Krishna V Komanduri

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing
    Krishna V Komanduri
    Department of Stem Cell Transplantation and Cellular Therapy, M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:4543-51. 2007
  2. pmc Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens
    William K Decker
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 113:4213-23. 2009
  3. pmc 2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1
    Roberto Carreno
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:32860-8. 2010
  4. doi request reprint Deficient T(H)-1 responses from TNF-alpha-matured and alpha-CD40-matured dendritic cells
    William K Decker
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    J Immunother 31:157-65. 2008
  5. doi request reprint Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLs
    Dan Li
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunother 33:975-82. 2010
  6. ncbi request reprint Functional assessment and specific depletion of alloreactive human T cells using flow cytometry
    Sergio L R Martins
    Transplant Immunology Section, Department of Blood and Marrow Transplantation, MD Anderson Cancer Center, SCRB 3 3019, Unit 900, 7455 Fannin St, Houston, TX 77030, USA
    Blood 104:3429-36. 2004
  7. doi request reprint Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation
    Yang Wang
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 15:1513-22. 2009
  8. ncbi request reprint Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes
    Marta Stanzani
    Transplant Immunology Section, Department of Blood and Marrow Transplantation, MD Anderson Cancer Center, SCRB 3 3019, Unit 900, 7455 Fannin St, Houston, TX 77030, USA
    Blood 105:2258-65. 2005
  9. ncbi request reprint Double loading of dendritic cell MHC class I and MHC class II with an AML antigen repertoire enhances correlates of T-cell immunity in vitro via amplification of T-cell help
    William K Decker
    Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, Department of Blood and Marrow Transplantation, Box 65, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Vaccine 24:3203-16. 2006
  10. ncbi request reprint CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans
    Marta Stanzani
    Transplant Immunology Laboratory, MD Anderson Cancer Center, SCRB 3 3019, 7455 Fannin St, Houston, TX 77030, USA
    Blood 103:1140-6. 2004

