D P Kontoyiannis

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi request reprint Rational approach to pulmonary infiltrates in leukemia and transplantation
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Unit 1463, 1400 Pressler Street, Houston, TX 77030, USA Electronic address
    Best Pract Res Clin Haematol 26:301-6. 2013
  2. pmc Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Leuk Lymphoma 54:1730-3. 2013
  3. pmc Future directions in mucormycosis research
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Infect Dis 54:S79-85. 2012
  4. doi request reprint Invasive mycoses: strategies for effective management
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Med 125:S25-38. 2012
  5. ncbi request reprint Systemic mycoses in the immunocompromised host: an update in antifungal therapy
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    J Hosp Infect 53:243-58. 2003
  6. ncbi request reprint Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 402, Houston, TX 77030, USA
    J Antimicrob Chemother 51:313-6. 2003
  7. ncbi request reprint Fluconazole toxicity is independent of oxidative stress and apoptotic effector mechanisms in Saccharomyces cerevisiae
    D P Kontoyiannis
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Mycoses 46:183-6. 2003
  8. pmc Manipulation of host angioneogenesis: A critical link for understanding the pathogenesis of invasive mold infections?
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Virulence 1:192-6. 2010
  9. ncbi request reprint Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignancies
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:292-9. 2003
  10. doi request reprint Antifungal prophylaxis in hematopoietic stem cell transplant recipients: the unfinished tale of imperfect success
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Bone Marrow Transplant 46:165-73. 2011

Collaborators

Detail Information

Publications147 found, 100 shown here

  1. doi request reprint Rational approach to pulmonary infiltrates in leukemia and transplantation
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Unit 1463, 1400 Pressler Street, Houston, TX 77030, USA Electronic address
    Best Pract Res Clin Haematol 26:301-6. 2013
    ..Diagnostic protocols vary by region, center, and the expertise of the staff. This mini review discusses the issues surrounding diffuse pulmonary infiltrates and provides some recommendations to deal with these issues. ..
  2. pmc Impaired bactericidal but not fungicidal activity of polymorphonuclear neutrophils in patients with chronic lymphocytic leukemia
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Leuk Lymphoma 54:1730-3. 2013
    ..However, differences in PMN microbicidal response against A. fumigatus in patients with CLL were associated with the degree of hypogammaglobulinemia...
  3. pmc Future directions in mucormycosis research
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Infect Dis 54:S79-85. 2012
    ..The evolving epidemiology, immunopathogenesis, molecular virulence studies, early diagnosis, and pitfalls in designing clinical studies of mucormycosis are discussed in this article...
  4. doi request reprint Invasive mycoses: strategies for effective management
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Med 125:S25-38. 2012
    ..This article discusses strategies for the effective management of invasive mycoses, with a particular focus on antifungal hepatotoxicity...
  5. ncbi request reprint Systemic mycoses in the immunocompromised host: an update in antifungal therapy
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    J Hosp Infect 53:243-58. 2003
    ..Ongoing and future studies will determine their exact role in the management of different mycoses. The acceleration of antifungal drug discovery offers promise for the management of these difficult to treat opportunistic infections...
  6. ncbi request reprint Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 402, Houston, TX 77030, USA
    J Antimicrob Chemother 51:313-6. 2003
    ..Caspofungin activity was enhanced by calcineurin/TOR inhibitors for all Aspergillus isolates studied. Further investigation of this pathway is warranted...
  7. ncbi request reprint Fluconazole toxicity is independent of oxidative stress and apoptotic effector mechanisms in Saccharomyces cerevisiae
    D P Kontoyiannis
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Mycoses 46:183-6. 2003
    ..cerevisiae. Our data further support the notion that mitochondrial toxicity in the presence of azoles is modulated by the conversion of ergosterol precursors to toxic sterols...
  8. pmc Manipulation of host angioneogenesis: A critical link for understanding the pathogenesis of invasive mold infections?
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Virulence 1:192-6. 2010
    ..This complex, yet emerging field might add another level of knowledge and therapeutic choices in the management of these devastated infections...
  9. ncbi request reprint Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignancies
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:292-9. 2003
    ..Therefore, the authors retrospectively evaluated the efficacy and toxicity of CAS plus liposomal amphotericin B (LipoAMB) in patients with documented (definite or probable) or possible IA...
  10. doi request reprint Antifungal prophylaxis in hematopoietic stem cell transplant recipients: the unfinished tale of imperfect success
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Bone Marrow Transplant 46:165-73. 2011
    ..Empiricism and reliance on institution-specific epidemiologic data are still expected to be a major part of the 'art and science' of risk stratification for fungal infections in SCT...
