Sergej Konoplev

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 124:414-20. 2005
  2. ncbi request reprint CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX Electronic address
    Clin Lymphoma Myeloma Leuk 13:686-92. 2013
  3. pmc Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Leuk Lymphoma 54:138-44. 2013
  4. ncbi request reprint Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Cancer 117:4689-95. 2011
  5. ncbi request reprint Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 38:1760-3. 2007
  6. ncbi request reprint Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:4737-44. 2009
  7. pmc Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation
    Weina Chen
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Cancer 115:5481-9. 2009
  8. pmc Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment
    V Lokesh Battula
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Blood 122:357-66. 2013
  9. pmc Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment
    Olga Frolova
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 13:858-70. 2012
  10. pmc Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells
    Twee Tsao
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, Unit 425, Houston, TX 77030, USA
    Ann Hematol 91:1861-70. 2012

Detail Information

Publications29

  1. ncbi request reprint Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 124:414-20. 2005
    ..CD23, usually of dim intensity, and CD11c are expressed commonly in LPL/WM. Rare CD5+ and CD10+ cases of LPL/WM also exist...
  2. ncbi request reprint CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX Electronic address
    Clin Lymphoma Myeloma Leuk 13:686-92. 2013
    ..In vitro studies have suggested that mutant nucleophosmin (NPM) decreases CXCR4-mediated chemotaxis by downregulating CXCR4, thereby linking the NPM and CXCR4 pathways...
  3. pmc Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Leuk Lymphoma 54:138-44. 2013
    ..All cases of Ph+ AML were negative for ABL1 and other gene mutations. One (20%) patient with CML-BP had ABL1 mutation; no patients had NPM1 mutations. These data suggest that Ph+ AML is distinct from CML-BP...
  4. ncbi request reprint Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Cancer 117:4689-95. 2011
    ..Data regarding the prognostic impact of CXCR4 in patients with B-acute lymphoblastic leukemia (B-ALL) are sparse and limited to the pediatric population...
  5. ncbi request reprint Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 38:1760-3. 2007
    ....
  6. ncbi request reprint Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:4737-44. 2009
    ..Nucleophosmin (NPM1) gene mutations are reported to predict a favorable prognosis in acute myeloid leukemia (AML) patients. Aberrant cytoplasmic localization of nucleophosmin (NPM) protein is reported be a surrogate for NPM1 gene mutation...
  7. pmc Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation
    Weina Chen
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Cancer 115:5481-9. 2009
    ..A small subset of patients with acute myeloid leukemia (AML) have cuplike nuclei. Other investigators have demonstrated that these neoplasms have distinctive clinicopathologic and molecular features...
  8. pmc Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment
    V Lokesh Battula
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Blood 122:357-66. 2013
    ..Given the established role of the leptin receptor in leukemia cells, the data suggest an important role of CTGF in MSC differentiation into adipocytes and of leptin in homing and progression of leukemia. ..
  9. pmc Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment
    Olga Frolova
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Biol Ther 13:858-70. 2012
    ..Hence, mTOR inhibition or blockade of HIF-1α-mediated signaling may play an important role in chemosensitization of ALL cells under hypoxic conditions of the BM microenvironment...
  10. pmc Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells
    Twee Tsao
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, Unit 425, Houston, TX 77030, USA
    Ann Hematol 91:1861-70. 2012
    ..5-AZA significantly reduced MCL-1 levels in two of three samples examined. Our data provide a molecular rationale for this combination strategy in AML therapy...
  11. doi request reprint Extranodal NK/T-cell lymphoma, nasal type: a report of 73 cases at MD Anderson Cancer Center
    Shaoying Li
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 37:14-23. 2013
    ..The International Prognostic Index score, anatomic site of disease, and proliferation rate had prognostic value in this patient cohort...
  12. ncbi request reprint Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue involving different sites
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Clin Pathol 134:112-8. 2010
    ....
  13. doi request reprint Residual monotypic plasma cells in patients with waldenstrom macroglobulinemia after therapy
    Fareed H Barakat
    Dept of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Clin Pathol 135:365-73. 2011
    ..This finding has implications for the immunophenotypic assessment of WM after therapy and may explain persistent IgM paraproteinemia in patients with WM with no evidence of a clonal B-lymphocyte population...
  14. doi request reprint TET2 mutations, myelodysplastic features, and a distinct immunoprofile characterize blastic plasmacytoid dendritic cell neoplasm in the bone marrow
