Maria M Konarska

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Repositioning of the reaction intermediate within the catalytic center of the spliceosome
    Maria M Konarska
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell 21:543-53. 2006
  2. ncbi request reprint Insights into the mechanisms of splicing: more lessons from the ribosome
    Maria M Konarska
    The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:2255-60. 2005
  3. pmc Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast
    Duncan J Smith
    The Rockefeller University, New York, NY 10065, USA
    Mol Cell 34:333-43. 2009
  4. pmc trans-splicing to spliceosomal U2 snRNA suggests disruption of branch site-U2 pairing during pre-mRNA splicing
    Duncan J Smith
    The Rockefeller University, New York, NY 10021, USA
    Mol Cell 26:883-90. 2007
  5. pmc "Nought may endure but mutability": spliceosome dynamics and the regulation of splicing
    Duncan J Smith
    The Rockefeller University, New York, NY 10065, USA
    Mol Cell 30:657-66. 2008
  6. ncbi request reprint Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing
    Li Liu
    The Rockefeller University, New York, New York 10021, USA
    Nat Struct Mol Biol 14:519-26. 2007
  7. pmc Identification and characterization of a short 2'-3' bond-forming ribozyme
    Duncan J Smith
    Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, New York 10065, USA
    RNA 15:8-13. 2009
  8. pmc A critical assessment of the utility of protein-free splicing systems
    Duncan J Smith
    Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, New York 10065, USA
    RNA 15:1-3. 2009
  9. pmc Mechanistic insights from reversible splicing catalysis
    Duncan J Smith
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    RNA 14:1975-8. 2008
  10. ncbi request reprint A sequence motif in the simian virus 40 (SV40) early core promoter affects alternative splicing of transcribed mRNA
    Elisenda Gendra
    Rockefeller University, New York, New York 10021, USA
    J Biol Chem 282:11648-57. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Repositioning of the reaction intermediate within the catalytic center of the spliceosome
    Maria M Konarska
    The Rockefeller University, New York, New York 10021, USA
    Mol Cell 21:543-53. 2006
    ..Changes in the relative occupancy of first and second step substrates at the catalytic center alter efficiency of the two steps of splicing, allowing use of suboptimal intron sequences and thereby altering substrate selectivity...
  2. ncbi request reprint Insights into the mechanisms of splicing: more lessons from the ribosome
    Maria M Konarska
    The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:2255-60. 2005
  3. pmc Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast
    Duncan J Smith
    The Rockefeller University, New York, NY 10065, USA
    Mol Cell 34:333-43. 2009
    ..These results provide insights into substrate selection during spliceosomal branching catalysis; additionally, this system provides a foundation and tool for future mechanistic splicing research...
  4. pmc trans-splicing to spliceosomal U2 snRNA suggests disruption of branch site-U2 pairing during pre-mRNA splicing
    Duncan J Smith
    The Rockefeller University, New York, NY 10021, USA
    Mol Cell 26:883-90. 2007
    ..Multiple spatially disparate splice sites in U2 can be used, calling into question both the fate of its pairing to the branch site and the details of its role in splicing catalysis...
  5. pmc "Nought may endure but mutability": spliceosome dynamics and the regulation of splicing
    Duncan J Smith
    The Rockefeller University, New York, NY 10065, USA
    Mol Cell 30:657-66. 2008
    ..Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction...
  6. ncbi request reprint Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing
    Li Liu
    The Rockefeller University, New York, New York 10021, USA
    Nat Struct Mol Biol 14:519-26. 2007
    ..Modulation of these events alters splice-site selection and splicing fidelity...
  7. pmc Identification and characterization of a short 2'-3' bond-forming ribozyme
    Duncan J Smith
    Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, New York 10065, USA
    RNA 15:8-13. 2009
    ..Our data have implications for the intrinsic reactivity of the large amount of RNA sequence space known to be transcribed in nature and for the validity and utility of the use of protein-free systems to study pre-mRNA splicing...
  8. pmc A critical assessment of the utility of protein-free splicing systems
    Duncan J Smith
    Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, New York 10065, USA
    RNA 15:1-3. 2009
    ....
  9. pmc Mechanistic insights from reversible splicing catalysis
    Duncan J Smith
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    RNA 14:1975-8. 2008
    ....
  10. ncbi request reprint A sequence motif in the simian virus 40 (SV40) early core promoter affects alternative splicing of transcribed mRNA
    Elisenda Gendra
    Rockefeller University, New York, New York 10021, USA
    J Biol Chem 282:11648-57. 2007
    ....
  11. pmc p54(nrb) associates with the 5' splice site within large transcription/splicing complexes
    Sei Kameoka
    The Rockefeller University, New York, NY 10021, USA
    EMBO J 23:1782-91. 2004
    ....
  12. pmc Spliceosomal snRNAs in the unicellular eukaryote Trichomonas vaginalis are structurally conserved but lack a 5'-cap structure
    Augusto Simoes-Barbosa
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095 1489, USA
    RNA 14:1617-31. 2008
    ..Despite the lack of a cap structure, U1, U2, U4, and U5 genes are transcribed by RNA polymerase II, whereas the U6 gene is transcribed by RNA polymerase III...
  13. ncbi request reprint Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants
    Charles C Query
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell 14:343-54. 2004
    ..This mechanistic commonality suggests that alteration of rearrangements represents an evolutionarily convenient way of modulating substrate selectivity...
  14. doi request reprint A purified catalytically competent spliceosome
    Maria M Konarska
    Nat Struct Mol Biol 15:222-4. 2008
  15. ncbi request reprint Splicing fidelity revisited
    Charles C Query
    Nat Struct Mol Biol 13:472-4. 2006
  16. pmc Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
    Yong Zhen Xu
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    EMBO J 23:376-85. 2004
    ..pombe. Together, these data are consistent with Prp5 being a bridge between U1 and U2 snRNPs at the time of pre-spliceosome formation...