  11. ncbi request reprint What is the significance of an isolated positive cryptococcal antigen in the cerebrospinal fluid of cancer patients?
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Mycoses 46:161-3. 2003
    ..Hence, an isolated cryptococcal antigen in the CSF has an unclear clinical value and must be interpreted with caution...
  12. ncbi request reprint Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: evidence of enhanced in vitro activity
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Diagn Microbiol Infect Dis 47:415-9. 2003
    ..fumigatus to itraconazole resulted in dose-dependent enhanced effects of caspofungin and vice versa. Our finding suggests a preferential role for azole-caspofungin sequential combinations and merits further in vivo investigation...
  13. doi request reprint Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database
    Dimitrios P Kontoyiannis
    The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Infect Dis 50:1091-100. 2010
    ..The incidence and epidemiology of invasive fungal infections (IFIs), a leading cause of death among hematopoeitic stem cell transplant (HSCT) recipients, are derived mainly from single-institution retrospective studies...
  14. doi request reprint Micafungin alone or in combination with other systemic antifungal therapies in hematopoietic stem cell transplant recipients with invasive aspergillosis
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Transpl Infect Dis 11:89-93. 2009
    ..Micafungin was well tolerated, even at high doses, and is a reasonable option for treatment of IA in this high-risk patient population...
  15. ncbi request reprint Toward more effective antifungal therapy: the prospects of combination therapy
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, and College of Pharmacy, University of Houston, 77030, USA
    Br J Haematol 126:165-75. 2004
    ..Despite the empiricism of combination antifungal therapy, certain principles help guide the use and study of these regimens...
  16. ncbi request reprint Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 191:1350-60. 2005
    ..Anecdotal evidence suggests a rise in zygomycosis in association with voriconazole (VRC) use in immunosuppressed patients...
  17. doi request reprint Caspofungin-non-susceptible Candida isolates in cancer patients
    Diamantis P Kofteridis
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Antimicrob Chemother 65:293-5. 2010
    ..To identify the frequency of caspofungin-non-susceptible Candida isolates in cancer patients with candidiasis...
  18. ncbi request reprint Sinus zygomycosis in a patient receiving voriconazole prophylaxis
    Michail S Lionakis
    Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Br J Haematol 129:2. 2005
  19. ncbi request reprint Itraconazole added to a lipid formulation of amphotericin B does not improve outcome of primary treatment of invasive aspergillosis
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:2334-7. 2005
    ..Itraconazole (ITC), a triazole with activity against Aspergillus, has been used in combination with AMB or lipid formulations of AMB (LipoAMB) in the treatment of IA, although the efficacy of this strategy is uncertain...
  20. ncbi request reprint Combination chemotherapy for invasive fungal infections: what laboratory and clinical studies tell us so far
    Dimitrios P Kontoyiannis
    Departments of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Box 402, 1515 Holcombe Blvd, Houston TX, USA
    Drug Resist Updat 6:257-69. 2003
    ..Such concepts include standardized methods for screening antifungal combinations in culture or in animals and collaborative efforts to collect clinical data on the efficacy and safety of combination regimens...
  21. ncbi request reprint Trichosporonosis in a tertiary care cancer center: risk factors, changing spectrum and determinants of outcome
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Scand J Infect Dis 36:564-9. 2004
    ..01). TS is associated with a high mortality rate in cancer patients. The spectrum of infection at our institution has shifted from a predominance of disseminated infection to CVC-related fungemias without evidence of tissue invasion...
  22. ncbi request reprint Invasive aspergillosis in 2002: an update
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, Box 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 21:161-72. 2002
    ..New exciting developments in the early diagnosis of invasive aspergillosis and the acceleration of antifungal drug discovery offer promise for the future...
  23. ncbi request reprint Antifungal drug resistance of pathogenic fungi
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Lancet 359:1135-44. 2002
    ..Better understanding of this resistance should assist in developing better detection strategies for preventing and treating refractory mycoses in the future...
  24. ncbi request reprint Outcome determinants of fusariosis in a tertiary care cancer center: the impact of neutrophil recovery
    D P Kontoyiannis
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Leuk Lymphoma 45:139-41. 2004
    ..Disseminated infection was the most common presentation. The majority (83%) received amphotericin B-based therapy. Thirty patients (71%) failed therapy. No patient with persistent neutropenia responded...
  25. pmc Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis
    Dimitrios P Kontoyiannis
    M D Anderson Cancer Center, University of Texas, Houston, Texas 77030 3930, USA
    Antimicrob Agents Chemother 52:735-8. 2008
    ....
