DWIGHT KONO

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    Marie Laure Santiago-Raber
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 197:777-88. 2003
  2. ncbi request reprint Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice
    Maria K Haraldsson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:5065-73. 2005
  3. pmc The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation
    M Katarina Haraldsson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunity 28:40-51. 2008
  4. ncbi request reprint TLRs and interferons: a central paradigm in autoimmunity
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, United States Electronic address
    Curr Opin Immunol 25:720-7. 2013
  5. pmc Requirements for innate immune pathways in environmentally induced autoimmunity
    KENNETH MICHAEL POLLARD
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    BMC Med 11:100. 2013
  6. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
  7. ncbi request reprint Genetics of SLE in mice
    Dwight H Kono
    Department of Immunology IMM3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Springer Semin Immunopathol 28:83-96. 2006
  8. ncbi request reprint The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance
    D H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 161:234-40. 1998
  9. ncbi request reprint Inhibition of lupus by genetic alteration of the interferon-alpha/beta receptor
    Dwight H Kono
    Department of Immunology IMM3, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmunity 36:503-10. 2003
  10. ncbi request reprint Genetic complementation in female (BXSB x NZW)F2 mice
    Dwight H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 171:6442-7. 2003

Collaborators

Detail Information

Publications32

  1. pmc Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    Marie Laure Santiago-Raber
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 197:777-88. 2003
    ..The data indicate that type-I IFNs are important mediators in the pathogenesis of murine lupus, and that reducing their activity in the human counterpart may be beneficial...
  2. ncbi request reprint Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice
    Maria K Haraldsson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:5065-73. 2005
    ..These findings establish the importance of Lbw2 in the BWF1 hybrid and indicate that Lbw2, by enhancing B cell hyperactivity, promotes the early polyclonal activation of B cells and subsequent production of autoantibodies...
  3. pmc The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation
    M Katarina Haraldsson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunity 28:40-51. 2008
    ..Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases...
  4. ncbi request reprint TLRs and interferons: a central paradigm in autoimmunity
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, United States Electronic address
    Curr Opin Immunol 25:720-7. 2013
    ..These priming events are responsible for initiating the adaptive responses that ultimately mediate the pathogenic process. ..
  5. pmc Requirements for innate immune pathways in environmentally induced autoimmunity
    KENNETH MICHAEL POLLARD
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    BMC Med 11:100. 2013
    ..Greater understanding of the innate mechanisms responsible for idiopathic and environmentally induced autoimmunity should yield new information into the processes that instigate and drive systemic autoimmunity...
  6. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
    ..Importantly, this helps provide an explanation for the high frequency of anti-nucleic acid Abs in lupus-like systemic autoimmunity...
  7. ncbi request reprint Genetics of SLE in mice
    Dwight H Kono
    Department of Immunology IMM3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Springer Semin Immunopathol 28:83-96. 2006
    ..Mouse models of lupus should continue to serve as a vital approach to defining the genetics of SLE...
  8. ncbi request reprint The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance
    D H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 161:234-40. 1998
    ....
  9. ncbi request reprint Inhibition of lupus by genetic alteration of the interferon-alpha/beta receptor
    Dwight H Kono
    Department of Immunology IMM3, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmunity 36:503-10. 2003
    ..These findings strongly support the targeting of IFN-alphabeta in SLE and suggest that definition of the specific pathways critical for disease induction will be important for optimal intervention...
  10. ncbi request reprint Genetic complementation in female (BXSB x NZW)F2 mice
    Dwight H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 171:6442-7. 2003
    ....
  11. ncbi request reprint Resistance to xenobiotic-induced autoimmunity maps to chromosome 1
    D H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 167:2396-403. 2001
    ....
  12. ncbi request reprint Development of lupus in BXSB mice is independent of IL-4
    D H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 164:38-42. 2000
    ..These findings directly demonstrate that IL-4 and, by inference, Th2 cells are not obligatory participants in the induction and maintenance of lupus in this strain...
  13. ncbi request reprint Genetic studies in systemic autoimmunity and aging
    D H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Res 21:111-22. 2000
    ..Other areas of investigation that we are actively engaged in are the role of T cell receptor repertoire in disease and the definition of cellular genes affected by infection with human immunodeficiency virus...
  14. ncbi request reprint TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    Roberto Baccala
    The Scripps Research Institute, Department of Immunology, La Jolla, California 93037, USA
    Nat Med 13:543-51. 2007
    ....
  15. ncbi request reprint Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice
    Ian F Robey
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:4624-9. 2004
    ..We suggest that the paucity of autoreactive specificities created in the N region-lacking repertoire, and the resultant protection afforded to the newborn, may be the reason that TdT expression is delayed in ontogeny...
  16. pmc Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity
    Brian R Lawson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 199:547-57. 2004
