Mei Yee Koh

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Passing the baton: the HIF switch
    Mei Yee Koh
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Trends Biochem Sci 37:364-72. 2012
  2. pmc Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 28:7081-95. 2008
  3. pmc HAF : the new player in oxygen-independent HIF-1alpha degradation
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Cycle 8:1359-66. 2009
  4. pmc The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 71:4015-27. 2011
  5. pmc EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis
    Weiwei Yang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 48:771-84. 2012
  6. pmc Inhibiting the hypoxia response for cancer therapy: the new kid on the block
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 15:5945-6. 2009
  7. doi HIF-1alpha and cancer therapy
    Mei Yee Koh
    Department of Experimental Therapeutics, M D Anderson Cancer Center, Houston, TX 77030, USA
    Recent Results Cancer Res 180:15-34. 2010

Detail Information

Publications7

  1. pmc Passing the baton: the HIF switch
    Mei Yee Koh
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Trends Biochem Sci 37:364-72. 2012
    ..Here, we review the significance of the HIF switch and the relation between HIF-1 and HIF-2 under both physiological and pathophysiological conditions...
  2. pmc Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 28:7081-95. 2008
    ..Therefore, HAF is the key mediator of a new HIF-1alpha-specific degradation pathway that degrades HIF-1alpha through a new, oxygen-independent mechanism...
  3. pmc HAF : the new player in oxygen-independent HIF-1alpha degradation
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Cycle 8:1359-66. 2009
    ..Finally, we review the significance of HAF as an isoform-specific E3 ligase in light of new information on the non-overlapping functions of HIF-1alpha and HIF-2alpha in cancer...
  4. pmc The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 71:4015-27. 2011
    ..Thus, HAF, by causing a switch from a HIF-1α- to HIF-2α-dependent response to hypoxia, provides a mechanism for more aggressive growth of tumors under prolonged hypoxia...
  5. pmc EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis
    Weiwei Yang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 48:771-84. 2012
    ..These findings highlight the distinct regulation of NF-κB by EGF, in contrast to TNF-α, and the importance of the metabolic cooperation between the EGFR and NF-κB pathways in PKM2 upregulation and tumorigenesis...
  6. pmc Inhibiting the hypoxia response for cancer therapy: the new kid on the block
    Mei Yee Koh
    Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 15:5945-6. 2009
    ..Here, we discuss the proposed mechanism of action of KC7F2 and its potential strengths and limitations in comparison with other promising HIF-1alpha inhibitors...
  7. doi HIF-1alpha and cancer therapy
    Mei Yee Koh
    Department of Experimental Therapeutics, M D Anderson Cancer Center, Houston, TX 77030, USA
    Recent Results Cancer Res 180:15-34. 2010
    ..In this chapter, we summarize recent findings regarding the regulation of HIF-1alpha and the progress made in identifying new therapeutic agents that inhibit HIF-1alpha...