  26. ncbi request reprint Pulmonary candidiasis in patients with cancer: an autopsy study
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 34:400-3. 2002
    ..For sputum culture, the sensitivity, specificity, and the positive and negative predictive values were 85%, 60%, 42%, and 93%, respectively; for bronchoalveolar lavage culture, these values were 71%, 57%, 29%, and 89%, respectively...
  27. ncbi request reprint Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1303-6. 2007
    ..Laboratory studies have demonstrated that iron is essential for Aspergillus growth and virulence...
  28. ncbi request reprint Invasive zygomycosis: update on pathogenesis, clinical manifestations, and management
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Infect Dis Clin North Am 20:581-607, vi. 2006
    ..Further reductions in mortality will require improved diagnostic and novel therapeutic approaches for this group of aggressive opportunistic molds...
  29. ncbi request reprint Decrease in the number of reported cases of zygomycosis among patients with diabetes mellitus: a hypothesis
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 44:1089-90. 2007
    ..Statins have been shown to direct inhibitory activity against a range of Zygomycetes molds, both in vitro and in vivo...
  30. pmc How I treat mucormycosis
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 118:1216-24. 2011
    ..However, serum drug concentration monitoring may be required to minimize breakthrough infection or relapsing mucormycosis associated with inadequate blood concentrations...
  31. ncbi request reprint Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin
    I I Raad
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 22:496-503. 2008
    ..03). In conclusion, posaconazole salvage therapy demonstrated greater efficacy and safety than HD-LPD/AMB alone or in combination with caspofungin in the salvage therapy of invasive aspergillosis in hematologic malignancy...
  32. pmc Overexpression of Sbe2p, a Golgi protein, results in resistance to caspofungin in Saccharomyces cerevisiae
    Nir Osherov
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Antimicrob Agents Chemother 46:2462-9. 2002
    ..cerevisiae. This transport pathway may provide insight into the tolerance or lack of sensitivity to caspofungin of some pathogenic fungi...
  33. doi request reprint Fungal endophthalmitis in a tertiary care cancer center: a review of 23 cases
    G A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 27:343-7. 2008
    ..FE in cancer patients occurs in the setting of severe, frequently disseminated opportunistic mycoses, is caused predominantly by hyalohyphomycetes, and is a marker for high 4-week mortality...
  34. doi request reprint Does pre-exposure of Aspergillus fumigatus to voriconazole or posaconazole in vitro affect its virulence and the in vivo activity of subsequent posaconazole or voriconazole, respectively? A study in a fly model of aspergillosis
    G A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Antimicrob Chemother 62:539-42. 2008
    ..Hence, it is important to determine whether Aspergillus pre-exposure to voriconazole or posaconazole diminishes subsequent posaconazole or voriconazole activity, respectively...
  35. ncbi request reprint Risk Factors for Candida tropicalis fungemia in patients with cancer
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 33:1676-81. 2001
    ..01). Also, the response of the breakthrough C. tropicalis fungemia was lower (P=.05). In conclusion, the host determinants associated with susceptibility to C. tropicalis are leukemia and prolonged neutropenia...
  36. doi request reprint Fatal cytomegalovirus pneumonia in patients with haematological malignancies: an autopsy-based case-control study
    H A Torres
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Clin Microbiol Infect 14:1160-6. 2008
    ..Complete remission of an HM does not preclude the development of CMV pneumonia among patients with prolonged lymphopenia...
  37. doi request reprint Immunocompromised hosts: immunopharmacology of modern antifungals
    R Ben-Ami
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Infect Dis 47:226-35. 2008
    ..Elucidation of the immunopharmacology of these drugs may aid in designing therapeutic regimens for specific clinical scenarios associated with defined immunological dysfunction...
  38. pmc Use of the Diversi Lab System for species and strain differentiation of Fusarium species isolates
    M Healy
    Bacterial Barcodes, Inc, Houston, TX 77030, USA
    J Clin Microbiol 43:5278-80. 2005
    ..rep-PCR dendrogram cluster analysis showed agreement with species sequence identification (elongation factor 1 alpha gene). Additionally, subtype differences within the same species were noted...
  39. ncbi request reprint Efflux-mediated resistance to fluconazole could be modulated by sterol homeostasis in Saccharomyces cerevisiae
    D P Kontoyiannis
    Department of Medical Specialties, Section of Infectious Diseases, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 47, Houston, TX 77030, USA
    J Antimicrob Chemother 46:199-203. 2000
    ..These results reinforce the emerging evidence in both S. cerevisiae and Candida albicans that sterols could serve as substrates for Pdr5p for transport across membranes...
