Research Topics
Genomes and GenesSpecies | DWIGHT KONOSummaryAffiliation: The Scripps Research Institute Country: USA Publications
Research Grants
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Publications
Type-I interferon receptor deficiency reduces lupus-like disease in NZB miceMarie Laure Santiago-Raber
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Exp Med 197:777-88. 2003..The data indicate that type-I IFNs are important mediators in the pathogenesis of murine lupus, and that reducing their activity in the human counterpart may be beneficial...
Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 miceMaria K Haraldsson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 174:5065-73. 2005..These findings establish the importance of Lbw2 in the BWF1 hybrid and indicate that Lbw2, by enhancing B cell hyperactivity, promotes the early polyclonal activation of B cells and subsequent production of autoantibodies...- The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutationM Katarina Haraldsson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Immunity 28:40-51. 2008..Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases... - The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalanceD H Kono
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 161:234-40. 1998.... - Development of lupus in BXSB mice is independent of IL-4D H Kono
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 164:38-42. 2000..These findings directly demonstrate that IL-4 and, by inference, Th2 cells are not obligatory participants in the induction and maintenance of lupus in this strain... - Genetic studies in systemic autoimmunity and agingD H Kono
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Immunol Res 21:111-22. 2000..Other areas of investigation that we are actively engaged in are the role of T cell receptor repertoire in disease and the definition of cellular genes affected by infection with human immunodeficiency virus... - Resistance to xenobiotic-induced autoimmunity maps to chromosome 1D H Kono
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 167:2396-403. 2001.... - Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupusDwight H Kono
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:12061-6. 2009..Importantly, this helps provide an explanation for the high frequency of anti-nucleic acid Abs in lupus-like systemic autoimmunity... - Genetics of SLE in miceDwight H Kono
Department of Immunology IMM3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA
Springer Semin Immunopathol 28:83-96. 2006..Mouse models of lupus should continue to serve as a vital approach to defining the genetics of SLE... - Inhibition of lupus by genetic alteration of the interferon-alpha/beta receptorDwight H Kono
Department of Immunology IMM3, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Autoimmunity 36:503-10. 2003..These findings strongly support the targeting of IFN-alphabeta in SLE and suggest that definition of the specific pathways critical for disease induction will be important for optimal intervention... - Genetic complementation in female (BXSB x NZW)F2 miceDwight H Kono
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 171:6442-7. 2003.... - Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunityBrian R Lawson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Exp Med 199:547-57. 2004..Thus, modulation of the cell cycle pathway may be a novel approach to reduce apoptosis-resistant pathogenic lymphocytes and to ameliorate systemic autoimmunity... - TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunityRoberto Baccala
The Scripps Research Institute, Department of Immunology, La Jolla, California 93037, USA
Nat Med 13:543-51. 2007.... - Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) miceIan F Robey
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 172:4624-9. 2004..We suggest that the paucity of autoreactive specificities created in the N region-lacking repertoire, and the resultant protection afforded to the newborn, may be the reason that TdT expression is delayed in ontogeny... 
Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus miceDjemel Ait-Azzouzene
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 185:1015-27. 2010....- Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ miceLisa C Watson
The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Immunol 177:1120-8. 2006.... - Type I interferons (alpha/beta) in immunity and autoimmunityArgyrios N Theofilopoulos
Immunology Department, The Scripps Research Institute, La Jolla, California 92037, USA
Annu Rev Immunol 23:307-36. 2005.... - Sensors of the innate immune system: their link to rheumatic diseasesArgyrios N Theofilopoulos
Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Nat Rev Rheumatol 6:146-56. 2010..These findings have resulted in a critical reappraisal of pathogenetic mechanisms, and provide a basis for the development of novel diagnostic and therapeutic modalities for these diseases... - Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB miceBrian R Lawson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 168:5928-32. 2002.... - Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunityK Michael Pollard
Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Ann N Y Acad Sci 987:236-9. 2003..Thus, these genes may be part of the downstream events following IFN-gamma/IFN-gamma receptor interaction that promote the development of autoimmunity... - Immunology and genetics of induced systemic autoimmunityK Michael Pollard
Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Autoimmun Rev 4:282-8. 2005.... - Costimulation requirements of induced murine systemic autoimmune diseaseK Michael Pollard
Department of Molecular and Experimental Medicine, The Scripps Institute, La Jolla, CA 92037, USA
J Immunol 173:5880-7. 2004..These findings indicate that breaking of self-tolerance in mHgIA requires signaling via both the CD28/B7 and CD40/CD40L pathways... - Mast cell function is not altered by Coronin-1A deficiencySanja Arandjelovic
Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92093, USA
J Leukoc Biol 88:737-45. 2010..We conclude that Coronin-1A activity is not required for mast cell function... - Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritisYifang Chen
Laboratory of B Cell Immunobiology, University of California, San Diego, La Jolla, CA 92093, USA
J Immunol 183:1346-59. 2009..These studies identify and characterize a previously unknown regulatory circuit by which a NAb product of innate-like B cells aids homeostasis by control of fundamental inflammatory pathways... - Interferons as pathogenic effectors in autoimmunityRoberto Baccala
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Immunol Rev 204:9-26. 2005.... - Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophagesNick N Gorgani
Department of Immunology IMM3, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 169:4745-51. 2002..The findings indicate that HRG, by acting as a bridge between DNA on apoptotic cells and FcgammaRI on HMDM, is a key physiological mediator of apoptotic cell clearance by macrophages... - Sensors of the innate immune system: their mode of actionRoberto Baccala
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Nat Rev Rheumatol 5:448-56. 2009..Although this sensing is beneficial to the host, excessive activation and/or engagement by self molecules might induce autoimmune and other inflammatory disorders... - Toxicology of autoimmune diseasesK Michael Pollard
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA
Chem Res Toxicol 23:455-66. 2010..Although a number of different pathways have been delineated for drug/chemical-induced autoimmunity, some similarities do exist, and a working model is proposed... - Immune pathology associated with altered actin cytoskeleton regulationDilki C Wickramarachchi
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Autoimmunity 43:64-75. 2010.... - Characterization of reciprocal Lmb1-4 interval MRL-Faslpr and C57BL/6-Faslpr congenic mice reveals significant effects from Lmb3Marie Laure Santiago-Raber
Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
J Immunol 178:8195-202. 2007..Identification of the underlying genetic alteration responsible for this quantitative trait locus should provide new insights into lupus-modifying genes...
Research Grants
- Heavy Metal-Induced AutoimmunityDWIGHT KONO; Fiscal Year: 2005....
- PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUSDWIGHT KONO; Fiscal Year: 2007..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
- Defining the effector gene repertoire in systemic autoimmunity by ENU mutagenesisDWIGHT KONO; Fiscal Year: 2007....
- Cell Cycle Inhibition in Systemic AutoimmunityDWIGHT KONO; Fiscal Year: 2009..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
- PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUSDWIGHT KONO; Fiscal Year: 2009..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
- HEAVY METAL INDUCED AUTOIMMUNITYDWIGHT KONO; Fiscal Year: 2000....
- PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUSDWIGHT KONO; Fiscal Year: 2003....
- Defining the effector gene repertoire in systemic autoimmunity by ENU mutagenesisDwight H Kono; Fiscal Year: 2010....