    ..Thus, modulation of the cell cycle pathway may be a novel approach to reduce apoptosis-resistant pathogenic lymphocytes and to ameliorate systemic autoimmunity...
  17. pmc Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice
    Djemel Ait-Azzouzene
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 185:1015-27. 2010
    ....
  18. ncbi request reprint Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice
    Lisa C Watson
    The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 177:1120-8. 2006
    ....
  19. doi request reprint Sensors of the innate immune system: their link to rheumatic diseases
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Rev Rheumatol 6:146-56. 2010
    ..These findings have resulted in a critical reappraisal of pathogenetic mechanisms, and provide a basis for the development of novel diagnostic and therapeutic modalities for these diseases...
  20. ncbi request reprint Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 987:236-9. 2003
    ..Thus, these genes may be part of the downstream events following IFN-gamma/IFN-gamma receptor interaction that promote the development of autoimmunity...
  21. ncbi request reprint Immunology and genetics of induced systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmun Rev 4:282-8. 2005
    ....
  22. ncbi request reprint Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB mice
    Brian R Lawson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 168:5928-32. 2002
    ....
  23. ncbi request reprint Costimulation requirements of induced murine systemic autoimmune disease
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Institute, La Jolla, CA 92037, USA
    J Immunol 173:5880-7. 2004
    ..These findings indicate that breaking of self-tolerance in mHgIA requires signaling via both the CD28/B7 and CD40/CD40L pathways...
  24. ncbi request reprint Type I interferons (alpha/beta) in immunity and autoimmunity
    Argyrios N Theofilopoulos
    Immunology Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Immunol 23:307-36. 2005
    ....
  25. pmc Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis
    Yifang Chen
    Laboratory of B Cell Immunobiology, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 183:1346-59. 2009
    ..These studies identify and characterize a previously unknown regulatory circuit by which a NAb product of innate-like B cells aids homeostasis by control of fundamental inflammatory pathways...
  26. ncbi request reprint Interferons as pathogenic effectors in autoimmunity
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 204:9-26. 2005
    ....
  27. pmc Mast cell function is not altered by Coronin-1A deficiency
    Sanja Arandjelovic
    Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92093, USA
    J Leukoc Biol 88:737-45. 2010
    ..We conclude that Coronin-1A activity is not required for mast cell function...
  28. ncbi request reprint Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophages
    Nick N Gorgani
    Department of Immunology IMM3, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:4745-51. 2002
    ..The findings indicate that HRG, by acting as a bridge between DNA on apoptotic cells and FcgammaRI on HMDM, is a key physiological mediator of apoptotic cell clearance by macrophages...
  29. pmc Toxicology of autoimmune diseases
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA
    Chem Res Toxicol 23:455-66. 2010
    ..Although a number of different pathways have been delineated for drug/chemical-induced autoimmunity, some similarities do exist, and a working model is proposed...
  30. ncbi request reprint Sensors of the innate immune system: their mode of action
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Rev Rheumatol 5:448-56. 2009
    ..Although this sensing is beneficial to the host, excessive activation and/or engagement by self molecules might induce autoimmune and other inflammatory disorders...
  31. pmc Immune pathology associated with altered actin cytoskeleton regulation
    Dilki C Wickramarachchi
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Autoimmunity 43:64-75. 2010
    ....
  32. ncbi request reprint Characterization of reciprocal Lmb1-4 interval MRL-Faslpr and C57BL/6-Faslpr congenic mice reveals significant effects from Lmb3
    Marie Laure Santiago-Raber
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 178:8195-202. 2007
    ..Identification of the underlying genetic alteration responsible for this quantitative trait locus should provide new insights into lupus-modifying genes...

Research Grants30

  1. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2005
    ....
  2. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2005
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  3. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2006
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  4. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2006
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  5. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2007
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  6. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2007
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  7. Defining the effector gene repertoire in systemic autoimmunity by ENU mutagenesis
    DWIGHT KONO; Fiscal Year: 2007
    ....
  8. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  9. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  10. Defining the effector gene repertoire in systemic autoimmunity by ENU mutagenesis
    DWIGHT KONO; Fiscal Year: 2009
    ....
  11. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2005
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  12. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2004
    ....
  13. HEAVY METAL INDUCED AUTOIMMUNITY
    DWIGHT KONO; Fiscal Year: 1999
    ....
  14. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2000
    ....
  15. HEAVY METAL INDUCED AUTOIMMUNITY
    DWIGHT KONO; Fiscal Year: 2000
    ....
  16. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2001
    ....
  17. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2001
    ....
  18. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2002
    ....
  19. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2002
    ....
  20. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2003
    ....
  21. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2003
    ....
  22. Defining the effector gene repertoire in systemic autoimmunity by ENU mutagenesis
    Dwight H Kono; Fiscal Year: 2010
    ....