  40. pmc Itraconazole preexposure attenuates the efficacy of subsequent amphotericin B therapy in a murine model of acute invasive pulmonary aspergillosis
    Russell E Lewis
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Antimicrob Agents Chemother 46:3208-14. 2002
    ..03). Higher doses of AMB did not overcome this antagonism. ITC preexposure was associated with poorer mycological efficacy and survival in mice treated subsequently with AMB for invasive pulmonary aspergillosis...
  41. ncbi request reprint Effect of fluconazole on agar invasion by Candida albicans
    D P Kontoyiannis
    Department of Internal Medicine Specialties, University of Texas M D Anderson Cancer Center, Houston, USA
    J Med Microbiol 50:78-82. 2001
    ..albicans strains that were resistant to fluconazole. This suggests that the degree to which fluconazole inhibits agar invasion by C. albicans hyphae could serve as a marker of susceptibility to azoles...
  42. ncbi request reprint Progressive disseminated aspergillosis in a bone marrow transplant recipient: response with a high-dose lipid formulation of amphotericin B
    D P Kontoyiannis
    Dept of Internal Medicine Specialties, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Clin Infect Dis 32:E94-6. 2001
    ..Despite the patient's abnormal baseline kidney function, the very high doses of lifoAmB were well tolerated and did not result in additional renal toxicity...
  43. pmc Overexpression of Erg11p by the regulatable GAL1 promoter confers fluconazole resistance in Saccharomyces cerevisiae
    D P Kontoyiannis
    Department of Internal Medicine Specialties, Section of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Antimicrob Agents Chemother 43:2798-800. 1999
    ..Here, we show that overexpression of Saccharomyces P-450 14alphaDM in S. cerevisiae, under the control of the regulatable promoter GAL1, results in azole resistance...
  44. ncbi request reprint High-dose caspofungin combination antifungal therapy in patients with hematologic malignancies and hematopoietic stem cell transplantation
    A Safdar
    Department of Infectious Diseases, Infection Control, and Employee Health, MD Anderson Cancer Center, Houston, TX 77030, USA
    Bone Marrow Transplant 39:157-64. 2007
    ..04) and/or interferon gamma (26 vs 5% in SD group; P=0.003) immune enhancement. Further studies are needed to evaluate efficacy of HD-CAP in severely immunosuppressed cancer patients with invasive fungal infections...
  45. ncbi request reprint High-dose fluconazole therapy for cancer patients with solid tumors and candidemia: an observational, noncomparative retrospective study
    H A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 402, Houston, TX 77030, USA
    Support Care Cancer 12:511-6. 2004
    ..Herein, we describe the outcome of 20 patients with solid tumors and candidemia treated with high-dose fluconazole (HDF) at The University of Texas M.D. Anderson Cancer Center (1998-2002)...
  46. doi request reprint Voriconazole-associated zygomycosis: a significant consequence of evolving antifungal prophylaxis and immunosuppression practices?
    G N Pongas
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Infect 15:93-7. 2009
    ..However, it is not known if this association reflects a true epidemiological link or represents a marker of changing immunosuppression occurring in parallel with the evolution of transplant practices and immunosuppression strategies...
  47. ncbi request reprint Influence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of Pneumocystis jiroveci pneumonia in cancer patients
    H A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Eur J Clin Microbiol Infect Dis 25:382-8. 2006
    ..jiroveci pneumonia in cancer patients may be affected by the category of cancer and the history of hematopoietic stem cell transplantation. P. jiroveci pneumonia remains a rare yet severe infection in cancer patients...
  48. ncbi request reprint Voriconazole-resistant disseminated Paecilomyces variotii infection in a neutropenic patient with leukaemia on voriconazole prophylaxis
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Infect 51:e225-8. 2005
    ..variotii infection in a neutropenic child with relapsed leukaemia who was on voriconazole prophylaxis. The P. variotii isolate was resistant to voriconazole in vitro. The patient responded to liposomal amphotericin B...
  49. ncbi request reprint Aspergillosis caused by non-fumigatus Aspergillus species: risk factors and in vitro susceptibility compared with Aspergillus fumigatus
    Harrys A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Diagn Microbiol Infect Dis 46:25-8. 2003
    ..group than in the A. fumigatus one. The Aspergillus species distribution in IA cases in our institution shows a predominance of the more antifungal-resistant or -tolerant non-fumigatus Aspergillus spp...
