Hartmuth C Kolb

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint The growing impact of click chemistry on drug discovery
    Hartmuth C Kolb
    The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, SP 227, La Jolla CA 92037, USA
    Drug Discov Today 8:1128-37. 2003
  2. ncbi request reprint In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors
    Antoni Krasinski
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 127:6686-92. 2005
  3. ncbi request reprint Inhibitors of HIV-1 protease by using in situ click chemistry
    Matthew Whiting
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, BCC 315, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 45:1435-9. 2006
  4. ncbi request reprint In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II
    Vani P Mocharla
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, SP 227, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:116-20. 2004
  5. ncbi request reprint In situ click chemistry: enzyme inhibitors made to their own specifications
    Roman Manetsch
    Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:12809-18. 2004
  6. ncbi request reprint "On water": unique reactivity of organic compounds in aqueous suspension
    Sridhar Narayan
    Department of Chemistry and The Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:3275-9. 2005
  7. ncbi request reprint Integrated microfluidics for parallel screening of an in situ click chemistry library
    Jinyi Wang
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 700 Westwood Plaza, Los Angeles, CA 90095, USA
    Angew Chem Int Ed Engl 45:5276-81. 2006

Collaborators

  • Sridhar Narayan
  • PALMER WILLIAM TAYLOR
  • MG FINN
  • K Barry Sharpless
  • Antoni Krasinski
  • Vani P Mocharla
  • Roman Manetsch
  • Matthew Whiting
  • Jinyi Wang
  • Zoran Radic
  • Jessica Raushel
  • John H Elder
  • Hsian Rong Tseng
  • Rachel J Lin
  • John Muldoon
  • Valery V Fokin
  • Arthur J Olson
  • Ying Chuan Lin
  • William Lindstrom
  • Michael E Phelps
  • Steven M Silverman
  • Guodong Sui
  • Benoit Colasson
  • Stefanie Röper
  • Chi Huey Wong
  • Lac V Lee

Detail Information

Publications7

  1. ncbi request reprint The growing impact of click chemistry on drug discovery
    Hartmuth C Kolb
    The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, SP 227, La Jolla CA 92037, USA
    Drug Discov Today 8:1128-37. 2003
    ..The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen bonding and dipole interactions...
  2. ncbi request reprint In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors
    Antoni Krasinski
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 127:6686-92. 2005
    ..Remarkably, despite the high binding affinity, the enzyme displayed a surprisingly low preference for one PIQ enantiomer over the other...
  3. ncbi request reprint Inhibitors of HIV-1 protease by using in situ click chemistry
    Matthew Whiting
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, BCC 315, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 45:1435-9. 2006
  4. ncbi request reprint In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II
    Vani P Mocharla
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, SP 227, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:116-20. 2004
  5. ncbi request reprint In situ click chemistry: enzyme inhibitors made to their own specifications
    Roman Manetsch
    Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:12809-18. 2004
    ..All in situ-generated compounds were extremely potent AChE inhibitors, because of the presence of multiple sites of interaction, which include the newly formed triazole nexus as a significant pharmacophore...
  6. ncbi request reprint "On water": unique reactivity of organic compounds in aqueous suspension
    Sridhar Narayan
    Department of Chemistry and The Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:3275-9. 2005
  7. ncbi request reprint Integrated microfluidics for parallel screening of an in situ click chemistry library
    Jinyi Wang
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 700 Westwood Plaza, Los Angeles, CA 90095, USA
    Angew Chem Int Ed Engl 45:5276-81. 2006