    Khaled Alayed
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas Department of Pathology, King Saud University, Riyadh, Saudi Arabia
    Am J Hematol 88:1055-61. 2013
    ....
  15. ncbi request reprint T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases
    Yang O Huh
    Department of Hematopathology, Unit 72, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 131:347-56. 2009
    ..The median hemoglobin level and absolute lymphocyte count were lower in patients with T-LGL/MDS (P < .05). The frequency of coexistent T-LGL and MDS at our institution suggests an etiologic relationship rather than simple coincidence...
  16. ncbi request reprint Usefulness of CD11a and CD18 in flow cytometric immunophenotypic analysis for diagnosis of acute promyelocytic leukemia
    Yi Zhou
    Dept of Hematopathology, Unit 72, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 138:744-50. 2012
    ..These data compare favorably with the combination of HLA-DR-, CD34-, and CD117+ for APL diagnosis, which had a sensitivity of 64% in this study...
  17. doi request reprint CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases
    Jesse Jaso
    Department of Pathology, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Hum Pathol 43:1436-43. 2012
    ..Our results show that CD5 expression is rare in MALT lymphoma, and is often associated with nongastric disease and an increased tendency to present with disseminated disease. Overall survival is excellent with appropriate therapy...
  18. pmc HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia
    Paolo Strati
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer 120:373-80. 2014
    ..Chronic myeloid leukemia (CML) may progress to blast phase (BP) at the rate of 1% to 1.5% per year. With the use of single-agent tyrosine kinase inhibitors, median overall survival ranges between 7 and 11 months...
  19. pmc Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment
    Ye Chen
    Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 119:4971-80. 2012
    ..The model could be useful for the study of leukemia biology and for the development of novel therapeutic modalities aimed at modifying the hematopoietic microenvironment...
  20. pmc Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104
    Juliana Benito
    Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e23108. 2011
    ..Together, these findings strongly suggest that targeting hypoxia in leukemic BM is feasible and may significantly improve leukemia therapy...
  21. ncbi request reprint Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype
    Sergej Konoplev
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 109:1152-6. 2007
    ..The prognostic significance of CXCR4 expression in patients with AML that have a normal karyotype and no evidence of FLT3 gene mutations was examined...
  22. ncbi request reprint Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment
    Claudiu V Cotta
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Ann Diagn Pathol 10:169-92. 2006
    ....
  23. ncbi request reprint MALT lymphoma involving the kidney: a report of 10 cases and review of the literature
    Mar Garcia
    The Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 128:464-73. 2007
    ..Our results indicate that kidney MALT lymphomas share similarities with MALT lymphomas arising at other sites in that MALT lymphoma-associated translocations and NF-kappaB activation occur in a subset of cases...
  24. ncbi request reprint Therapy may unmask hypoplastic myelodysplastic syndrome that mimics aplastic anemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1520-6. 2007
    ..There has been controversy regarding whether the initial diagnosis of AA is correct or whether these patients have hypocellular MDS at the onset of pancytopenia...
  25. pmc Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
    Zhihong Zeng
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 113:6215-24. 2009
    ..Disruption of these interactions with CXCR4 inhibitors represents a novel strategy of sensitizing leukemic cells by targeting their protective bone marrow microenvironment...
  26. doi request reprint A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas
    David S Hong
    Department ofInvestigational Cancer Therapeutics, Phase I Clinical Trials Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:3396-406. 2012
    ....
  27. pmc Hypocellular acute myeloid leukemia in adults: analysis of the clinical outcome of 123 patients
    Aref Al-Kali
    Department of Hematology, Mayo Clinic, Rochester, MN, USA
    Haematologica 97:235-40. 2012
    ..It is unclear in the literature whether the outcome of hypocellular acute myeloid leukemia differs from that of non-hypocellular acute myeloid leukemia...
  28. ncbi request reprint Advances in the pathologic diagnosis and biology of acute myeloid leukemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Ann Diagn Pathol 10:39-65. 2006
    ..This review focuses on a practical approach to diagnosis of AML according to current standard of practice and discusses some of recent changes in the field of AML...
  29. ncbi request reprint PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL
    Yoko Tabe
    Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer Biol Ther 6:1967-77. 2007
    ..In summary, these results provide rationale for the combined targeting of RAR and PPARgamma nuclear receptors in the therapy of APL...