  50. ncbi request reprint The epidemiology of Candida glabrata and Candida albicans fungemia in immunocompromised patients with cancer
    Gerald P Bodey
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Med 112:380-5. 2002
    ..This yeast is less susceptible to fluconazole in vitro than is Candida albicans. We compared the characteristics of patients who had C. glabrata and C. albicans candidemia at a large cancer center...
  51. pmc Itraconazole-amphotericin B antagonism in Aspergillus fumigatus: an E-test-based strategy
    D P Kontoyiannis
    Section of Infectious Diseases, Department of Internal Medicine Specialties, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 44:2915-8. 2000
    ..An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B. This in vitro antagonism was reversible...
  52. ncbi request reprint Significance of aspergillemia in patients with cancer: a 10-year study
    D P Kontoyiannis
    Departments of Internal Medicine Specialties and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Clin Infect Dis 31:188-9. 2000
    ..The significance of aspergillemia in 36 cancer patients over a 10-year period was evaluated. True aspergillemia was rare, occurred late in the course of aspergillosis, and was seen exclusively in patients with hematologic malignancies...
  53. ncbi request reprint Stenotrophomonas maltophilia pneumonia in cancer patients without traditional risk factors for infection, 1997-2004
    G Aisenberg
    Department of Infectious Diseases, Infection Control, and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Clin Microbiol Infect Dis 26:13-20. 2007
    ..51-241.2; p < 0.0006). The results of this study indicate S. maltophilia pneumonia is a serious infection even in non-neutropenic, non-ICU patients with cancer...
  54. ncbi request reprint Update on antifungal drug resistance mechanisms of Aspergillus fumigatus
    G Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Drug Resist Updat 8:344-58. 2005
    ..This review examines challenges in the diagnosis, epidemiology, and mechanisms of antifungal drug resistance in A. fumigatus...
  55. ncbi request reprint Fungal osteoarticular infections in patients treated at a comprehensive cancer centre: a 10-year retrospective review
    P R Kumashi
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Infect 12:621-6. 2006
    ..FOAI is a rare, yet severe, manifestation of localised or systemic mycoses, caused predominantly by moulds, and is seen typically in patients with haematological malignancies...
  56. ncbi request reprint Increased frequency of non-fumigatus Aspergillus species in amphotericin B- or triazole-pre-exposed cancer patients with positive cultures for aspergilli
    Michail S Lionakis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Diagn Microbiol Infect Dis 52:15-20. 2005
    ..These Aspergillus isolates were found to be AMB-resistant by the more sensitive E-test method...
  57. ncbi request reprint Breakthrough candidemia in patients with cancer differs from de novo candidemia in host factors and Candida species but not intensity
    Dimitrios P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Infect Control Hosp Epidemiol 23:542-5. 2002
    ..To evaluate the risk factors associated with breakthrough candidemia in patients with cancer and to compare them with those of de novo candidemia in this patient population...
  58. ncbi request reprint Effects of liposomal amphotericin B versus an amphotericin B lipid complex on liver histopathology in patients with hematologic malignancies and invasive fungal infections: a retrospective, nonrandomized autopsy study
    Georgios Chamilos
    Department of Infectious Diseases and Infection Control, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Ther 29:1980-6. 2007
    ..Because LFT abnormalities are multifactorial in severely immunocompromised patients, uncertainty remains regarding the clinical significance of these laboratory findings...
  59. pmc Zygomycetes hyphae trigger an early, robust proinflammatory response in human polymorphonuclear neutrophils through toll-like receptor 2 induction but display relative resistance to oxidative damage
    G Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Antimicrob Agents Chemother 52:722-4. 2008
    ..Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF-kappaB pathway-related genes...
  60. ncbi request reprint Proven pulmonary cryptococcosis due to capsule-deficient Cryptococcus neoformans does not differ clinically from proven pulmonary cryptococcosis due to capsule-intact Cr. neoformans
    H A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mycoses 48:21-4. 2005
    ..neoformans. The presentations and outcomes did not differ significantly between the groups...
  61. pmc Utility of galactomannan enzyme immunoassay and (1,3) beta-D-glucan in diagnosis of invasive fungal infections: low sensitivity for Aspergillus fumigatus infection in hematologic malignancy patients
    R Y Hachem
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Microbiol 47:129-33. 2009
    ..The diagnostic marker BG was shown to have a higher sensitivity than that of GM in detecting IA and other mold infections in hematologic malignancy patients...
