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Species | Sergej KonoplevSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenström macroglobulinemiaSergej Konoplev
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
Am J Clin Pathol 124:414-20. 2005..CD23, usually of dim intensity, and CD11c are expressed commonly in LPL/WM. Rare CD5+ and CD10+ cases of LPL/WM also exist...
Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemiaSergej Konoplev
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Leuk Lymphoma 54:138-44. 2013..All cases of Ph+ AML were negative for ABL1 and other gene mutations. One (20%) patient with CML-BP had ABL1 mutation; no patients had NPM1 mutations. These data suggest that Ph+ AML is distinct from CML-BP...- Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemiaSergej Konoplev
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, USA
Cancer 117:4689-95. 2011..Data regarding the prognostic impact of CXCR4 in patients with B-acute lymphoblastic leukemia (B-ALL) are sparse and limited to the pediatric population... - Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesisSergej Konoplev
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 38:1760-3. 2007.... - Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosisSergej Konoplev
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 115:4737-44. 2009..Nucleophosmin (NPM1) gene mutations are reported to predict a favorable prognosis in acute myeloid leukemia (AML) patients. Aberrant cytoplasmic localization of nucleophosmin (NPM) protein is reported be a surrogate for NPM1 gene mutation... 
Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutationWeina Chen
Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Cancer 115:5481-9. 2009..A small subset of patients with acute myeloid leukemia (AML) have cuplike nuclei. Other investigators have demonstrated that these neoplasms have distinctive clinicopathologic and molecular features...- Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cellsTwee Tsao
Department of Leukemia, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, Unit 425, Houston, TX 77030, USA
Ann Hematol 91:1861-70. 2012..5-AZA significantly reduced MCL-1 levels in two of three samples examined. Our data provide a molecular rationale for this combination strategy in AML therapy... - Extranodal NK/T-cell lymphoma, nasal type: a report of 73 cases at MD Anderson Cancer CenterShaoying Li
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 37:14-23. 2013..The International Prognostic Index score, anatomic site of disease, and proliferation rate had prognostic value in this patient cohort... - Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironmentOlga Frolova
Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer Biol Ther 13:858-70. 2012..Hence, mTOR inhibition or blockade of HIF-1α-mediated signaling may play an important role in chemosensitization of ALL cells under hypoxic conditions of the BM microenvironment... - Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue involving different sitesSergej Konoplev
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Am J Clin Pathol 134:112-8. 2010.... - Residual monotypic plasma cells in patients with waldenstrom macroglobulinemia after therapyFareed H Barakat
Dept of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Am J Clin Pathol 135:365-73. 2011..This finding has implications for the immunophenotypic assessment of WM after therapy and may explain persistent IgM paraproteinemia in patients with WM with no evidence of a clonal B-lymphocyte population... - T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine casesYang O Huh
Department of Hematopathology, Unit 72, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Am J Clin Pathol 131:347-56. 2009..The median hemoglobin level and absolute lymphocyte count were lower in patients with T-LGL/MDS (P < .05). The frequency of coexistent T-LGL and MDS at our institution suggests an etiologic relationship rather than simple coincidence... - Usefulness of CD11a and CD18 in flow cytometric immunophenotypic analysis for diagnosis of acute promyelocytic leukemiaYi Zhou
Dept of Hematopathology, Unit 72, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Clin Pathol 138:744-50. 2012..These data compare favorably with the combination of HLA-DR-, CD34-, and CD117+ for APL diagnosis, which had a sensitivity of 64% in this study... - CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 casesJesse Jaso
Department of Pathology, The University of Texas Medical School at Houston, Houston, TX 77030, USA
Hum Pathol 43:1436-43. 2012..Our results show that CD5 expression is rare in MALT lymphoma, and is often associated with nongastric disease and an increased tendency to present with disseminated disease. Overall survival is excellent with appropriate therapy... - Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironmentYe Chen
Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Blood 119:4971-80. 2012..The model could be useful for the study of leukemia biology and for the development of novel therapeutic modalities aimed at modifying the hematopoietic microenvironment... - Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104Juliana Benito
Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 6:e23108. 2011..Together, these findings strongly suggest that targeting hypoxia in leukemic BM is feasible and may significantly improve leukemia therapy... - Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotypeSergej Konoplev
Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 109:1152-6. 2007..The prognostic significance of CXCR4 expression in patients with AML that have a normal karyotype and no evidence of FLT3 gene mutations was examined... - Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AMLZhihong Zeng
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 113:6215-24. 2009..Disruption of these interactions with CXCR4 inhibitors represents a novel strategy of sensitizing leukemic cells by targeting their protective bone marrow microenvironment... - Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environmentClaudiu V Cotta
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Ann Diagn Pathol 10:169-92. 2006.... - MALT lymphoma involving the kidney: a report of 10 cases and review of the literatureMar Garcia
The Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Am J Clin Pathol 128:464-73. 2007..Our results indicate that kidney MALT lymphomas share similarities with MALT lymphomas arising at other sites in that MALT lymphoma-associated translocations and NF-kappaB activation occur in a subset of cases... - Therapy may unmask hypoplastic myelodysplastic syndrome that mimics aplastic anemiaSergej Konoplev
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 110:1520-6. 2007..There has been controversy regarding whether the initial diagnosis of AA is correct or whether these patients have hypocellular MDS at the onset of pancytopenia... - A phase i first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomasDavid S Hong
Department ofInvestigational Cancer Therapeutics, Phase I Clinical Trials Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 18:3396-406. 2012.... - Hypocellular acute myeloid leukemia in adults: analysis of the clinical outcome of 123 patientsAref Al-Kali
Department of Hematology, Mayo Clinic, Rochester, MN, USA
Haematologica 97:235-40. 2012..It is unclear in the literature whether the outcome of hypocellular acute myeloid leukemia differs from that of non-hypocellular acute myeloid leukemia... - PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APLYoko Tabe
Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Cancer Biol Ther 6:1967-77. 2007..In summary, these results provide rationale for the combined targeting of RAR and PPARgamma nuclear receptors in the therapy of APL... - Advances in the pathologic diagnosis and biology of acute myeloid leukemiaSergej Konoplev
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4095, USA
Ann Diagn Pathol 10:39-65. 2006..This review focuses on a practical approach to diagnosis of AML according to current standard of practice and discusses some of recent changes in the field of AML...