Collaborators

Detail Information

Publications18

  1. pmc Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing
    Krishna V Komanduri
    Department of Stem Cell Transplantation and Cellular Therapy, M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:4543-51. 2007
    ..Strategies that improve the engraftment of lymphoid precursors, protect the thymus during pretransplant conditioning, and/or augment the recovery of thymopoiesis may improve outcomes after CBT...
  2. pmc Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens
    William K Decker
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 113:4213-23. 2009
    ....
  3. pmc 2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1
    Roberto Carreno
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:32860-8. 2010
    ..As a novel activation-specific monoclonal antibody, 2E8 is a potentially useful reagent for blocking high affinity LFA-1 and modulating T cell activation in research and therapeutics...
  4. doi request reprint Deficient T(H)-1 responses from TNF-alpha-matured and alpha-CD40-matured dendritic cells
    William K Decker
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    J Immunother 31:157-65. 2008
    ..Empirically, the data suggest that DCs matured with these agents are deficient in the induction of type 1 T-helper responses. We further speculate that DCs matured by these methods might be suboptimal for the priming of naive responses...
  5. doi request reprint Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLs
    Dan Li
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunother 33:975-82. 2010
    ....
  6. ncbi request reprint Functional assessment and specific depletion of alloreactive human T cells using flow cytometry
    Sergio L R Martins
    Transplant Immunology Section, Department of Blood and Marrow Transplantation, MD Anderson Cancer Center, SCRB 3 3019, Unit 900, 7455 Fannin St, Houston, TX 77030, USA
    Blood 104:3429-36. 2004
    ..This approach also was applied to specifically enrich or deplete human virus-specific T cells...
  7. doi request reprint Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation
    Yang Wang
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 15:1513-22. 2009
    ..In addition, treatment with lovastatin impaired donor-derived T cell proliferation in vivo. Taken together, these results indicate the important role of lovastatin in the treatment of GVHD...
  8. ncbi request reprint Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes
    Marta Stanzani
    Transplant Immunology Section, Department of Blood and Marrow Transplantation, MD Anderson Cancer Center, SCRB 3 3019, Unit 900, 7455 Fannin St, Houston, TX 77030, USA
    Blood 105:2258-65. 2005
    ..These studies suggest that the production of gliotoxin by AF may constitute an important immunoevasive mechanism that is mediated by direct effects on antigen-presenting cells and both direct and indirect effects on T cells...
  9. ncbi request reprint Double loading of dendritic cell MHC class I and MHC class II with an AML antigen repertoire enhances correlates of T-cell immunity in vitro via amplification of T-cell help
    William K Decker
    Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, Department of Blood and Marrow Transplantation, Box 65, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Vaccine 24:3203-16. 2006
    ..Enhanced recall responses appeared to be influenced by CD40/CD40L signaling, underscoring the importance of T-cell help in the generation and perpetuation of the adaptive immune response...
  10. ncbi request reprint CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans
    Marta Stanzani
    Transplant Immunology Laboratory, MD Anderson Cancer Center, SCRB 3 3019, 7455 Fannin St, Houston, TX 77030, USA
    Blood 103:1140-6. 2004
    ....
  11. ncbi request reprint Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units
    Marcos de Lima
    Department of Blood and Marrow Transplantation, Pathology, and Leukaemia, M D Anderson Cancer Center, Houston, TX 77030, USA
    Br J Haematol 119:773-6. 2002
    ..Triple chimaerism was present from relapse until death due to leukaemia. This approach may potentially improve UCB transplantation outcome for adults lacking a histocompatible donor...
  12. ncbi request reprint Graft-versus-host disease after allogeneic stem cell transplantation: evolving concepts and novel therapies including photopheresis
    Krishna V Komanduri
    Transplant Immunology Section, Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 12:1-6. 2006
    ....
  13. pmc Detection of gliotoxin in experimental and human aspergillosis
    Russell E Lewis
    University of Houston College of Pharmacy 1441 Moursund St 423, Houston, TX 77030, USA
    Infect Immun 73:635-7. 2005
    ..5 +/- 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA...
  14. ncbi request reprint Chronic graft-versus-host disease after allogeneic stem cell transplantation: challenges in prevention, science, and supportive care
    Richard W Joseph
    Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, USA
    J Support Oncol 6:361-72. 2008
    ..The review places particular emphasis on general principles governing the optimal supportive management of cGVHD and examines recent consensus recommendations regarding its diagnosis and management by organ system...
  15. ncbi request reprint Intraarterial platelet infusion for patients with intractable gastrointestinal hemorrhage and severe refractory thrombocytopenia
    David C Madoff
    Division of Diagnostic Imaging, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 325, Houston, Texas 77030 4009, USA
    J Vasc Interv Radiol 15:393-7. 2004
    ..In both patients, after IA platelet infusion, blood product requirements were immediately reduced, bleeding from the GI tract resolved by clinical and laboratory criteria, and no significant bowel ischemia was seen...
  16. ncbi request reprint Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8+ T cells
    Evren Ozdemir
    Transplant Immunology Section, Department of Blood and Marrow Transplantation, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 100:3690-7. 2002
    ..These data suggest that the inability to control CMV reactivation following allogeneic SCT is due to the impaired function of antigen-specific CD8(+) T cells rather than an inability to recover sufficient numbers of CMV-specific T cells...
  17. ncbi request reprint Effects of Aspergillus fumigatus gliotoxin and methylprednisolone on human neutrophils: implications for the pathogenesis of invasive aspergillosis
    Enrico Orciuolo
    Department of Oncology, Transplant and Advances in Medicine, University of Pisa, Italy
    J Leukoc Biol 82:839-48. 2007
    ..Our results suggest that although GT may suppress the adaptive immune response, GT may also serve to increase PMN-mediated inflammation, which is likely to play an important role in tissue destruction in the setting of IA...
  18. pmc Lymphoid reconstruction and vaccines
    Ronald E Gress
    Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Biol Blood Marrow Transplant 13:17-22. 2007
    ..As this review demonstrates, investigators are not limited to being passive observers of this immune reconstitution; rather, we have an opportunity to shape the allografted T cells repertoire to selectively augment immune function...