrig
    Department of Neurology, University of California Irvine, Irvine, CA 92697 4292, USA
    Brain 129:642-54. 2006
    ....
  85. pmc Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
    Benjamin Boutrel
    Center for Psychiatric Neuroscience and Service Universitaire de Psychiatrie de l Enfant et de l Adolescent, Centre Hospitalier Universitaire Vaudois Département de Psychiatrie, University of Lausanne, Prilly, Switzerland
    Proc Natl Acad Sci U S A 102:19168-73. 2005
    ..These findings reveal a previously unidentified role for hypocretins in driving drug seeking through activation of stress pathways in the brain...
  86. ncbi Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, University Victor Segalen Bordeaux2, CNRS UMR 5541, 33076, Bordeaux, France
    Psychopharmacology (Berl) 180:473-90. 2005
    ..The transition from initial drug use to drug addiction has been proposed to result from an allostatic decrease in reward function driven by an overactivation of brain antireward processes...
  87. pmc Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 27:13140-50. 2007
    ..We conclude that D1 receptor knock-out mice do not reliably self-administer cocaine and that the D1 receptor is critical for the reinforcing effects of cocaine and other dopamine agonists, but not food or opioids, in mice...
  88. ncbi Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats
    Luis Stinus
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux II, Bordeaux, Cedex, France
    Neuropsychopharmacology 30:90-8. 2005
    ..In addition, these results suggest that CRF1 antagonists can block the aversive stimulus effects of opiate withdrawal and may be potential therapeutic targets for opiate dependence...
  89. ncbi Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie Desadaptations, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Psychopharmacology (Berl) 172:450-4. 2004
    ..The present study tested the hypothesis that escalating use of cocaine is associated with chronic alterations in dopamine neurotransmission...
  90. ncbi Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons
    Scott C Steffensen
    Department of Psychology 1050 SWKT, Brigham Young University, Provo, UT 84602, USA
    Exp Neurol 202:139-51. 2006
    ....

Research Grants66

  1. Central mechanisms of nicotine reinforcement and dependence
    George Koob; Fiscal Year: 2009
    ..abstract_text> ..
  2. DOPAMINE PARTIAL AGONISTS AND COCAINE DEPENDENCE
    George Koob; Fiscal Year: 1999
    ..These studies will help elucidate the effectiveness of dopamine partial agonists with a wide range of intrinsic efficacies in modifying various phases of the natural history of psychostimulant dependence. ..
  3. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT & DEPENDENCE
    George Koob; Fiscal Year: 1993
    ..These studies have important implications for our understanding of the neural substrates involved in opiate seeking behavior and the drug abuse process...
  4. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 1993
    ..The results obtained will go far to identify the neuropharmacological mechanism of action for cocaine reinforcement and thus should provide important clues to neuropharmacological basis of cocaine dependence and abuse...
  5. CENTRAL MECHANISMS OF OPIATE REINFORCEMENT AND DEPENDENC
    George Koob; Fiscal Year: 2003
    ....
  6. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2009
    ....
  7. Central Mechanisms of Opiate Reinforcement and Dependence
    George Koob; Fiscal Year: 2007
    ....
  8. Neurpsychopharmacology-Multidisciplinary Training
    George Koob; Fiscal Year: 2007
    ..In summary, the training program discussed herein provides a dynamic environment for fellows to develop a strong foundation to pursue a career in the neuropsychopharmacology of alcoholism. ..
  9. CNS EFFECTS OF ALCOHOL: CELLULAR NEUROBIOLOGY
    George Koob; Fiscal Year: 2007
    ..Training and information dissemination to the San Diego community will be effected by the training opportunities of the Center including an NIAAA training grant and the Education Component. ..
  10. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2007
    ..data to understand the neurobiologic changes in reward and stress systems in the extended amygdala associated with ethanol dependence and provide a framework for future diagnostic and medications development for alcoholism treatment ..
  11. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George Koob; Fiscal Year: 2004
    ..Specific Aim 4 will then characterize the transition from moderate to excessive methamphetamine-seeking behavior and investigate whether partial dopamine agonists modify drug intake in rats with a history of drug escalation. ..
  12. Integrative Neuroscience Initiative on Alcoholism
    George Koob; Fiscal Year: 2007
    ..The INIA program will be directed by an Administrative Core in close cooperation with the Executive Committee, Steering Committee, and with the continual advice of the Scientific Advisory Board. ..
  13. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2009
    ..Such information is critical for the development of new treatments for cocaine addiction as well as for the development of strategies to identify individuals vulnerable for the development of cocaine addiction. ..
  14. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George F Koob; Fiscal Year: 2010
    ....
  15. DOPAMINE PARTIAL AGONISTS AND PSYCHOSTIMULANT DEPENDENCE
    George F Koob; Fiscal Year: 2010
    ....
  16. NEURONAL SUBSTRATES OF COCAINE REWARD
    George F Koob; Fiscal Year: 2010
    ....
  17. Central mechanisms of nicotine reinforcement and dependence
    George F Koob; Fiscal Year: 2010
    ....
  18. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 1991
    ..These results should have important implications not only for our understanding of the neurobiology of ethanol intoxication but may lead to the development of viable pharmacological intervention in alcoholism...
  19. NEURONAL SUBSTRATES OF COCAINE REWARD
    George Koob; Fiscal Year: 2003
    ..Such information is essential for the development of new treatments for drug addiction as well as for the development of strategies to identify vulnerability to the development of addiction. ..