  62. ncbi request reprint Cryptococcosis in patients with cancer
    D P Kontoyiannis
    Department of Internal Medicine Specialties, Section of Infectious Diseases, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Clin Infect Dis 32:E145-50. 2001
    ..Fluconazole monotherapy was successful in 92% of patients. In conclusion, cryptococcosis is rare in patients with cancer and appears to have a relatively good diagnostic yield and therapeutic outcome...
  63. ncbi request reprint Modulation of fluconazole sensitivity by the interaction of mitochondria and erg3p in Saccharomyces cerevisiae
    D P Kontoyiannis
    The University of Texas M D Anderson Cancer Center, Section of Infectious Diseases, 1515 Holcombe Boulevard, Box 47, Houston, TX 77030, USA
    J Antimicrob Chemother 46:191-7. 2000
    ..These results indicate that mitochondria function as important physiological partners with Erg3p in the accumulation of toxic sterol intermediates in the presence of azoles...
  64. ncbi request reprint Fluconazole vs. amphotericin B for the management of candidaemia in adults: a meta-analysis
    D P Kontoyiannis
    Department of Internal Medical Specialties, Section of Infectious Diseases, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 47, Houston, Texas 77030, USA
    Mycoses 44:125-35. 2001
    ..However, fluconazole may be less effective than amphotericin B in candidaemias caused by some non-albicans Candida species...
  65. ncbi request reprint Invasive aspergillosis in patients with hematologic malignancies
    Nathan P Wiederhold
    University of Houston College of Pharmacy, Houston, Texas 77030, USA
    Pharmacotherapy 23:1592-610. 2003
    ..The problems and controversies associated with defining optimal treatment strategies for invasive aspergillosis in this heavily immunocompromised population are highlighted...
  66. ncbi request reprint Cytomegalovirus infection in patients with lymphoma: an important cause of morbidity and mortality
    Harrys A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Clin Lymphoma Myeloma 6:393-8. 2006
    ..We sought to determine the risk factors and outcome of CMV-A and CMV-D among patients with lymphoma...
  67. pmc Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice
    Russell E Lewis
    Department of Clinical Sciences and Administration, The University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund Street, Houston, TX 77030, USA
    Antimicrob Agents Chemother 51:1078-81. 2007
    ..The beneficial immunomodulatory properties of E-lipo appear to compensate for their lack of direct antifungal activity...
  68. pmc Pharmacodynamic activity of amphotericin B deoxycholate is associated with peak plasma concentrations in a neutropenic murine model of invasive pulmonary aspergillosis
    Nathan P Wiederhold
    The University of Texas at Austin College of Pharmacy, Austin, TX, USA
    Antimicrob Agents Chemother 50:469-73. 2006
    ..These data predict that less frequently administered, higher dosages of AMB would optimize efficacy...
  69. ncbi request reprint Candidemia in a tertiary care cancer center: in vitro susceptibility and its association with outcome of initial antifungal therapy
    Anastasia Antoniadou
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Medicine (Baltimore) 82:309-21. 2003
    ..04, but not in univariate analysis), indicating the complexity of the variables that influence the response to antifungal treatment in cancer patients with candidemia...
  70. pmc Paradoxical effect of Echinocandins across Candida species in vitro: evidence for echinocandin-specific and candida species-related differences
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Antimicrob Agents Chemother 51:2257-9. 2007
    ..parapsilosis, C. tropicalis, C. krusei, and C. glabrata), paradoxical growth was more frequent with caspofungin than micafungin or anidulafungin, was unrelated to MIC, and was strikingly absent in C. glabrata isolates...
  71. ncbi request reprint Multiple-species candidemia in patients with cancer
    Maha R Boktour
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:1860-5. 2004
    ..Candidemia is a common cause of bloodstream infections in patients with cancer, with the majority of these infections being caused by a single Candida species. Studies of multiple-species candidemia (MSC) have rarely been reported...
  72. doi request reprint Phaeohyphomycosis in a tertiary care cancer center
    Ronen Ben-Ami
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Infect Dis 48:1033-41. 2009
    ..To assess the range of clinical presentations and outcomes of phaeohyphomycosis in patients with cancer, we reviewed cases diagnosed at the M. D. Anderson Cancer Center (Houston, TX)...
  73. ncbi request reprint Caspofungin as primary antifungal prophylaxis in stem cell transplant recipients
    Lillian S Chou
    Division of Pharmacy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacotherapy 27:1644-50. 2007
    ....
  74. ncbi request reprint In vitro pharmacodynamics of rapid versus continuous infusion of amphotericin B deoxycholate against Candida species in the presence of human serum albumin
    Russell E Lewis
    The University of Houston College of Pharmacy, Houston, TX 77030, USA
    J Antimicrob Chemother 57:288-93. 2006
    ..Therefore, we compared the PD activity of simulated continuous versus rapid infusion strategies of AMB in killing of AMB-susceptible and -resistant Candida species using an in vitro pharmacodynamic model...
  75. ncbi request reprint Listeria monocytogenes infection in patients with cancer
    G A Rivero
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Diagn Microbiol Infect Dis 47:393-8. 2003
    ..LT contributed to death in 9 (75%) of the 12 patients who died. Meningoencephalitis had the worst prognosis (3 of 6 cases were fatal). Treatment of central nervous system LT continues to have a high failure rate...
  76. ncbi request reprint Fruit flies as a minihost model for studying drug activity and virulence in Aspergillus
    M S Lionakis
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Med Mycol 43:S111-4. 2005
    ..Drosophila may offer the distinct advantage of performing fast, inexpensive high-throughput screening of compounds for anti-Aspergillus activity and putative Aspergillus mutants for their role in Aspergillus virulence...
  77. doi request reprint Utility of early versus late fiberoptic bronchoscopy in the evaluation of new pulmonary infiltrates following hematopoietic stem cell transplantation
    V R Shannon
    Department of Pulmonary Medicine, The University of Texas at MD Anderson Cancer Center, Houston, TX 77030, USA
    Bone Marrow Transplant 45:647-55. 2010
    ..0351). Major FOB-related complications occurred in only three (0.6%) patients. We conclude that early referral for FOB in this patient setting is associated with higher diagnostic yields and may favorably impact survival...
  78. ncbi request reprint Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA
    N Osherov
    Division of Pathology and Laboratory Medicine, and Department of Internal Medicine Specialties, Section of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Antimicrob Chemother 48:75-81. 2001
    ..nidulans as a promising model fungus for the analysis of drug resistance and susceptibility in the pathogenic fungus A. fumigatus...
  79. ncbi request reprint Infections caused by Fusarium species
    H A Torres
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Chemother 15:28-35. 2003
    ..Here we give an overview of the epidemiology, pathogenesis, clinical manifestations, antifungal susceptibility and management of fusariosis...
  80. ncbi request reprint Zygomycosis in the 1990s in a tertiary-care cancer center
    D P Kontoyiannis
    Department of Internal Medicine Specialties, Section of Infectious Diseases, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 30:851-6. 2000
    ..Therapy with high-dose amphotericin B, combined with aggressive surgery and immune reconstitution, offers the best chance for survival of cancer patients with zygomycosis...
  81. ncbi request reprint The significance of blood cultures positive for emerging saprophytic moulds in cancer patients
    M S Lionakis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Microbiol Infect 10:922-5. 2004
    ..True fungaemia was seen only in leukaemia patients and allogeneic bone marrow transplant recipients. S. apiospermum and S. prolificans were the commonest causes of true fungaemia...
  82. pmc Antifungal activity of amphotericin B, fluconazole, and voriconazole in an in vitro model of Candida catheter-related bloodstream infection
    Russell E Lewis
    University of Houston College of Pharmacy, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 46:3499-505. 2002
    ..Lack of in vitro antifungal activity against biofilm-encased organisms appeared to be the primary reason for mycological failure of antifungal regimens in the model...
  83. pmc Comparative analysis of amphotericin B lipid complex and liposomal amphotericin B kinetics of lung accumulation and fungal clearance in a murine model of acute invasive pulmonary aspergillosis
    Russell E Lewis
    The University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund St, Houston, TX 77030, USA
    Antimicrob Agents Chemother 51:1253-8. 2007
    ..However, pharmacodynamic differences between the two formulations were less apparent when mice were dosed at 10 mg/kg/day...
  84. ncbi request reprint Aspergillus susceptibility testing in patients with cancer and invasive aspergillosis: difficulties in establishing correlation between in vitro susceptibility data and the outcome of initial amphotericin B therapy
    Michail S Lionakis
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacotherapy 25:1174-80. 2005
    ....
  85. pmc Efficacy of single-dose liposomal amphotericin B or micafungin prophylaxis in a neutropenic murine model of invasive pulmonary aspergillosis
    Russell E Lewis
    University of Houston College of Pharmacy, Texas Medical Center Campus, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 52:4178-80. 2008
    ....
  86. doi request reprint Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Infect Dis 47:503-9. 2008
    ..Zygomycosis is an emerging opportunistic mycosis among immunocompromised patients with a particularly poor prognosis...
  87. doi request reprint Increased virulence of Zygomycetes organisms following exposure to voriconazole: a study involving fly and murine models of zygomycosis
    Gregory A Lamaris
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, University of Houston, Houston, TX 77030, USA
    J Infect Dis 199:1399-406. 2009
    ..We tested the latter hypothesis, using 2 phylogenetically disparate zygomycosis models...
  88. ncbi request reprint Micafungin in combination with voriconazole in Aspergillus species: a pharmacodynamic approach for detection of combined antifungal activity in vitro
    Russell E Lewis
    University of Houston College of Pharmacy, Houston, TX, USA
    J Antimicrob Chemother 56:887-92. 2005
    ....
  89. pmc Cutaneous model of invasive aspergillosis
    Ronen Ben-Ami
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Antimicrob Agents Chemother 54:1848-54. 2010
    ..This novel cutaneous model system should be applicable to comparative studies of the pathogenesis, treatment, and tissue specificity of IA...
  90. pmc Attenuation of itraconazole fungicidal activity following preexposure of Aspergillus fumigatus to fluconazole
    Wei Liu
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 47:3592-7. 2003
    ..This phenotypic adaptation is not captured by a routine MIC determination but requires MFC measurement. The in vivo significance of this in vitro phenomenon requires further investigation...
  91. pmc Lovastatin has significant activity against zygomycetes and interacts synergistically with voriconazole
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control, and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 50:96-103. 2006
    ..01). LOV is significantly active against zygomycetes and synergizes with triazoles inherently resistant to them, such as VRC. The clinical significance of these findings needs to be further explored...
  92. doi request reprint Candida lusitaniae fungemia in cancer patients: risk factors for amphotericin B failure and outcome
    Bradley J Atkinson
    Department of Pharmacy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Med Mycol 46:541-6. 2008
    ..Clinically, C. lusitaniae fungemia was more frequently associated with stem cell transplant and neutropenia. C. lusitaniae, even originally susceptible to AMB, might be less amenable to AMB therapy...
  93. ncbi request reprint Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity
    Nathan P Wiederhold
    The University of Houston College of Pharmacy and The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Infect Dis 190:1464-71. 2004
    ..We conducted a dosage-fractionation study to characterize the in vivo pharmacodynamics of CAS activity during IPA, using immunosuppressed mice inoculated intranasally with Aspergillus fumigatus...
  94. ncbi request reprint Central venous catheter-associated Nocardia bacteremia: an unusual manifestation of nocardiosis
    D P Kontoyiannis
    Department of Internal Medicine Specialties, University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Clin Infect Dis 31:617-8. 2000
    ..The limited clinical experience suggests that discontinuing the catheter and embarking on a relatively short course of appropriate antibiotics results in a good outcome...
  95. doi request reprint Monotherapy with caspofungin for candidaemia in adult patients with cancer: a retrospective, single institution study
    Nikolaos V Sipsas
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Int J Antimicrob Agents 34:95-8. 2009
    ....
  96. ncbi request reprint The rationale of combination antifungal therapy in severely immunocompromised patients: empiricism versus evidence-based medicine
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, USA
    Curr Opin Infect Dis 19:380-5. 2006
    ..Herein we review recent advances in the area of antifungal combinations in high-risk patients to separate empiricism from evidence-based medicine...
  97. doi request reprint Invasive fusariosis in patients with hematologic malignancies at a cancer center: 1998-2009
    Marcela Campo
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Infect 60:331-7. 2010
    ..Fusarium species cause severe infections in patients with hematologic malignancies. Few data are available concerning the outcome of fusariosis in the era of the expanding antifungal armamentarium...
  98. pmc Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis
    Michail S Lionakis
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 50:294-7. 2006
    ..PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice...
  99. ncbi request reprint Diagnosis of invasive septate mold infections. A correlation of microbiological culture and histologic or cytologic examination
    Jeffrey J Tarrand
    Division of Pathology and Laboratory Medicine, Box 84, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 119:854-8. 2003
    ..A flavus was isolated significantly more frequently from tissue than from BAL and BW samples...
  100. ncbi request reprint Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003)
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, Laboratory Medicine, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Haematologica 91:986-9. 2006
    ..The complex and evolving epidemiology of IFI in severely immunocompromised patients is not well captured by current diagnostic methods...
  101. ncbi request reprint Predictors of pulmonary zygomycosis versus invasive pulmonary aspergillosis in patients with cancer
    Georgios Chamilos
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Infect Dis 41:60-6. 2005
    ..Most cases of PZ in such patients develop as breakthrough infections if treatment with antifungal agents effective against Aspergillus species is administered. However, clinical criteria to differentiate PZ from IPA are lacking...